Discovery of New SiRNA Delivery Agents

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Unknown venue

• Publication date

  2010-11-30

• Fields of study

  Biology, Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1002/9780470923733.CH5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• pH-responsive polymeric sirna carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of polo-like kinase 1.

  2010cited by this paper
• Development of a novel endosomolytic diblock copolymer for siRNA delivery.

  2009cited by this paper
• The Trp Cage Motif as a Scaffold for the Display of a Randomized Peptide Library on Bacteriophage T7*

  2007cited by this paper
• The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing.

  2007cited by this paper
• Transvascular delivery of small interfering RNA to the central nervous system

  2007cited by this paper
• siRNA delivery into human T cells and primary cells with carbon-nanotube transporters.

  2007cited by this paper
• Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice.

  2007cited by this paper
• Strategies for silencing human disease using RNA interference

  2007cited by this paper
• A non-covalent peptide-based strategy for siRNA delivery.

  2007cited by this paper
• Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides.

  2007cited by this paper
• Peptide-guided gene delivery

  2007cited by this paper
• Applications of High-Throughput RNA Interference Screens to Problems in Cell and Developmental Biology

  2007cited by this paper
• Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1

  2007cited by this paper
• First step of the cell‐penetrating peptide mechanism involves Rac1 GTPase‐dependent actin‐network remodelling

  2007cited by this paper
• siRNA delivery by a transferrin‐associated lipid‐based vector: a non‐viral strategy to mediate gene silencing

  2007cited by this paper
• Lipid-based Nanoparticles for Nucleic Acid Delivery

  2007cited by this paper
• Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis.

  2007cited by this paper
• Systemic siRNA delivery via hydrodynamic intravascular injection.

  2007cited by this paper
• Innovative nanotechnologies for the delivery of oligonucleotides and siRNA.

  2006cited by this paper
• Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.

  2006cited by this paper
• Rational design and in vitro and in vivo delivery of Dicer substrate siRNA

  2006cited by this paper
• Induction of the interferon response by siRNA is cell type- and duplex length-dependent.

  2006cited by this paper
• Actin regulation in endocytosis

  2006cited by this paper
• Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo.

  2006cited by this paper
• RNA Interference-Mediated Gene Silencing of Pleiotrophin Through Polyethylenimine-Complexed Small Interfering RNAs In Vivo Exerts Antitumoral Effects in Glioblastoma Xenografts

  2006cited by this paper
• A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium

  2006cited by this paper
• Big gulps: specialized membrane domains for rapid receptor-mediated endocytosis.

  2006cited by this paper
• Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma.

  2006cited by this paper
• RNAi silencing of exogenous and endogenous reporter genes using a macrocyclic octaamine as a "compact" siRNA carrier. Studies on the nonsilenced residual activity.

  2006cited by this paper
• The cellular functions of clathrin

  2006cited by this paper
• Intravenous Delivery of Anti-RhoA Small Interfering RNA Loaded in Nanoparticles of Chitosan in Mice: Safety and Efficacy in Xenografted Aggressive Breast Cancer

  2006cited by this paper
• Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery

  2006cited by this paper
• Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras

  2006cited by this paper
• Chemically Modified Short Interfering Hybrids (siHYBRIDS): Nanoimmunoliposome Delivery In Vitro and In Vivo for RNAi of HER-2

  2006cited by this paper
• Engineering mucosal RNA interference in vivo.

  2006cited by this paper
• Construction of folate-conjugated pRNA of bacteriophage phi29 DNA packaging motor for delivery of chimeric siRNA to nasopharyngeal carcinoma cells

  2006cited by this paper
• Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids (Review)

  2006cited by this paper
• Structural Basis for Double-Stranded RNA Processing by Dicer

  2006cited by this paper
• ICS-283: a system for targeted intravenous delivery of siRNA

  2006cited by this paper
• Probing the Solvent-Assisted Nucleation Pathway in Chemical Self-Assembly

  2006cited by this paper
• Get off my back! Rapid receptor internalization through circular dorsal ruffles.

  2006cited by this paper
• Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

  2006cited by this paper
• Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs.

  2006cited by this paper
• Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions.

  2006cited by this paper
• Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect

  2006cited by this paper
• RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy

  2006cited by this paper
• The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing

  2006cited by this paper
• Aptamer mediated siRNA delivery

  2006cited by this paper
• A peptidomimetic siRNA transfection reagent for highly effective gene silencing.

  2006cited by this paper
• ErbB receptors: new insights on mechanisms and biology.

  2006cited by this paper
• Immunoliposomes for cancer therapy.

  2006cited by this paper
• Nanoparticle–aptamer bioconjugates for cancer targeting

  2006cited by this paper
• Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging

  2006cited by this paper
• Efficient delivery of an antisense oligodeoxyribonucleotide formulated in folate receptor-targeted liposomes.

  2006cited by this paper
• RNAi-mediated gene silencing in non-human primates

  2006cited by this paper
• Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes.

  2005cited by this paper
• Cellular Uptake of Unconjugated TAT Peptide Involves Clathrin-dependent Endocytosis and Heparan Sulfate Receptors*

  2005cited by this paper
• Designing scaffolds of peptides for phage display libraries.

  2005cited by this paper
• Advances in nasal drug delivery through tight junction technology

  2005cited by this paper
• Optimizing drug delivery systems using systematic "design of experiments." Part I: fundamental aspects.

  2005cited by this paper
• Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma.

  2005cited by this paper
• Intracellular trafficking of nonviral vectors

  2005cited by this paper
• Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

  2005cited by this paper
• Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

  2005cited by this paper
• Smart polymeric carriers for enhanced intracellular delivery of therapeutic macromolecules

  2005cited by this paper
• Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers

  2005cited by this paper
• Cationic TAT peptide transduction domain enters cells by macropinocytosis.

  2005cited by this paper
• Design and development of polymers for gene delivery

  2005cited by this paper
• RNA interference in biology and disease.

  2005cited by this paper
• Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

  2005cited by this paper
• Cell-penetrating peptides: tools for intracellular delivery of therapeutics

  2005cited by this paper
• Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

  2005cited by this paper
• Aptamers: an emerging class of therapeutics.

  2005cited by this paper
• Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung.

  2005cited by this paper
• RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes.

  2005cited by this paper
• Inhibition of respiratory viruses by nasally administered siRNA

  2005cited by this paper
• Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology.

  2005cited by this paper
• Aptamers against extracellular targets for in vivo applications.

  2005cited by this paper
• Specific Delivery of Therapeutic RNAs to Cancer Cells via the Dimerization Mechanism of phi29 Motor pRNA

  2005cited by this paper
• Optimizing drug delivery systems using systematic "design of experiments." Part II: retrospect and prospects.

  2005cited by this paper
• Arginine-rich motifs present multiple interfaces for specific binding by RNA.

  2005cited by this paper
• The prospect of silencing disease using RNA interference.

  2005cited by this paper
• RNAi and the P-body connection

  2005cited by this paper
• Conjugates of oligonucleotides and analogues with cell penetrating peptides as gene silencing agents.

  2005cited by this paper
• Modeling the endosomal escape of cell-penetrating peptides: transmembrane pH gradient driven translocation across phospholipid bilayers.

  2005cited by this paper
• RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells.

  2005cited by this paper
• Small hairpin RNAs efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model.

  2005cited by this paper
• Erratum to “Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers” [Biochim. Biophys. Acta 1744 (2005) 273–286]

  2005cited by this paper
• Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis

  2004cited by this paper
• Membrane binding and translocation of cell-penetrating peptides.

  2004cited by this paper
• Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle.

  2004cited by this paper
• Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells

  2004cited by this paper
• Caveolae--an alternative endocytotic pathway for targeted drug delivery.

  2004cited by this paper
• Spreading silence with Sid

  2004cited by this paper
• Systemic siRNA-Mediated Gene Silencing: A New Approach to Targeted Therapy of Cancer

  2004cited by this paper
• Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

  2004cited by this paper
• Application of statistical 'design of experiments' methods in drug discovery.

  2004cited by this paper
• Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA.

  2004cited by this paper
• Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis.

  2004cited by this paper
• Rational siRNA design for RNA interference

  2004cited by this paper

• No citing papers are available for this paper.