The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway

No abstract is available for this paper.

• Publication year

  2013

• Venue

  EMBO Journal

• Publication date

  2013-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2013.63PMID 23503588PMCID PMC3981172
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Widespread RNA 3'-end oligouridylation in mammals.

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• Regulation of cytoplasmic mRNA decay

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• Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility

  2012cited by this paper
• Ways and means of eukaryotic mRNA decay.

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• Regulation of cytoplasmic mRNA decay

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• Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

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• P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.

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• The CR3 motif of Rrp44p is important for interaction with the core exosome and exosome function

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• Structural and functional insights into eukaryotic mRNA decapping

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• Comprehensive phenotypic analysis of single‐gene deletion and overexpression strains of Saccharomyces cerevisiae

  2011cited by this paper
• The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1

  2011cited by this paper
• Functions of the cytoplasmic exosome.

  2011cited by this paper
• Cellular stress induces cytoplasmic RNA granules in fission yeast.

  2011influential reference
• Importance of polyadenylation in the selective elimination of meiotic mRNAs in growing S. pombe cells

  2010cited by this paper
• Polyadenylation and beyond: emerging roles for noncanonical poly(A) polymerases

  2010cited by this paper
• Decapping activators in Saccharomyces cerevisiae act by multiple mechanisms.

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• Dis3‐like 1: a novel exoribonuclease associated with the human exosome

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• The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

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• RiboSys, a high-resolution, quantitative approach to measure the in vivo kinetics of pre-mRNA splicing and 3'-end processing in Saccharomyces cerevisiae.

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• Conserved RNaseII domain protein functions in cytoplasmic mRNA decay and suppresses Arabidopsis decapping mutant phenotypes

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• Comparative multiplexed mass spectrometric analyses of endogenously expressed yeast nuclear and cytoplasmic exosomes.

  2009cited by this paper
• RNAi in Budding Yeast

  2009cited by this paper
• CUCU Modification of mRNA Promotes Decapping and Transcript Degradation in Aspergillus nidulans

  2009cited by this paper
• 3′ uridylation precedes decapping in a novel pathway of bulk mRNA turnover

  2009influential reference
• The many pathways of RNA degradation.

  2009cited by this paper
• Small RNAs in transcriptional gene silencing and genome defence

  2009cited by this paper
• The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome

  2009cited by this paper
• P bodies promote stress granule assembly in Saccharomyces cerevisiae

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• The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities

  2008cited by this paper
• Endonucleolytic RNA cleavage by a eukaryotic exosome

  2008cited by this paper
• Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.

  2008influential reference
• Stress granules: the Tao of RNA triage.

  2008cited by this paper
• Analysis of cytoplasmic mRNA decay in Saccharomyces cerevisiae.

  2008influential reference
• The 3' ends of mature transcripts are generated by a processosome complex in fission yeast mitochondria.

  2008cited by this paper
• The highways and byways of mRNA decay

  2007cited by this paper
• 3' Terminal oligo U-tract-mediated stimulation of decapping.

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  2007cited by this paper
• Analysis of P-body assembly in Saccharomyces cerevisiae.

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  2007influential reference
• ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe

  2006cited by this paper
• RNA-quality control by the exosome

  2006cited by this paper
• Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex

  2006cited by this paper
• Silver staining of proteins in polyacrylamide gels

  2006cited by this paper
• A single mutation in Escherichia coli ribonuclease II inactivates the enzyme without affecting RNA binding

  2005cited by this paper
• RNA degradation by the exosome is promoted by a nuclear polyadenylation complex.

  2005cited by this paper
• Processing bodies require RNA for assembly and contain nontranslating mRNAs.

  2005cited by this paper
• Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

  2005cited by this paper
• Uridine Addition After MicroRNA-Directed Cleavage

  2004cited by this paper
• Messenger RNA Turnover in Eukaryotes: Pathways and Enzymes

  2004cited by this paper
• The Yeast Mitochondrial Degradosome

  2003cited by this paper
• Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

  2003cited by this paper
• Global analysis of protein localization in budding yeast

  2003cited by this paper
• The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation.

  2001influential reference
• A Sm‐like protein complex that participates in mRNA degradation

  2000cited by this paper
• Yeast Sm-like proteins function in mRNA decapping and decay

  2000cited by this paper
• A generic protein purification method for protein complex characterization and proteome exploration

  1999influential reference
• Heterologous modules for efficient and versatile PCR‐based gene targeting in Schizosaccharomyces pombe

  1998cited by this paper
• The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex

  1998influential reference
• The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.

  1997cited by this paper
• The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.

  1997cited by this paper
• The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.

  1996cited by this paper
• Turnover mechanisms of the stable yeast PGK1 mRNA

  1995cited by this paper
• Synthetic lethality of sep1 (xrn1) ski2 and sep1 (xrn1) ski3 mutants of Saccharomyces cerevisiae is independent of killer virus and suggests a general role for these genes in translation control

  1995cited by this paper
• Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.

  1991cited by this paper
• nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine.

  1990cited by this paper

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• RNA-Degrading Exosome Complexes: Molecular Mechanisms and Structural Insights.

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• Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability.

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• The Bacterial Counterparts of the Eukaryotic Exosome: An Evolutionary Perspective.

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• The Eukaryotic RNA Exosome: Methods and Protocols

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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018influential citation
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  2018cites this paper
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  2018cites this paper
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