The Role of Carnitine in Cell Metabolism

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Chemistry

• Identifiers
  DOI 10.1007/978-1-4615-6005-0_1
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Errata and corrigenda

  2008cited by this paper
• Solubilization and separation of two distinct carnitine acyltransferases from hepatic microsomes: characterization of the malonyl-CoA-sensitive enzyme.

  1995cited by this paper
• The Carnitine System

  1995cited by this paper
• Polyunsaturated n-3 and n-6 fatty acids at a low level in the diet alter mitochondrial outer membrane parameters in Wistar rat liver☆

  1995cited by this paper
• Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine palmitoyltransferase-I.

  1995cited by this paper
• Fatty acid beta-oxidation in peroxisomes and mitochondria: the first, unequivocal evidence for the involvement of carnitine in shuttling propionyl-CoA from peroxisomes to mitochondria.

  1995cited by this paper
• Microsomal carnitine acyltransferases.

  1995cited by this paper
• Increased pivaloylcarnitine in the liver of the sodium pivalate treated rat exposed to clofibrate.

  1995cited by this paper
• Mitochondrial Carnitine Palmitoyltransferase I Isoform Switching in the Developing Rat Heart (*)

  1995cited by this paper
• Carnitine-dependent pathways in heart muscle

  1995cited by this paper
• Effects of tetradecylthiopropionic acid and tetradecylthioacrylic acid on rat liver lipid metabolism.

  1995cited by this paper
• A stress-regulated protein, GRP58, a member of thioredoxin superfamily, is a carnitine palmitoyltransferase isoenzyme.

  1994cited by this paper
• Utilization of intracellular acylcarnitine pools by mononuclear phagocytes.

  1994cited by this paper
• Characterization of the malonyl-CoA-sensitive carnitine palmitoyltransferase (CPTo) of a rat heart mitochondrial particle. Evidence that the catalytic unit is CPTi.

  1994cited by this paper
• Malonyl-CoA-sensitive and -insensitive carnitine palmitoyltransferase activities of microsomes are due to different proteins.

  1994cited by this paper
• Peroxisomal beta-oxidation of branched chain fatty acids in rat liver. Evidence that carnitine palmitoyltransferase I prevents transport of branched chain fatty acids into mitochondria.

  1994cited by this paper
• Evidence for the Involvement of Carnitine‐Dependent Long‐Chain Acyltransferases in Neuronal Triglyceride and Phospholipid Fatty Acid Turnover

  1994cited by this paper
• Cholate extracts of mitochondrial outer membranes increase inhibition by malonyl-CoA of carnitine palmitoyltransferase-I by a mechanism involving phospholipids.

  1994cited by this paper
• The peroxisomal beta-oxidation enzyme system of rat heart. Basal level and effect of the peroxisome proliferator clofibrate.

  1994cited by this paper
• Changes in carnitine palmitoyltransferase-I mRNA abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity.

  1994cited by this paper
• Effects of insulin treatment of diabetic rats on hepatic partitioning of fatty acids between oxidation and esterification, phospholipid and acylglycerol synthesis, and on the fractional rate of secretion of triacylglycerol in vivo.

  1994cited by this paper
• Kinetic properties of carnitine palmitoyltransferase I in cultured neonatal rat cardiac myocytes.

  1994cited by this paper
• Expression of a cDNA for rat liver carnitine palmitoyltransferase I in yeast establishes that catalytic activity and malonyl-CoA sensitivity reside in a single polypeptide.

  1994cited by this paper
• Involvement of microsomal vesicles in part of the sensitivity of carnitine palmitoyltransferase I to malonyl-CoA inhibition in mitochondrial fractions of rat liver.

  1994cited by this paper
• Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.

  1994cited by this paper
• Expression of liver carnitine palmitoyltransferase I and II genes during development in the rat.

  1994cited by this paper
• Catalytically important domains of rat carnitine palmitoyltransferase II as determined by site-directed mutagenesis and chemical modification. Evidence for a critical histidine residue.

  1994cited by this paper
• Evidence against direct involvement of phosphorylation in the activation of carnitine palmitoyltransferase by okadaic acid in rat hepatocytes.

  1994cited by this paper
• Hepatic carnitine palmitoyltransferase-I has two independent inhibitory binding sites for regulation of fatty acid oxidation.

  1994cited by this paper
• Monitoring the partitioning of hepatic fatty acids in vivo: keeping track of control.

  1994cited by this paper
• Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions.

  1994cited by this paper
• More Direct Evidence for a Malonyl-CoA–Carnitine Palmitoyltransferase I Interaction as a Key Event in Pancreatic β-Cell Signaling

  1994cited by this paper
• Inhibition of carnitine palmitoyltransferase I by hepatocyte swelling

  1994cited by this paper
• Inhibitors of mitochondrial carnitine palmitoyltransferase I limit the action of proteases on the enzyme. Isolation and partial amino acid analysis of a truncated form of the rat liver isozyme.

  1993cited by this paper
• Skeletal muscle mitochondrial β-oxidation of dicarboxylates

  1993cited by this paper
• Acylcarnitine formation and fatty acid oxidation in hepatocytes from rats treated with tetradecylthioacetic acid (a 3-thia fatty acid).

  1993cited by this paper
• Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function.

  1993cited by this paper
• Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart.

  1993cited by this paper
• Physiological state and the sensitivity of liver mitochondrial outer membrane carnitine palmitoyltransferase to malonyl-CoA. Correlations with assay temperature, salt concentration and membrane lipid composition.

  1992cited by this paper
• Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyltransferase I in isolated rat hepatocytes.

  1992cited by this paper
• Conferral of malonyl coenzyme A sensitivity to purified rat heart mitochondrial carnitine palmitoyltransferase.

  1992cited by this paper
• Evidence for malonyl-CoA-sensitive carnitine acyl-CoA transferase activity in sarcoplasmic reticulum of canine heart.

  1992cited by this paper
• The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas.

  1992cited by this paper
• Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

  1992cited by this paper
• Current concepts in carnitine research

  1992cited by this paper
• Myocardial carnitine palmitoyltransferase of the mitochondrial outer membrane is not altered by fasting.

  1992cited by this paper
• Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes.

  1992cited by this paper
• Effect of insulin on the properties of liver carnitine palmitoyltransferase in the starved rat: assessment by the euglycemic hyperinsulinemic clamp.

  1991cited by this paper
• Carnitine palmitoyltransferase in human erythrocyte membrane. Properties and malonyl-CoA sensitivity.

  1991cited by this paper
• Effects of cholesterol loading of mouse macrophages on carnitine palmitoyltransferase activity and sensitivity to inhibition by malonyl-CoA.

  1991cited by this paper
• Malonyl-CoA inhibits proteolysis of carnitine palmitoyltransferase.

  1991cited by this paper
• Surplus acylcarnitines in the plasma of starved rats derive from the liver.

  1990cited by this paper
• The involvement of carnitine intermediates in peroxisomal fatty acid oxidation: a study with 2-bromofatty acids.

  1990cited by this paper
• Re-evaluation of the interaction of malonyl-CoA with the rat liver mitochondrial carnitine palmitoyltransferase system by using purified outer membranes.

  1990cited by this paper
• Characterization of a solubilized malonyl-CoA-sensitive carnitine palmitoyltransferase from the mitochondrial outer membrane as a protein distinct from the malonyl-CoA-insensitive carnitine palmitoyltransferase of the inner membrane.

  1990cited by this paper
• Sensitivity of inhibition of rat liver mitochondrial outer-membrane carnitine palmitoyltransferase by malonyl-CoA to chemical- and temperature-induced changes in membrane fluidity.

  1990cited by this paper
• Activity and expression of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the starved-to-fed transition.

  1990cited by this paper
• Effects of thia-substituted fatty acids on mitochondrial and peroxisomal beta-oxidation. Studies in vivo and in vitro.

  1990cited by this paper
• The medium-chain carnitine acyltransferase activity associated with rat liver microsomes is malonyl-CoA sensitive.

  1990cited by this paper
• Carnitine palmitoyltransferase (CPT2) from liver mitochondrial inner membrane becomes inhibitable by malonyl‐CoA if reconstituted with outer membrane malonyl‐CoA binding protein

  1990cited by this paper
• Identification and purification of the carnitine carrier from rat liver mitochondria.

  1990cited by this paper
• Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation.

  1989cited by this paper
• Induction of ketogenesis and fatty acid oxidation by glucagon and cyclic AMP in cultured hepatocytes from rabbit fetuses. Evidence for a decreased sensitivity of carnitine palmitoyltransferase I to malonyl-CoA inhibition after glucagon or cyclic AMP treatment.

  1989cited by this paper
• L-carnitine acyltransferase in intact peroxisomes is inhibited by malonyl-CoA.

  1989cited by this paper
• Carnitine deficiency induced by pivampicillin and pivmecillinam therapy.

  1989cited by this paper
• Decreased hepatic fatty acid oxidation at weaning in the rat is not linked to a variation of malonyl-CoA concentration.

  1988cited by this paper
• Effects of endurance exercise on carnitine palmitoyltransferase I from rat heart, skeletal muscle and liver mitochondria.

  1988cited by this paper
• Uptake, metabolism and release of carnitine and acylcarnitines in the perfused rat liver.

  1988cited by this paper
• Formation and excretion of branched-chain acylcarnitines and branched-chain hydroxy acids in the perfused rat kidney.

  1988cited by this paper
• Effects of ethanol feeding on the activity and regulation of hepatic carnitine palmitoyltransferase I.

  1988cited by this paper
• Rapid stimulation of liver palmitoyl-CoA synthetase, carnitine palmitoyltransferase and glycerophosphate acyltransferase compared to peroxisomal beta-oxidation and palmitoyl-CoA hydrolase in rats fed high-fat diets.

  1988cited by this paper
• Carnitine palmitoyltransferase: characterization of a labile detergent-extracted malonyl-CoA-sensitive enzyme from rat liver mitochondria.

  1987cited by this paper
• Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes.

  1987cited by this paper
• Purification and properties of the soluble carnitine palmitoyltransferase from bovine liver mitochondria.

  1987cited by this paper
• Transport and function of L-carnitine and L-propionylcarnitine: relevance to some cardiomyopathies and cardiac ischemia.

  1987cited by this paper
• Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors.

  1987cited by this paper
• Enhanced uptake of carnitine by perfused rat liver following starvation.

  1987cited by this paper
• Effect of insulin and glucagon on the uptake of carnitine by perfused rat liver.

  1987cited by this paper
• Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. II. Use of detergents and antibodies.

  1987cited by this paper
• Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA.

  1987cited by this paper
• Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane.

  1987cited by this paper
• Different sites of inhibition of carnitine palmitoyltransferase by malonyl-CoA, and by acetyl-CoA and CoA, in human skeletal muscle.

  1987cited by this paper
• An essential requirement of cardiolipin for mitochondrial carnitine acylcarnitine translocase activity. Lipid requirement of carnitine acylcarnitine translocase.

  1986cited by this paper
• Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria.

  1986cited by this paper
• Carnitine palmitoyltransferase: activation and inactivation in liver mitochondria from fed, fasted, hypo- and hyperthyroid rats.

  1986cited by this paper
• Is carnitine palmitoyltransferase inhibited by a malonyl-CoA-binding unit in the mitochondria?

  1986cited by this paper
• Clinical aspects of human carnitine deficiency

  1986cited by this paper
• Inhibition of oxidative metabolism by propionic acid and its reversal by carnitine in isolated rat hepatocytes.

  1986cited by this paper
• Hysteretic behaviour of carnitine palmitoyltransferase. The effect of preincubation with malonyl-CoA.

  1986cited by this paper
• epsilon-N-trimethyllysine availability regulates the rate of carnitine biosynthesis in the growing rat.

  1986cited by this paper
• Metabolism and excretion of carnitine and acylcarnitines in the perfused rat kidney.

  1986cited by this paper
• Regulation by oestrogen of carnitine palmitoyltransferase in hepatic mitochondria.

  1986cited by this paper
• Interacting effects of L-carnitine and malonyl-CoA on rat liver carnitine palmitoyltransferase.

  1985cited by this paper
• Microcompartmentation of transported carnitine, acetylcarnitine and ADP occurs in the mitochondrial matrix. Implications for transport measurements and metabolism.

  1985cited by this paper
• Phosphorylation of carnitine palmitoyltransferase and activation by glucagon in isolated rat hepatocytes

  1985cited by this paper
• Relationship between lipogenesis, ketogenesis, and malonyl-CoA content in isolated hepatocytes from the obese Zucker rat adapted to a high-fat diet.

  1985cited by this paper
• Regulation of carnitine palmitoyltransferase activity by malonyl-CoA in mitochondria from sheep liver, a tissue with a low capacity for fatty acid synthesis.

  1985cited by this paper
• Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine.

  1985cited by this paper
• Carnitine palmitoyltransferase. Activation by palmitoyl-CoA and inactivation by malonyl-CoA.

  1985cited by this paper
• Specificity of two different purified acylcarnitine hydrolases from rat liver, their identity with other carboxylesterases, and their possible function.

  1985cited by this paper

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