A Metabolomic Perspective of Small Molecule Toxicity

No abstract is available for this paper.

• Publication year

  2009

• Venue

  General, Applied and Systems Toxicology

• Publication date

  2009-12-15

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/9780470744307.GAT016
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• MassTRIX: mass translator into pathways

  2008cited by this paper
• Identification of Novel Toxicity-associated Metabolites by Metabolomics and Mass Isotopomer Analysis of Acetaminophen Metabolism in Wild-type and Cyp2e1-null Mice*

  2008cited by this paper
• Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis.

  2008cited by this paper
• Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice

  2008cited by this paper
• Radiation Metabolomics. 1. Identification of Minimally Invasive Urine Biomarkers for Gamma-Radiation Exposure in Mice

  2008cited by this paper
• Evidence of different metabolic phenotypes in humans

  2008cited by this paper
• UvA-DARE ( Digital Academic Repository ) Assessment of PLSDA cross validation

  2008cited by this paper
• A metabolomic perspective of melatonin metabolism in the mouse.

  2008cited by this paper
• Quality control for plant metabolomics: reporting MSI-compliant studies.

  2008cited by this paper
• Preprocessing, classification modeling and feature selection using flow injection electrospray mass spectrometry metabolite fingerprint data

  2008cited by this paper
• Metabolic Profiling as a Tool for Understanding Mechanisms of Toxicity

  2008cited by this paper
• Application of the Random Forest Classification Method to Peaks Detected from Mass Spectrometric Proteomic Profiles of Cancer Patients and Controls

  2008cited by this paper
• Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models.

  2008cited by this paper
• 1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death

  2008cited by this paper
• Metabolite identification via the Madison Metabolomics Consortium Database

  2008cited by this paper
• PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.

  2008cited by this paper
• UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation.

  2008cited by this paper
• Classification of Breast Cancer versus Normal Samples from Mass Spectrometry Profiles Using Linear Discriminant Analysis of Important Features Selected by Random Forest

  2008cited by this paper
• Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry

  2007cited by this paper
• The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases.

  2007cited by this paper
• A gentle guide to the analysis of metabolomic data.

  2007cited by this paper
• Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline.

  2007cited by this paper
• Influence of acute phytochemical intake on human urinary metabolomic profiles.

  2007cited by this paper
• Quantitative Analysis of Mouse Urine Volatiles: In Search of MHC-Dependent Differences

  2007cited by this paper
• Normalization method for metabolomics data using optimal selection of multiple internal standards

  2007cited by this paper
• A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.

  2007cited by this paper
• Metabolomics of a superorganism.

  2007cited by this paper
• A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model

  2007cited by this paper
• Whole-grain and refined wheat flours show distinct metabolic profiles in rats as assessed by a 1H NMR-based metabonomic approach.

  2007cited by this paper
• Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles.

  2007cited by this paper
• Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.

  2007cited by this paper
• Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals.

  2007cited by this paper
• Chemometrics in metabonomics.

  2007cited by this paper
• Monitoring diet effects via biofluids and their implications for metabolomics studies.

  2007cited by this paper
• Complex mixtures that may contain mutagenic and/or genotoxic components: a need to assess in vivo target-site effect(s) associated with in vitro-positive(s).

  2007cited by this paper
• The Metabolomics Standards Initiative

  2007cited by this paper
• A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse.

  2006cited by this paper
• Susceptibility of human metabolic phenotypes to dietary modulation.

  2006cited by this paper
• Metabolomic database annotations via query of elemental compositions: Mass accuracy is insufficient even at less than 1 ppm

  2006cited by this paper
• EGFR Activation and Ultraviolet Light-Induced Skin Carcinogenesis

  2006cited by this paper
• Metabolic profiling of glucuronides in human urine by LC-MS/MS and partial least-squares discriminant analysis for classification and prediction of gender.

  2006cited by this paper
• Establishing Reporting Standards for Metabolomic and Metabonomic Studies: A Call for Participation

  2006cited by this paper
• Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans.

  2006cited by this paper
• XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.

  2006cited by this paper
• Communication regarding metabonomic identification of two distinct phenotypes in Sprague-Dawley (Crl:CD(SD)) rats.

  2006cited by this paper
• Urinary Metabolite Profiling Reveals CYP1A2-Mediated Metabolism of NSC686288 (Aminoflavone)

  2006cited by this paper
• An obesity-associated gut microbiome with increased capacity for energy harvest

  2006cited by this paper
• Metabolomics Standards Workshop and the development of international standards for reporting metabolomics experimental results

  2006cited by this paper
• Mice convert melatonin to 6-sulphatoxymelatonin.

  2006cited by this paper
• Predicting interpretability of metabolome models based on behavior, putative identity, and biological relevance of explanatory signals

  2006cited by this paper
• UvA-DARE ( Digital Academic Repository ) Centering , scaling and transformations : improving the biological information content of metabolomics data

  2006cited by this paper
• Urinary metabolites and antioxidant products of exogenous melatonin in the mouse

  2006cited by this paper
• CYP2E1

  2006cited by this paper
• Applications of metabolomics in agriculture.

  2006cited by this paper
• Metabonomics in toxicology: a review.

  2005cited by this paper
• Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat.

  2005cited by this paper
• Host-Bacterial Mutualism in the Human Intestine

  2005cited by this paper
• A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats.

  2005cited by this paper
• Tumor classification by tissue microarray profiling: random forest clustering applied to renal cell carcinoma

  2005cited by this paper
• Metabonomic identification of two distinct phenotypes in Sprague-Dawley (Crl:CD(SD)) rats.

  2005cited by this paper
• Elucidation of Gene-to-Gene and Metabolite-to-Gene Networks in Arabidopsis by Integration of Metabolomics and Transcriptomics*

  2005cited by this paper
• A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice.

  2005cited by this paper
• Metabolomics – the link between genotypes and phenotypes

  2004cited by this paper
• Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects.

  2004cited by this paper
• A proposed framework for the description of plant metabolomics experiments and their results

  2004cited by this paper
• Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification.

  2004cited by this paper
• Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana.

  2004cited by this paper
• Honor thy symbionts

  2003cited by this paper
• Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences.

  2003cited by this paper
• Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles

  2003cited by this paper
• Ion suppression in mass spectrometry.

  2003cited by this paper
• Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism.

  2002cited by this paper
• Synthesis and analysis of conjugates of the major vitamin E metabolite, α-CEHC

  2002cited by this paper
• Metabonomic applications in toxicity screening and disease diagnosis.

  2002cited by this paper
• Application of metabolomics to plant genotype discrimination using statistics and machine learning

  2002cited by this paper
• HETEROCYCLIC AROMATIC AMINE METABOLISM, DNA ADDUCT FORMATION, MUTAGENESIS, AND CARCINOGENESIS

  2002cited by this paper
• Orthogonal projections to latent structures (O‐PLS)

  2002cited by this paper
• Random Forests

  2001cited by this paper
• Metabonomic investigations into hydrazine toxicity in the rat.

  2001cited by this paper
• Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition.

  2001cited by this paper
• 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.

  1999cited by this paper
• Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity.

  1998cited by this paper
• Looking at enzymes in action in the 1950s

  1994cited by this paper
• Pharmacogenetics. Enigmatic variations.

  1988cited by this paper
• The conjugation of benzoic acid in the African bat, Epomops franqueti.

  1977cited by this paper
• Benzoylglutamic acid, a metabolite of benzoic acid in Indian fruit bats

  1975cited by this paper
• The identification of urinary acids by coupled gas chromatography-mass spectrometry.

  1971cited by this paper
• The metabolic interconversion of arecoline and arecoline 1-oxide in the rat.

  1971cited by this paper
• Metabolic profiles: gas-phase methods for analysis of metabolites.

  1971cited by this paper
• The fate of benzoic acid in various species.

  1970cited by this paper
• Mercapturic acid formation during the metabolism of arecoline and arecaidine in the rat.

  1969cited by this paper
• Detoxication mechanisms in man

  1963cited by this paper
• Rate of excretion of radioactive sulfur and its concentration in some tissues of the rat after intraperitoneal administration of labeled sodium sulfate.

  1949cited by this paper
• Fluorimetric And Microbiological Assays Of Riboflavine In Malted Preparations

  1949cited by this paper
• Metabolism of Isocysteine, Labeled with Radiosulfur (S35), in the Rat

  1949cited by this paper
• Separation of the higher monoamino-acids by counter-current liquid-liquid extraction: the amino-acid composition of wool.

  1941cited by this paper
• A new form of chromatogram employing two liquid phases: A theory of chromatography. 2. Application to the micro-determination of the higher monoamino-acids in proteins.

  1941cited by this paper

• Peptides as Therapeutic Agents for Dengue Virus

  2017cites this paper
• Kernel approaches for differential expression analysis of mass spectrometry-based metabolomics data

  2015cites this paper
• Metabolomics: an essential tool to understand the function of peroxisome proliferator-activated receptor alpha.

  2013cites this paper
• Radiation metabolomics and its potential in biodosimetry

  2011cites this paper
• Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling.

  2011cites this paper
• by Plasma Metabolomics and Lipid Profiling Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed

  2011cites this paper
• Analysis and simulation of metabolic networks: application to HEPG2

  2010cites this paper
• Radiation Metabolomics. 3. Biomarker Discovery in the Urine of Gamma-Irradiated Rats Using a Simplified Metabolomics Protocol of Gas Chromatography-Mass Spectrometry Combined with Random Forests Machine Learning Algorithm

  2009cites this paper
• The role of mass spectrometry-based metabolomics in medical countermeasures against radiation.

  2009cites this paper