Secreted Wnt Inhibitors or Modulators

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Unknown venue

• Publication date

  2014-03-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/9781118444122.CH13
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling.

  2014cited by this paper
• A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling

  2013cited by this paper
• Hematopoietic stem cell fate decisions are regulated by Wnt antagonists: comparisons and current controversies.

  2013cited by this paper
• Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis.

  2013cited by this paper
• Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline.

  2013cited by this paper
• Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.

  2012cited by this paper
• Sizzled Is Unique among Secreted Frizzled-related Proteins for Its Ability to Specifically Inhibit Bone Morphogenetic Protein-1 (BMP-1)/Tolloid-like Proteinases*

  2012cited by this paper
• The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling*

  2012cited by this paper
• The Wnt antagonist Wif‐1 interacts with CTGF and inhibits CTGF activity

  2012cited by this paper
• Targeting the Wnt pathway in cancer: the emerging role of Dickkopf-3.

  2012cited by this paper
• The Wnt inhibitor secreted Frizzled‐Related Protein 1 (sFRP1) promotes human Th17 differentiation

  2012cited by this paper
• Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers.

  2012cited by this paper
• Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants.

  2012cited by this paper
• Repeated Evolution of Identical Domain Architecture in Metazoan Netrin Domain-Containing Proteins

  2012cited by this paper
• A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway

  2012cited by this paper
• The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling

  2012cited by this paper
• Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors.

  2012cited by this paper
• Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.

  2012cited by this paper
• Inaugural Article: Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility

  2012cited by this paper
• Genome-Wide Detection of Gene Extinction in Early Mammalian Evolution

  2011cited by this paper
• Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

  2011cited by this paper
• SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis

  2011cited by this paper
• Polarized notum Activation at Wounds Inhibits Wnt Function to Promote Planarian Head Regeneration

  2011cited by this paper
• Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4

  2011cited by this paper
• Secreted frizzled-related proteins are required for Wnt/β-catenin signalling activation in the vertebrate optic cup

  2011cited by this paper
• Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein

  2011cited by this paper
• Inhibition of Connective Tissue Growth Factor Overexpression in Diabetic Retinopathy by SERPINA3K via Blocking the WNT/β-Catenin Pathway

  2010cited by this paper
• The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema.

  2010cited by this paper
• sFRP2 Suppression of Bone Morphogenic Protein (BMP) and Wnt Signaling Mediates Mesenchymal Stem Cell (MSC) Self-renewal Promoting Engraftment and Myocardial Repair*

  2010cited by this paper
• Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family

  2010cited by this paper
• Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

  2010cited by this paper
• The advantages and disadvantages of sfrp1 and sfrp2 expression in pathological events.

  2010cited by this paper
• Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response.

  2010cited by this paper
• Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer

  2009cited by this paper
• Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice.

  2009cited by this paper
• Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization.

  2009cited by this paper
• TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling.

  2009cited by this paper
• Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells.

  2009cited by this paper
• Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range

  2009cited by this paper
• Association of single nucleotide polymorphisms in secreted frizzled‐related protein 1 gene with bone mineral density in Japanese women

  2009cited by this paper
• Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure.

  2008cited by this paper
• The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate

  2008cited by this paper
• Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction*

  2008cited by this paper
• Binding of sFRP-3 to EGF in the Extra-Cellular Space Affects Proliferation, Differentiation and Morphogenetic Events Regulated by the Two Molecules

  2008cited by this paper
• Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

  2008cited by this paper
• Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface.

  2008cited by this paper
• Secreted Frizzled Related Protein 2 is a procollagen C proteinase enhancer with a role in myocardial infarction-associated fibrosis

  2008cited by this paper
• Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/β‐catenin and the planar cell polarity pathways during early trunk formation in mouse

  2008cited by this paper
• Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation.

  2008cited by this paper
• IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

  2008cited by this paper
• Genetic Analyses in a Sample of Individuals With High or Low BMD Shows Association With Multiple Wnt Pathway Genes

  2007cited by this paper
• Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

  2007cited by this paper
• Inhibition of SFRP1 Reduces Severity of Periodontitis

  2007cited by this paper
• Wnt3a binds to several sFRPs in the nanomolar range.

  2007cited by this paper
• Variation in the secreted frizzled‐related protein‐3 gene and risk of Osteolysis and heterotopic ossification after total hip arthroplasty

  2007cited by this paper
• Wise retained in the endoplasmic reticulum inhibits Wnt signaling by reducing cell surface LRP6.

  2007cited by this paper
• Mutational Analysis of Norrin-Frizzled4 Recognition*

  2006cited by this paper
• Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein

  2006cited by this paper
• Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases.

  2006cited by this paper
• An ancient Wnt-Dickkopf antagonism in Hydra

  2006cited by this paper
• Shisa2 promotes the maturation of somitic precursors and transition to the segmental fate in Xenopus embryos

  2006cited by this paper
• Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation

  2006cited by this paper
• Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.

  2006cited by this paper
• Function and biological roles of the Dickkopf family of Wnt modulators

  2006cited by this paper
• The Wnt antagonist secreted frizzled‐related protein‐1 controls osteoblast and osteocyte apoptosis

  2005cited by this paper
• Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF.

  2005cited by this paper
• Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling*

  2005cited by this paper
• SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor*

  2005cited by this paper
• The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog.

  2005cited by this paper
• Gene expression profiling of orbital adipose tissue from patients with Graves' ophthalmopathy: a potential role for secreted frizzled-related protein-1 in orbital adipogenesis.

  2005cited by this paper
• SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor

  2005cited by this paper
• Tsukushi functions as an organizer inducer by inhibition of BMP activity in cooperation with chordin.

  2004cited by this paper
• Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

  2004cited by this paper
• Wnt signaling: Ig-norrin the dogma.

  2004cited by this paper
• Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity.

  2004cited by this paper
• The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice.

  2004cited by this paper
• The extracellular matrix component WIF-1 is expressed during, and can modulate, retinal development.

  2004cited by this paper
• Autocrine/Paracrine Secreted Frizzled-related Protein 2 Induces Cellular Resistance to Apoptosis

  2004cited by this paper
• Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex

  2004cited by this paper
• Secreted Frizzled‐Related Protein‐1 Inhibits RANKL‐Dependent Osteoclast Formation

  2004cited by this paper
• Wnt proteins are lipid-modified and can act as stem cell growth factors

  2003cited by this paper
• Endogenous Cerberus activity is required for anterior head specification in Xenopus

  2003cited by this paper
• Cell fate specification and competence by Coco, a maternal BMP, TGFβ and Wnt inhibitor

  2003cited by this paper
• Wise, a context-dependent activator and inhibitor of Wnt signalling

  2003cited by this paper
• Reduction of Infarct Size and Prevention of Cardiac Rupture in Transgenic Mice Overexpressing FrzA

  2003cited by this paper
• Disulfide Bond Assignments of Secreted Frizzled-related Protein-1 Provide Insights about Frizzled Homology and Netrin Modules*

  2002cited by this paper
• Secreted Frizzled-related proteins: searching for relationships and patterns.

  2002cited by this paper
• Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β

  2002cited by this paper
• Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

  2002cited by this paper
• HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient.

  2002cited by this paper
• Uterine Sensitization-Associated Gene-1: A Novel Gene Induced Within the Rat Endometrium at the Time of Uterine Receptivity/Sensitization for the Decidual Cell Reaction1

  2002cited by this paper
• Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation

  2002cited by this paper
• Wingful, an extracellular feedback inhibitor of Wingless.

  2002cited by this paper
• Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).

  2001cited by this paper
• The Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Is a Receptor for Connective Tissue Growth Factor*

  2001cited by this paper
• The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins

  2001cited by this paper
• LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

  2001cited by this paper
• The BMP antagonists cerberus-like and noggin do not interact during mouse forebrain development.

  2001cited by this paper
• Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.

  2001cited by this paper
• Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

  2001cited by this paper

• Positive and negative regulation of Shh signalling in vertebrate retinal development

  2018cites this paper
• Role of TGF-β and Wnt antagonist gene sFRP4 in predicting overall survival and clinic-pathological outcomes in lung cancer patients treated with platinum based doublet chemotherapy

  2017cites this paper
• Wnt signaling in the heart fields: Variations on a common theme

  2016influential citation