Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Neurophysiology

• Publication date

  2008-02-01

• Fields of study

  Biology, Medicine, Materials Science

• Identifiers
  DOI 10.1152/JN.00658.2007PMID 18046008PMCID PMC2652198
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Triphasic Intrinsic Signal: Implications for Functional Imaging

  2007cited by this paper
• Penetrating arterioles are a bottleneck in the perfusion of neocortex

  2007cited by this paper
• Duration-dependent response of SI to vibrotactile stimulation in squirrel monkey.

  2007cited by this paper
• Bidirectional control of CNS capillary diameter by pericytes

  2006cited by this paper
• Compartment-Resolved Imaging of Activity-Dependent Dynamics of Cortical Blood Volume and Oximetry

  2005cited by this paper
• Further nonlinearities in neurovascular coupling in rodent barrel cortex

  2005cited by this paper
• Neurovascular coupling investigated with two‐dimensional optical imaging spectroscopy in rat whisker barrel cortex

  2005influential reference
• Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity.

  2005cited by this paper
• Spatiotemporal Evolution of Functional Hemodynamic Changes and Their Relationship to Neuronal Activity

  2005cited by this paper
• Concurrent fMRI and optical measures for the investigation of the hemodynamic response function

  2005cited by this paper
• Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex

  2005cited by this paper
• Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin

  2005cited by this paper
• Long Duration Stimuli and Nonlinearities in the Neural–Haemodynamic Coupling

  2005cited by this paper
• Nonlinear coupling of neural activity and CBF in rodent barrel cortex

  2004cited by this paper
• Linear and nonlinear relationships between neuronal activity, oxygen metabolism, and hemodynamic responses.

  2004cited by this paper
• Spatiotemporal evolution of excitation and inhibition in the rat barrel cortex investigated with multielectrode arrays.

  2004cited by this paper
• Stimulus frequency dependence of the linear relationship between local cerebral blood flow and field potential evoked by activation of rat somatosensory cortex.

  2004cited by this paper
• On the nature of the BOLD fMRI contrast mechanism.

  2004cited by this paper
• Cortical electrical stimulation alters erythrocyte perfusion pattern in the cerebral capillary network of the rat.

  2003cited by this paper
• The Hemodynamic Impulse Response to a Single Neural Event

  2003cited by this paper
• The Origin of Cortical Surround Receptive Fields Studied in the Barrel Cortex

  2003influential reference
• A control system approach for evaluating somatosensory activation by laser-Doppler flowmetry in the rat cortex.

  2003cited by this paper
• Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.

  2003cited by this paper
• Spatial Integration of Vascular Changes with Neural Activity in Mouse Cortex

  2002cited by this paper
• Blood capillary distribution correlates with hemodynamic-based functional imaging in cerebral cortex.

  2002cited by this paper
• Temporally staggered forelimb stimulation modulates barrel cortex optical intrinsic signal responses to whisker stimulation.

  2002cited by this paper
• Evolving concepts of cortical radial and areal specification.

  2002cited by this paper
• The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal.

  2002cited by this paper
• Signal source separation in the analysis of neural activity in brain.

  2001cited by this paper
• Evidence and lack of evidence for the initial dip in the anesthetized rat: implications for human functional brain imaging.

  2001cited by this paper
• An FMRI method to determine specific drug-induced modulations of functional activations using a pharmacokinetic model

  2001cited by this paper
• Role For Capillaries In Coupling Blood Flow With Metabolism

  2000cited by this paper
• Spatial–Temporal Distribution of Whisker-Evoked Activity in Rat Somatosensory Cortex and the Coding of Stimulus Location

  2000cited by this paper
• Remote arteriolar dilations in response to muscle contraction under capillaries.

  2000cited by this paper
• Scopolamine-sensitive and resistant components of increase in cerebral cortical blood flow elicited by periaqueductal gray matter of rats.

  1999influential reference
• Spectroscopic analysis of changes in remitted illumination: the response to increased neural activity in brain.

  1999cited by this paper
• Varying the degree of single-whisker stimulation differentially affects phases of intrinsic signals in rat barrel cortex.

  1999cited by this paper
• Optical Intrinsic Signal Imaging Responses Are Modulated in Rodent Somatosensory Cortex during Simultaneous Whisker and Forelimb Stimulation

  1998cited by this paper
• Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation.

  1997cited by this paper
• Local and propagated vascular responses evoked by focal synaptic activity in cerebellar cortex.

  1997cited by this paper
• Interactions Between Electrical Activity and Cortical Microcirculation Revealed by Imaging Spectroscopy: Implications for Functional Brain Mapping

  1996cited by this paper
• Cytochrome-oxidase blobs in cat primary visual cortex

  1995cited by this paper
• Spontaneous waves of cerebral blood flow associated with a pattern of electrocortical activity.

  1994influential reference
• Specialized vascularization of the primate visual cortex

  1991cited by this paper
• Current source-density and neuromagnetic analysis of the direct cortical response in rat cortex.

  1988cited by this paper
• Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.

  1985cited by this paper
• Theory of current source-density analysis and determination of conductivity tensor for anuran cerebellum.

  1975cited by this paper
• The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units.

  1970cited by this paper
• The structural organization of layer IV in the somatosensory region (S I) of mouse cerebral cortex

  1970cited by this paper
• Receptive fields of single neurones in the cat's striate cortex

  1959cited by this paper
• Behavioral/systems/cognitive Functional Signal-and Paradigm-dependent Linear Relationships between Synaptic Activity and Hemodynamic Responses in Rat Somatosensory Cortex

  year unknowncited by this paper

• Somatostatin-expressing interneurons induce early NO-driven and late specific astrocyte-mediated vasodilation

  2025cites this paper
• Brain Endothelial Gap Junction Coupling Enables Rapid Vasodilation Propagation During Neurovascular Coupling

  2025cites this paper
• Clemastine ameliorates cognitive deficits in an experimental rat model of chronic cerebral hypoperfusion

  2025cites this paper
• Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling

  2025cites this paper
• Neurovascular coupling over cortical brain areas and resting state network connectivity with and without rigidified carotid artery

  2025cites this paper
• Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

  2025cites this paper
• Disassociating cerebral vasomotion from low frequency spontaneous neurovascular coupling

  2025cites this paper
• Refining hemodynamic correction in in vivo wide-field fluorescent imaging through linear regression analysis

  2024cites this paper
• Mesoscopic mapping of hemodynamic responses and neuronal activity during pharmacologically induced interictal spikes in awake and anesthetized mice

  2024influential citation
• Characterisation of laminar and vascular spatiotemporal dynamics of CBV and BOLD signals using VASO and ME-GRE at 7T in humans

  2024cites this paper
• Distal activity patterns shape the spatial specificity of neurovascular coupling

  2024cites this paper
• Capillary responses to functional and pathological activations rely on the capillary states at rest

  2023cites this paper
• Concurrent intrinsic optical imaging and fMRI at ultra‐high field using magnetic field proof optical components

  2023cites this paper
• Temporal mirror-symmetry in functional signals recorded from rat barrel cortex with optical coherence tomography.

  2022cites this paper
• Optical Imaging-Based Guidance of Viral Microinjections and Insertion of a Laminar Electrophysiology Probe Into a Predetermined Barrel in Mouse Area S1BF

  2021cites this paper
• Mesoscopic Mapping of Ictal Neurovascular Coupling in Awake Behaving Mice Using Optical Spectroscopy and Genetically Encoded Calcium Indicators

  2021cites this paper
• Environmental enrichment enhances post-ischemic cerebral blood flow and functional hyperemia in the ipsilesional somatosensory cortex.

  2020cites this paper
• Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling

  2020cites this paper
• More than just summed neuronal activity: how multiple cell types shape the BOLD response

  2020cites this paper
• Differential contribution of excitatory and inhibitory neurons in shaping neurovascular coupling in different epileptic neural states

  2020influential citation
• Validating layer-specific VASO across species

  2020cites this paper
• Sub-millimetre resolution laminar fMRI using Arterial Spin Labelling in humans at 7 T

  2020cites this paper
• Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging

  2020influential citation
• Excitation-Inhibition Imbalance Leads to Alteration of Neuronal Coherence and Neurovascular Coupling under Acute Stress

  2020influential citation
• A Network Architecture for Bidirectional Neurovascular Coupling in Rat Whisker Barrel Cortex

  2019cites this paper
• Laminar fMRI at ultra-high fields: Acquisition and analysis strategies

  2019cites this paper
• Neurovascular Coupling under Chronic Stress Is Modified by Altered GABAergic Interneuron Activity

  2019influential citation
• Functional Neuroimaging of Nociceptive and Pain‐Related Activity in the Spinal Cord and Brain: Insights From Neurovascular Coupling Studies

  2018cites this paper
• Analysis of resting-state neurovascular coupling and locomotion-associated neural dynamics using wide-field optical mapping

  2018cites this paper
• Optical imaging and modulation of neurovascular responses

  2018cites this paper
• Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection

  2018influential citation
• The pial vasculature of the mouse develops according to a sensory-independent program

  2018cites this paper
• The effects of capillary transit time heterogeneity on the BOLD signal

  2018cites this paper
• Functional ultrasound neuroimaging: a review of the preclinical and clinical state of the art.

  2018cites this paper
• Physiological and Pathological Brain Activation in the Anesthetized Rat Produces Hemodynamic-Dependent Cortical Temperature Increases That Can Confound the BOLD fMRI Signal

  2017cites this paper
• Linking brain vascular physiology to hemodynamic response in ultra‐high field MRI

  2017cites this paper
• Noise and non‐neuronal contributions to the BOLD signal: applications to and insights from animal studies

  2017cites this paper
• Foundations of layer-specific fMRI and investigations of neurophysiological activity in the laminarized neocortex and olfactory bulb of animal models

  2017cites this paper
• Correction to ‘Precision mapping of the vibrissa representation within murine primary somatosensory cortex’

  2017cites this paper
• Design of a multimodal optical imaging system and microprism for in vivo investigation of cocaine induced CBF disruption

  2017cites this paper
• Volumetric Spatial Correlations of Neurovascular Coupling Studied using Single Pulse Opto-fMRI

  2017cites this paper
• Laminar fMRI: What can the time domain tell us?

  2017cites this paper
• Intracranial mechanisms for preserving brain blood flow in health and disease

  2017cites this paper
• From brain to blood vessels and back: a noninvasive optical imaging approach

  2017cites this paper
• Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation

  2017influential citation
• Effective Connectivity Measured Using Optogenetically Evoked Hemodynamic Signals Exhibits Topography Distinct from Resting State Functional Connectivity in the Mouse

  2017cites this paper
• Submillimeter-resolution fMRI: Toward understanding local neural processing.

  2016cites this paper
• Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches

  2016cites this paper
• Taking the “initial dip” into cellular mechanisms of neurovascular coupling

  2016cites this paper
• Two-photon imaging of cerebral hemodynamics and neural activity in awake and anesthetized marmosets.

  2016cites this paper
• Intra ‐ cranial mechanisms for preserving brain blood flow in health and disease

  2016cites this paper
• Precision mapping of the vibrissa representation within murine primary somatosensory cortex

  2016cites this paper
• Neural correlates of single vessel hemodynamic responses in vivo

  2016cites this paper
• A novel method for classifying cortical state to identify the accompanying changes in cerebral hemodynamics

  2016cites this paper
• Imaging fast electrical activity in the brain with electrical impedance tomography

  2016cites this paper
• An automated workflow for the anatomo-functional mapping of the barrel cortex.

  2016cites this paper
• Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime

  2015cites this paper
• Using a novel source-localized phase regressor technique for evaluation of the vascular contribution to semantic category area localization in BOLD fMRI

  2015cites this paper
• Long-Latency Reductions in Gamma Power Predict Hemodynamic Changes That Underlie the Negative BOLD Signal

  2015influential citation
• Considerations for resting state functional MRI and functional connectivity studies in rodents

  2015cites this paper
• Decomposition methods for the fusion of multimodal neuroimaging data

  2015cites this paper
• Layer-Specific fMRI Responses to Excitatory and Inhibitory Neuronal Activities in the Olfactory Bulb

  2015cites this paper
• Optical electrocorticogram (OECoG) using wide-field calcium imaging reveals the divergence of neuronal and glial activity during acute rodent seizures.

  2015cites this paper
• Corrigendum: Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime

  2015cites this paper
• Spatiotemporal properties of sensory integration in the mouse barrel cortex

  2015cites this paper
• Multivariate Machine Learning Methods for Fusing Multimodal Functional Neuroimaging Data

  2015cites this paper
• Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response

  2015cites this paper
• Voltage-Sensitive Dye Imaging, Intrinsic Optical Signals

  2014cites this paper
• Chronic assessment of cerebral hemodynamics during rat forepaw electrical stimulation using functional ultrasound imaging

  2014cites this paper
• Simultaneous Functional Magnetic Resonance and Two-Dimensional Optical Imaging Spectroscopy

  2014cites this paper
• Functional Imaging of Cerebral Oxygenation with Intrinsic Optical Contrast and Phosphorescent Probes

  2014cites this paper
• Contributions and complexities from the use of in vivo animal models to improve understanding of human neuroimaging signals

  2014cites this paper
• International Journal of Chemistry and Pharmaceutical Sciences

  2014cites this paper
• A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

  2014cites this paper
• Optical Imaging of Neocortical Dynamics

  2014cites this paper
• Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures

  2014cites this paper
• Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures

  2014cites this paper
• Epilepsy: the next generation drugs (a review)

  2014cites this paper
• Neural and hemodynamic responses elicited by forelimb- and photo-stimulation in channelrhodopsin-2 mice: insights into the hemodynamic point spread function.

  2014cites this paper
• Coupling mechanism and significance of the BOLD signal: a status report.

  2014cites this paper
• Functional Connectivity in Rat Brain at 200 μm Resolution

  2014cites this paper
• The resting‐state neurovascular coupling relationship: rapid changes in spontaneous neural activity in the somatosensory cortex are associated with haemodynamic fluctuations that resemble stimulus‐evoked haemodynamics

  2013cites this paper
• Improved blood velocity measurements with a hybrid image filtering and iterative Radon transform algorithm

  2013cites this paper
• Integration of Multivariate Data Streams With Bandpower Signals

  2013cites this paper
• Analysis of time and space invariance of BOLD responses in the rat visual system.

  2013cites this paper
• The effects of focal epileptic activity on regional sensory-evoked neurovascular coupling and postictal modulation of bilateral sensory processing

  2013cites this paper
• Complex spatiotemporal haemodynamic response following sensory stimulation in the awake rat☆

  2013cites this paper
• Effects of a peptide isolated from γ-casein hydrolysates on rat arterial blood pressure assay carried out under different anaesthetic drugs treatment

  2013cites this paper
• IL-1β-mediated changes in cerebral perfusion and neural activity in a rat model of neuroinflammation and excitotoxicity

  2013influential citation
• Spatiotemporal characteristics and vascular sources of neural-specific and -nonspecific fMRI signals at submillimeter columnar resolution

  2013cites this paper
• Event-related near-infrared spectroscopy detects conflict in the motor cortex in a Stroop task.

  2012cites this paper
• Microvascular changes in late‐life schizophrenia and mood disorders: stereological assessment of capillary diameters in anterior cingulate cortex

  2012cites this paper
• Data-driven analysis for multimodal neuroimaging

  2012cites this paper
• Functional near Infrared Optical Imaging in Cognitive Neuroscience: An Introductory Review

  2012cites this paper
• Improved decoding of neural activity from fMRI signals using non-separable spatiotemporal deconvolutions

  2012influential citation
• Dynamic Neurovascular Coupling and Uncoupling during Ictal Onset, Propagation, and Termination Revealed by Simultaneous In Vivo Optical Imaging of Neural Activity and Local Blood Volume

  2012influential citation
• Frontiers in Optical Imaging of Cerebral Blood Flow and Metabolism

  2012cites this paper
• Quantitative estimates of stimulation-induced perfusion response using two-photon fluorescence microscopy of cortical microvascular networks

  2012cites this paper
• Early and Late Stimulus-Evoked Cortical Hemodynamic Responses Provide Insight into the Neurogenic Nature of Neurovascular Coupling

  2012cites this paper
• Inter-Trial Variability in Sensory-Evoked Cortical Hemodynamic Responses: The Role of the Magnitude of Pre-Stimulus Fluctuations

  2012cites this paper