[Immunodeficiency with hyper-IgM].

Immunodeficiency caused by mutations in the gene encoding the CD40 ligand. It is characterized by decreased levels of IgG, IgA, and IgE, and normal or increased levels of IgM. Patients are at an increased risk of infections and development of malignancies.

• Publication year

  2020

• Venue

  Ryōikibetsu shōkōgun shirīzu

• Publication date

  2020-02-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.32388/adqlzoPMID 9833471
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2000cites this paper
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  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
• Noninfectious immunologic disorders in adults.

  1999cites this paper
• CD40 ligand expression deficiency in a female carrier of the X‐linked hyper‐IgM syndrome as a result of X chromosome lyonization

  1999cites this paper
• Role of CD40 Ligand in Mycobacterium avium Infection

  1999cites this paper
• CD40 Ligand Knockout Mice

  1998cites this paper
• Immunodeficiency with elevated IgM, lymphoid hyperplasia, autoimmune anemia, and thrombocytopenia.

  1998cites this paper
• IL‐10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells

  1998cites this paper
• The hyper-IgM (HIM) syndrome

  1998cites this paper
• Molecular basis for X-linked immunodeficiencies.

  1997cites this paper
• CD40/CD40 ligand interactions in normal, reactive and malignant lympho-hematopoietic tissues.

  1997cites this paper
• In vivo but not in vitro stimulations rescue of the defective class switching to IgG or IgA in B-cells of immunodeficiency with hyper IgM.

  1997cites this paper
• Hyper-IgM syndrome associated with rheumatoid arthritis: report of RA in a patient with primary impaired CD40 pathway.

  1996influential citation
• The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells

  1996cites this paper
• Molecular and genetic basis of X-linked immunodeficiency disorders

  1994cites this paper