Molecular approaches to treatment of hepatocellular carcinoma.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Digestive and Liver Disease

• Publication date

  2010-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S1590-8658(10)60515-4PMID 20547313PMCID PMC3693074
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The hallmarks of cancer

  2012cited by this paper
• Global cancer statistics

  2011cited by this paper
• Epigenetics in cancer.

  2010cited by this paper
• Lin28 Enhances Tumorigenesis and is Associated With Advanced Human Malignancies

  2009cited by this paper
• Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.

  2009cited by this paper
• Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo.

  2009cited by this paper
• Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study.

  2009cited by this paper
• Pathogenesis of hepatocellular carcinoma and molecular therapies

  2009cited by this paper
• Design and endpoints of clinical trials in hepatocellular carcinoma.

  2008cited by this paper
• Focal gains of VEGFA and molecular classification of hepatocellular carcinoma.

  2008cited by this paper
• Sorafenib in advanced hepatocellular carcinoma.

  2008cited by this paper
• Design and Endpoints of Clinical Trials in Hepatocellular Carcinoma

  2008cited by this paper
• Molecular targeted therapies in hepatocellular carcinoma

  2008influential reference
• Pivotal role of mTOR signaling in hepatocellular carcinoma.

  2008cited by this paper
• Transcriptional silencing of the TMS1/ASC tumour suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells

  2007cited by this paper
• Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.

  2007cited by this paper
• Survival and apoptosis: a dysregulated balance in liver cancer

  2007cited by this paper
• Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis.

  2007cited by this paper
• Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas

  2007cited by this paper
• Genomics and signaling pathways in hepatocellular carcinoma.

  2007influential reference
• Angiogenesis and anti-angiogenesis in hepatocellular carcinoma.

  2006cited by this paper
• Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.

  2006cited by this paper
• Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma.

  2006cited by this paper
• Hepatocellular carcinoma pathogenesis: from genes to environment

  2006cited by this paper
• Global Cancer Statistics, 2002

  2005cited by this paper
• Management of hepatocellular carcinoma

  2005cited by this paper
• Cancer genes and the pathways they control

  2004cited by this paper
• Hepatocellular carcinoma

  2003cited by this paper
• Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival

  2003cited by this paper
• Progression of Hepatocellular Carcinoma Differential Impact of Telomere Dysfunction on Initiation and Updated Version

  2003cited by this paper
• Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis.

  2001cited by this paper
• Prognosis of Hepatocellular Carcinoma: The BCLC Staging Classification

  1999cited by this paper

• Subgingival microbial community structure in HCC patients with periodontitis: 16S rRNA sequencing, functional prediction, and phenotypic profiling.

  2026cites this paper
• Navigating liver cancer: Precision targeting for enhanced treatment outcomes

  2025cites this paper
• Unveiling the anticancer power of vinca rosea leaves: A pharmacognostical and phytochemical approach

  2025cites this paper
• Biochemical and Histopathological Study on the Exposure of Volatile Organic Compound (Benzene) and the Protective Effects of Oral Ascorbic Acid and Solenostemma argeal Extract Administrations in Adult Male Rats

  2025cites this paper
• Thymoquinone-conjugated liposomes improve cytotoxic and proapoptotic effects against hepatocellular cancer by altering the EGFR/ERK/MEK signaling axis

  2025cites this paper
• Immunosuppressive tumor microenvironment in the progression, metastasis, and therapy of hepatocellular carcinoma: from bench to bedside

  2024cites this paper
• Evaluation of the anticancer activity of Origanum Marjoram as a safe natural drink for daily use

  2023cites this paper
• The role of CSTF2 in cancer: from technology to clinical application

  2023cites this paper
• Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3′-kinase/protein kinase B/mammalian target of rapamycin pathway

  2022cites this paper
• The effects of several abiotic elicitors on the expression of genes of key enzymes involved in the parthenolide biosynthetic pathway and its content in feverfew plant (Tanacetum parthenium L.)

  2022cites this paper
• Use of Natural Products and Their Derivative in Cancer Research for the Discovery of Safer Treatments

  2022cites this paper
• Prevention and Treatment of Hepatocellular Carcinoma Using miRNAs.

  2022cites this paper
• Role of Herbal Medicines in Hepatocellular Carcinoma

  2022cites this paper
• Phytochemical and biological studies of betel leaf (Piper betle L.): Review on paradigm and its potential benefits in human health

  2022cites this paper
• Low FTO expression serves as a potential biomarker for diagnosis and prognosis of patients with liver cancer

  2022cites this paper
• 3D-Hepatocellular Carcinoma (3D-HCC) Models of Diffused and Aggregated Spheroids using a 96-Pillar/Well Plate

  2021cites this paper
• A review of the mechanisms of anti-cancer activities of some medicinal plants–biochemical perspectives

  2021cites this paper
• Effect of Medicinal Plants against Lung Cancer

  2021cites this paper
• Three-Dimensional Aggregated Spheroid Model of Hepatocellular Carcinoma Using a 96-Pillar/Well Plate

  2021cites this paper
• Anti-Cancer Effect of Moroccan Cobra Naja haje Venom and Its Fractions against Hepatocellular Carcinoma in 3D Cell Culture

  2021cites this paper
• Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches

  2021cites this paper
• Thymoquinone, an Active Compound of Nigella Sativa: Role in Prevention and Treatment of Cancer.

  2020cites this paper
• Ethnobotanical Study of Medicinal Plants of Kashmir Valley, India Having Anticancer Properties

  2020cites this paper
• Expression of MAPK and PI3K/AKT/mTOR Proteins according to the Chronic Liver Disease Etiology in Hepatocellular Carcinoma

  2020cites this paper
• Construction of a potential microRNA, transcription factor and mRNA regulatory network in hepatocellular carcinoma

  2020cites this paper
• In vitro antioxidant, antimicrobial and antiproliferative studies of four different extracts of Orthosiphon stamineus, Gynura procumbens and Ficus deltoidea

  2019cites this paper
• IN VITRO EVALUATION OF ANTIDIABETIC AND CYTOTOXICITY POTENTIALS OF THE RHIZOME EXTRACT OF DRYNARIA QUERCIFOLIA (L.)

  2019cites this paper
• A REVIEW ON HERBAL AND MEDICINAL PLANTS: A NEW DIMENSION FOR THE ANTICANCER TREATMENT

  2019cites this paper
• AN OVERVIEW OF COLORECTAL CANCER: IMPLICATION OF TWO MEDICINAL PLANTS IN THEIR TREATMENT

  2019cites this paper
• Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133+ HCC.

  2019cites this paper
• TCF4/β-Catenin Complex Activates Smo and Gli1 to Promote Migration and Proliferation of Hepatocellular Carcinoma Cells

  2019cites this paper
• Recent Advances in Metabolites from Medicinal Plants in Cancer Prevention and Treatment

  2019cites this paper
• Etiology and Pathogenesis of Hepatocellular Carcinoma

  2018cites this paper
• Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma

  2018cites this paper
• High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype

  2018cites this paper
• Integrated multi-omics data analysis identifying novel drug sensitivity-associated molecular targets of hepatocellular carcinoma cells

  2018cites this paper
• Piper betle Linn. in Cancer: Past, Present, and Future

  2018cites this paper
• MiR-758-3p suppresses proliferation, migration and invasion of hepatocellular carcinoma cells via targeting MDM2 and mTOR.

  2017cites this paper
• Recombinant adeno-associated virus expressing a p53-derived apoptotic peptide (37AA) inhibits HCC cells growth in vitro and in vivo

  2017cites this paper
• Diverse Signaling Pathways and Current Status of Molecular Targeted Treatments for Hepatocellular Carcinoma.

  2017cites this paper
• Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1

  2017cites this paper
• Cellular characteristics of keratin 19-positive canine hepatocellular tumours explain its aggressive behaviour

  2017cites this paper
• GSK-3β suppresses HCC cell dissociation in vitro by upregulating epithelial junction proteins and inhibiting Wnt/β-catenin signaling pathway

  2017cites this paper
• Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.

  2017cites this paper
• Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study

  2017cites this paper
• Crude Flavonoid Extract of Medicinal Herb Zingibar officinale Inhibits Proliferation and Induces Apoptosis in Hepatocellular Carcinoma Cells.

  2017cites this paper
• Epigenetics and Its Role in Human Cancer

  2017cites this paper
• Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma

  2017cites this paper
• Synthesis and bio-molecular study of (+)-N-Acetyl-α-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

  2016cites this paper
• Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis

  2016cites this paper
• Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21CIP1/WAF1 in the liver

  2016cites this paper
• Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1.

  2016cites this paper
• Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p 21 CIP 1 / WAF 1 in the liver

  2016cites this paper
• In-vitro cytotoxicity studies on methanolic leaf extract of embelia ribes burm f - an important traditional medicinal plant of Kerala

  2016cites this paper
• Role of Neoadjuvant and Adjuvant Treatment in HCC Recurrence After Liver Transplantation

  2016cites this paper
• Recurrence of Hepatocellular Carcinoma Following Liver Transplantation Within Milan Criteria

  2016cites this paper
• Targeting cancer stem cells as a therapeutic approach in liver cancer.

  2015cites this paper
• Disruption of TGF-β Pathway and Epithelial-Mesenchymal Transition Phenotype

  2015cites this paper
• Genetic and epigenetic aspects of initiation and progression of hepatocellular carcinoma.

  2015cites this paper
• Dramatic Improvement of Proteomic Analysis of Zebrafish Liver Tumor by Effective Protein Extraction with Sodium Deoxycholate and Heat Denaturation

  2015cites this paper
• DNA Polymerases as targets for gene therapy of hepatocellular carcinoma

  2015cites this paper
• Osthole promotes anti-tumor immune responses in tumor-bearing mice with hepatocellular carcinoma

  2015cites this paper
• Effects of shRNA-Mediated SOX9 Inhibition on Cell Proliferation and Apoptosis in Human HCC Cell Line Hep3B Mediated by Ultrasound-Targeted Microbubble Destruction (UTMD)

  2015cites this paper
• Current and future treatments for hepatocellular carcinoma.

  2015cites this paper
• The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications

  2015cites this paper
• Assessment of biological activity and UPLC–MS based chromatographic profiling of ethanolic extract of Ochradenus arabicus

  2015cites this paper
• Molecular Mechanism and Prediction of Sorafenib Chemoresistance in Human Hepatocellular Carcinoma

  2015cites this paper
• A Novel Therapeutic Combination Sequentially Targeting Aurora B and Bcl-xL in Hepatocellular Carcinoma

  2015cites this paper
• Neo-adjuvant therapy for hepatocellular carcinoma before liver transplantation: where do we stand?

  2014cites this paper
• In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells.

  2014cites this paper
• DNA Polymerases as Targets for Gene Therapy of Hepa tocyte 1 Carcinoma

  2014cites this paper
• Regulation of MET receptor signaling by SOCS1 and its implications for hepatocellular carcinoma.

  2014cites this paper
• β-Ionone Inhibits Persistent Preneoplastic Lesions During the Early Promotion Phase of Rat Hepatocarcinogenesis: TGF-α, NF-κB, and p53 as Cellular Targets

  2014cites this paper
• Cancer Therapy : Preclinical BRaf andMEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma

  2014cites this paper
• Pretreatment MicroRNA Level and Outcome in Sorafenib-treated Hepatocellular Carcinoma

  2014influential citation
• FoxO proteins: regulation and molecular targets in liver cancer.

  2014cites this paper
• BRaf and MEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma

  2014cites this paper
• The role of inflammation and liver cancer.

  2014cites this paper
• Hayvan ve İnsanlarda Hepatosellüler Karsinomun Erken Teşhisinde Alfa-L Fukosidaz'in Alfa-fetoproteine olan Üstünlüğü Priority of Alpha-L- Fucosidase Over Alpha fetoprotein in Early Detection of Hepatocellular Carcinoma in Animals and Human

  2014cites this paper
• PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma

  2013cites this paper
• MARCATORI MOLECOLARI AD IMPATTO TRASLAZIONALE NEL CARCINOMA EPATOCELLULARE

  2013cites this paper
• Efecto de la melatonina sobre la proliferación, apoptosis y angiogénesis en un modelo in vitro de hepatocarcinoma

  2013cites this paper
• Targets and Approaches to Control Hepatocellular Carcinoma in Future

  2013cites this paper
• Transforming growth factor α immunoreactivity. A study in hepatocellular carcinoma and in non-neoplastic liver tissue.

  2012cites this paper
• Modulation of Epigenetic Targets for Anticancer Therapy: Clinicopathological Relevance, Structural Data and Drug Discovery Perspectives

  2012cites this paper
• Growth Inhibition and Apoptosis Induced by Osthole, A Natural Coumarin, in Hepatocellular Carcinoma

  2012cites this paper
• Adenoviral gene therapy in hepatocellular carcinoma: a review

  2012cites this paper
• Hepatocellular Carcinoma: Focus on Different Aspects of Management

  2012cites this paper
• Evidence-based Anticancer Materia Medica for Hepatocellular Carcinoma

  2012cites this paper
• HIV-TAT-fused FHIT protein functions as a potential pro-apoptotic molecule in hepatocellular carcinoma cells.

  2012cites this paper
• DNA Methylation-regulated miR-193a-3p Dictates Resistance of Hepatocellular Carcinoma to 5-Fluorouracil via Repression of SRSF2 Expression*

  2011cites this paper
• Effects of E2F1-cyclin E1-E2 circuit down regulation in hepatocellular carcinoma cells.

  2011cites this paper
• Diagnostic and Prognostic Molecular Markers in Hepatocellular Carcinoma

  2011cites this paper
• Bases moleculares de los nuevos tratamientos del carcinoma hepatocelular

  2011cites this paper
• Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: in vitro evaluation, cell cycle analysis and QSAR studies.

  2011cites this paper
• Growth inhibition and apoptosis induced by lupeol, a dietary triterpene, in human hepatocellular carcinoma cells.

  2011cites this paper
• Molecular pathogenesis of hepatocellular carcinoma.

  2011cites this paper
• Role of Class II nuclear receptors in liver carcinogenesis.

  2011cites this paper
• Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus

  2011influential citation
• Development of Bioanalytical Methods for Clinical Applications and Drug Screening

  2011cites this paper