Roles of rapH and rapG in Positive Regulation of Rapamycin Biosynthesis in Streptomyces hygroscopicus

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Bacteriology

• Publication date

  2007-04-27

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/JB.00129-07PMID 17468238PMCID PMC1913445
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapamycin biosynthesis: Elucidation of gene product function.

  2006cited by this paper
• Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.

  2005cited by this paper
• A New Modular Polyketide Synthase in the Erythromycin Producer Saccharopolyspora erythraea

  2005cited by this paper
• mTOR-targeted therapy of cancer with rapamycin derivatives.

  2005cited by this paper
• Insights into the Biosynthesis of the Benzoquinone Ansamycins Geldanamycin and Herbimycin, Obtained by Gene Sequencing and Disruption

  2005cited by this paper
• Regulation of secondary metabolism in streptomycetes.

  2005cited by this paper
• Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.

  2004cited by this paper
• Modulation of AraC family member activity by protein ligands

  2004cited by this paper
• In Vivo Analysis of the Regulatory Genes in the Nystatin Biosynthetic Gene Cluster of Streptomyces noursei ATCC 11455 Reveals Their Differential Control Over Antibiotic Biosynthesis

  2004cited by this paper
• Strain improvement for fermentation and biocatalysis processes by genetic engineering technology

  2004cited by this paper
• Positive control of tylosin biosynthesis: pivotal role of TylR

  2004cited by this paper
• Hereditary Pancreatic Endocrine Tumours

  2004cited by this paper
• Rapamycins: Mechanisms of Action and Cellular Resistance

  2003cited by this paper
• Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

  2003cited by this paper
• Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

  2003cited by this paper
• Integration Site for Streptomyces Phage φBT1 and Development of Site-Specific Integrating Vectors

  2003cited by this paper
• Structural Model of MalK, the ABC Subunit of the Maltose Transporter of Escherichia coli

  2002cited by this paper
• Differential roles of two SARP‐encoding regulatory genes during tylosin biosynthesis

  2002cited by this paper
• Increasing the efficiency of heterologous promoters in actinomycetes.

  2002cited by this paper
• Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae

  2002cited by this paper
• Identification and cloning of a type III polyketide synthase required for diffusible pigment biosynthesis in Saccharopolyspora erythraea ‡

  2002cited by this paper
• Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

  2002cited by this paper
• Parallel pathways for oxidation of 14‐membered polyketide macrolactones in Saccharopolyspora erythraea

  2002cited by this paper
• Type III secretion chaperone‐dependent regulation: activation of virulence genes by SicA and InvF in Salmonella typhimurium

  2001cited by this paper
• Mechanisms of resistance to rapamycins.

  2001cited by this paper
• Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway ofStreptomyces venezuelae

  2001cited by this paper
• The AraC transcriptional activators.

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway of Streptomyces venezuelae

  2001cited by this paper
• Leafy Gall Formation Is Controlled byfasR, an AraC-Type Regulatory Gene inRhodococcus fascians

  2000cited by this paper
• The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

  2000cited by this paper
• Practical streptomyces genetics

  2000cited by this paper
• Green fluorescent protein as a reporter for spatial and temporal gene expression in Streptomyces coelicolor A3(2).

  1999cited by this paper
• Organization and Control of the Tylosin-Biosynthetic Genes of Streptomyces fradiae

  1999cited by this paper
• A subfamily of MalT-related ATP-dependent regulators in the LuxR family.

  1999cited by this paper
• Characterization of Binding Sequences for Butyrolactone Autoregulator Receptors in Streptomycetes

  1999cited by this paper
• Evidence that the Extracytoplasmic Function Sigma Factor ςE Is Required for Normal Cell Wall Structure in Streptomyces coelicolor A3(2)

  1999cited by this paper
• A subfamily of MalT-related ATP-dependent regulators in the LuxR family.

  1999cited by this paper
• Mutational Biosynthesis of Novel Rapamycins by a Strain of Streptomyces hygroscopicus NRRL 5491 Disrupted inrapL, Encoding a Putative Lysine Cyclodeaminase

  1998influential reference
• The ABC maltose transporter

  1998cited by this paper
• Arm-domain interactions in AraC.

  1998cited by this paper
• 2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression.

  1997cited by this paper
• A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR‐like DNA‐binding fold

  1997cited by this paper
• Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.

  1996cited by this paper
• Transcriptional regulation of the Rhodococcus rhodochrous J1 nitA gene encoding a nitrilase.

  1996cited by this paper
• The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

  1995cited by this paper
• Accumulation of bldA-specified tRNA is temporally regulated in Streptomyces coelicolor A3(2)

  1993influential reference
• Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

  1992cited by this paper
• Identification of Streptomyces coelicolor genes involved in regulation of antibiotic synthesis.

  1992cited by this paper
• Action of CAP on the malT promoter in vitro

  1983cited by this paper
• Methods for characterization of Streptomyces species

  1966cited by this paper

• Reporter systems in actinomycetes: Versatile tools for natural product discovery and production.

  2026cites this paper
• Rapamycin Plays a Pivotal Role in the Potent Antifungal Activity Exhibited Against Verticillium dahliae by Streptomyces iranensis OE54 and Streptomyces lacaronensis sp. nov. Isolated from Olive Roots

  2025cites this paper
• Targeted genome mining for natural product discovery.

  2025cites this paper
• Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases.

  2025cites this paper
• Enhancement of FK520 production in Streptomyces hygroscopicus var. ascomyceticus ATCC 14891 by overexpressing the regulatory gene fkbR2

  2025cites this paper
• Transcriptional regulators of secondary metabolite biosynthesis in Streptomyces

  2024cites this paper
• Formulation of cost-effective medium and optimization studies for enhanced production of rapamycin

  2023cites this paper
• Development of a CRISPR/Cas9D10A Nickase (nCas9)-Mediated Genome Editing Tool in Streptomyces.

  2023cites this paper
• Molecular and therapeutic insights of rapamycin: a multi-faceted drug from Streptomyces hygroscopicus

  2023cites this paper
• Crossregulation of rapamycin and elaiophylin biosynthesis by RapH in Streptomyces rapamycinicus

  2022influential citation
• Impact of novel microbial secondary metabolites on the pharma industry

  2022cites this paper
• Recent Advances in Construction of the Efficient Producers of Riboflavin and Flavin Nucleotides (FMN, FAD) in the Yeast Candida famata.

  2021cites this paper
• FACTORS AFFECTING RAPAMYCIN (SIROLIMUS) PRODUCTION-A REVIEW

  2021cites this paper
• Bifurcation drives the evolution of assembly-line biosynthesis

  2021cites this paper
• Streptomyces: host for refactoring of diverse bioactive secondary metabolites

  2021cites this paper
• Combining transposon mutagenesis and reporter genes to identify novel regulators of the topA promoter in Streptomyces

  2021cites this paper
• Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

  2021cites this paper
• Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium Streptomyces lohii

  2021cites this paper
• The Application of Regulatory Cascades in Streptomyces: Yield Enhancement and Metabolite Mining

  2020cites this paper
• Reconstitution of a mini‐gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus

  2020cites this paper
• Microbial Production of Antibiotics Using Metabolic Engineering

  2020cites this paper
• In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

  2020cites this paper
• Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in Streptomyces

  2020cites this paper
• Engineering of Microbial Biosynthetic Pathways

  2020cites this paper
• Antibiotic drug discovery: Challenges and perspectives in the light of emerging antibiotic resistance.

  2020cites this paper
• Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in industrial Streptomyces

  2020cites this paper
• Improved production of antifungal angucycline Sch47554 by manipulating three regulatory genes in Streptomyces sp. SCC‐2136

  2019cites this paper
• Construction and application of a “superplasmid” for enhanced production of antibiotics

  2019cites this paper
• Important role of a LAL regulator StaR in the staurosporine biosynthesis and high-production of Streptomyces fradiae CGMCC 4.576

  2019cites this paper
• Identification of the regulon FkbN for ascomycin biosynthesis and its interspecies conservation analysis as LAL family regulator

  2019cites this paper
• The Continuous Story of the Miraculous Drug, Rapamycin

  2019cites this paper
• Dissolution of the Disparate: Co-ordinate Regulation in Antibiotic Biosynthesis

  2019cites this paper
• A Review of the Microbial Production of Bioactive Natural Products and Biologics

  2019cites this paper
• Exploring the Capacity of Bacteria for Natural Product Biosynthesis

  2019influential citation
• LmbU, a Cluster-Situated Regulator for Lincomycin, Consists of a DNA-Binding Domain, an Auto-Inhibitory Domain, and Forms Homodimer

  2019cites this paper
• Current Update on Rapamycin Production and its Potential Clinical Implications

  2019cites this paper
• Characterization of a LAL-type regulator NemR in nemadectin biosynthesis and its application for increasing nemadectin production in Streptomyces cyaneogriseus

  2019cites this paper
• Biosynthesis of Quinolidomicin, the Largest Known Macrolide of Terrestrial Origin: Identification and Heterologous Expression of a Biosynthetic Gene Cluster over 200 kb.

  2018cites this paper
• Advancement of Biotechnology by Genetic Modifications.

  2018cites this paper
• Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges

  2018cites this paper
• Discovery of the actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin

  2018cites this paper
• Discovery of novel bioactive natural products driven by genome mining.

  2018cites this paper
• Uncovering the unexplored diversity of thioamidated ribosomal peptides in Actinobacteria using the RiPPER genome mining tool

  2018cites this paper
• Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces

  2017cites this paper
• Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics

  2017cites this paper
• An overview of rapamycin: from discovery to future perspectives

  2017influential citation
• Enhancement of rapamycin production by metabolic engineering in Streptomyces hygroscopicus based on genome-scale metabolic model

  2017cites this paper
• Approaches towards the enhanced production of Rapamycin by Streptomyces hygroscopicus MTCC 4003 through mutagenesis and optimization of process parameters by Taguchi orthogonal array methodology

  2017cites this paper
• Approaches towards the enhanced production of Rapamycin by Streptomyces hygroscopicus MTCC 4003 through mutagenesis and optimization of process parameters by Taguchi orthogonal array methodology

  2017cites this paper
• SlnR is a positive pathway-specific regulator for salinomycin biosynthesis in Streptomyces albus

  2017cites this paper
• Regulation of Secondary Metabolites of Actinobacteria

  2017cites this paper
• Engineering microbial hosts for production of bacterial natural products.

  2016cites this paper
• Characterization of three positive regulators for tetramycin biosynthesis in Streptomyces ahygroscopicus.

  2016cites this paper
• Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster

  2016cites this paper
• Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.

  2016cites this paper
• SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development

  2016cites this paper
• Immunosuppressants: Remarkable Microbial Products

  2015cites this paper
• An overview on transcriptional regulators in Streptomyces.

  2015influential citation
• Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727

  2015cites this paper
• Comparative analysis of rapamycin biosynthesis clusters between Actinoplanes sp. N902-109 and Streptomyces hygroscopicus ATCC29253.

  2015cites this paper
• Identification of AstG1, A LAL Family Regulator that Positively Controls Ansatrienins Production in Streptomyces sp. XZQH13

  2015cites this paper
• Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin by Streptomyces globisporus

  2015cites this paper
• The impacto of the oxidative stress response on tacrolimus production by S. Tsukubaensis NRRL 18488

  2015cites this paper
• Characterization of negative regulatory genes for the biosynthesis of rapamycin in Streptomyces rapamycinicus and its application for improved production

  2014cites this paper
• Genome mining of Streptomyces ambofaciens

  2014cites this paper
• Studies on process optimization methods for rapamycin production using Streptomyces hygroscopicus ATCC 29253

  2014cites this paper
• Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes.

  2013cites this paper
• Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506)

  2013cites this paper
• Exploring and Exploiting Gene Networks That Regulate Natural Products Biosynthesis in Actinobacteria

  2013cites this paper
• Identification and Characterization of the Cuevaene A Biosynthetic Gene Cluster in Streptomyces sp. LZ35

  2013cites this paper
• SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea

  2013cites this paper
• Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies

  2013cites this paper
• Precursor engineering and cell physiological regulation for high level rapamycin production by Streptomyces hygroscopicus

  2013cites this paper
• FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

  2012influential citation
• Essential role of genetics in the advancement of biotechnology.

  2012cites this paper
• Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.

  2012cites this paper
• Waking up Streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors.

  2012cites this paper
• Roles of fkbN in Positive Regulation and tcs7 in Negative Regulation of FK506 Biosynthesis in Streptomyces sp. Strain KCTC 11604BP

  2012cites this paper
• Cascades and networks of regulatory genes that control antibiotic biosynthesis.

  2012cites this paper
• Streptomyces temperate bacteriophage integration systems for stable genetic engineering of actinomycetes (and other organisms)

  2012cites this paper
• Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

  2011cites this paper
• Metabolic engineering and classic selection of the yeast Candida famata (Candida flareri) for construction of strains with enhanced riboflavin production.

  2011cites this paper
• Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

  2011cites this paper
• A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253

  2011influential citation
• Enhanced rapamycin production in Streptomyces hygroscopicus by integrative expression of aveR, a LAL family transcriptional regulator

  2011influential citation
• Molecular insights on the biosynthesis of antitumour compounds by actinomycetes

  2011cites this paper
• Discovering Metabolic Products of Cryptic Biosynthetic Pathways

  2011cites this paper
• Robust reporter system based on chalcone synthase rppA gene from Saccharopolyspora erythraea.

  2010cites this paper
• Identification of three positive regulators in the geldanamycin PKS gene cluster of Streptomyces hygroscopicus JCM4427.

  2010cites this paper
• Biosynthesis of rapamycin and its regulation: past achievements and recent progress

  2010cites this paper
• Activation of a silent type I polyketide synthase gene cluster in Streptomyces ambofaciens ATCC23877 : isolation and characterization of a novel giant macrolide

  2010cites this paper
• A DNA-binding factor, ArfA, interacts with the bldH promoter and affects undecylprodigiosin production in Streptomyces lividans.

  2009cites this paper
• Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis

  2009cites this paper
• Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs.

  2009cites this paper
• Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027

  2009cites this paper
• Regulatory Elements in Tetracycline-Encoding Gene Clusters: the otcG Gene Positively Regulates the Production of Oxytetracycline in Streptomyces rimosus

  2009cites this paper
• Enhanced Heterologous Production of Desosaminyl Macrolides and Their Hydroxylated Derivatives by Overexpression of the pikD Regulatory Gene in Streptomyces venezuelae

  2008cites this paper
• A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea

  2008cites this paper
• Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering.

  2008cites this paper
• Organization of the Biosynthetic Gene Cluster for the Polyketide Antitumor Macrolide, Pladienolide, in Streptomyces platensis Mer-11107

  2008cites this paper