Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Nature Immunology

• Publication date

  2003-02-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ni902PMID 12577056
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Immunodeficiency with hyper-IgM].

  2020cited by this paper
• Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

  2003cited by this paper
• Expression of ICOS In Vivo Defines CD4 Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

  2003cited by this paper
• Vulvar squamous cell carcinoma in young women: a clinicopathologic study of 21 cases.

  2002cited by this paper
• ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells

  2002cited by this paper
• Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease.

  2002cited by this paper
• ICOS and CD28 reversely regulate IL‐10 on re‐activation of human effector T cells with mature dendritic cells

  2002cited by this paper
• The right place at the right time: novel B7 family members regulate effector T cell responses.

  2002cited by this paper
• The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses.

  2002cited by this paper
• ICOS is essential for effective T-helper-cell responses

  2001cited by this paper
• ICOS is critical for CD40-mediated antibody class switching

  2001cited by this paper
• Current perspectives on common variable immunodeficiency (CVID)

  2001cited by this paper
• ICOS co-stimulatory receptor is essential for T-cell activation and function

  2001cited by this paper
• B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency: CD27 pathway defects identify subsets of severely immuno-compromised patients.

  2001cited by this paper
• Cutting Edge: Critical Role of Inducible Costimulator in Germinal Center Reactions1

  2001cited by this paper
• The Metabolic and Molecular Bases of Inherited Disease

  2001cited by this paper
• Induction, binding specificity and function of human ICOS

  2000cited by this paper
• Study of the B cell memory compartment in common variable immunodeficiency

  2000cited by this paper
• Impaired up‐regulation of CD86 in B cells of "type A" common variable immunodeficiency patients

  2000cited by this paper
• Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)

  2000cited by this paper
• Defective recruitment and activation of ZAP‐70 in common variable immunodeficiency patients with T cell defects

  2000cited by this paper
• Fine Mapping of IGAD1 in IgA Deficiency and Common Variable Immunodeficiency: Identification and Characterization of Haplotypes Shared by Affected Members of 101 Multiple-Case Families12

  2000cited by this paper
• Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells1

  2000cited by this paper
• Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand

  2000cited by this paper
• ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

  1999cited by this paper
• Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predisposition.

  1999cited by this paper
• Costimulatory regulation of T cell function.

  1999cited by this paper
• B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha.

  1999cited by this paper
• T-cell co-stimulation through B7RP-1 and ICOS

  1999cited by this paper
• ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

  1999cited by this paper
• Common variable immunodeficiency: clinical and immunological features of 248 patients.

  1999cited by this paper
• Primary Immunodeficiency Diseases Report of an IUIS Scientific Committee

  1999cited by this paper
• IL‐10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells

  1998cited by this paper
• Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndrome.

  1998cited by this paper
• Defective integration of activating signals derived from the T cell receptor (TCR) and costimulatory molecules in both CD4+ and CD8+ T lymphocytes of common variable immunodeficiency (CVID) patients

  1997cited by this paper
• Common variable immunodeficiency: how many diseases?

  1997cited by this paper
• Lack of specific antibody response in common variable immunodeficiency (CVID) associated with failure in production of antigen‐specific memory T cells

  1997cited by this paper
• Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3.

  1997cited by this paper
• Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency

  1996cited by this paper
• L‐selectin in patients with common variable immunodeficiency (CVID): a comparative study with normal individuals

  1996cited by this paper
• Ordering of Human Bone Marrow B Lymphocyte Precursors by Single-Cell Polymerase Chain Reaction Analyses of the Rearrangement Status of the Immunoglobulin H and L Chain Gene Loci

  1996cited by this paper
• Evidence for a generalized signaling abnormality in B cells from patients with common variable immunodeficiency.

  1995cited by this paper
• The nature and mechanisms of human gene mutation

  1995cited by this paper
• [Defects in the immunoglobulin producing cells in bone marrow of patients with variable immunodeficiency syndrome].

  1995cited by this paper
• Preclinical studies with the anti-CD19-saporin immunotoxin BU12-SAPORIN for the treatment of human-B-cell tumours.

  1995cited by this paper
• CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.

  1994cited by this paper
• Defective Expression of CD40 Ligand on T Cells Causes “X‐Linked Immunodeficiency with Hyper‐IgM (HIGM1)”

  1994cited by this paper
• Intestinal B cell defects in common variable immunodeficiency

  1994cited by this paper
• Functional abnormalities of CD8+ T cells define a unique subset of patients with common variable immunodeficiency.

  1993cited by this paper
• Possible role of IL‐2 deficiency for hypogammaglobulinaemia in patients with common variable immunodeficiency

  1992cited by this paper
• Immunodeficiency with hyper-IgM (HIM).

  1992cited by this paper
• Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

  1992cited by this paper
• Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C

  1991cited by this paper
• Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2.

  1990cited by this paper
• Optimization of northern analysis by vacuum-blotting, RNA-transfer visualization, and ultraviolet fixation.

  1990cited by this paper
• Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but proliferate normally upon activation by mitogens.

  1989cited by this paper
• Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching

  1986cited by this paper
• Analysis of Human Genetic Linkage

  1985cited by this paper
• International Union of Immunological Societies (IUIS), report-July 1974: Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood

  1975cited by this paper
• J Am Soc Nephrol 13: 1517–1526, 2002 Renal Tubular Epithelial Expression of the Costimulatory Molecule B7RP-1 (Inducible Costimulator Ligand)

  year unknowncited by this paper

• Inducible T‐Cell Co‐Stimulator (ICOS) and ICOS Ligand: Dealing With a Two‐Faced Cancer Immunoregulatory System

  2025cites this paper
• Common Variable Immune Deficiency Disorders (CVID) in the Indigenous Māori of Aotearoa (New Zealand) Are Associated With a High Prevalence of Bronchiectasis and Complete IgA Deficiency

  2025cites this paper
• Novel pathogenic variants in CTLA4 and LRBA immune dysregulation: Reduced CTLA-4 expression with normal expression of co-stimulatory surface molecules.

  2025cites this paper
• TACI and BTK gene analysis in predominantly antibody deficiencies among the primary immunodeficiency disorder patients in Bangladesh

  2025cites this paper
• Clinical, immunological, and genetic landscape of common variable immunodeficiency in Morocco: a nationwide multicenter study

  2025cites this paper
• Ardisia japonica (Thunb.) Blume and Lespedeza cuneata G. Don may treat chronic obstructive pulmonary disease by targeting HK2 and PTAFR

  2025cites this paper
• A Broad Spectrum of Liver Manifestations in Common Variable Immunodeficiency Syndrome—Two Case Reports and a Literature Overview

  2025cites this paper
• Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development

  2024cites this paper
• Inborn errors of immunity in adulthood

  2024cites this paper
• Early Onset Inflammatory Bowel Disease Due to Immunodeficiency as a Result of ICOS Gene Homozygous Mutation

  2024cites this paper
• Using T-Cell Subsets to Better Characterize Immunoresiliency and Immunodeficiency in Patients with Recurrent Infections

  2024cites this paper
• Immune checkpoint modulators in early clinical development for the treatment of type 1 diabetes

  2024cites this paper
• Revealing disease subtypes and heterogeneity in common variable immunodeficiency through transcriptomic analysis

  2024cites this paper
• ICOS agonist vopratelimab modulates follicular helper T cells and improves B cell function in common variable immunodeficiency.

  2024cites this paper
• A novel IKZF1 variant in a family with autosomal dominant CVID: A case for expanding exon coverage in inborn errors of immunity.

  2024cites this paper
• Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

  2024cites this paper
• 2q33 Deletions Underlying Syndromic and Non-syndromic CTLA4 Deficiency

  2024cites this paper
• The rapidly expanding genetic spectrum of Common Variable Immunodeficiency-like disorders.

  2023cites this paper
• Of Mycelium and Men: Inherent Human Susceptibility to Fungal Diseases

  2023cites this paper
• T helper 2 cells in asthma

  2023cites this paper
• The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation

  2023cites this paper
• Inborn errors of human B cell development, differentiation, and function

  2023cites this paper
• The transcription factor Mef2d regulates B:T synapse–dependent GC-TFH differentiation and IL-21–mediated humoral immunity

  2023cites this paper
• Pathologic and molecular insights in nodal T-follicular helper cell lymphomas

  2023cites this paper
• Common Variable Immunodeficiency: A Paradox of Immunodeficiency and Autoimmunity

  2023cites this paper
• Common variable immunodeficiency, cross currents, and prevailing winds

  2023cites this paper
• Recalcitrant Cutaneous Warts in a Family with Inherited ICOS Deficiency.

  2022cites this paper
• Immunophenotypic and functional analysis of lymphocyte subsets in common variable immunodeficiency patients without monogenic defects

  2022cites this paper
• Common Variable Immunodeficiency: More Pathways than Roads to Rome.

  2022cites this paper
• Members of the Regulatory Lymphocyte Club in Common Variable Immunodeficiency

  2022cites this paper
• Immunomodulatory Properties of Immune Checkpoint Inhibitors—More than Boosting T-Cell Responses?

  2022cites this paper
• ICOS Gene Polymorphisms (IVS1 + 173 T/C and c. 1624 C/T) in Primary Sjögren’s Syndrome Patients: Analysis of ICOS Expression

  2022cites this paper
• Autoimmune disorders associated with common variable immunodeficiency: prediction, diagnosis, and treatment

  2022cites this paper
• Non-coding autoimmune risk variant accelerates T peripheral helper cell development via ICOS

  2022cites this paper
• Identification of novel NFKB1 and ICOS frameshift variants in patients with CVID.

  2022cites this paper
• Inducible costimulator ligand (ICOSL) on CD19+ B cells is involved in immunopathological damage of rheumatoid arthritis (RA)

  2022cites this paper
• Inborn errors of immunity associated with defects of self‐tolerance checkpoints: The CD28 family

  2022cites this paper
• Expression of ICOS in the salivary glands of patients with primary Sjogren's syndrome and its molecular mechanism

  2022cites this paper
• ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells

  2022cites this paper
• Leveraging Systems Immunology to Optimize Diagnosis and Treatment of Inborn Errors of Immunity

  2022cites this paper
• Copy Number Analysis in a Large Cohort Suggestive of Inborn Errors of Immunity Indicates a Wide Spectrum of Relevant Chromosomal Losses and Gains

  2022cites this paper
• Inducible Co-Stimulator (ICOS) in transplantation: A review.

  2022cites this paper
• Inborn Errors of Immunity and Cancer

  2021cites this paper
• Specific Immune Response and Cytokine Production in CD70 Deficiency

  2021cites this paper
• The role of ICOS in allergic disease: Positive or Negative?

  2021cites this paper
• Inmunodeficiencia común variable, diagnóstico clínico y de laboratorio y genes más comunes

  2021cites this paper
• Predominantly Antibody Deficiencies

  2021cites this paper
• Immunotherapy With Recombinant Alt a 1 Suppresses Allergic Asthma and Influences T Follicular Cells and Regulatory B Cells in Mice

  2021cites this paper
• Combined T and B Lymphocyte Deficiencies

  2021cites this paper
• [Common variable immunodeficiency disorders: Updated diagnostic criteria and genetics].

  2021cites this paper
• [Autoimmune diseases in patients with common variable immunodeficiency].

  2021cites this paper
• Monogenic Adult-Onset Inborn Errors of Immunity

  2021influential citation
• Perspective: Application of the American College of Medical Genetics Variant Interpretation Criteria to Common Variable Immunodeficiency Disorders

  2021cites this paper
• Role of endocytosis and trans‐endocytosis in ICOS costimulator‐induced downmodulation of the ICOS Ligand

  2021cites this paper
• Primary antibody deficiencies in Turkey: molecular and clinical aspects

  2021cites this paper
• Critical roles of ICOS in controlling Foxp3-expressing T follicular cell subsets during early-stage germinal center reactions

  2021cites this paper
• CTLA4-Ig–Based Bifunctional Costimulation Inhibitor Blocks CD28 and ICOS Signaling to Prevent T Cell Priming and Effector Function

  2021cites this paper
• Pulmonary granulomatosis of genetic origin

  2021cites this paper
• Inborn Error of Immunity: A Journey Through Novel Genes and Clinical Presentation

  2021cites this paper
• ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency.

  2021cites this paper
• Biological Therapy in Primary Sjögren's Syndrome: Effect on Salivary Gland Function and Inflammation

  2021cites this paper
• Autoimmunity in Cellular Immunodeficiencies

  2021cites this paper
• Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity

  2021cites this paper
• The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity

  2021cites this paper
• Gastrointestinal Manifestations of Immunodeficiency

  2021cites this paper
• Common Variable Immunodeficiency-Like Disorders

  2021cites this paper
• Kostimulatorische und -inhibitorische Signale für T-Zellen

  2021cites this paper
• Chronically Activated T-cells Retain Their Inflammatory Properties in Common Variable Immunodeficiency

  2021influential citation
• Microwave ablation induces Th1-type immune response with activation of ICOS pathway in early-stage breast cancer

  2021cites this paper
• Low-dose influenza vaccine Grippol Quadrivalent with adjuvant Polyoxidonium induces a T helper-2 mediated humoral immune response and increases NK cell activity.

  2020cites this paper
• Targeting co-stimulatory molecules in autoimmune disease

  2020cites this paper
• Beyond monogenetic rare variants: tackling the low rate of genetic diagnoses in predominantly antibody deficiency

  2020cites this paper
• Human inborn errors of immunity caused by defects of receptor and proteins of cellular membrane.

  2020cites this paper
• The genetic heterogeneity of common variable immunodeficiency (CVID)

  2020cites this paper
• A rare case of pulmonary disease combining alpha-1-antitrypsin deficiency and common variable immunodeficiency.

  2020cites this paper
• Whole exome sequencing identifies compound heterozygous variants of CR2 gene in monozygotic twin patients with common variable immunodeficiency

  2020cites this paper
• Molecular and cellular mechanisms underlying defective antibody responses

  2020cites this paper
• B Cell Disorders in Children—Part I

  2020cites this paper
• Hypogammaglobulinemia and common variable immune deficiency

  2020cites this paper
• Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

  2020cites this paper
• Primäre Immundefekte und Autoimmunität

  2020cites this paper
• Phenotypically defined subpopulations of circulating follicular helper T cells in common variable immunodeficiency

  2020cites this paper
• ICOS Deficiency

  2020cites this paper
• Non-infectious Complications of Common Variable Immunodeficiency: Updated Clinical Spectrum, Sequelae, and Insights to Pathogenesis

  2020cites this paper
• Defective Bcl‐2 expression in memory B cells from common variable immunodeficiency patients

  2020cites this paper
• Common variable immune deficiency, central diabetes insipidus, and anemia

  2020cites this paper
• ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain

  2020cites this paper
• Immune dysregulation in patients with RAG deficiency and other forms of combined immune deficiency.

  2020cites this paper
• Follicular helper T cells recruit eosinophils into host liver by producing CXCL12 during Schistosoma japonicum infection

  2020cites this paper
• Functions of Tfh Cells in Common Variable Immunodeficiency

  2020cites this paper
• Immunoglobulin Class Switch Recombination Defects

  2020cites this paper
• Heterogeneity of Liver Disease in Common Variable Immunodeficiency Disorders

  2020cites this paper
• A rare case of pulmonary disease combining alpha-1-antitrypsin deficiency and common variable immunodeficiency

  2020cites this paper
• The Immune Dysregulation of Common Variable Immunodeficiency Disorders.

  2020cites this paper
• A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly

  2020cites this paper
• Autoimmunity in Primary Immunodeficiency Disorders

  2020cites this paper
• A Patient with Novel ICOS Mutation Presented with Progressive Loss of B Cells

  2020cites this paper
• Targeting co-stimulatory molecules in autoimmune disease

  2020cites this paper
• Regulatory T cells in patients with early untreated rheumatoid arthritis: Phenotypic changes in the course of methotrexate treatment.

  2020cites this paper
• Class switch recombination defects

  2020cites this paper