Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of drug targeting (Print)

• Publication date

  2004-12-01

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1080/10611860400015936PMID 15621689
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• A review of blood-brain barrier transport techniques.

  2003influential reference
• In Situ Blood–Brain Barrier Transport of Nanoparticles

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• Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier

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• Brain Delivery of Biotin Bound to a Conjugate of Neutral Avidin and Cationized Human Albumin

  1994cited by this paper
• Permeability of neutral vs. anionic dextrans in cultured brain microvascular endothelium.

  1990cited by this paper
• Sequential appearance of anionic domains in the developing blood-brain barrier.

  1990cited by this paper
• Ultracytochemical characterization of anionic sites in the wall of brain capillaries

  1989cited by this paper
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  1984influential reference
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  1983influential reference
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