APP mouse models for Alzheimer's disease preclinical studies

Animal models of human diseases that accurately recapitulate clinical pathology are indispensable for understanding molecular mechanisms and advancing preclinical studies. The Alzheimer's disease (AD) research community has historically used first‐generation transgenic (Tg) mouse models that overexpress proteins linked to familial AD (FAD), mutant amyloid precursor protein (APP), or APP and presenilin (PS). These mice exhibit AD pathology, but the overexpression paradigm may cause additional phenotypes unrelated to AD. Second‐generation mouse models contain humanized sequences and clinical mutations in the endogenous mouse App gene. These mice show Aβ accumulation without phenotypes related to overexpression but are not yet a clinical recapitulation of human AD. In this review, we evaluate different APP mouse models of AD, and review recent studies using the second‐generation mice. We advise AD researchers to consider the comparative strengths and limitations of each model against the scientific and therapeutic goal of a prospective preclinical study.

• Publication year

  2017

• Venue

  EMBO Journal

• Publication date

  2017-08-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.15252/embj.201797397PMID 28768718PMCID 5579350
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting neoantigens to augment antitumour immunity

  2017cited by this paper
• Genomic variants, genes, and pathways of Alzheimer's disease: An overview

  2017cited by this paper
• Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

  2017cited by this paper
• Alzheimer’s disease: experimental models and reality

  2017cited by this paper
• Bidirectional Crosstalk between Lymphatic Endothelial Cell and T Cell and Its Implications in Tumor Immunity

  2017cited by this paper
• APP mouse models for Alzheimer's disease preclinical studies

  2017cited by this paper
• PLD3 gene and processing of APP

  2017cited by this paper
• The discovery of Alzheimer‐causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”

  2017cited by this paper
• Differential contribution of APP metabolites to early cognitive deficits in a TgCRND8 mouse model of Alzheimer’s disease

  2017influential reference
• Induced pluripotent stem cells as a discovery tool for Alzheimer׳s disease.

  2017cited by this paper
• Innate immunity in Alzheimer’s disease: the relevance of animal models?

  2017cited by this paper
• Defeating Alzheimer's disease and other dementias: a priority for European science and society.

  2016cited by this paper
• Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau

  2016cited by this paper
• Cognitive deficits in single App knock-in mouse models.

  2016influential reference
• Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein‐specific antibodies

  2016cited by this paper
• Network abnormalities and interneuron dysfunction in Alzheimer disease

  2016cited by this paper
• Alzheimer's therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies.

  2016cited by this paper
• CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis.

  2016cited by this paper
• The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

  2016cited by this paper
• World Alzheimer report 2016: improving healthcare for people living with dementia: coverage, quality and costs now and in the future

  2016cited by this paper
• The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients

  2016cited by this paper
• Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways.

  2016cited by this paper
• Ubiquitin-Dependent And Independent Signals In Selective Autophagy.

  2016cited by this paper
• Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.

  2016cited by this paper
• AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer’s Disease

  2016cited by this paper
• Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment

  2016cited by this paper
• Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression

  2016influential reference
• Alzheimer's disease

  2016cited by this paper
• The amyloid hypothesis of Alzheimer's disease at 25 years

  2016cited by this paper
• Genomics of Alzheimer Disease: A Review.

  2016cited by this paper
• The Amyloid Precursor Protein—A Novel Player within the Molecular Array of Presynaptic Nanomachines

  2016cited by this paper
• Genome Engineering with TALE and CRISPR Systems in Neuroscience

  2016cited by this paper
• The Cellular Phase of Alzheimer's Disease.

  2016cited by this paper
• Toward more predictive genetic mouse models of Alzheimer's disease.

  2016cited by this paper
• Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism

  2015cited by this paper
• Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

  2015cited by this paper
• Clearance systems in the brain—implications for Alzheimer disease

  2015cited by this paper
• Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models

  2015cited by this paper
• Rodent models for Alzheimer’s disease drug discovery

  2015cited by this paper
• The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans

  2015cited by this paper
• An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

  2015cited by this paper
• Systematic Review of the Relationship between Amyloid-β Levels and Measures of Transgenic Mouse Cognitive Deficit in Alzheimer’s Disease

  2015cited by this paper
• η-Secretase processing of APP inhibits neuronal activity in the hippocampus

  2015cited by this paper
• Clearance systems in the brain-implications for Alzheimer disease.

  2015cited by this paper
• Mutation in the 3’untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy

  2015cited by this paper
• A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

  2015cited by this paper
• A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

  2015cited by this paper
• Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease

  2015cited by this paper
• Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits

  2015cited by this paper
• ScaleS: an optical clearing palette for biological imaging

  2015cited by this paper
• Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

  2015cited by this paper
• Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells.

  2015cited by this paper
• A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

  2014cited by this paper
• Alzheimer's disease genetics: from the bench to the clinic.

  2014cited by this paper
• Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment.

  2014cited by this paper
• Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport

  2014cited by this paper
• Molecular Mechanisms of Alzheimer’s Disease Protection by the A673T Allele of Amyloid Precursor Protein

  2014cited by this paper
• The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

  2014cited by this paper
• Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow

  2014cited by this paper
• The Alzheimer Disease Protective Mutation A2T Modulates Kinetic and Thermodynamic Properties of Amyloid-β (Aβ) Aggregation*

  2014cited by this paper
• Unfolded protein response signaling by transcription factor XBP‐1 regulates ADAM10 and is affected in Alzheimer's disease

  2014cited by this paper
• An aberrant sugar modification of BACE 1 blocks its lysosomal targeting in Alzheimerís disease

  2014cited by this paper
• Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking.

  2014cited by this paper
• Amyloid precursor protein and neural development

  2014cited by this paper
• Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

  2014cited by this paper
• Single App knock-in mouse models of Alzheimer's disease

  2014influential reference
• Cognitive components in mice and humans: combining genetics and touchscreens for medical translation.

  2013cited by this paper
• Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease

  2013influential reference
• The evolution of brains from early mammals to humans.

  2013cited by this paper
• Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

  2013cited by this paper
• TREM2 and neurodegenerative disease.

  2013cited by this paper
• TREM2 and neurodegenerative disease.

  2013cited by this paper
• Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

  2013cited by this paper
• TREM 2 and Neurodegenerative Disease

  2013cited by this paper
• Aβ secretion and plaque formation depend on autophagy.

  2013cited by this paper
• Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease

  2013cited by this paper
• TREM2 and neurodegenerative disease.

  2013cited by this paper
• TREM2 variants in Alzheimer's disease.

  2013cited by this paper
• Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

  2012influential reference
• Alzheimer mechanisms and therapeutic strategies.

  2012cited by this paper
• A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

  2012cited by this paper
• The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

  2012cited by this paper
• Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization.

  2012cited by this paper
• Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.

  2012influential reference
• Cerebral cortical development in rodents and primates.

  2012cited by this paper
• Amyloid deposition and advanced age fails to induce Alzheimer's type progression in a double knock-in mouse model.

  2012cited by this paper
• Differential Effects between γ-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice

  2012cited by this paper
• National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

  2012cited by this paper
• Mechanistic involvement of the calpain‐calpastatin system in Alzheimer neuropathology

  2012influential reference
• Alzheimer's disease.

  2011cited by this paper
• The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing

  2011cited by this paper
• Analysis of Amyloid Precursor Protein Function in Drosophila melanogaster

  2011cited by this paper
• Brain Endothelial Cells Produce Amyloid β from Amyloid Precursor Protein 770 and Preferentially Secrete the O-Glycosylated Form*

  2010cited by this paper
• Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP.

  2010cited by this paper
• Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

  2010cited by this paper
• Alzheimer disease.

  2010cited by this paper
• Alzheimer's disease: clinical trials and drug development

  2010cited by this paper
• Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

  2010cited by this paper
• Probing the biology of Alzheimer's disease in mice.

  2010cited by this paper
• 'Too much good news' - are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

  2010cited by this paper

• Experimental Models and Translational Strategies in Neuroprotective Drug Development with Emphasis on Alzheimer’s Disease

  2026cites this paper
• GABAB Receptor signaling in CA1 Pyramidal Cells is not Regulated by Aging in the APP/PS1 Mouse Model of Amyloid Pathology

  2026cites this paper
• Mutations associated with Alzheimer's disease and aged serum synergistically elicit blood-brain barrier dysfunction in a tissue-engineered model.

  2026cites this paper
• Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software

  2026influential citation
• Abnormal Hearing Phenotypes in “Ignorome” Knockout Mice as Predictors of Cognitive Dysfunction

  2026cites this paper
• Neuronal age drives β-sheet accumulation and, together with ApoE4, enhances synaptic Aβ localization in APPNL-F neurons

  2026cites this paper
• The difference in immunohistochemical reactivity of monoclonal antibodies against amino-terminal residues of amyloid-β peptide.

  2026cites this paper
• Effects of Different Dietary Restriction Regimens on Cognitive Function and Pathological Markers in Alzheimer's Disease Mouse Models：A Systematic Review and Meta-Analysis.

  2026cites this paper
• Membrane Proteome Remodeling in Female APP Mice Following Muscarinic Acetylcholine Receptor M1 Modulation Revealed by Peptidisc Enabled DIA-MS

  2026cites this paper
• Isogenic cortical organoids enable precision targeting of APP variant-specific pathways in Alzheimer’s disease

  2026cites this paper
• A multi-target therapeutic framework for Alzheimer's disease: an integrative mechanistic review.

  2026cites this paper
• Gradient magnitude-based texture feature of the entorhinal cortex as a biomarker for Alzheimer's disease.

  2026cites this paper
• DNA methylation and the APP gene: dietary influences in the context of Alzheimer’s disease—a mini review

  2026cites this paper
• Single-cell RNA sequencing reveals disease associated changes in brain endothelial cells in the 5XFAD mouse

  2026cites this paper
• Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpression

  2026cites this paper
• The molecular fidelity of Aβ pathology in 5xFAD and AppNL−FPsen1P117L mice revealed by cryo-EM

  2026cites this paper
• Disrupted hippocampal replay is associated with reduced offline map stabilization in an Alzheimer's mouse model.

  2026cites this paper
• Metformin Restores Innate Fear Deficits in Young Adult Female APP/PS1 Mice via Basolateral Amygdala Activation

  2026cites this paper
• The 3xTg-AD Mouse Model: A Comprehensive Tool for Understanding Alzheimer’s Disease

  2026cites this paper
• Inductively coupled plasma – mass spectrometry to evaluate the impact of long-term Zn supplementation in liver tissue of APP/PS1 mouse model of Alzheimer's disease

  2026cites this paper
• Region-resolved proteomic map of the human brain: functional interconnections and neurological implications

  2026cites this paper
• APOE-ε4 genotype and western diet synergistically aggravate synaptic dysfunction in Alzheimer's disease via D-serine disruption.

  2026cites this paper
• Neuroadaptation in neurodegenerative diseases: compensatory mechanisms and therapeutic approaches.

  2025cites this paper
• Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations

  2025cites this paper
• Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice

  2025cites this paper
• Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer’s Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty Acids

  2025cites this paper
• Amyloid precursor protein and presenilin‐1 knock‐in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss

  2025cites this paper
• In Vivo Seeding of Amyloid-β Protein and Implications in Modeling Alzheimer’s Disease Pathology

  2025cites this paper
• Alzheimer’s Disease, β-Amyloid Peptides, and Ubiquitin-Proteasome System: Nutritherapeutic Insights

  2025cites this paper
• Impaired synaptic plasticity in behaving mice by inactivation of presenilin and accumulation of the neurexin gamma-secretase proteolytic substrate.

  2025cites this paper
• Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer’s Disease Spectrum

  2025cites this paper
• ND‐AMD: A Web‐Based Database for Animal Models of Neurological Disease With Analysis Tools

  2025cites this paper
• Mutation in Wdr45 leads to early motor dysfunction and widespread aberrant axon terminals in a beta-propeller protein associated neurodegeneration (BPAN) patient-inspired mouse model

  2025cites this paper
• Isotope Encoded Spatial Biology Identifies Amyloid Plaque-Age-Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity

  2025cites this paper
• Targeting UAF1 Alleviate Neurotoxicity by Inhibiting APP/NLRP3 Axis-Mediated Pyroptosis and Apoptosis

  2025cites this paper
• Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways

  2025cites this paper
• Bidirectional effects of orexin receptor antagonists on long-term potentiation in the hippocampus of wild type and Alzheimer's disease model mice.

  2025cites this paper
• Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer’s disease

  2025cites this paper
• Advances in non-human primate models for Alzheimer's disease research.

  2025cites this paper
• APOE4-APP interactions exert early influences on cerebrovascular structure and function: implications for Alzheimer’s disease

  2025cites this paper
• Histone Lactylation as an Epigenetic Regulator in Alzheimer’s Disease Pathophysiology: A Narrative Review

  2025cites this paper
• AMPKα2 signals amino acid insufficiency to inhibit protein synthesis.

  2025cites this paper
• Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s disease

  2025cites this paper
• Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain

  2025cites this paper
• An Overview of Transgenic Mouse Models for the Study of Alzheimer’s Disease

  2025influential citation
• Sleep-Wake Transitions Are Impaired in the AppNL-G-F Mouse Model of Early Onset Alzheimer’s Disease

  2025cites this paper
• Advances in physiological and clinical relevance of hiPSC-derived brain models for precision medicine pipelines

  2025cites this paper
• Advancing Alzheimer's disease treatment: A literature review on senolytic intervention

  2025cites this paper
• Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer’s disease

  2025cites this paper
• The biological scaling of Alzheimer’s disease neuropathological changes across primate species

  2025cites this paper
• Enhancing Membrane Repair Using Recombinant MG53/TRIM72 (rhMG53) Reduces Neurotoxicity in Alzheimer’s Disease Models

  2025cites this paper
• Effect of chronic alcohol feeding using the Lieber-DeCarli diet on Alzheimer’s disease pathology in Tg2576 mice

  2025cites this paper
• Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease

  2025cites this paper
• New insight into the role of altered brain cholesterol metabolism in the pathogenesis of AD: a unifying cholesterol hypothesis and new therapeutic approach for AD.

  2025cites this paper
• Stem cell therapy offers new hope for the treatment of Alzheimer’s disease

  2025cites this paper
• Small molecule heterocycles: design and synthesis of novel fluorescent Benzothiazoles for early detection of Alzheimer’s disease

  2025cites this paper
• Analysis of the Relationship Between NLRP3 and Alzheimer's Disease in Oligodendrocytes based on Bioinformatics and In Vitro Experiments.

  2025cites this paper
• Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community

  2025cites this paper
• Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model

  2025cites this paper
• Rodent models of Alzheimer's disease: critical analysis of current hypotheses and pathways for future research.

  2025cites this paper
• Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation

  2025cites this paper
• Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases.

  2025cites this paper
• Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer's disease: A meta-analysis 2015–2023

  2025cites this paper
• Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review

  2025cites this paper
• Short-Term Inhibition of NOX2 Prevents the Development of Aβ-Induced Pathology in Mice

  2025cites this paper
• Beyond the brain: early autonomic dysfunction in Alzheimer’s disease

  2025cites this paper
• Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life

  2025cites this paper
• Impaired insulin receptor function alters psychiatric behaviors without affecting circadian rhythms in a mouse model of Alzheimer's disease

  2025cites this paper
• Intervertebral disc impairments in a mouse model of Alzheimer’s Disease

  2025cites this paper
• Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock‐In Mouse Model of Amyloidopathy

  2025cites this paper
• Intermittent supplementation with Akkermansia muciniphila and galactooligosaccharides modulates Alzheimer’s disease progression, gut microbiota, and colon short-chain fatty acid profiles in mice

  2025cites this paper
• Impaired theta and low-gamma directed information flow in the hippocampal-prefrontal circuit underlies working memory deficits in APP/PS1 mice

  2025cites this paper
• Deciphering Alzheimer's disease: Molecular mechanisms, preclinical models and strategies to overcome Blood-Brain-Barrier.

  2025cites this paper
• Ageing, Neurodegeneration and the Endocannabinoid System.

  2025cites this paper
• Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases

  2025cites this paper
• Advancement in modeling of Alzheimer’s disease: a comprehensive review of preclinical screening platforms

  2025cites this paper
• Therapeutic Implications of Allopregnanolone in Alzheimer's Related Depression.

  2025cites this paper
• Vertebrate and Invertebrate Animal Models for the Study of Down Syndrome

  2025cites this paper
• Beyond Transgenic Mice: Emerging Models and Translational Strategies in Alzheimer’s Disease

  2025cites this paper
• Astrocytic Hevin/SPARCL‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

  2025cites this paper
• A decade progress in the phenotyping of AppNL-G-F knock-in mouse model of Alzheimer's disease.

  2025cites this paper
• Altered APP trafficking drives amyloidogenic processing in primary neurons from the AppNL-F knock-in mouse model of Alzheimer's disease.

  2025cites this paper
• Microglial Responses to Alzheimer's Disease Pathology: Insights From “Omics” Studies

  2025cites this paper
• Reviewing the possible connection between cerebral amyloid angiopathy and blood–brain barrier integrity in Down syndrome

  2025cites this paper
• Active Immunization: A Novel Therapeutic Strategy for Treating Alzheimer's Disease.

  2025cites this paper
• Amyloid‐β Seeds in Alzheimer's Disease: Research Challenges and Implications

  2025cites this paper
• Disease-modifying effect of donepezil on APP/PS1 mice at different stages of Alzheimer’s disease

  2025cites this paper
• Hippocampal and cortical activities reflect early hyperexcitability in an Alzheimer's mouse model

  2025cites this paper
• A comprehensive insight into baicalein and baicalin: neuroprotective perspectives in Alzheimer’s disease

  2025cites this paper
• Repeat Opioid Use Modulates Microglia Activity and Amyloid Beta Clearance in a Mouse Model of Alzheimer’s Disease

  2025cites this paper
• High-Fat Diet-Induced Excessive Accumulation of Cerebral Cholesterol Esters and Microglial Dysfunction Exacerbate Alzheimer's Disease Pathology in APPNL−G−F mice

  2025cites this paper
• Selection of five different types of animal models of Alzheimer’s disease: based on pathological similarity and research objectives

  2025cites this paper
• Experimental evidence that readily diffusible forms of Aβ from Alzheimer’s disease brain have seeding activity

  2025cites this paper
• Age-Dependent, Odorant-Specific Changes in Olfactory Sensitivity in an Alzheimer’s Disease Mouse Model

  2025cites this paper
• Human and mouse proteomics reveals the shared pathways in Alzheimer’s disease and delayed protein turnover in the amyloidome

  2025cites this paper
• The gut–brain axis in Alzheimer’s disease is shaped by commensal gut microbiota derived extracellular vesicles

  2025cites this paper
• Tacrolimus mitigates pathological patterns in mouse models of Alzheimer's disease.

  2025cites this paper
• Complement therapeutics in neurodegenerative diseases.

  2025cites this paper
• Boldine as a neuroprotective agent against motor neuron degeneration in models of amyotrophic lateral sclerosis

  2025cites this paper
• Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer’s disease mice: Potential role in chronic heavy alcohol feeding

  2024cites this paper