Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2011-01-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1015125108PMID 21217057PMCID PMC3029719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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• STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.

  2009cited by this paper
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• Linking folding and binding.

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• STIM1 is a calcium sensor specialized for digital signaling.

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• STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

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  2008cited by this paper
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  2008cited by this paper
• Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

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• Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2.

  2008cited by this paper
• Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation*

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• Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

  2008influential reference
• Free-energy linkage between folding and calcium binding in EF-hand proteins.

  2008influential reference
• Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion

  2007cited by this paper
• STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels.

  2007cited by this paper
• Stored Ca 2 Depletion-induced Oligomerization of Stromal Interaction Molecule 1 ( STIM 1 ) via the EF-SAM Region AN INITIATION MECHANISM FOR CAPACITIVE Ca 2 ENTRY *

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• Orai1 is an essential pore subunit of the CRAC channel

  2006cited by this paper
• Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

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• CRACM1 multimers form the ion-selective pore of the CRAC channel.

  2006cited by this paper
• Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

  2006cited by this paper
• Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum

  2006cited by this paper
• CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca2+ Entry

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• STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels

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• Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

  2006cited by this paper
• Stored Ca2+ Depletion-induced Oligomerization of Stromal Interaction Molecule 1 (STIM1) via the EF-SAM Region

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• The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions

  2006cited by this paper
• STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.

  2005cited by this paper
• STIM1, an essential and conserved component of store-operated Ca2+ channel function

  2005cited by this paper
• The Many Faces of SAM

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• STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

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  1986cited by this paper

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• STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling

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• Viral subversion of host cell Ca²⁺ signaling through STIM1-Orai1-mediated SOCE: mechanisms and implications.

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• 3,3'-Diindolylmethane inhibits the proliferation of esophageal squamous cell carcinoma cells via downregulation of STIM1

  2024cites this paper
• STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated Ca2+ entry and mitochondrial Ca2+ homeostasis in cardiomyocytes.

  2024cites this paper
• A Deep Dive into the N-Terminus of STIM Proteins: Structure–Function Analysis and Evolutionary Significance of the Functional Domains

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• Activation mechanisms and structural dynamics of STIM proteins

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• Regulatory mechanisms controlling store-operated calcium entry

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• Differential Expression of Genes Regulating Store-operated Calcium Entry in Conjunction With Mitochondrial Dynamics as Potential Biomarkers for Cancer: A Single-Cell RNA Analysis

  2022cites this paper
• STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases

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• The Role of Lipids in CRAC Channel Function

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• Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions

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• Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth

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• Metastasis enhancer PGRMC1 boosts store-operated Ca2+ entry by uncoiling Ca2+ sensor STIM1 for focal adhesion turnover and actomyosin formation.

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• Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer’s Disease

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  2020cites this paper
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  2020cites this paper
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