The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes.

All HLA-B locus molecules have either the Bw4 or Bw6 epitopes. In addition, the Bw4 epitope is found on HLA-Aw23, Aw24, and A32, and Bw6 is also found on HLA-Cw3. The structural basis for these determinants and the evolution of their distribution among products of the HLA-B locus has been a long standing puzzle. To identify residues that may be involved in these determinants, we have cloned a gene for A32 and sequenced the protein encoding exons. Comparison of the predicted protein sequence with other HLA-A,B,C sequences identified residues 79 through 83 of the alpha 1 domain as having a pattern of polymorphic substitution that correlates with the presence and absence of the Bw4 and Bw6 epitopes.

• Publication year

  1986

• Venue

  Journal of Immunology

• Publication date

  1986-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.137.11.3671PMID 2431040
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The structure and evolution of the HLA--Bw4 and Bw6 antigens.

  2008cited by this paper
• Second locus HL-A antigens and 4a or 4b.

  2008cited by this paper
• HLA monoclonal antibody registry: a proposal.

  2008cited by this paper
• Monoclonal rat anti-MHC alloantibodies detectHLA-linked polymorphisms in humans

  2005cited by this paper
• A public HLA antigen associated with HLA-A9, Aw32, and Bw4

  2005cited by this paper
• Antigenic determinants of the HLA-B7 molecule; Bw6- and B7-specific determinants are spatially separate

  2004cited by this paper
• DNA sequence of the coding region of the HLA-B44 gene

  2004cited by this paper
• The monoclonal antibody CR11-351 discriminates HLA-A2 variants identified by T cells

  2004cited by this paper
• Expression of an HLA-Bw6-related specificity by the HLA-Cw3 molecule

  2004cited by this paper
• The HLA-AW24 gene: Sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes

  2004cited by this paper
• Evolution of HLA antigenic determinants: Species cross-reactions of monoclonal antibodies

  2004cited by this paper
• Comparison of one-dimensional IEF patterns for serologically detectable HLA-A and B allotypes

  2004cited by this paper
• Gene conversion-like mechanisms may generate polymorphism in human class I genes.

  1986cited by this paper
• Comparative structural analysis of HLA-A3 antigens distinguishable by cytotoxic T lymphocytes: variant E1.

  1985cited by this paper
• The complete primary structure of HLA-Bw58.

  1985cited by this paper
• Structural analysis of an HLA-B27 functional variant: identification of residues that contribute to the specificity of recognition by cytolytic T lymphocytes.

  1985cited by this paper
• Exon shuffling in vivo can generate novel HLA class I molecules.

  1985cited by this paper
• Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level.

  1985cited by this paper
• Primary structure of papain-solubilized human histocompatibility antigen HLA-B27.

  1985cited by this paper
• Monoclonal antibodies prepared against Dictyostelium actin: characterization and interactions with actin

  1984cited by this paper
• Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA‐CW3).

  1984cited by this paper
• Complete nucleotide sequence of a functional class I HLA gene, HLA‐A3: implications for the evolution of HLA genes.

  1984cited by this paper
• Isolation of HLA locus-specific DNA probes from the 3'-untranslated region.

  1984cited by this paper
• Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes.

  1984cited by this paper
• Structural analysis of HLA-A2 antigen from immunoselected mutant 8.6.1: further definition of an HLA-A2-specific serological determinant.

  1983cited by this paper
• Primary structure of papain-solubilized human histocompatibility antigen HLA-B40 (-Bw60). An outline of alloantigenic determinants.

  1983cited by this paper
• A cytotoxic monoclonal IgM antibody (Tü 101) directed against an antigenic determinant shared between the HLA-A allospecificities A2 and A28.

  1983cited by this paper
• The DNA sequence of the H‐2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.

  1983cited by this paper
• The structure of a mutant H–2 gene suggests that the generation of polymorphism in H–2 genes may occur by gene conversion-like events

  1983cited by this paper
• Monoclonal antibody against HLA-Aw32 + A25. Is HLA-Aw32 an allele with no unique antigenic determinant?

  1983cited by this paper
• Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex.

  1983cited by this paper
• Monoclonal antibody (Tü48) defining alloantigenic class I determinants specific for HLA-Bw4 and HLA-Aw23,-Aw24 as well as -Aw32.

  1982cited by this paper
• Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies.

  1979cited by this paper
• The antigens 4a and 4b in rhesus monkeys and stumptailed macaques.

  1976cited by this paper
• HLA‐B specificities and w4, w6 specificities are on the same polypeptide

  1976cited by this paper
• W4(4a) and W6(4b) in diverse human populations. Demonstration of their genetic identity in population and segregation studies.

  1975cited by this paper
• Continuous cultures of fused cells secreting antibody of predefined specificity

  1975cited by this paper

• Prediction of KIR3DL1 and human leukocyte antigen binding

  2025cites this paper
• HLA epitopes - Empirically defined as conformational amino acids sequences of the HLA antigen and are likely to be part of the binding sites of anti-HLA antibodies.

  2022cites this paper
• A new strategy for systematically classifying HLA alleles into serological specificities

  2022cites this paper
• A NK Cell Odyssey: From Bench to Therapeutics Against Hematological Malignancies

  2022cites this paper
• KIR in Allogeneic Hematopoietic Stem Cell Transplantation: Need for a Unified Paradigm for Donor Selection

  2022cites this paper
• Natural Killer Cell Receptors and Ligands Are Associated With Markers of HIV-1 Persistence in Chronically Infected ART Suppressed Patients

  2022cites this paper
• Immunity against Chronic Myeloid Leukemia KIR3DL1 Allotype-Dependent Modulation of NK Cell

  2021cites this paper
• Hidden Patterns of Anti-HLA Class I Alloreactivity Revealed Through Machine Learning

  2021influential citation
• The Role of the HLA Class I α2 Helix in Determining Ligand Hierarchy for the Killer Cell Ig-like Receptor 3DL1

  2021cites this paper
• The Education of NK Cells Determines Their Responsiveness to Autologous HIV-Infected CD4 T Cells

  2019cites this paper
• Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody‐dependent (AD) NK cell activation and ADCC

  2019cites this paper
• KIR3DL1/S1 Allotypes Contribute Differentially to the Development of Behçet Disease

  2019cites this paper
• Two to Tango: Co-evolution of Hominid Natural Killer Cell Receptors and MHC

  2019cites this paper
• Natural Killer Cells from HIV Infected Slow Progressors Who Carry the Protective HLA-B * 27 Allele and Inhibitory KIR 3 DL 1 Receptors Have Elevated Poly-Functional Potential Compared to Bw 6 Homozygotes

  2018cites this paper
• This information is current as with Three Functional Types of MHC-B Bonobos Maintain Immune System Diversity

  2017cites this paper
• Natural Killer (NK) Cell Education Differentially Influences HIV Antibody-Dependent NK Cell Activation and Antibody-Dependent Cellular Cytotoxicity

  2017cites this paper
• Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy.

  2017cites this paper
• Bonobos Maintain Immune System Diversity with Three Functional Types of MHC-B

  2017cites this paper
• HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined

  2017cites this paper
• Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles

  2017cites this paper
• NK Cells Expressing the Inhibitory Killer Immunoglobulin-Like Receptors (iKIR) KIR2DL1, KIR2DL3 and KIR3DL1 Are Less Likely to Be CD16+ than Their iKIR Negative Counterparts

  2016cites this paper
• The differential impact of natural killer (NK) cell education via KIR2DL3 and KIR3DL1 on CCL4 secretion in the context of in‐vitro HIV infection

  2016cites this paper
• Natural killer cell education does not affect the magnitude of granzyme B delivery to target cells by antibody-dependent cellular cytotoxicity

  2015cites this paper
• Functional analysis of NK cell subsets activated by 721.221 and K562 HLA‐null cells

  2015cites this paper
• A Higher Frequency of NKG2A+ than of NKG2A− NK Cells Responds to Autologous HIV-Infected CD4 Cells irrespective of Whether or Not They Coexpress KIR3DL1

  2015cites this paper
• Co‐evolution of MHC class I and variable NK cell receptors in placental mammals

  2015cites this paper
• HIV Protective KIR3DL1/S1-HLA-B Genotypes Influence NK Cell-Mediated Inhibition of HIV Replication in Autologous CD4 Targets

  2014cites this paper
• Time to Seroconversion in HIV-Exposed Subjects Carrying Protective versus Non Protective KIR3DS1/L1 and HLA-B Genotypes

  2014cites this paper
• Alloantibody to a Bw4 Epitope in a Bw4+ B*27: 05 Patient

  2014cites this paper
• Investigating the role of the D0 domain of KIR3DL1 in ligand interaction and exploring the effect of LILRB1 on KIR3DL1 signaling

  2013cites this paper
• Identification of a novel DRB1 allele through intergenic recombination between HLA-DRB1 and HLA-DRB3∗02 in a Chinese family.

  2013cites this paper
• Direct binding to antigen-coated beads refines the specificity and cross-reactivity of four monoclonal antibodies that recognize polymorphic epitopes of HLA class I molecules.

  2013cites this paper
• Inhibitory Killer Immunoglobulin-like Receptors to self HLA-B and HLA-C ligands contribute differentially to Natural Killer cell functional potential in HIV infected slow progressors.

  2012cites this paper
• Immunology of Human Papillomaviruses

  2012cites this paper
• Receptor-Ligand Requirements for Increased NK Cell Polyfunctional Potential in Slow Progressors Infected with HIV-1 Coexpressing KIR3DL1*h/*y and HLA-B*57

  2011cites this paper
• Natural Killer Cells from HIV Infected Slow Progressors Who Carry the Protective HLA-B*27 Allele and Inhibitory KIR3DL1 Receptors Have Elevated Poly-Functional Potential Compared to Bw6 Homozygotes

  2011cites this paper
• Variable NK Cell Receptors Exemplified by Human KIR3DL1/S1

  2011cites this paper
• High-resolution, three-dimensional modeling of human leukocyte antigen class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes.

  2011cites this paper
• CHAPTER 39 – Histocompatibility: HLA and other systems

  2011cites this paper
• Coevolution of Killer Cell Ig-Like Receptors with HLA-C To Become the Major Variable Regulators of Human NK Cells

  2010cites this paper
• Regulators of Human NK Cells with HLA-C To Become the Major Variable Coevolution of Killer Cell Ig-Like Receptors

  2010cites this paper
• HLA-B with KIR 3 DL 1 + Epitope That Affect Interaction of Bw 4 Polymorphic Sites Away from the Bw 4

  2008cites this paper
• Polymorphic Sites Away from the Bw4 Epitope That Affect Interaction of Bw4+ HLA-B with KIR3DL11

  2008cites this paper
• Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans

  2007cites this paper
• HLA class I epitopes: recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens.

  2007cites this paper
• LA Class I Epitopes: Recognition of inding Sites by mAbs or Eluted lloantibody Confirmed With Single ecombinant Antigens

  2007cites this paper
• Molecular mapping of a new public HLA class I epitope shared by all HLA-B and HLA-C antigens and defined by a monoclonal antibody

  2006cites this paper
• Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6

  2006cites this paper
• ChickenMhc alloantiserum cross-reactivity analysis by hemagglutination and flow cytometry

  2006cites this paper
• MHC class I molecules and kirs in human history, health and survival

  2005cites this paper
• Definition of epitopes on HLA class I molecules by polyclonal antipeptide sera

  2005cites this paper
• Quantitative estimation of HLA-A and HLA-B antigens carrying the Bw4 supertypic specificity in human peripheral blood lymphocytes

  2004cites this paper
• A transposable epitope of HLA-137, B40 molecules

  2004cites this paper
• Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles

  2004cites this paper
• Which came first, MHC class I or class II?

  2004cites this paper
• Nomenclature for factors of the HLA system, 1989

  2004cites this paper
• Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing

  2004cites this paper
• A new public antigen shared by all HLA-A locus products except HLA-A23, -A24, -A32, and -A25 is probably influenced by the amino acid residue at position 79 in the α1 domain

  2004cites this paper
• Sequence and evolution of cattle MHC class I cDNAs: concerted evolution has not taken place in cattle

  2004cites this paper
• The MHC E locus in macaques is polymorphic and is conserved between macaques and humans

  2004cites this paper
• Human HLA specific antibodies crossreact with swine leucocyte antigens

  2002cites this paper
• Identification of a new HLA-B allele, B*3705 containing a Bw6 sequence motif.

  2002cites this paper
• New alleles in the B44 family including B*44022, B*44032, B*4411, B*4420, B*4421, B*4424, and B*8301.

  2001cites this paper
• EFFECT OF Bw4 AND Bw6 EPITOPE MISMATCHES ON ANTIBODY PRODUCTION, ACUTE AND CHRONIC REJECTION, AND GRAFT SURVIVAL IN RENAL ALLOGRAFTS

  2001cites this paper
• HLA Class II Antigens and Alleles: Workshops and Nomenclature

  2000cites this paper
• HLA-A*2416: a new allele of the HLA-A19 lineage.

  2000cites this paper
• Origins of the first HLA specificities.

  2000cites this paper
• Unexpected Bw4 and Bw6 reactivity patterns in new alleles.

  2000cites this paper
• The humoral immune response against an HLA class I allodeterminant correlates with the HLA-DR phenotype of the responder.

  1999cites this paper
• Identification, sequencing and serology of HLA-B*3527.

  1999cites this paper
• Molecular analyses of five new chimpanzee MHC class I alleles: implications for differences between evolutional mechanisms of HLA-A, -B, and -C loci.

  1999cites this paper
• NK cell natural cytotoxicity and IFN-gamma production are not always coordinately regulated: engagement of DX9 KIR+ NK cells by HLA-B7 variants and target cells.

  1998cites this paper
• Patterns of reticulate evolution for the classical class I and II HLA loci

  1998cites this paper
• The MHC Genes

  1997cites this paper
• Episodic evolution and turnover of HLA-B in the indigenous human populations of the Americas.

  1997cites this paper
• Major histocompatibility complex (MHC) class I recognition by natural killer cells.

  1997cites this paper
• Conformational changes in MHC class I molecules

  1997cites this paper
• Specificity and function of immunoglobulin superfamily NK cell inhibitory and stimulatory receptors

  1997cites this paper
• Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor.

  1997cites this paper
• Epitope specificity of HLA class I alloantibodies: II. Stability of cross-reactive group antibody patterns over extended time periods.

  1997cites this paper
• Nucleotide sequence analysis of an HLA-B47 variant (HLA-B*4702).

  1997cites this paper
• Methods for exploring evolution in multigene families, including application to the human major histocompatibility complex

  1997cites this paper
• AN IMMUNOCYTOCHEMICAL STUDY OF MHC CLASS I EXPRESSION ON HUMAN LANGERHANS CELLS AND MELANOCYTES

  1997cites this paper
• Chicken Mhc alloantiserum cross-reactivity analysis by hemagglutination and flow cytometry

  1996cites this paper
• Novel alleles HLA-B*7802 and B*51022: evidence for convergency in the HLA-B5 family.

  1996cites this paper
• Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigens types appear genetically regulated, but not linked to major histocompatibililty complex haplotype

  1996cites this paper
• Role of HLA-B*5101 binding nonamer peptides in formation of the HLA-Bw4 public epitope.

  1996cites this paper
• Structural definition of the A*74 group: implications for matching in bone marrow transplantation with alternative donors.

  1996cites this paper
• Janet E. Fulton Evelyn E. Young Larry D. Bacon

  1996cites this paper
• Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.

  1996cites this paper
• An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501.

  1996cites this paper
• Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells.

  1996cites this paper
• NK cells and CTL: opposite sides of the same coin.

  1996cites this paper
• HLA-B*1303: a new example of poor correlation between serology and structure.

  1996cites this paper
• HLA-Cw allele analysis by PCR-restriction fragment length polymorphism: study of known and additional alleles.

  1995cites this paper
• The enigma of the natural killer cell

  1995cites this paper
• Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802].

  1995cites this paper
• The Origins of HLA‐A,B,C Polymorphism

  1995cites this paper
• NK cell recognition of MHC class I. NK cells are sensitive to peptide-binding groove and surface alpha-helical mutations that affect T cells.

  1995cites this paper
• Functional analysis of avian class I (BFIV) glycoproteins by epitope tagging and mutagenesis in vitro

  1995cites this paper