The Ubiquitous Protein Domain EAL Is a Cyclic Diguanylate-Specific Phosphodiesterase: Enzymatically Active and Inactive EAL Domains

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Bacteriology

• Publication date

  2005-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/JB.187.14.4774-4781.2005PMID 15995192PMCID PMC1169503
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• C‐di‐GMP: the dawning of a novel bacterial signalling system

  2005cited by this paper
• Cyclic Diguanylate Is a Ubiquitous Signaling Molecule in Bacteria: Insights into Biochemistry of the GGDEF Protein Domain

  2005cited by this paper
• Structural basis of activity and allosteric control of diguanylate cyclase.

  2004cited by this paper
• Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain.

  2004cited by this paper
• PsfR, a factor that stimulates psbAI expression in the cyanobacterium Synechococcus elongatus PCC 7942.

  2004cited by this paper
• Cyclic di-GMP as a bacterial second messenger.

  2004cited by this paper
• GGDEF and EAL domains inversely regulate cyclic di‐GMP levels and transition from sessility to motility

  2004cited by this paper
• Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria?

  2004cited by this paper
• Cyclic diguanylate (c‐di‐GMP) regulates Vibrio cholerae biofilm formation

  2004influential reference
• Bacterial signal transduction network in a genomic perspective.

  2004influential reference
• Role of the GGDEF protein family in Salmonella cellulose biosynthesis and biofilm formation

  2004cited by this paper
• Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus

  2003cited by this paper
• Vibrio parahaemolyticus scrABC, a Novel Operon Affecting Swarming and Capsular Polysaccharide Regulation

  2002cited by this paper
• Characterization of a direct oxygen sensor heme protein from Escherichia coli. Effects of the heme redox states and mutations at the heme-binding site on catalysis and structure.

  2002cited by this paper
• Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity.

  2001cited by this paper
• GGDEF domain is homologous to adenylyl cyclase

  2001cited by this paper
• Novel domains of the prokaryotic two-component signal transduction systems.

  2001influential reference
• Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor.

  2001cited by this paper
• Three cdg Operons Control Cellular Turnover of Cyclic Di-GMP in Acetobacter xylinum: Genetic Organization and Occurrence of Conserved Domains in Isoenzymes

  1998influential reference
• Multiple sequence alignment with Clustal X.

  1998cited by this paper
• Polypeptide composition of bacterial cyclic diguanylic acid-dependent cellulose synthase and the occurrence of immunologically crossreacting proteins in higher plants.

  1991cited by this paper
• The cyclic diguanylic acid regulatory system of cellulose synthesis in Acetobacter xylinum. Chemical synthesis and biological activity of cyclic nucleotide dimer, trimer, and phosphothioate derivatives.

  1990cited by this paper
• Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid

  1987cited by this paper
• Control of cellulose synthesis Acetobacter xylinum. A unique guanyl oligonucleotide is the immediate activator of the cellulose synthase

  1986cited by this paper
• Identification and Characterization of a Vibrio cholerae Gene, mbaA , Involved in Maintenance of Biofilm Architecture

  year unknowncited by this paper

• Regulatory divergence and functional diversification of a c-di-GMP-controlled sigma factor in Actinomycetota

  2026cites this paper
• Architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species

  2025cites this paper
• A horizontally acquired cyclic di-GMP phosphodiesterase regulated by zinc and quorum sensing

  2025cites this paper
• A cyclic di-GMP phosphodiesterase in the VSP-2 island of Vibrio cholerae is regulated by zinc and quorum sensing

  2025influential citation
• Optogenetic tools for optimizing key signalling nodes in synthetic biology.

  2025cites this paper
• Staphylococcus aureus uses a GGDEF protein to recruit diacylglycerol kinase to the membrane for lipid recycling

  2025cites this paper
• eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling.

  2025cites this paper
• An updated view of bacterial endophytes as antimicrobial agents against plant and human pathogens

  2024cites this paper
• Building permits—control of type IV pilus assembly by PilB and its cofactors

  2024cites this paper
• pGpG-signaling regulates virulence and global transcriptomic targets in Erwinia amylovora

  2024cites this paper
• Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain

  2024cites this paper
• Discovery of deep-sea coral symbionts from a novel clade of marine bacteria with severely reduced genomes

  2024influential citation
• High efficacy treatment of murine Pseudomonas aeruginosa catheter-associated urinary tract infections using the c-di-GMP modulating anti-biofilm compound Disperazol in combination with ciprofloxacin

  2024cites this paper
• Choline metabolism modulates cyclic-di-GMP signaling and virulence of Pseudomonas aeruginosa in a macrophage infection model

  2024cites this paper
• Old role with new feature: T2SS ATPase as a cyclic-di-GMP receptor to regulate antibiotic production

  2024cites this paper
• Lysobacter enzymogenes: a fully armed biocontrol warrior1

  2024cites this paper
• Interbacterial Biofilm Competition through a Suite of Secreted Metabolites.

  2024cites this paper
• Co-regulation of Thermosensor Pathogenic Factors by C-di-GMP-Related Two-Component Systems and a cAMP Receptor-like Protein (Clp) in Stenotrophomonas maltophilia

  2024cites this paper
• A PilZ domain protein interacts with the transcriptional regulator HinK to regulate type VI secretion system in Pseudomonas aeruginosa

  2024cites this paper
• Transcriptomic Response of Rhizobium leguminosarum to Acidic Stress and Nutrient Limitation Is Versatile and Substantially Influenced by Extrachromosomal Gene Pool

  2024cites this paper
• Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain

  2024cites this paper
• Signals behind Listeria monocytogenes virulence mechanisms

  2024cites this paper
• Moonlighting Crypto-Enzymes and Domains as Ancient and Versatile Signaling Devices

  2024cites this paper
• Cell-autonomous diversification in bacteria arises from calcium dynamics self-organizing at a critical point

  2023cites this paper
• Identification and expression profiling of c-di-GMP signaling genes in the probiotic strain Escherichia coli Nissle 1917 during adhesion to the intestinal epithelial cells

  2023cites this paper
• Nucleotides as Bacterial Second Messengers

  2023cites this paper
• Silver nanoparticles disturb treatment performance in constructed wetlands: Responses of biofilm and hydrophyte

  2023cites this paper
• Cooperative Regulation of Flagellar Synthesis by Two EAL-Like Proteins upon Salmonella Entry into Host Cells

  2023cites this paper
• Structural analysis of novel drug targets for mitigation of Pseudomonas aeruginosa biofilms.

  2023cites this paper
• Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus pathogenicity.

  2023cites this paper
• Conserved FimK Truncation Coincides with Increased Expression of Type 3 Fimbriae and Cultured Bladder Epithelial Cell Association in Klebsiella quasipneumoniae

  2022cites this paper
• Frequency modulation of a bacterial quorum sensing response

  2022cites this paper
• Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP

  2022cites this paper
• 1 Main Manuscript for 2 Differential ligand-selective control of opposing enzymatic activities 3 within a bifunctional c-di-GMP enzyme 4

  2022cites this paper
• The RNA-Binding Protein ProQ Impacts Exopolysaccharide Biosynthesis and Second Messenger Cyclic di-GMP Signaling in the Fire Blight Pathogen Erwinia amylovora

  2022cites this paper
• Functional Annotation of Hypothetical Proteins From the Enterobacter cloacae B13 Strain and Its Association With Pathogenicity

  2022cites this paper
• Three-dimensional structure of a mycobacterial oligoribonuclease reveals a unique C-terminal tail that stabilizes the homodimer

  2022cites this paper
• Dual GGDEF/EAL-Domain Protein RmcA Controls the Type III Secretion System of Pseudomonas aeruginosa by Interaction with CbrB.

  2022cites this paper
• Genome characterization of a uropathogenic Pseudomonas aeruginosa isolate PA_HN002 with cyclic di-GMP-dependent hyper-biofilm production

  2022cites this paper
• ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa

  2022cites this paper
• Elongation factor P modulates Acinetobacter baumannii physiology and virulence as a cyclic dimeric guanosine monophosphate effector

  2022cites this paper
• Mutational Analysis of Vibrio fischeri c-di-GMP-Modulating Genes Reveals Complex Regulation of Motility

  2022cites this paper
• C-di-GMP and Its Role in Regulation of Natural Products Production

  2022cites this paper
• The HD-GYP domain protein of Shewanella putrefaciens YZ08 regulates biofilm formation and spoilage activities.

  2022cites this paper
• PA0575 (RmcA) interacts with other c-di-GMP metabolizing proteins in Pseudomonas aeruginosa PAO1.

  2022cites this paper
• Characterisation of sequence–structure–function space in sensor–effector integrators of phytochrome-regulated diguanylate cyclases

  2022influential citation
• Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes

  2022cites this paper
• Pseudomonas aeruginosa post‐translational responses to elevated c‐di‐GMP levels

  2022cites this paper
• The Wsp chemosensory system modulates c-di-GMP-dependent biofilm formation by integrating DSF quorum sensing through the WspR-RpfG complex in Lysobacter

  2022cites this paper
• A pGpG-specific phosphodiesterase regulates cyclic di-GMP signaling in Vibrio cholerae

  2022cites this paper
• Roles of the second messenger c‐di‐GMP in bacteria: Focusing on the topics of flagellar regulation and Vibrio spp.

  2022cites this paper
• Vibrio cholerae V-cGAP3 Is an HD-GYP Phosphodiesterase with a Metal Tunable Substrate Selectivity.

  2022cites this paper
• The Sia System and c-di-GMP Play a Crucial Role in Controlling Cell-Association of Psl in Planktonic P. aeruginosa

  2022cites this paper
• In Vitro Selection of Enterobacter cloacae with Cefepime, Meropenem, and Ceftazidime-Avibactam Generate Diverse Resistance Mechanisms.

  2022cites this paper
• BldD-based bimolecular fluorescence complementation for in vivo detection of the second messenger cyclic di-GMP

  2021cites this paper
• Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme

  2021cites this paper
• Evolutionary flexibility in routes to mat formation by Pseudomonas

  2021cites this paper
• Evolution of a σ–(c-di-GMP)–anti-σ switch

  2021cites this paper
• Identification and Characterization of Four c-di-GMP-Metabolizing Enzymes from Streptomyces ghanaensis ATCC14672 Involved in the Regulation of Morphogenesis and Moenomycin A Biosynthesis

  2021cites this paper
• Molecular and structural facets of c-di-GMP signalling associated with biofilm formation in Pseudomonas aeruginosa.

  2021cites this paper
• Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa

  2021cites this paper
• Antifungal weapons of Lysobacter, a mighty biocontrol agent.

  2021cites this paper
• Evolutionary flexibility in routes to mat formation by Pseudomonas

  2021cites this paper
• Recent evidence for multifactorial biofilm regulation by heme sensor proteins NosP and H-NOX.

  2021cites this paper
• The ever-expanding world of bacterial cyclic oligonucleotide second messengers.

  2021cites this paper
• Coordinated control of the type IV pili and c‐di‐GMP‐dependent antifungal antibiotic production in L ysobacter by the response regulator PilR

  2021cites this paper
• The cyclic di-GMP network is a global regulator of phase-transition and attachment-dependent host colonization in Erwinia amylovora

  2021cites this paper
• c-di-GMP Inhibits Early Sporulation in Clostridioides difficile

  2021cites this paper
• Enzymatic activity of the blue light‐regulated phosphodiesterase BlrP1 from Klebsiella pneumoniae shows a nonlinear dependence on light intensity

  2021cites this paper
• A Trigger Phosphodiesterase Modulates the Global c-di-GMP Pool, Motility, and Biofilm Formation in Vibrio parahaemolyticus

  2021cites this paper
• Diguanylate Cyclase and Phosphodiesterase Interact To Maintain the Specificity of Cyclic di-GMP Signaling in the Regulation of Antibiotic Synthesis in Lysobacter enzymogenes

  2021cites this paper
• c-di-GMP Homeostasis Is Critical for Heterocyst Development in Anabaena sp. PCC 7120

  2021cites this paper
• Epinephrine affects gene expression levels and has a complex effect on biofilm formation in Micrococcus luteus strain C01 isolated from human skin

  2021cites this paper
• PdeA is required for the rod shape morphology of Brucella abortus

  2021cites this paper
• Photoactivated Adenylyl Cyclases: Fundamental Properties and Applications.

  2021cites this paper
• Clp is a “busy” transcription factor in the bacterial warrior, Lysobacter enzymogenes

  2021cites this paper
• Sensory Perception in Bacterial Cyclic Diguanylate Signal Transduction

  2021cites this paper
• Global Transcriptional Repression of Diguanylate Cyclases by MucR1 Is Essential for Sinorhizobium-Soybean Symbiosis

  2021cites this paper
• Regulation of Biofilm Exopolysaccharide Production by Cyclic Di-Guanosine Monophosphate

  2021cites this paper
• Cyclic di-GMP Signaling Systems in the Gram-Positive Bacillus cereus Group

  2020cites this paper
• Specialized and shared functions of diguanylate cyclases and phosphodiesterases in Streptomyces development

  2020cites this paper
• The World of Cyclic Dinucleotides in Bacterial Behavior

  2020cites this paper
• Cyclic di-GMP Signaling in Bacillus subtilis

  2020cites this paper
• Enzymatic Degradation of Linear Dinucleotide Intermediates of Cyclic Dinucleotides

  2020cites this paper
• Sensory Domains That Control Cyclic di-GMP-Modulating Proteins: A Critical Frontier in Bacterial Signal Transduction

  2020cites this paper
• Functional characterization of multiple PAS domain-containing diguanylate cyclases in Synechocystis sp. PCC 6803.

  2020cites this paper
• Insights into the Molecular Basis of Biofilm Dispersal from Crystal Structures of Didomain Containing Proteins

  2020cites this paper
• Measuring Individual Cell Cyclic di-GMP: Identifying Population Diversity and Cyclic di-GMP Heterogeneity

  2020cites this paper
• Microbial Cyclic Di-Nucleotide Signaling

  2020cites this paper
• Cyclic di-GMP Signaling in Salmonella enterica serovar Typhimurium

  2020cites this paper
• c-di-GMP-related phenotypes are modulated by the interaction between a diguanylate cyclase and a polar hub protein

  2020cites this paper
• The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa

  2020cites this paper
• Evaluation and characterization of the predicted diguanylate cyclase‐encoding genes in Pseudomonas aeruginosa

  2020cites this paper
• Fluorescent cyclic dinucleotides.

  2020cites this paper
• Knockout of Diguanylate Cyclase Genes in Lysobacter enzymogenes to Improve Production of Antifungal Factor and Increase Its Application in Seed Coating

  2020cites this paper
• Azorhizobium caulinodans c-di-GMP phosphodiesterase Chp1 involved in motility, EPS production, and nodulation of the host plant

  2020cites this paper
• Unconventional Cyclic di-GMP Signaling in Escherichia coli

  2020cites this paper
• The Transcription Regulator and c-di-GMP Phosphodiesterase PdeL Represses Motility in Escherichia coli

  2020cites this paper
• A Cyclic di-GMP Network Is Present in Gram-Positive Streptococcus and Gram-Negative Proteus Species

  2020cites this paper
• Cyclic di-GMP signaling controlling the free-living lifestyle of alpha-proteobacterial rhizobia

  2020cites this paper