Physiology and Pathophysiology of the DUOXes

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2006-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/ars.2006.8.1563PMID 16987011
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A>C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect.

  2006cited by this paper
• NADPH Oxidases: New Regulators of Old Functions

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• Identification of a Novel Partner of Duox EFP1, A THIOREDOXIN-RELATED PROTEIN*

  2005cited by this paper
• Dual oxidase2 is expressed all along the digestive tract.

  2005cited by this paper
• A new case of congenital goiter with hypothyroidism caused by a homozygous p.R277X mutation in the exon 7 of the thyroglobulin gene: a mutational hot spot could explain the recurrence of this mutation.

  2005cited by this paper
• Identification of a Novel Partner of Duox

  2005cited by this paper
• Dual Oxidase-2 Has an Intrinsic Ca2+-dependent H2O2-generating Activity*

  2005cited by this paper
• Genetics of congenital hypothyroidism

  2005cited by this paper
• Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings

  2005cited by this paper
• Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells.

  2005cited by this paper
• Involvement of NADPH Oxidase Isoforms and Src Family Kinases in CD95-dependent Hepatocyte Apoptosis*

  2005cited by this paper
• Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium

  2005cited by this paper
• A Direct Role for Dual Oxidase in Drosophila Gut Immunity

  2005influential reference
• Cigarette smoke condensate induces MMP-12 gene expression in airway-like epithelia.

  2005cited by this paper
• Regulated hydrogen peroxide production by Duox in human airway epithelial cells.

  2005cited by this paper
• The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal.

  2005cited by this paper
• Regulation of H2O2 generation in thyroid cells does not involve Rac1 activation.

  2005cited by this paper
• The oxidative burst at fertilization is dependent upon activation of the dual oxidase Udx1.

  2004cited by this paper
• Tissue distribution and putative physiological function of NOX family NADPH oxidases.

  2004cited by this paper
• NADPH Oxidase-dependent Acid Production in Airway Epithelial Cells*

  2004cited by this paper
• Pendred syndrome and DFNB4‐mutation screening of SLC26A4 by denaturing high‐performance liquid chromatography and the identification of eleven novel mutations

  2004cited by this paper
• Age-dependent variation of follicular size and expression of iodine transporters in human thyroid tissue.

  2004cited by this paper
• Targeting of the Dual Oxidase 2 N-terminal Region to the Plasma Membrane*

  2004cited by this paper
• Structural and functional characterization of the two human ThOX/Duox genes and their 5′-flanking regions

  2004cited by this paper
• Identification of a truncated dual oxidase 2 (DUOX2) messenger ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes.

  2003cited by this paper
• Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect

  2003cited by this paper
• Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense

  2003influential reference
• Caenorhabditis elegans exoskeleton collagen COL‐19: An adult‐specific marker for collagen modification and assembly, and the analysis of organismal morphology

  2003cited by this paper
• Correlation between the loss of thyroglobulin iodination and the expression of thyroid-specific proteins involved in iodine metabolism in thyroid carcinomas.

  2003cited by this paper
• [Serial analysis of gene expression].

  2002influential reference
• Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases

  2002cited by this paper
• Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.

  2002cited by this paper
• Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.

  2002cited by this paper
• Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells.

  2002cited by this paper
• Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.

  2002cited by this paper
• Goiter and hypothyroidism in two siblings due to impaired Ca(+2)/NAD(P)H-dependent H(2)O(2)-generating activity.

  2001cited by this paper
• Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase Flavoprotein DUOX Genes and Proteins in Human Papillary and Follicular Thyroid Carcinomas

  2001cited by this paper
• Up to date with human thyroglobulin.

  2001cited by this paper
• Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues.

  2001cited by this paper
• Genetic defects in thyroid hormone supply (ch. 16b) [www.thyroidmanager.org/chapter16/16-text.htm]

  2001cited by this paper
• Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox

  2001cited by this paper
• Thyroid oxidase (THOX2) gene expression in the rat thyroid cell line FRTL-5.

  2000cited by this paper
• Cloning of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family*

  2000cited by this paper
• Novel homologs of gp91phox.

  2000cited by this paper
• UvA-DARE ( Digital Academic Repository ) Molecular analysis of mutated thyroid peroxidase detected in patients with total iodide organification defects

  2000cited by this paper
• A premature stopcodon in thyroglobulin messenger RNA results in familial goiter and moderate hypothyroidism.

  1999cited by this paper
• Evolving concepts of thyroid hormone action.

  1999cited by this paper
• Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy

  1999cited by this paper
• Purification of a Novel Flavoprotein Involved in the Thyroid NADPH Oxidase

  1999cited by this paper
• A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia.

  1998cited by this paper
• Two frequent missense mutations in Pendred syndrome.

  1998cited by this paper
• Recurrent T354P mutation of the Na+/I- symporter in patients with iodide transport defect.

  1998cited by this paper
• Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients.

  1998cited by this paper
• Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)

  1997cited by this paper
• Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease.

  1996cited by this paper
• Cloning and characterization of the thyroid iodide transporter

  1996cited by this paper
• The G Protein–coupled Receptor Family and One of Its Members, the TSH Receptor a

  1995cited by this paper
• Serial Analysis of Gene Expression

  1995cited by this paper
• Effect of P1-purinergic agonist on thyrotropin stimulation of H2O2 generation in FRTL-5 and porcine thyroid cells.

  1994cited by this paper
• Chronic granulomatous disease.

  1994cited by this paper
• Excessive production of reactive oxygen metabolites by inflamed colon: analysis by chemiluminescence probe.

  1992cited by this paper
• The H2O2-generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid.

  1991cited by this paper
• Nuclear thyroid hormone receptors.

  1990cited by this paper
• Peroxidases in chemistry and biology

  1990cited by this paper
• Superoxide anion is the initial product in the hydrogen peroxide formation catalyzed by NADPH oxidase in porcine thyroid plasma membrane.

  1989cited by this paper
• Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis.

  1989cited by this paper
• Ca2+ regulation of thyroid NADPH‐dependent H2O2 generation

  1988cited by this paper
• Ca2+ regulation of thyroid NADPH-dependent H2O2 generation.

  1988cited by this paper
• Abnormal H2O2 supply in the thyroid of a patient with goiter and iodine organification defect.

  1987cited by this paper
• Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs.

  1987cited by this paper
• NADPH-dependent H2O2 generation and peroxidase activity in thyroid particular fraction.

  1984cited by this paper
• Thyroglobulin from human goiters. Effects of iodination on sedimentation and iodoamino acid synthesis.

  1967cited by this paper

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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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• Reactive oxygen species induce antiviral innate immune response through IFN-λ regulation in human nasal epithelial cells.

  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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• Hypothiocyanous acid: benign or deadly?

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• Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

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• Innate immunity and gut-microbe mutualism in Drosophila.

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• Amphotericin B up‐regulates angiogenic genes in hepatocellular carcinoma cell lines

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• CD95 ligand is a proliferative and antiapoptotic signal in quiescent hepatic stellate cells.

  2008cites this paper
• Reactive oxygen species generation at the plasma membrane for antibody control.

  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
• Roles of hydrogen peroxide in thyroid physiology and disease.

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  2006cites this paper