Nitrite Regulates Hypoxic Vasodilation via Myoglobin-Dependent Nitric Oxide Generation

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Circulation

• Publication date

  2012-07-17

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1161/CIRCULATIONAHA.111.087155PMID 22685116PMCID PMC3410747
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human Neuroglobin Functions as a Redox-regulated Nitrite Reductase*

  2011cited by this paper
• Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats.

  2011cited by this paper
• Nitrite Potently Inhibits Hypoxic and Inflammatory Pulmonary Arterial Hypertension and Smooth Muscle Proliferation via Xanthine Oxidoreductase–Dependent Nitric Oxide Generation

  2010cited by this paper
• Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice

  2010cited by this paper
• The role of vascular myoglobin in nitrite-mediated blood vessel relaxation

  2010cited by this paper
• Nitrite Therapy After Cardiac Arrest Reduces Reactive Oxygen Species Generation, Improves Cardiac and Neurological Function, and Enhances Survival via Reversible Inhibition of Mitochondrial Complex I

  2009cited by this paper
• Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle.

  2009cited by this paper
• Cytoglobin Is Expressed in the Vasculature and Regulates Cell Respiration and Proliferation via Nitric Oxide Dioxygenation*

  2009cited by this paper
• Nitrite directly vasodilates hypoxic vasculature via nitric oxide‐dependent and ‐independent pathways

  2009cited by this paper
• Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation.

  2009cited by this paper
• Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish

  2009cited by this paper
• Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury

  2008cited by this paper
• Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia: Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase

  2008cited by this paper
• Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans

  2008influential reference
• The functional nitrite reductase activity of the heme-globins.

  2008cited by this paper
• Nitrite Reductase Activity of Cytochrome c*

  2008cited by this paper
• Nitrite Reductase Function of Deoxymyoglobin: Oxygen Sensor and Regulator of Cardiac Energetics and Function

  2007cited by this paper
• Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation

  2007cited by this paper
• Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities.

  2007cited by this paper
• Hemoglobin oxygen fractional saturation regulates nitrite-dependent vasodilation of aortic ring bioassays.

  2007cited by this paper
• Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration

  2007cited by this paper
• Hypoxia-inducible myoglobin expression in nonmuscle tissues.

  2006cited by this paper
• Nitric oxide synthase reduces nitrite to NO under anoxia

  2006cited by this paper
• Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes.

  2006cited by this paper
• Effects of dietary nitrate on blood pressure in healthy volunteers.

  2006cited by this paper
• Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver.

  2005cited by this paper
• Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.

  2005cited by this paper
• Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues

  2005cited by this paper
• Textbook of Medical Physiology

  2005cited by this paper
• Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage.

  2005cited by this paper
• Cellular targets and mechanisms of nitros(yl)ation: An insight into their nature and kinetics in vivo

  2004cited by this paper
• Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

  2003cited by this paper
• Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.

  2003cited by this paper
• Plasma Nitrosothiols Contribute to the Systemic Vasodilator Effects of Intravenously Applied NO: Experimental and Clinical Study on the Fate of NO in Human Blood

  2002cited by this paper
• Chemical nature of nitric oxide storage forms in rat vascular tissue

  2002cited by this paper
• Evidence for in vivo transport of bioactive nitric oxide in human plasma.

  2002cited by this paper
• K(ATP)(+) channels, nitric oxide, and adenosine are not required for local metabolic coronary vasodilation.

  2001cited by this paper
• Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans.

  2000cited by this paper
• Disruption of myoglobin in mice induces multiple compensatory mechanisms.

  1999cited by this paper
• Coronary hemodynamics in endothelial NO synthase knockout mice.

  1998cited by this paper
• Effects of pH on vascular tension: which are the important mechanisms?

  1996cited by this paper
• Acidosis-induced coronary arteriolar dilation is mediated by ATP-sensitive potassium channels in vascular smooth muscle.

  1996cited by this paper
• Enzyme-independent formation of nitric oxide in biological tissues

  1995cited by this paper
• Literature

  1994cited by this paper
• Contribution of prostaglandins in hypoxia-induced vasodilatation in isolated rabbit hearts. Relation to adenosine and KATP channels

  1994cited by this paper
• The L-arginine: nitric oxide pathway.

  1993cited by this paper
• The L-arginine-nitric oxide pathway.

  1993cited by this paper
• Different Mechanisms of Hypoxic Relaxation in Canine Coronary Arteries and Rat Abdominal Aortas

  1992cited by this paper
• Hypoxia-induced change in prostanoids production and coronary flow in isolated rat heart.

  1991cited by this paper
• Hypoxic vasodilatation in isolated, perfused guinea‐pig heart: an analysis of the underlying mechanisms.

  1991cited by this paper
• Canine coronary vasodepressor responses to hypoxia are abolished by 8-phenyltheophylline.

  1989cited by this paper
• Effect of endothelium on basal and on stimulated accumulation and efflux of cyclic GMP in rat isolated aorta

  1989cited by this paper
• Morphological characterization of cultured bovine aortic endothelial cells and the effects of atriopeptin II and sodium nitroprusside on cellular and extracellular accumulation of cyclic GMP.

  1988cited by this paper
• The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia

  1984cited by this paper
• Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

  1981cited by this paper
• Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.

  1981cited by this paper
• N-nitroso compounds

  1981cited by this paper
• Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations.

  1977cited by this paper
• Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs.

  1953cited by this paper
• The Action of Nitrite on Haemoglobin in the Absence of Oxygen

  1937cited by this paper

• Unraveling the General Trend of the Reaction of Nitrite with Diiron(II)-polychalcogenides.

  2025cites this paper
• Promotion of nitric oxide production: mechanisms, strategies, and possibilities

  2025cites this paper
• Targeted treatment for craniopharyngioma

  2025cites this paper
• Reduction of Nitrite to Nitric Oxide by Tetranuclear Iron(II)-Polychalcogenides: Direct Reduction by Iron(II) vs the Reaction of Nitrite with Coordinated Polychalcogenides.

  2025cites this paper
• Hemoglobins in ischemic brain damage: from fetal hemoglobin to neuroglobin

  2025cites this paper
• A Mononitrosyl Diiron(II) Compound Catalyzes the Reduction of Nitrite to Nitric Oxide.

  2025cites this paper
• Nitrate as Warden of Nitric Oxide Homeostasis in Mammals

  2025cites this paper
• Functional Nonheme Diiron(II) Complexes Catalyze the Direct Reduction of Nitrite to Nitric Oxide in Relevance to the Diiron Protein YtfE.

  2025cites this paper
• Thiocarboxylate and Acid Chloride Mediated Generation of Nitric Oxide from a Dinickel(II)-Bis(ONO) Complex Involving the Formation of Perthionitrite and O-Nitrosyl Carboxylate.

  2025cites this paper
• Facilitating Nitrite-Derived S-Nitrosothiol Formation in the Upper Gastrointestinal Tract in the Therapy of Cardiovascular Diseases

  2024cites this paper
• Reduction of Nitrite in an Iron(II)-Nitrito Compound by Thiols and Selenol Produces Dinitrosyl Iron Complexes via an {FeNO}7 Intermediate.

  2024cites this paper
• Inhibitory effects of puerarin on myometrium contraction during rat menstrual cycle and its underlying mechanisms

  2024cites this paper
• Myoglobin deficiency impairs maximal oxygen uptake and exercise performance: a lesson from Mb−/− mice

  2024cites this paper
• Effects of Acute Beetroot Juice Supplementation and Exercise on Cardiovascular Function in Healthy Men in Preliminary Study: A Randomized, Double-Blinded, Placebo-Controlled, and Crossover Trial

  2024cites this paper
• NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer

  2024cites this paper
• Myoglobin Inhibits Breast Cancer Cell Fatty Acid Oxidation and Migration via Heme-dependent Oxidant Production and Not Fatty Acid Binding.

  2024cites this paper
• Myoglobin Inhibits Breast Cancer Cell Fatty Acid Oxidation and Migration via Heme-dependent Oxidant Production and Not Fatty Acid Binding

  2024cites this paper
• A Moonlighting Job for alpha-Globin in Blood Vessels.

  2024cites this paper
• Tyrosine kinase inhibitors and atherosclerosis: A close but complicated relationship.

  2023cites this paper
• Cutaneous melanoma

  2023cites this paper
• Loss of resilience contributes to detrusor underactivity in advanced age

  2023cites this paper
• The Effect of Potassium Nitrate Supplementation on the Force and Properties of Extensor digitorum longus (EDL) Muscles in Mice

  2023cites this paper
• Tissue Perfusion and Diffusion and Cellular Respiration: Transport and Utilization of Oxygen

  2023cites this paper
• Reduction of nitrite to nitric oxide and generation of reactive chalcogen species by mononuclear Fe(II) and Zn(II) complexes of thiolate and selenolate.

  2023cites this paper
• Effects of Life-Long Supplementation of Potassium Nitrate on Male Mice Longevity and Organs Pathology

  2022cites this paper
• Cardiac Effects of BRAF and MEK Inhibitors: Mechanisms and Clinical Management

  2022cites this paper
• A physiologically relevant role for NO stored in vascular smooth muscle cells: A novel theory of vascular NO signaling

  2022cites this paper
• Nitrite Concentration in the Striated Muscles Is Reversely Related to Myoglobin and Mitochondrial Proteins Content in Rats

  2022cites this paper
• Nitric oxide improves regeneration and prevents calcification in bio-hybrid vascular grafts via regulation of vascular stem/progenitor cells.

  2022cites this paper
• Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure

  2021cites this paper
• Pannexin 1 Channels Control the Hemodynamic Response to Hypoxia by Regulating O2-Sensitive Extracellular ATP in Blood.

  2021cites this paper
• Dabrafenib and Trametinib

  2021cites this paper
• The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity.

  2021cites this paper
• The role of globins in cardiovascular physiology.

  2021cites this paper
• Endothelial alpha globin is a nitrite reductase

  2021cites this paper
• Nitric Oxide and Oxidative Stress Changes at Depth in Breath-Hold Diving

  2021cites this paper
• Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase

  2020cites this paper
• Alterations in glutathione, nitric oxide and 3-nitrotyrosine levels following exercise and/or hyperbaric oxygen treatment in mice with diet-induced diabetes

  2020cites this paper
• Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest

  2020cites this paper
• Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases.

  2020cites this paper
• The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway

  2020cites this paper
• Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport

  2020cites this paper
• The reactive species interactome

  2020cites this paper
• Montmorency cherry supplement does not affect aerobic exercise performance in healthy men.

  2020cites this paper
• An emerging perspective on sex differences: Intersecting S-nitrosothiol and aldehyde signaling in the heart

  2020cites this paper
• Structural and functional alterations of nitric oxide synthase 3 due to missense variants associate with high-altitude pulmonary edema through dynamic study

  2020cites this paper
• Pregnant alpha-1-microglobulin (A1M) knockout mice exhibit features of kidney and placental damage, hemodynamic changes and intrauterine growth restriction

  2020cites this paper
• Efectos de la suplementación con zumo de remolacha sobre la respuesta neuromuscular: revisión sistemática (Effect of beet juice supplementation (BJ) on neuromuscular response: a systematic review)

  2020cites this paper
• The role of myoglobin in the evolution of mammalian diving capacity - The August Krogh principle applied in molecular and evolutionary physiology.

  2020cites this paper
• Hypoxia and metabolic inhibitors alter the intracellular ATP:ADP ratio and membrane potential in human coronary artery smooth muscle cells

  2020cites this paper
• The Effect of Nitric Oxide on Remote Ischemic Preconditioning in Renal Ischemia Reperfusion Injury in Rats

  2019influential citation
• The influence of amaranth (Amaranthus hypochondriacus) dietary nitrates on the aerobic capacity of physically active young persons

  2019cites this paper
• The role of gasotransmitters in neonatal physiology.

  2019cites this paper
• Catalase-Like Antioxidant Activity is Unaltered in Hypochlorous Acid Oxidized Horse Heart Myoglobin

  2019cites this paper
• Cardiovascular Adverse Events Associated With BRAF and MEK Inhibitors

  2019cites this paper
• Mechanisms impairing blood pressure responses to nitrite and nitrate.

  2019cites this paper
• Compensatory mechanisms in myoglobin deficient mice preserve NO homeostasis.

  2019cites this paper
• Vascular smooth muscle cell‐specific progerin expression in a mouse model of Hutchinson–Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite

  2019cites this paper
• Sexual dimorphism in the control of skeletal muscle interstitial Po2 of heart failure rats: effects of dietary nitrate supplementation.

  2019cites this paper
• Reciprocal regulation of sulfite oxidation and nitrite reduction by mitochondrial sulfite oxidase.

  2019cites this paper
• Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy.

  2019cites this paper
• Myoglobin as a versatile peroxidase: Implications for a more important role for vertebrate striated muscle in antioxidant defense.

  2019cites this paper
• Myoglobin induces mitochondrial fusion, thereby inhibiting breast cancer cell proliferation

  2019cites this paper
• Nitric oxide application for myocardial protection in coronary artery disease

  2019cites this paper
• Cardiovascular diseases in patients receiving small molecules with anti-vascular endothelial growth factor activity: A meta-analysis of approximately 29,000 cancer patients

  2018cites this paper
• Vasoactivity of nitrite in the iliac artery of the toad Rhinella marina.

  2018cites this paper
• Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase.

  2018cites this paper
• Basic science and nitric oxide: from ischemia-reperfusion injury to red hair, Moyamoya disease, achalasia and intraoperative awareness

  2018cites this paper
• The dichotomous role of H2S in cancer cell biology? Déjà vu all over again.

  2018cites this paper
• Nitric Oxide Signalling in Yeast.

  2018cites this paper
• Die lösliche Guanylatcyclase als mögliches intraerythrozytäres Ziel im systemischen NO-Metabolismus

  2018cites this paper
• Mouse cardiac mitochondria do not separate in subsarcolemmal and interfibrillar subpopulations.

  2018cites this paper
• Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway

  2018influential citation
• Angiotensin-(1-7)-induced Mas receptor activation attenuates atherosclerosis through a nitric oxide-dependent mechanism in apolipoproteinE-KO mice

  2018cites this paper
• Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation

  2018cites this paper
• Nitrite potentiates the vasodilatory signaling of S-nitrosothiols.

  2018cites this paper
• Effect of dietary nitrate supplementation on conduit artery blood flow, muscle oxygenation, and metabolic rate during handgrip exercise.

  2018cites this paper
• Effect of dietary nitrate supplementation on conduit artery blood flow , muscle 1 oxygenation , and metabolic rate during handgrip exercise 2

  2018cites this paper
• Effects of Oral Supplementation With Nitrate-Rich Beetroot Juice in Patients With Pulmonary Arterial Hypertension-Results From BEET-PAH, an Exploratory Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

  2018cites this paper
• Impact of mitochondrial nitrite reductase on hemodynamics and myocardial contractility

  2017cites this paper
• Protection by nitrite against the ischemic effects induced by acute myocardial infarction in mice

  2017cites this paper
• A novel physiological role for cardiac myoglobin in lipid metabolism

  2017cites this paper
• Cytoglobin at the Crossroads of Vascular Remodeling.

  2017cites this paper
• Cardiovascular Adverse Events in Patients With Cancer Treated With Bevacizumab: A Meta‐Analysis of More Than 20 000 Patients

  2017cites this paper
• Cytosolic BNIP3 Dimer Interacts with Mitochondrial BAX Forming Heterodimers in the Mitochondrial Outer Membrane under Basal Conditions

  2017cites this paper
• Update on Nitrite Reduction in Ischemic Disease: Mechanisms and Clinical Translation

  2017cites this paper
• Nanoantibiotics: a new paradigm for the treatment of surgical infection.

  2017cites this paper
• The effect of dietary nitrates on vascular function and exercise capacity in chronic kidney disease

  2017cites this paper
• S-nitrosation of calpains is associated with cardioprotection in myocardial I/R injury.

  2017cites this paper
• Nitrite-Nitric Oxide Signaling and Cardioprotection.

  2017cites this paper
• Nitric oxide release by deoxymyoglobin nitrite reduction during cardiac ischemia: A mathematical model.

  2017influential citation
• Exploring Redox Biology in physiology and disease

  2017cites this paper
• Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

  2017cites this paper
• The Medicinal Chemistry of Nitrite as a Source of Nitric Oxide Signaling.

  2017cites this paper
• Nitric oxide release via oxygen atom transfer from nitrite at copper(ii).

  2017cites this paper
• NOS, NO, and the Red Cell

  2017cites this paper
• Recent insights into nitrite signaling processes in blood

  2017cites this paper
• Heme Protein Metabolism of NO and Nitrite

  2017cites this paper
• The Mitochondrion: A Physiological Target of Nitrite

  2017cites this paper
• Nitrite-Mediated Hypoxic Vasodilation Predicted from Mathematical Modeling and Quantified from in Vivo Studies in Rat Mesentery

  2017cites this paper