Role of NADPH Oxidase in β Cell Dysfunction

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-94-007-6686-0_46
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• NADPH Oxidase 4 Regulates Cardiomyocyte Differentiation via Redox Activation of c-Jun Protein and the cis-Regulation of GATA-4 Gene Transcription*

  2013cited by this paper
• Dual effect of advanced glycation end products in pancreatic islet apoptosis

  2013cited by this paper
• Regulation of NOX-1 expression in beta cells: a positive feedback loop involving the Src-kinase signaling pathway.

  2013cited by this paper
• The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite.

  2013cited by this paper
• Activation of apocynin-sensitive NADPH oxidase (Nox2) activity in INS-1 832/13 cells under glucotoxic conditions

  2013cited by this paper
• Protein farnesylation is requisite for mitochondrial fuel-induced insulin release

  2012cited by this paper
• Expression of NADPH oxidase in human pancreatic islets.

  2012cited by this paper
• NADPH oxidase 2 plays a critical role in dysfunction and apoptosis of pancreatic β-cells induced by very low-density lipoprotein

  2012cited by this paper
• NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion

  2012cited by this paper
• NOX5: from basic biology to signaling and disease.

  2012cited by this paper
• Reactive oxygen species generation in fungal development and pathogenesis.

  2012cited by this paper
• Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.

  2012cited by this paper
• Angiotensin II-induced JNK activation is mediated by NAD(P)H oxidase in isolated rat pancreatic islets.

  2012cited by this paper
• Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.

  2012cited by this paper
• Role of peroxisomes in ROS/RNS-metabolism: implications for human disease.

  2012cited by this paper
• Positive regulation of NADPH oxidase 5 by proinflammatory-related mechanisms in human aortic smooth muscle cells.

  2012cited by this paper
• Advanced glycation end-products induce injury to pancreatic beta cells through oxidative stress.

  2012cited by this paper
• Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels.

  2012cited by this paper
• Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or “All that you did and did not want to know about Nox inhibitory peptides”

  2012cited by this paper
• A burst of plant NADPH oxidases.

  2012cited by this paper
• ROS signaling: the new wave?

  2011cited by this paper
• Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2.

  2011cited by this paper
• NAD(P)H oxidase participates in the palmitate‐induced superoxide production and insulin secretion by rat pancreatic islets

  2011cited by this paper
• Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

  2011cited by this paper
• Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5.

  2011cited by this paper
• Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.

  2011cited by this paper
• Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets

  2011cited by this paper
• Advanced Glycation End Products Are Direct Modulators of β-Cell Function

  2011cited by this paper
• Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy.

  2010cited by this paper
• Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

  2010cited by this paper
• Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1–Independent Pathways in Human Endothelial Cells

  2010cited by this paper
• Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

  2010cited by this paper
• NADPH Oxidase NOX1 Controls Autocrine Growth of Liver Tumor Cells through Up-regulation of the Epidermal Growth Factor Receptor Pathway*

  2010cited by this paper
• NOX2 Deficiency Protects Against Streptozotocin-Induced β-Cell Destruction and Development of Diabetes in Mice

  2010cited by this paper
• Nox4 B-loop Creates an Interface between the Transmembrane and Dehydrogenase Domains*

  2010cited by this paper
• NADPH oxidase-derived reactive oxygen species: involvement in vascular physiology and pathology

  2010cited by this paper
• NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

  2010cited by this paper
• Suppression of NADPH oxidase 2 substantially restores glucose‐induced dysfunction of pancreatic NIT‐1 cells

  2010cited by this paper
• A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.

  2010cited by this paper
• NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

  2010cited by this paper
• First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis.

  2010cited by this paper
• Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction.

  2010cited by this paper
• Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β‐cells

  2010cited by this paper
• The endoplasmic reticulum stress response in the pancreatic β‐cell

  2010cited by this paper
• Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues

  2009cited by this paper
• Dual oxidases and hydrogen peroxide in a complex dialogue between host mucosae and bacteria.

  2009cited by this paper
• Activation of Dual Oxidases Duox1 and Duox2

  2009cited by this paper
• Endosomal Nox2 Facilitates Redox-Dependent Induction of NF-κB by TNF-α

  2009cited by this paper
• Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes

  2009cited by this paper
• Transforming Growth Factor-/ Smad 3 Signaling Regulates Insulin Gene Transcription and Pancreatic Islet-Cell Function *

  2009cited by this paper
• Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis.

  2009cited by this paper
• NADPH oxidases and angiotensin II receptor signaling.

  2009cited by this paper
• Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

  2009cited by this paper
• Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

  2009cited by this paper
• Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

  2009cited by this paper
• Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta-cells.

  2009cited by this paper
• Functions and regulation of the Nox family in the filamentous fungus Podospora anserina: a new role in cellulose degradation

  2009cited by this paper
• Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli.

  2009cited by this paper
• Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation

  2009cited by this paper
• NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype.

  2008cited by this paper
• Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract

  2008cited by this paper
• Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

  2008cited by this paper
• Activation of NADPH oxidase 1 in tumour colon epithelial cells.

  2008cited by this paper
• The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1.

  2008cited by this paper
• Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells.

  2008cited by this paper
• Oxidative stress: the vulnerable beta-cell.

  2008cited by this paper
• NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition.

  2008cited by this paper
• NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?

  2008cited by this paper
• Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

  2008cited by this paper
• Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6

  2008cited by this paper
• Reactive Oxygen Species Derived from NOX1/NADPH Oxidase Enhance Inflammatory Pain

  2008cited by this paper
• NOX5, a new "radical" player in human atherosclerosis?

  2008cited by this paper
• NADPH Oxidases NOX-1 and NOX-2 Require the Regulatory Subunit NOR-1 To Control Cell Differentiation and Growth in Neurospora crassa

  2008cited by this paper
• Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype.

  2008cited by this paper
• Induction of Apoptosis of β Cells of the Pancreas by Advanced Glycation End‐Products, Important Mediators of Chronic Complications of Diabetes Mellitus

  2008cited by this paper
• Impaired insulin secretion by diphenyleneiodium associated with perturbation of cytosolic Ca2+ dynamics in pancreatic beta-cells.

  2008cited by this paper
• Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells.

  2008cited by this paper
• Nox1-dependent superoxide production controls colon adenocarcinoma cell migration.

  2008cited by this paper
• Role of Nox2 in elimination of microorganisms

  2008cited by this paper
• Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan.

  2008cited by this paper
• Structure, regulation and evolution of Nox‐family NADPH oxidases that produce reactive oxygen species

  2008cited by this paper
• Transplantation and beyond

  2008cited by this paper
• Regulation of Nox and Duox enzymatic activity and expression.

  2007cited by this paper
• NOX family NADPH oxidases: not just in mammals.

  2007cited by this paper
• Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line

  2007cited by this paper
• Cytokine Activation of Nuclear Factor &kgr;B in Vascular Smooth Muscle Cells Requires Signaling Endosomes Containing Nox1 and ClC-3

  2007cited by this paper
• NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation.

  2007cited by this paper
• Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells.

  2007cited by this paper
• The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.

  2007cited by this paper
• Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy.

  2007cited by this paper
• Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products.

  2007cited by this paper
• Novel sources of reactive oxygen species in the human body.

  2007cited by this paper
• Nox1 downstream of 12‐lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells

  2007cited by this paper
• NOX5 variants are functionally active in endothelial cells.

  2007cited by this paper
• Differential susceptibility of chick and mouse islets to streptozotocin and its co-relation with islet antioxidant status

  2007cited by this paper
• Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion

  2007cited by this paper
• The oxidation of apocynin catalyzed by myeloperoxidase: proposal for NADPH oxidase inhibition.

  2007cited by this paper
• NOX1/NADPH oxidase negatively regulates nerve growth factor-induced neurite outgrowth.

  2006cited by this paper
• cAMP-response Element-binding Protein Mediates Acid-induced NADPH Oxidase NOX5-S Expression in Barrett Esophageal Adenocarcinoma Cells*

  2006cited by this paper
• Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium

  2006cited by this paper

• Expression, localization and regulation of NADPH oxidases in pancreatic beta cells

  2025cites this paper
• Interleukin-12 (IL-12)/STAT4 Axis Is an Important Element for β-Cell Dysfunction Induced by Inflammatory Cytokines

  2015cites this paper