Neuroinflammation and Perioperative Neurocognitive Disorders

Neuroinflammation has become a key hallmark of neurological complications including perioperative pathologies such as postoperative delirium and longer-lasting postoperative cognitive dysfunction. Dysregulated inflammation and neuronal injury are emerging from clinical studies as key features of perioperative neurocognitive disorders. These findings are paralleled by a growing body of preclinical investigations aimed at better understanding how surgery and anesthesia affect the central nervous system and possibly contribute to cognitive decline. Herein, we review the role of postoperative neuroinflammation and underlying mechanisms in immune-to-brain signaling after peripheral surgery.

• Publication year

  2019

• Venue

  Anesthesia and Analgesia

• Publication date

  2019-03-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1213/ANE.0000000000004053PMID 30883423PMCID 6437083
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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