Involvement of 5-HT1A Receptors in Homeostatic and Stress-Induced Adaptive Regulations of Paradoxical Sleep: Studies in 5-HT1A Knock-Out Mice

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Neuroscience

• Publication date

  2002-06-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1523/JNEUROSCI.22-11-04686.2002PMID 12040075PMCID PMC6758830
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The influence of ipsapirone, a 5-HT1A agonist, on sleep patterns of healthy subjects

  2005cited by this paper
• Detection of the release of 5-hydroxyindole compounds in the hypothalamus and the n. raphe dorsalis throughout the sleep-waking cycle and during stressful situations in the rat: a polygraphic and voltammetric approach

  2004cited by this paper
• Serotonin and sleep.

  2002cited by this paper
• Regional patterns of compensation following genetic deletion of either 5-hydroxytryptamine(1A) or 5-hydroxytryptamine(1B) receptor in the mouse.

  2001cited by this paper
• Restraint increases prolactin and REM sleep in C57BL/6J mice but not in BALB/cJ mice.

  2001cited by this paper
• Role of dorsal raphe neurons in paradoxical sleep generation in the cat: no evidence for a serotonergic mechanism

  2001influential reference
• Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal

  2001cited by this paper
• Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.

  2000influential reference
• Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT(7) receptor.

  2000cited by this paper
• Serotonin type-1A receptor imaging in depression.

  2000cited by this paper
• Serotonin and the sleep/wake cycle: special emphasis on microdialysis studies.

  2000cited by this paper
• Somatodendritic localization of 5‐HT1A and preterminal axonal localization of 5‐HT1B serotonin receptors in adult rat brain

  2000cited by this paper
• Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist

  2000cited by this paper
• Effect of electric foot shocks, immobilization, and corticosterone administration on the sleep-wake pattern in the rat.

  2000influential reference
• Influence of stress duration on the sleep rebound induced by immobilization in the rat: a possible role for corticosterone.

  1999influential reference
• Altered Emotional States in Knockout Mice Lacking 5-HT1A or 5-HT1B Receptors

  1999cited by this paper
• Key Role of 5-HT1B Receptors in the Regulation of Paradoxical Sleep as Evidenced in 5-HT1B Knock-Out Mice

  1999cited by this paper
• Behavioral State Control through Differential Serotonergic Inhibition in the Mesopontine Cholinergic Nuclei: A Simultaneous Unit Recording and Microdialysis Study

  1998cited by this paper
• Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.

  1998cited by this paper
• Effects of adrenalectomy and subsequent corticosterone replacement on rat sleep state and EEG power spectra.

  1998cited by this paper
• Homeostatic regulation of REM sleep in humans during extended sleep.

  1998influential reference
• Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.

  1998cited by this paper
• What do the mushroom bodies do for the insect brain? an introduction.

  1998cited by this paper
• Involvement of stress in the sleep rebound mechanism induced by sleep deprivation in the rat: use of alpha-helical CRH(9—41)

  1998cited by this paper
• Are sleep disturbances risk factors for anxiety, depressive and addictive disorders?

  1998cited by this paper
• Are sleep disturbances risk factors for anxiety, depressive and addictive disorders?

  1998influential reference
• Increased anxiety of mice lacking the serotonin1A receptor.

  1998cited by this paper
• Involvement of stress in the sleep rebound mechanism induced by sleep deprivation in the rat: use of alpha-helical CRH(9—41)

  1998cited by this paper
• Anxiety and increased aggression as pacemakers of depression.

  1998influential reference
• Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice

  1997cited by this paper
• Sleep/waking effects of a selective 5-HT1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats.

  1997cited by this paper
• Serotonin at the Laterodorsal Tegmental Nucleus Suppresses Rapid-Eye-Movement Sleep in Freely Behaving Rats

  1997cited by this paper
• Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

  1996cited by this paper
• Immunocytochemical localization of serotonin1A receptors in the rat central nervous system

  1996cited by this paper
• Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat

  1996cited by this paper
• Role of the locus coeruleus in the sleep rebound following two different sleep deprivation methods in the rat.

  1996influential reference
• Noradrenergic activity in rat brain during rapid eye movement sleep deprivation and rebound sleep.

  1995cited by this paper
• Evidence for a sleep-promoting influence of stress.

  1995influential reference
• Sleep increase after immobilization stress: role of the noradrenergic locus coeruleus system in the rat.

  1995cited by this paper
• International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

  1994cited by this paper
• Central administration of two 5-HT receptor agonists: effect on REM sleep initiation and PGO waves.

  1994influential reference
• Serotonergic synaptic input to cholinergic neurons in the rat mesopontine tegmentum.

  1994cited by this paper
• Dose-Related Suppression of REM Sleep and PGO Waves by the Serotonin-1 Agonist Eltoprazine

  1993cited by this paper
• Effects of ipsapirone, a 5‐HT1A agonist, on sleep/wakefulness cycles: probable post‐synaptic action

  1993cited by this paper
• 5-HT1-like receptor agonists enhance wakefulness.

  1992cited by this paper
• Dose‐dependent effects of the 5‐HT1A receptor agonist 8‐OH‐DPAT on sleep and wakefulness in the rat

  1992cited by this paper
• Neurobiological structure of the revised limit cycle reciprocal interaction model of REM cycle control

  1992cited by this paper
• Effects induced by the electrical stimulation of the nucleus raphe dorsalis upon hypothalamic release of 5-hydroxyindole compounds and sleep parameters in the rat.

  1991cited by this paper
• Direct Immunohistochemical Evidence of the Existence of 5‐HT1A Autoreceptors on Serotoninergic Neurons in the Midbrain Raphe Nuclei

  1990cited by this paper
• Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats

  1986cited by this paper
• Presence of a paradoxical sleep (PS) factor in the cerebrospinal fluid of PS-deprived rats.

  1984cited by this paper
• Serotoninergic mechanisms and sleep rebound.

  1983influential reference
• REM latency: a psychobiologic marker for primary depressive disease.

  1976influential reference

• Insomnia treatment based on the regulation of the GABAergic system: traditional Chinese medicine perspectives and therapeutic approaches

  2026cites this paper
• Optimizing Sleep in Athletes: The Potential of α-Lactalbumin in Nutrition Intervention

  2025cites this paper
• 5-Hydroxytryptamine receptors in GtoPdb v.2025.1

  2025cites this paper
• 5-Hydroxytryptamine receptors in GtoPdb v.2025.3

  2025cites this paper
• Acupuncture in circadian rhythm sleep–wake disorders and its potential neurochemical mechanisms

  2024cites this paper
• Regulation of stress-induced sleep perturbations by dorsal raphe VGLUT3 neurons in male mice.

  2024cites this paper
• Heukharang lettuce (Lactuca sativa L.) leaf extract displays sleep-promoting effects through GABAA receptor.

  2023cites this paper
• 5-Hydroxytryptamine receptors in GtoPdb v.2023.1

  2023cites this paper
• Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors

  2022cites this paper
• Network pharmacology and pharmacological evaluation for deciphering novel indication of Sishen Wan in insomnia treatment.

  2022cites this paper
• Mutation of the Drosophila serotonin transporter dSERT disrupts courtship and feeding and increases both daytime and nighttime sleep

  2022influential citation
• Sleep-Wake Neurochemistry.

  2022cites this paper
• Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion

  2022cites this paper
• Modulating role of serotonergic signaling in sleep and memory

  2021cites this paper
• Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis

  2021cites this paper
• Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

  2020cites this paper
• Nelumbo nucifera promotes non-rapid eye movement sleep by regulating GABAergic receptors in rat model.

  2020cites this paper
• Better Sleep at Night: How Light Influences Sleep in Drosophila

  2020cites this paper
• What single‐unit recording studies tell us about the basic mechanisms of sleep and wakefulness

  2020cites this paper
• Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice.

  2020cites this paper
• Serotonergic modulation of the states of vigilance

  2019cites this paper
• Genes and Ion Channels in the Circadian and Homeostatic Regulation of Sleep

  2019cites this paper
• Selective activation of serotoninergic dorsal raphe neurons facilitates sleep through anxiolysis.

  2019cites this paper
• 5-Hydroxytryptamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response

  2018cites this paper
• The GABAergic Gudden's dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep‐wake behavior in the mouse

  2018cites this paper
• Behavioural state‐specific neurons in the mouse medulla involved in sleep‐wake switching

  2018cites this paper
• Behavior of Adult 5-HT1A Receptor Knockout Mice Exposed to Stress During Prenatal Development.

  2018cites this paper
• Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine

  2018cites this paper
• Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery

  2018influential citation
• Dorsal Raphe Serotonin Neurons Mediate CO2-Induced Arousal from Sleep

  2018cites this paper
• Sleep-Wake Neurochemistry.

  2018cites this paper
• Thermoregulation-Independent Regulation of Sleep by Serotonin Revealed in Mice Defective in Serotonin Synthesis

  2018cites this paper
• Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases

  2018cites this paper
• The Evolution and Function of Sleep

  2017cites this paper
• Not a single but multiple populations of GABAergic neurons control sleep.

  2017cites this paper
• Chapter 29 – Genetics and Genomic Basis of Sleep in Rodents

  2017cites this paper
• Lack of GSK3&bgr; activation and modulation of synaptic plasticity by dopamine in 5‐HT1A‐receptor KO mice

  2017cites this paper
• Extracellular regulated protein kinaseis critical for the role of 5‐HT1a receptor in modulating nNOS expression and anxiety‐related behaviors

  2017cites this paper
• Optogenetic Investigation of Arousal Circuits

  2017cites this paper
• 5-HT1A receptor: Role in the regulation of different types of behavior

  2017cites this paper
• Contribution of 5-HT 2 receptor subtypes to sleep-wakefulness and respiratory control , and functional adaptations in knock-out mice lacking 5-HT 2 A receptors

  2016cites this paper
• Serotnin as a possible biomarker in obstructive sleep apnea.

  2016cites this paper
• 5-HT1А рецептор: роль в регуляции различных видов поведения

  2016cites this paper
• Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.

  2016influential citation
• Effects of pharmacological manipulation of the serotonergic/cholinergic systems on sleep structure in two 5-HT1A genotypes: Implications for a model of depression

  2015cites this paper
• The truncated TrkB receptor influences mammalian sleep.

  2015cites this paper
• Stress, arousal, and sleep.

  2015cites this paper
• Effect of Dopaminergic D1 Receptors on Plasticity Is Dependent of Serotoninergic 5-HT1A Receptors in L5-Pyramidal Neurons of the Prefrontal Cortex

  2015cites this paper
• Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression

  2015cites this paper
• Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism

  2015cites this paper
• Effects of lighting condition on circadian behavior in 5-HT1A receptor knockout mice.

  2015cites this paper
• NREM sleep hypersomnia and reduced sleep/wake continuity in a neuroendocrine mouse model of anxiety/depression based on chronic corticosterone administration.

  2014cites this paper
• Ghrelin and Sleep Regulation

  2014cites this paper
• Central Functions of the Ghrelin Receptor

  2014cites this paper
• Implication de la sérotonine et des récepteurs 5-HT2 dans le remodelage valvulaire cardiaque

  2014cites this paper
• Intact brown adipose tissue thermogenesis is required for restorative sleep responses after sleep loss

  2014cites this paper
• 5-HT(1A) receptors direct the orientation of plasticity in layer 5 pyramidal neurons of the mouse prefrontal cortex.

  2013cites this paper
• Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons

  2013cites this paper
• The acute inhibition of rapid eye movement sleep by citalopram may impair spatial learning and passive avoidance in mice

  2013cites this paper
• Altered serotonergic neurotransmission as a main player in the pathophysiology of Alzheimer's disease : structural and ultrastructural studies in a triple transgenic mouse model of the disease

  2012cites this paper
• Neuropharmacology of Sleep and Wakefulness: 2012 Update.

  2012cites this paper
• Neural Circuitry Responsible for Sleep and Wakefulness

  2012cites this paper
• Mammalian sleep genetics

  2012cites this paper
• Chapter 11 – Raphe Nuclei

  2012cites this paper
• Control of sleep and wakefulness.

  2012cites this paper
• Serotonin conflict in sleep-feeding.

  2012cites this paper
• Impaired wake‐promoting mechanisms in ghrelin receptor‐deficient mice

  2012cites this paper
• What keeps us awake? The role of the ascending arousal systems in the regulation of sleep and wakefulness mediated by the basal forebrain

  2012cites this paper
• Molecular Mechanisms Of Sleep/wake Regulation And Memory Formation In Young And Aged Mice

  2012cites this paper
• Régulation de la veille et du sommeil : les acteurs moléculaires

  2011cites this paper
• Serotonin-1AAutoreceptorsAreNecessaryandSufficientfor theNormalFormationofCircuitsUnderlyingInnateAnxiety

  2011cites this paper
• Genetic basis of sleep in rodents

  2011cites this paper
• Serotonin control of sleep-wake behavior.

  2011cites this paper
• Capítulo 22 – Aspectos genéticos y trastornos del sueño en el ser humano y en los animales de experimentación

  2011cites this paper
• Behavioral / Systems / Cognitive Serotonin-1 A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety

  2011cites this paper
• Genetics of Electroencephalo graphy During Wakefulness and Sleep

  2011cites this paper
• Effects of serotonergic drugs on locomotor activity and vigilance states in ring doves.

  2011cites this paper
• The Role of 5-HT2A/2C Receptors in Sleep and Waking

  2011cites this paper
• Freud‐2/CC2D1B mediates dual repression of the serotonin‐1A receptor gene

  2011cites this paper
• Cibles sérotoninergiques et non sérotoninergiques des ISRS : approches pharmacologique et génétique in vivo chez la souris

  2011cites this paper
• Rapid eye movement sleep deprivation disrupts context-modulated effects on morphine locomotor sensitization in mice.

  2011cites this paper
• The Genetics of Sleep: Insight from Rodent Models.

  2011cites this paper
• Chapter 7 – Neural Control of Sleep in Mammals

  2011cites this paper
• [Sleep and wakefulness regulation: molecular players].

  2011cites this paper
• Brainstem mechanisms of paradoxical (REM) sleep generation

  2011cites this paper
• REM Sleep Rebound as an Adaptive Response to Stressful Situations

  2011cites this paper
• Dysfunction of the Hypothalamic‐Pituitary‐Adrenal axis in STX1A Knockout Mice

  2011cites this paper
• Genetics of Electroencephalography During Wakefulness and Sleep

  2011cites this paper
• Genetic analysis of sleep.

  2010cites this paper
• CHAPTER 4.13 – The Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression

  2010cites this paper
• Heterogeneous distribution of the serotonin 5‐HT1A receptor mRNA in chemically identified neurons of the mouse rostral brainstem: Implications for the role of serotonin in the regulation of wakefulness and REM sleep

  2010cites this paper
• Neuropharmacology of Sleep and Wakefulness.

  2010cites this paper
• The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep.

  2010cites this paper
• Targeting the tryptophan hydroxylase 2 gene for functional analysis in mice and serotonergic differentiation of embryonic stem cells

  2010cites this paper
• Altered Sleep Homeostasis after Restraint Stress in 5-HTT Knock-Out Male Mice: A Role for Hypocretins

  2009cites this paper
• 5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor.

  2009cites this paper
• Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review

  2009cites this paper
• Chapter 22 – Human and Animal Genetics of Sleep and Sleep Disorders

  2009cites this paper
• The ability of stress to alter sleep in mice is sensitive to reproductive hormones.

  2009cites this paper