Magainin 2 in action: distinct modes of membrane permeabilization in living bacterial and mammalian cells.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biophysical Journal

• Publication date

  2008-12-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1529/biophysj.108.133488PMID 18835901PMCID PMC2599864
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro.

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• Glycosaminoglycans inhibit the antibacterial activity of LL-37 in biological fluids.

  2006influential reference
• An Alternative Bactericidal Mechanism of Action for Lantibiotic Peptides That Target Lipid II

  2006cited by this paper
• Molecular mechanism of antimicrobial peptides: the origin of cooperativity.

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• MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain.

  2003cited by this paper
• Positively charged DNA-binding proteins cause apparent cell membrane translocation.

  2002cited by this paper
• Antimicrobial peptides of multicellular organisms

  2002cited by this paper
• Position-dependent hydrophobicity of the antimicrobial magainin peptide affects the mode of peptide-lipid interactions and selective toxicity.

  2002cited by this paper
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  2001cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Relationship of membrane curvature to the formation of pores by magainin 2.

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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Membrane pores induced by magainin.

  1996cited by this paper
• Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl

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• Molecular basis for membrane selectivity of an antimicrobial peptide, magainin 2.

  1995cited by this paper
• Orientational and aggregational states of magainin 2 in phospholipid bilayers.

  1994cited by this paper
• Physicochemical determinants for the interactions of magainins 1 and 2 with acidic lipid bilayers.

  1991cited by this paper
• The pH dependence of headgroup and acyl chain structure and dynamics of phosphatidylserine, studied by 2H-NMR.

  1990cited by this paper
• Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers.

  1990influential reference
• All-D amino acid-containing channel-forming antibiotic peptides.

  1990cited by this paper
• Antimicrobial activity of synthetic magainin peptides and several analogues.

  1988cited by this paper
• Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.

  1988cited by this paper
• Studies on the phospholipids and morphology of protoplasts of Bacillus megaterium

  1967cited by this paper
• Studies of the phospholipids and morphology of protoplasts of Bacillus megaterium.

  1967cited by this paper

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