Revisiting the role of the insula in addiction.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Trends in Cognitive Sciences

• Publication date

  2015-07-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.tics.2015.05.005PMID 26066588PMCID PMC4486609
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• From affect to control: Functional specialization of the insula in motivation and regulation

  2017cited by this paper
• The insula: a critical neural substrate for craving and drug seeking under conflict and risk

  2014cited by this paper
• Altered cingulate and insular cortex activation during risk-taking in methamphetamine dependence: losses lose impact.

  2014cited by this paper
• Damage to insula abolishes cognitive distortions during simulated gambling

  2014cited by this paper
• Interoception and drug addiction.

  2014cited by this paper
• Current and former methamphetamine-dependent adults show attenuated brain response to pleasant interoceptive stimuli

  2014cited by this paper
• Interactive effects of chronic cigarette smoking and age on brain volumes in controls and alcohol‐dependent individuals in early abstinence

  2014cited by this paper
• You are the danger: attenuated insula response in methamphetamine users during aversive interoceptive decision-making.

  2014cited by this paper
• Striatum and insula dysfunction during reinforcement learning differentiates abstinent and relapsed methamphetamine-dependent individuals.

  2014cited by this paper
• Basal ganglia plus insula damage yields stronger disruption of smoking addiction than basal ganglia damage alone.

  2014cited by this paper
• Cigarette Exposure, Dependence, and Craving Are Related to Insula Thickness in Young Adult Smokers

  2014cited by this paper
• Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence.

  2013cited by this paper
• Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference

  2013cited by this paper
• Power failure: why small sample size undermines the reliability of neuroscience

  2013cited by this paper
• Down-regulation of amygdala and insula functional circuits by varenicline and nicotine in abstinent cigarette smokers.

  2013cited by this paper
• Potential Reporting Bias in fMRI Studies of the Brain

  2013cited by this paper
• Methamphetamine dependent individuals show attenuated brain response to pleasant interoceptive stimuli.

  2013cited by this paper
• Decoding the role of the insula in human cognition: functional parcellation and large-scale reverse inference.

  2013cited by this paper
• Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta‐analysis and systematic review

  2013cited by this paper
• The human insula: Architectonic organization and postmortem MRI registration.

  2013cited by this paper
• Effects of reward and punishment on brain activations associated with inhibitory control in cigarette smokers.

  2013cited by this paper
• Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

  2013cited by this paper
• Probing the Frontostriatal Loops Involved in Executive and Limbic Processing via Interleaved TMS and Functional MRI at Two Prefrontal Locations: A Pilot Study

  2013cited by this paper
• Are there volumetric brain differences associated with the use of cocaine and amphetamine-type stimulants?

  2013cited by this paper
• Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats

  2013cited by this paper
• A neurocognitive approach to understanding the neurobiology of addiction.

  2013cited by this paper
• Insula’s functional connectivity with ventromedial prefrontal cortex mediates the impact of trait alexithymia on state tobacco craving

  2013cited by this paper
• Resting state functional connectivity in addiction: Lessons learned and a road ahead

  2012cited by this paper
• Meta-analytic clustering of the insular cortex: Characterizing the meta-analytic connectivity of the insula when involved in active tasks

  2012cited by this paper
• Reduced grey matter in the posterior insula as a structural vulnerability or diathesis to addiction.

  2012cited by this paper
• A Role for the Insular Cortex in Long-Term Memory for Context-Evoked Drug Craving in Rats

  2012cited by this paper
• The influence of head motion on intrinsic functional connectivity MRI

  2012cited by this paper
• Neural substrates of smoking cue reactivity: A meta-analysis of fMRI studies

  2012cited by this paper
• Smoking Cessation 1 Year Poststroke and Damage to the Insular Cortex

  2012cited by this paper
• Altered prefrontal and insular cortical thickness in adolescent marijuana users.

  2011cited by this paper
• Dynamic Reconfiguration of Structural and Functional Connectivity Across Core Neurocognitive Brain Networks with Development

  2011cited by this paper
• Large-scale automated synthesis of human functional neuroimaging data

  2011cited by this paper
• Reduced striatal volume in cocaine-dependent patients

  2011cited by this paper
• The differences in neural network activity between methamphetamine abusers and healthy subjects performing an emotion‐matching task: functional MRI study

  2011cited by this paper
• Methamphetamine users show greater than normal age-related cortical gray matter loss.

  2011cited by this paper
• Adolescent smokers show decreased brain responses to pleasurable food images compared with nonsmokers.

  2011cited by this paper
• Deconstructing craving: dissociable cortical control of cue reactivity in nicotine addiction.

  2011cited by this paper
• New Findings on Biological Factors Predicting Addiction Relapse Vulnerability

  2011cited by this paper
• Identification of hyperactive intrinsic amygdala network connectivity associated with impulsivity in abstinent heroin addicts.

  2011cited by this paper
• Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence

  2011cited by this paper
• Insular lesions and smoking cessation after first-ever ischemic stroke: a 3-month follow-up.

  2010cited by this paper
• Exploring the brain network: a review on resting-state fMRI functional connectivity.

  2010cited by this paper
• A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis

  2010cited by this paper
• Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity

  2010cited by this paper
• The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making

  2010cited by this paper
• Saliency, switching, attention and control: a network model of insula function

  2010cited by this paper
• Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction.

  2010cited by this paper
• Alterations in brain structure and functional connectivity in prescription opioid-dependent patients.

  2010cited by this paper
• Global and local morphometric differences in recently abstinent methamphetamine-dependent individuals

  2010cited by this paper
• The sentient self

  2010cited by this paper
• Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users

  2010cited by this paper
• The hidden island of addiction: the insula.

  2009cited by this paper
• At the heart of the ventral attention system: The right anterior insula

  2009cited by this paper
• The Iowa Gambling Task in fMRI images

  2009cited by this paper
• Altered impulse control in alcohol dependence: neural measures of stop signal performance.

  2009cited by this paper
• Functional organization of the human anterior insular cortex.

  2009cited by this paper
• Distinct roles of prefrontal cortical subregions in the Iowa Gambling Task.

  2009cited by this paper
• How do you feel — now? The anterior insula and human awareness

  2009cited by this paper
• Value representations in the primate striatum during matching behavior.

  2008cited by this paper
• A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks

  2008cited by this paper
• IMAGING STUDY: Modulation of brain response to emotional images by alcohol cues in alcohol‐dependent patients

  2008cited by this paper
• Damage to the Insula Disrupts Addiction to Cigarette Smoking

  2007cited by this paper
• Inactivation of the Interoceptive Insula Disrupts Drug Craving and Malaise Induced by Lithium

  2007cited by this paper
• A core system for the implementation of task sets.

  2006cited by this paper
• The somatic marker hypothesis: A neural theory of economic decision

  2005cited by this paper
• Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective

  2005cited by this paper
• The neural basis of financial risk taking.

  2005cited by this paper
• Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

  2005cited by this paper
• Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain

  2004cited by this paper
• The Neural Basis of Economic Decision-Making in the Ultimatum Game

  2003cited by this paper
• How do you feel? Interoception: the sense of the physiological condition of the body

  2002cited by this paper
• Pain, temperature, and the sense of the body

  1996cited by this paper

• Patterns of structural brain differences in cocaine use disorder: Integrating multilevel frequentist, Bayesian, and coordinate-based meta-analyses.

  2026cites this paper
• Impact of environmental enrichment on heroin-induced neuroadaptations in the insula, nucleus accumbens and ventral tegmental area.

  2026cites this paper
• Effects of morphine self-administration on brain structure and microglial phenotypic diversity in the absence of neuronal loss in male Wistar rats.

  2026cites this paper
• Psychedelics and substance use disorder treatment.

  2025cites this paper
• Multi-task Intracranial EEG recordings reveal a Comprehensive Role of the Human Dorsal Anterior Insula in High-Level Cognition

  2025cites this paper
• Distinct insula subdivisions of resting-state functional connectivity in individuals with opioid and methamphetamine use disorders.

  2025cites this paper
• Lifespan investigation of brain volumetric changes associated with substance use disorders

  2025cites this paper
• iTRAQ proteomic analysis of the anterior insula in morphine‐induced conditioned place preference rats with high‐frequency deep brain stimulation intervention

  2025cites this paper
• N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder

  2025cites this paper
• Lifespan investigation of brain volumetric changes associated with substance use disorders

  2025cites this paper
• Social support influences effective neural connections during food cue processing and overeating: A bottom-up pathway

  2025cites this paper
• Heterogeneity of human insular cortex: five principles of functional organization across multiple cognitive domains

  2025cites this paper
• How does methamphetamine affect the brain? A systematic review of magnetic resonance imaging studies.

  2025cites this paper
• Abnormal Structural Nodes of the Reward Network Associated with Impulsive Traits in Cannabis Use Disorder.

  2025cites this paper
• Maltreatment effects on cognitive control functional connectivity across adolescence: Prospective links to young adult mental health.

  2025cites this paper
• Heterogeneity of human insular cortex: Five principles of functional organization across multiple cognitive domains

  2025cites this paper
• Let’s focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders

  2024cites this paper
• Altered dynamic functional connectivity of insular subdivisions among male cigarette smokers

  2024cites this paper
• Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

  2024cites this paper
• Clavulanic Acid Decreases Cocaine Cue Reactivity in Addiction-Related Brain Areas, a Randomized fMRI Pilot Study.

  2024cites this paper
• Deficits in proactive avoidance and neural responses to drinking motives in problem drinkers

  2024cites this paper
• The Insular Cortex: An Interface Between Sensation, Emotion and Cognition

  2024cites this paper
• Brain Regions in Adolescents with Non-Suicidal Self-Injury: An ALE Meta-Analysis of fMRI Studies

  2024cites this paper
• D1-Like and D2-Like Dopamine Receptors in the Rat Prefrontal Cortex: Impacts of Genetic Generalized Epilepsies and Social Behavioral Deficits

  2024cites this paper
• Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat.

  2024cites this paper
• Alterations in self-reported sensory gating and interoception in individuals frequently using cannabis

  2024cites this paper
• Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain

  2024cites this paper
• Learning and memory processes in behavioural addiction: A systematic review.

  2024cites this paper
• Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking

  2024cites this paper
• Decoding and modifying dynamic attentional bias in gaming disorder

  2024cites this paper
• Increased ventral anterior insular connectivity to sports betting availability indexes problem gambling

  2024cites this paper
• Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder

  2024cites this paper
• Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat

  2024cites this paper
• Interplay of mindfulness, psychological empowerment and ostracism: an empirical study in the university setting

  2024cites this paper
• Brain mechanisms discriminating enactive mental simulations of running and plogging

  2024cites this paper
• Intrinsic functional and structural network organization in the macaque insula

  2024cites this paper
• Clinical efficacy of deep transcranial magnetic stimulation (dTMS) in psychiatric and cognitive disorders: A systematic review.

  2024cites this paper
• Altered neurobehavioral reward response predicts psychotic-like experiences in youth exposed to cannabis prenatally

  2024cites this paper
• A Region of Interest Analysis Focusing on the Insular and Cingulate Cortices

  2024cites this paper
• Multifaceted Neuroimaging Data Integration via Analysis of Subspaces.

  2024cites this paper
• Altered insular functional activity among electronic cigarettes users with nicotine dependence

  2024cites this paper
• Bilateral insular cortical lesions reduce sensitivity to the adverse consequences of acute ethanol intoxication in Pavlovian conditioning procedures.

  2024cites this paper
• rTMS effects on urges and severity of tobacco use disorder operate independently of a retrieval-extinction component and involve frontal-striatal pathways.

  2024cites this paper
• Engagement for Alcohol Escalates in the 5-Choice Serial Reaction Time Task After Intermittent Access.

  2024cites this paper
• Diet quality, nutritional status and taste recognition are impaired in men with substance use disorder.

  2023cites this paper
• Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.

  2023cites this paper
• Be More Mindful: Targeting Addictive Responses by Integrating Mindfulness with Cognitive Bias Modification or Cue Exposure Interventions.

  2023cites this paper
• Altered neural activity in the reward-related circuit associated with anhedonia in mild to moderate Major Depressive Disorder.

  2023cites this paper
• Connected minds in disconnected bodies: Exploring the role of interoceptive sensibility and alexithymia in problematic use of the internet.

  2023cites this paper
• Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics

  2023cites this paper
• Still a "Hidden Island"? The Rodent Insular Cortex in Drug Seeking, Reward, and Risk.

  2023cites this paper
• The Psychobiology of Problematic Use of Social Media

  2023cites this paper
• Blunted neurobehavioral loss anticipation predicts relapse to stimulant drug use.

  2023cites this paper
• Connecting Circuits with Networks in Addiction Neuroscience: A Salience Network Perspective

  2023cites this paper
• The Role of the Insular Cortex in Pain

  2023cites this paper
• Do mindfulness-based interventions change brain function in people with substance dependence? A systematic review of the fMRI evidence

  2023cites this paper
• Neural correlates of model-based behavior in internet gaming disorder and alcohol use disorder

  2023cites this paper
• Physical Exercise to Redynamize Interoception in Substance use Disorders

  2023cites this paper
• Morphological study of neuropeptide Y expression in human and mouse anterior insular cortex: overexpression in the insular cortex and nucleus accumbens in obese mice on a long-term obesogenic diet.

  2023cites this paper
• The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference

  2023cites this paper
• Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults

  2023cites this paper
• Reduced anterior insular cortex volume in male heroin addicts: a postmortem study

  2023cites this paper
• Disgust sensitivity and behavioural inhibitory systems in binge eating disorder: associations with eating pathology

  2023cites this paper
• Altered Functional Connectivity of the Nucleus Accumbens and Amygdala in Cyber Addiction: A Resting State Functional Magnetic Resonance Imaging Study

  2023cites this paper
• The traps of adaptation: Addiction as maladaptive referent-dependent evaluation

  2023cites this paper
• Early-onset smoking theory of compulsivity development: a neurocognitive model for the development of compulsive tobacco smoking

  2023cites this paper
• Ventromedial frontoinsular connectivity is associated with long-term smoking behavior change in aging

  2023cites this paper
• "Listen to your heart": A novel interoceptive strategy for real-time fMRI neurofeedback training of anterior insula activity

  2023cites this paper
• Opioid withdrawal: role in addiction and neural mechanisms

  2023cites this paper
• Association Between Dispositional Mindfulness, Clinical Characteristics, and Emotion Regulation in Women Entering Substance Use Disorder Treatment: an fMRI Study

  2022cites this paper
• Decreased functional connectivity in salience network is associated with symptom severity in betel quid‐dependent chewers

  2022cites this paper
• Chronic tobacco smoking, impaired reward-based decision-making, and role of insular cortex: A comparison between early-onset smokers and late-onset smokers

  2022cites this paper
• A Review of Functional Brain Differences Predicting Relapse in Substance Use Disorder: Actionable Targets for New Methods of Noninvasive Brain Stimulation.

  2022cites this paper
• Longitudinal resting-state functional connectivity changes in the insular subdivisions of abstinent individuals with opioid use disorder.

  2022influential citation
• Brain recovery of the NAc fibers and prediction of craving changes in person with heroin addiction: A longitudinal study.

  2022cites this paper
• Quantifying GABA in Addiction: A Review of Proton Magnetic Resonance Spectroscopy Studies

  2022cites this paper
• Effects of Persistent Binge Drinking on Brain Structure in Emerging Adults: A Longitudinal Study

  2022cites this paper
• Common and Distinct Neural Correlates of Intertemporal and Risky Decision-Making: Meta-Analytical Evidence for the Dual-System Theory.

  2022cites this paper
• Constructing Craving: Applying the Theory of Constructed Emotion to Urge States

  2022cites this paper
• Reward Processing in Alcohol-Dependent Patients and First-Degree Relatives: Functional Brain Activity During Anticipation of Monetary Gains and Losses.

  2022cites this paper
• Delay discounting and alcohol consumption correlate with dorsal anterior insula activation during choice in nontreatment‐seeking heavy drinkers

  2022cites this paper
• Alcohol use disorder‐associated structural and functional characteristics of the insula

  2022cites this paper
• Effects of baclofen on insular gain anticipation in alcohol-dependent patients — a randomized, placebo-controlled, pharmaco-fMRI pilot trial

  2022cites this paper
• Neurochemical Changes in the Insular Cortex and Anterior Cingulate Cortex in Intact Males and Females of the First Generation of Rats Exposed to Chronic Ethanol Consumption

  2022cites this paper
• Insula lesions reduce stimulus-driven control of behavior during odor-guided decision-making and autoshaping.

  2022cites this paper
• Altered Spontaneous Brain Activity in Betel Quid Dependence Chewers: A Resting-State Functional MRI Study With Percent Amplitude of Fluctuation

  2022cites this paper
• Deep rTMS of the insula and prefrontal cortex in smokers with schizophrenia: Proof-of-concept study

  2022cites this paper
• From a systems view to spotting a hidden island: A narrative review implicating insula function in alcoholism.

  2022cites this paper
• Self-navigating the “Island of Reil”: a systematic review of real-time fMRI neurofeedback training of insula activity

  2022cites this paper
• How distinct functional insular subdivisions mediate interacting neurocognitive systems

  2022cites this paper
• Neural Correlates of Physical Activity Moderate the Association Between Problematic Mobile Phone Use and Psychological Symptoms

  2022cites this paper
• Altered striatal-opercular intrinsic connectivity reflects decreased aversion to losses in alcohol use disorder.

  2022cites this paper
• Translational Structural and Functional Signatures of Chronic Alcohol Effects in Mice.

  2022cites this paper
• The intersection of empathy and addiction.

  2022cites this paper
• To learn or to gain: neural signatures of exploration in human decision-making

  2021cites this paper
• A ilha escondida de Reil: córtex insular e sua participação nas respostas emocionais, vícios e tomadas de decisões

  2021cites this paper
• Toward an Integrative Conceptualization of Maladaptive Consumer Behavior

  2021cites this paper
• A Triple-System Neural Model of Maladaptive Consumption

  2021cites this paper
• Day-to-day opioid withdrawal symptoms, psychological distress, and opioid craving in patients with chronic pain prescribed opioid therapy.

  2021cites this paper
• The relationship between disgust sensitivity and BMI: is the food disgusting or am I?

  2021cites this paper