Molecular and Cellular Pathobiology Cancer Research Hypoxia Modulates EWS-FLI 1 Transcriptional Signature and Enhances the Malignant Properties of Ewing ' s Sarcoma Cells In vitro

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumorigenesis and Neoplastic Progression Hypoxia Inducible Factor-1 Inactivation Unveils a Link between Tumor Cell Metabolism and Hypoxia-Induced Cell Death

  2010cited by this paper
• GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein*

  2009cited by this paper
• The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatellite Sequences with Potential Transcriptional Activation Function

  2009cited by this paper
• A Molecular Function Map of Ewing's Sarcoma

  2009influential reference
• EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells.

  2008cited by this paper
• Regulation of gene expression by hypoxia.

  2008cited by this paper
• The role of hypoxia-inducible factors in tumorigenesis

  2008cited by this paper
• Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors

  2008cited by this paper
• The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α

  2008cited by this paper
• A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature

  2008cited by this paper
• Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration.

  2008cited by this paper
• IGF1 Is a Common Target Gene of Ewing's Sarcoma Fusion Proteins in Mesenchymal Progenitor Cells

  2008cited by this paper
• Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance

  2007cited by this paper
• Hypoxia-driven selection of the metastatic phenotype

  2007cited by this paper
• Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism.

  2007cited by this paper
• Effects of hypoxia on tumor metabolism

  2007cited by this paper
• Single-chain antibodies to the EWS NH(2) terminus structurally discriminate between intact and chimeric EWS in Ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo.

  2006cited by this paper
• Insulin‐like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma

  2006cited by this paper
• Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

  2005cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• Context matters: the hen or egg problem in Ewing's sarcoma.

  2005cited by this paper
• PAGE: Parametric Analysis of Gene Set Enrichment

  2005cited by this paper
• DNA Microarrays Reveal Relationship of Ewing Family Tumors to Both Endothelial and Fetal Neural Crest-Derived Cells and Define Novel Targets

  2004cited by this paper
• A Model-Based Background Adjustment for Oligonucleotide Expression Arrays

  2004cited by this paper
• O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1.

  2004cited by this paper
• Bioconductor: open software development for computational biology and bioinformatics

  2004cited by this paper
• EWS/FLI function varies in different cellular backgrounds.

  2003cited by this paper
• PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

  2003cited by this paper
• Bach1 Functions as a Hypoxia-inducible Repressor for the Heme Oxygenase-1 Gene in Human Cells*

  2003cited by this paper
• Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model.

  2003cited by this paper
• Investigating hypoxic tumor physiology through gene expression patterns

  2003cited by this paper
• Hypoxia Actively Represses Transcription by Inducing Negative Cofactor 2 (Dr1/DrAP1) and Blocking Preinitiation Complex Assembly*

  2003cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• Hypoxia — a key regulatory factor in tumour growth

  2002cited by this paper
• HIF-1 and tumor progression: pathophysiology and therapeutics.

  2002cited by this paper
• Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors

  2002cited by this paper
• Supplemental Information for

  2002cited by this paper
• Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.

  2001cited by this paper
• Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy.

  2001cited by this paper
• Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer.

  2000cited by this paper
• Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer.

  2000cited by this paper
• Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

  1999cited by this paper
• Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

  1998cited by this paper
• Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer.

  1998cited by this paper
• Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

  1998cited by this paper
• EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

  1997cited by this paper
• DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

  1994cited by this paper

• Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

  2023influential citation
• Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications

  2023cites this paper
• Liquid biopsy in bone sarcomas and identification of new biomarkers

  2022cites this paper
• A Novel Defined Hypoxia-Related Gene Signature for Prognostic Prediction of Patients With Ewing Sarcoma

  2022cites this paper
• Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma

  2022cites this paper
• Hypoxia-inducible factor (HIF)–mediated effects of the hypoxic niche in bone cancer

  2022cites this paper
• The importance of fusion protein activity in Ewing sarcoma and the cell intrinsic and extrinsic factors that regulate it: A review

  2022cites this paper
• Regulation of Metastasis in Ewing Sarcoma

  2022cites this paper
• The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites

  2021cites this paper
• PDX-Derived Ewing’s Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures

  2021cites this paper
• Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

  2021cites this paper
• Hypoxia and its therapeutic possibilities in paediatric cancers

  2020cites this paper
• Imatinib Revives the Therapeutic Potential of Metformin on Ewing Sarcoma by Attenuating Tumor Hypoxic Response and Inhibiting Convergent Signaling Pathways.

  2020influential citation
• Cellular plasticity and drug resistance in sarcoma.

  2020cites this paper
• The Role of C-X-C Chemokine Receptor Type 4 (CXCR4) in Cell Adherence and Spheroid Formation of Human Ewing’s Sarcoma Cells under Simulated Microgravity

  2019cites this paper
• Clinicopathological and prognostic value of hypoxia-inducible factor-1α in patients with bone tumor: a systematic review and meta-analysis

  2019cites this paper
• New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions

  2019cites this paper
• Hypoxia induces lineage modulation of Ewing’s sarcoma tumor cells into EWS-FLI-1 + vascular pericytes

  2019cites this paper
• Prognostic profiling of the immune cell microenvironment in Ewing´s Sarcoma Family of Tumors

  2019cites this paper
• The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation

  2019cites this paper
• Personalized genomic analysis based on circulating tumor cells of extra-skeletal Ewing sarcoma of the uterus: A case report of a 16-year-old Korean female

  2018cites this paper
• Ewing sarcoma

  2018cites this paper
• Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells

  2017cites this paper
• Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

  2017influential citation
• Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease

  2017cites this paper
• The progress about HIFs and bone tumor

  2016cites this paper
• In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis.

  2016cites this paper
• Micro-Environmental Stress Induces Src-Dependent Activation of Invadopodia and Cell Migration in Ewing Sarcoma

  2016influential citation
• Next steps in preventing Ewing sarcoma progression.

  2016cites this paper
• Cancer stem cells of sarcoma

  2016cites this paper
• TRAIL-based therapy in pediatric bone tumors: how to overcome resistance.

  2015cites this paper
• Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma

  2015cites this paper
• The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth

  2015influential citation
• New therapeutic targets in Ewing sarcoma: from pre-clinical proof-of-concept to clinical trials

  2015cites this paper
• Signaling mechanisms of the epithelial-mesenchymal transition

  2014cites this paper
• Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma

  2014cites this paper
• Overlapping and Discrete Functions of the Matricellular Proteins CCN1 and CCN2 during Endochondral Bone Formation

  2013cites this paper
• Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma

  2013cites this paper
• Hypoxia-inducible Factor (HIF)-1α and CCN2 Form a Regulatory Circuit in Hypoxic Nucleus Pulposus Cells

  2013cites this paper
• Hypoxia-Inducible Factors: Mediators of Cancer Progression; Prognostic and Therapeutic Targets in Soft Tissue Sarcomas

  2013cites this paper
• Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects

  2013influential citation
• Variability in functional p53 reactivation by PRIMA-1Met/APR-246 in Ewing sarcoma

  2013cites this paper
• Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis

  2013cites this paper
• Drugs targeting the bone microenvironment: new therapeutic tools in Ewing's sarcoma?

  2013cites this paper
• V-ATPase is a candidate therapeutic target for Ewing sarcoma.

  2013cites this paper
• Molecular mechanisms of ETS transcription factor-mediated tumorigenesis

  2013cites this paper
• Metformin as an Adjuvant Drug against Pediatric Sarcomas: Hypoxia Limits Therapeutic Effects of the Drug

  2013influential citation
• Cancer and the Cellular Response to Hypoxia

  2013cites this paper
• Hypoxia-inducible Factor ( HIF )-1 and CCN 2 Form a Regulatory Circuit in Hypoxic Nucleus Pulposus Cells

  2013cites this paper
• Bone Sarcomas: From Biology to Targeted Therapies

  2012cites this paper
• The effect of EWS and its oncogenic derivative EWS-FLl1 on transcriptional and post-transcriptional gene regulation in Ewing sarcoma

  2012cites this paper
• Genomics and Systems Biology of Mammalian Cell Culture

  2012cites this paper
• The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease

  2012cites this paper
• Hypoxia-regulated target genes implicated in tumor metastasis

  2012cites this paper
• Oxidative stress and therapeutic opportunities: focus on the Ewing’s sarcoma family of tumors

  2011cites this paper
• The tumor microenvironment: part 1.

  2011cites this paper
• Hypoxia, stem cells and bone tumor.

  2011cites this paper
• Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

  2011cites this paper
• Heterogeneous Role of the Glutathione Antioxidant System in Modulating the Response of ESFT to Fenretinide in Normoxia and Hypoxia

  2011cites this paper
• Intercohort Gene Expression Co-Analysis Reveals Chemokine Receptors as Prognostic Indicators in Ewing's Sarcoma

  2010cites this paper