Connective tissue growth factor: a mediator of TGF-β action on fibroblasts

Abstract Connective tissue growth factor (CTGF) is a cysteine-rich mitogenic peptide that binds heparin and is secreted by fibroblasts after activation with transforming growth factor beta (TGF-β). CTGF is a member of a highly conserved family of peptides that include immediate early gene products cef10, cyr61, fisp12 ; a putative avian proto-oncogene, nov ; and a drosophila gene, twisted gastrulation, tsg , that controls medial mesoderm induction during dorsal-ventral axis pattern formation, a process also controlled by TGF-β related peptides ( dpp, scw ). In the adult mammal, CTGF functions as a downstream mediator of TGF-β action on connective tissue cells, where it stimulates cell proliferation and extracellular matrix synthesis. CTGF does not appear to act on epithelial cells or immune cells. Because the biological actions of TGF-β are complex and affect many different cell types, CTGF may serve as a more specific target for selective intervention in processes involving connective tissue formation during wound repair or fibrotic disorders. Northern blot and in situ hybridization studies have demonstrated that CTGF is coordinately expressed with TGF-β in every fibrotic disorder examined to date. Agents that inhibit CTGF production or action could lead to the development of new therapeutic approaches for the control of fibrotic disorders in humans.

• Publication year

  1997

• Venue

  Cytokine & Growth Factor Reviews

• Publication date

  1997-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1359-6101(97)00010-5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Ciba Foundation Symposium

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