How quantitative differences in dendritic cell maturation can direct TH1/TH2-cell polarization

The polarization of TH1 or TH2 responses by dendritic cells (DCs) requires distinct maturation conditions. Our data indicate that quantitative differences in DC maturation dictate a TH1 or TH2-cell polarization outcome. We discuss how chromatin remodeling at DC loci coding for pro-inflammatory vs. polarizing cytokines may explain differential TH-cell polarization.

• Publication year

  2013

• Venue

  Oncoimmunology

• Publication date

  2013-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/onci.22796PMID 23525517PMCID 3601159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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