Cytokine Control of Interstitial Collagenase and Collagenase-3 Gene Expression in Human Chondrocytes*

Human collagenase-3 expression, previously seen only in a breast tumor tissue, is here shown to be expressed in primary human chondrocytes derived from the joint tissue and in transformed human chondrocytes. Its mRNA is inducible by the inflammatory cytokines interleukin-1β plus tumor necrosis factor-α, but not by phorbol 12-myristate 13-acetate and only slightly by the growth factors platelet-derived growth factor and epidermal growth factor. Human synovial fibroblasts, another prominent cell type in the joint tissue, do not produce collagenase-3 message. Expression of the murine collagenase, which is possibly the counterpart of human collagenase-3, is induced by interleukin-1β plus tumor necrosis factor-α, and its full induction requires the presence of the transcription factor, c-FOS. This family of transcription factors also plays a role in induction of human collagenase-3, since it binds to the AP-1 site of this matrix metalloproteinase.

• Publication year

  1996

• Venue

  Journal of Biological Chemistry

• Publication date

  1996-09-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/JBC.271.38.23577PMID 8798568
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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