Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Industrial Microbiology & Biotechnology

• Publication date

  2013-06-19

• Fields of study

  Biology, Medicine, Chemistry, Engineering

• Identifiers
  DOI 10.1007/s10295-013-1301-7PMID 23779221
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel chemobiosynthetic approach for exclusive production of FK506.

  2012influential reference
• Induction of Holomycin Production and Complex Metabolic Changes by the argR Mutation in Streptomyces clavuligerus NP1

  2012cited by this paper
• Effect of different biosynthetic precursors on the production of nargenicin A1 from metabolically engineered Nocardia sp. CS682.

  2012cited by this paper
• Enhancement of tacrolimus productivity in Streptomyces tsukubaensis by the use of novel precursors for biosynthesis.

  2012cited by this paper
• Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination Systems

  2012cited by this paper
• In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement

  2012cited by this paper
• Metabolic Flux Analysis and Principal Nodes Identification for Daptomycin Production Improvement by Streptomyces roseosporus

  2011cited by this paper
• Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor

  2011cited by this paper
• Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

  2011cited by this paper
• Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

  2011cited by this paper
• Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256

  2011cited by this paper
• The future of industrial antibiotic production: From random mutagenesis to synthetic biology

  2011cited by this paper
• Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis

  2010cited by this paper
• Origin of the Allyl Group in FK506 Biosynthesis*

  2010cited by this paper
• Increased glycopeptide production after overexpression of shikimate pathway genes being part of the balhimycin biosynthetic gene cluster.

  2010cited by this paper
• Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites

  2010cited by this paper
• Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides

  2010cited by this paper
• Generation of high rapamycin producing strain via rational metabolic pathway‐based mutagenesis and further titer improvement with fed‐batch bioprocess optimization

  2010cited by this paper
• In Silico Identification of Gene Amplification Targets for Improvement of Lycopene Production

  2010cited by this paper
• Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

  2009influential reference
• Regulation of tacrolimus production by altering primary source of carbons and amino acids

  2009cited by this paper
• Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering.

  2009cited by this paper
• Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering.

  2008cited by this paper
• Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants

  2008cited by this paper
• Exogenous shikimic acid stimulates rapamycin biosynthesis inStreptomyces hygroscopicus

  2008cited by this paper
• The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.

  2007cited by this paper
• Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli.

  2007cited by this paper
• Roles of rapH and rapG in Positive Regulation of Rapamycin Biosynthesis in Streptomyces hygroscopicus

  2007cited by this paper
• Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster.

  2006cited by this paper
• Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea

  2006cited by this paper
• Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli.

  2005cited by this paper
• Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum.

  2004influential reference
• Biochemical characterization of the SgcA1 alpha-D-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production.

  2004cited by this paper
• Involvement of a Cytochrome P450 Monooxygenase in Thaxtomin A Biosynthesis by Streptomyces acidiscabies

  2002cited by this paper
• Increasing the efficiency of heterologous promoters in actinomycetes.

  2002cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Practical streptomyces genetics

  2000cited by this paper
• Mutational Biosynthesis of Novel Rapamycins by a Strain of Streptomyces hygroscopicus NRRL 5491 Disrupted inrapL, Encoding a Putative Lysine Cyclodeaminase

  1998cited by this paper
• The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.

  1998cited by this paper
• Nutrient effects on FK-506, a new immunosuppressant, production by Streptomyces sp. in a defined medium

  1997cited by this paper
• The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.

  1997cited by this paper
• Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520

  1996influential reference
• Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus

  1995cited by this paper
• FK‐506–A Novel Immunosuppressant

  1993cited by this paper
• The immediate precursor of the nitrogen-containing ring of rapamycin is free pipecolic acid

  1993cited by this paper
• Effect of exogeneous methyl oleate on the time course of some parameters of Streptomyces hygroscopicus NRRL B-1865 culture

  1993cited by this paper
• FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

  1987cited by this paper
• Chorismate Mutase from Streptomyces aureofaciens: a Heat-Stable Enzyme

  1973cited by this paper
• Methods for characterization of Streptomyces species

  1966cited by this paper
• COLORIMETRIC METHOD FOR DETER-MINATION OF SUGAR AND RELATED SUBSTANCE

  1956cited by this paper

• Regulatory orchestration of FK506 biosynthesis in Streptomyces tsukubaensis NRRL 18488 revealed through systematic analysis

  2025cites this paper
• Enhancement of FK520 production in Streptomyces hygroscopicus var. ascomyceticus ATCC 14891 by overexpressing the regulatory gene fkbR2

  2025cites this paper
• Enhancement of tacrolimus production in Streptomyces tsukubaensis by genetic engineering and process optimization

  2025influential citation
• The Immunosuppressant Tacrolimus (FK506) Facing the 21st Century: Past Findings, Present Applications and Future Trends

  2024cites this paper
• Production improvement of FK506 in Streptomyces tsukubaensis by metabolic engineering strategy.

  2023cites this paper
• Progress and challenges in the biofoundry of immunosuppressants: From process to practice

  2022cites this paper
• Recent Advancements on the Synthesis and Biological Significance of Pipecolic Acid and its Derivatives

  2022cites this paper
• Synthetic Biology and Metabolic Engineering in Actinobacteria for Natural Product Production

  2022cites this paper
• Title 1 Combination of Atmospheric and Room Temperature Plasma ( ARTP ) mutagenesis , 2 Genome shuffling and Dimethyl sulfoxide ( DMSO ) feeding to improve FK 506 3 production in Streptomyces tsukubaensis 4

  2021cites this paper
• Combination of atmospheric and room temperature plasma (ARTP) mutagenesis, genome shuffling and dimethyl sulfoxide (DMSO) feeding to improve FK506 production in Streptomyces tsukubaensis

  2021cites this paper
• Optimization of tetramycin production in Streptomyces ahygroscopicus S91

  2021cites this paper
• Improvement of tacrolimus production in Streptomyces tsukubaensis by mutagenesis and optimization of fermentation medium using Plackett–Burman design combined with response surface methodology

  2021cites this paper
• Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus

  2021influential citation
• Comparative metabolomics analysis of amphotericin B high-yield mechanism for metabolic engineering

  2021cites this paper
• Enhanced ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by employing polyhydroxybutyrate as an intracellular carbon reservoir and optimizing carbon addition

  2021cites this paper
• Elevation of FK506 production by regulatory pathway engineering and medium optimization in Streptomyces tsukubaensis

  2021cites this paper
• Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis

  2021cites this paper
• Biosynthetic Potential of Streptomyces Rationalizes Genome-Based Bioprospecting

  2021cites this paper
• Group Contribution as Selection Criteria for Nutrients Fermentation Media in the Production of Tacrolimus

  2021influential citation
• Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties

  2020cites this paper
• Increasing Ascomycin Yield in Streptomyces Hygroscopicus var. Ascomyceticus by Using Polyhydroxybutyrate as an Intracellular Carbon Supply Station

  2020cites this paper
• Bioengineering of Anti‐Inflammatory Natural Products

  2020cites this paper
• The Onset of Tacrolimus Biosynthesis in Streptomyces tsukubaensis Is Dependent on the Intracellular Redox Status

  2020influential citation
• Characterization and directed evolution of propionyl-CoA carboxylase and its application in succinate biosynthetic pathway with two CO2 fixation reactions.

  2020cites this paper
• Amphotericin B biosynthesis in Streptomyces nodosus: quantitative analysis of metabolism via LC–MS/MS based metabolomics for rational design

  2020cites this paper
• Evaluation of carbon:nitrogen ratio in semi-defined culture medium to tacrolimus biosynthesis by Streptomyces tsukubaensis and the effect on bacterial growth

  2020cites this paper
• Mutasynthesis for Natural Product Bioengineering

  2019cites this paper
• Enhanced production of individual ganoderic acids by integrating Vitreoscilla haemoglobin expression and calcium ion induction in liquid static cultures of Ganoderma lingzhi

  2019influential citation
• Enhancing the production of tacrolimus by engineering target genes identified in important primary and secondary metabolic pathways and feeding exogenous precursors

  2019cites this paper
• Identification of the regulon FkbN for ascomycin biosynthesis and its interspecies conservation analysis as LAL family regulator

  2019cites this paper
• Analysis and validation of the pho regulon in the tacrolimus-producer strain Streptomyces tsukubaensis: differences with the model organism Streptomyces coelicolor

  2018cites this paper
• Manipulating the expression of SARP family regulator BulZ and its target gene product to increase tacrolimus production

  2018cites this paper
• Genome‐Scale Metabolic Reconstruction of Actinomycetes for Antibiotics Production

  2018cites this paper
• Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches

  2018influential citation
• How Chorismatases Regulate Distinct Reaction Channels in a Single Conserved Active Pocket: Mechanistic Analysis with QM/MM (ONIOM) Investigations.

  2018cites this paper
• Identification and metabolomic analysis of chemical elicitors for tacrolimus accumulation in Streptomyces tsukubaensis

  2018cites this paper
• Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus

  2017cites this paper
• A genome-scale dynamic flux balance analysis model of Streptomyces tsukubaensis NRRL18488 to predict the targets for increasing FK506 production

  2017cites this paper
• Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings

  2017cites this paper
• Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics

  2017cites this paper
• dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome

  2017cites this paper
• Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil

  2017cites this paper
• Enhancement of rapamycin production by metabolic engineering in Streptomyces hygroscopicus based on genome-scale metabolic model

  2017cites this paper
• Improving Production of Tacrolimus In Streptomyces Tacrolimicus (ATCC 55098) Through Development of Novel Mutant by Dual Mutagenesis

  2017cites this paper
• Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4′-OH)MeLeu]4-CsA overproduction

  2017cites this paper
• Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

  2017cites this paper
• Metabolic Engineering for Production of Small Molecule Drugs: Challenges and Solutions

  2016cites this paper
• Metabolic engineering of natural product biosynthesis in actinobacteria.

  2016influential citation
• Improvement of FK506 production by synthetic biology approaches

  2016influential citation
• Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus

  2016cites this paper
• FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19

  2016cites this paper
• The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects

  2016cites this paper
• The impacto of the oxidative stress response on tacrolimus production by S. Tsukubaensis NRRL 18488

  2015cites this paper
• Use of three-carbon chain compounds as biosynthesis precursors to enhance tacrolimus production in Streptomyces tsukubaensis.

  2015cites this paper
• Increased valinomycin production in mutants of Streptomyces sp. M10 defective in bafilomycin biosynthesis and branched-chain α-keto acid dehydrogenase complex expression

  2015cites this paper
• Identification of the Lomofungin Biosynthesis Gene Cluster and Associated Flavin-Dependent Monooxygenase Gene in Streptomyces lomondensis S015

  2015cites this paper
• Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes.

  2015cites this paper
• Biosynthetic Modularity Rules in the Bisintercalator Family of Antitumor Compounds

  2014cites this paper
• Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies

  2014cites this paper
• Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506)

  2013influential citation