On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X7 receptor antagonist A-438079

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of neural transmission

• Publication date

  2010-04-13

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00702-010-0400-0PMID 20387084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A new road to neuroinflammation in Parkinson's disease?

  2008cited by this paper
• The Nigro-Striatal DA Neurons and Mechanisms of Their Degeneration in Parkinson’s Disease

  2008cited by this paper
• The novel cyclooxygenase-2 inhibitor GW637185X protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

  2008cited by this paper
• From development to degeneration and regeneration of the nervous system

  2008cited by this paper
• Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity.

  2007cited by this paper
• Discovery of P2X7 receptor‐selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states

  2007influential reference
• Extracellular ATP Mediates Necrotic Cell Swelling in SN4741 Dopaminergic Neurons through P2X7 Receptors*

  2007cited by this paper
• The P2X7 Receptor: A Key Player in IL-1 Processing and Release

  2006cited by this paper
• Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

  2006cited by this paper
• A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

  2006cited by this paper
• Uncoupling protein 2/3 immunoreactivity and the ascending dopaminergic and noradrenergic neuronal systems: relevance for volume transmission.

  2006cited by this paper
• Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons.

  2006cited by this paper
• The P2X7 Receptor: A Key Player in IL-1 Processing and Release1

  2006cited by this paper
• The nigrostriatal DA pathway and Parkinson's disease.

  2006cited by this paper
• Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists

  2006influential reference
• Encyclopedia of Sensors

  2006cited by this paper
• Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP.

  2005influential reference
• Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

  2005cited by this paper
• Characterization of a functional P2X7‐like receptor in cerebellar granule neurons from P2X7 knockout mice

  2005cited by this paper
• Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice.

  2005cited by this paper
• Reanalysis of P2X7 Receptor Expression in Rodent Brain

  2004cited by this paper
• Activation and response to axotomy of microglia in the facial motor nuclei of G93A superoxide dismutase transgenic mice.

  2000cited by this paper
• The Cytolytic P2Z Receptor for Extracellular ATP Identified as a P2X Receptor (P2X7)

  1996cited by this paper
• Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding.

  1994cited by this paper
• 6-Hydroxy-dopamine induced degeneration of central monoamine neurons.

  1968influential reference

• P2X7 receptors as targets for neuroprotection.

  2026cites this paper
• Changes in nucleotide and nucleoside metabolism in zebrafish brain exposed to paraquat and 6-hydroxydopamine

  2025cites this paper
• P2RX7 Dynamics in CNS Disorders: Molecular Insights and Therapeutic Perspectives

  2025cites this paper
• Weizmannia coagulans BC99 Improve Cognitive Impairment Induced by Chronic Sleep Deprivation via Inhibiting the Brain and Intestine’s NLRP3 Inflammasome

  2025cites this paper
• New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease

  2025cites this paper
• Pyroptosis; igniting neuropsychiatric disorders from mild depression to aging-related neurodegeneration.

  2025cites this paper
• P2RX7 modulates the function of human microglia-like cells and mediates the association of IL18 with Alzheimer’s disease traits

  2025cites this paper
• IL-1RA Disrupts ATP Activation of P2RX7 in Human Monocyte-Derived Microglia-like Cells

  2024cites this paper
• Inhibition of P2X7R alleviates neuroinflammation and brain edema after traumatic brain injury by suppressing the NF-κB/NLRP3 inflammasome pathway

  2024cites this paper
• A current review on P2X7 receptor antagonist patents in the treatment of neuroinflammatory disorders: a patent review on antagonists

  2024cites this paper
• Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases

  2024cites this paper
• Druggable targets for Parkinson’s disease: transcriptomics based Mendelian randomization study

  2024cites this paper
• Increased Cerebrospinal Fluid Adenosine 5′-Triphosphate Levels in Patients with Guillain–Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy

  2024cites this paper
• Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration

  2024cites this paper
• Purinergic Receptor (P2X7R): A Promising Anti-Parkinson’s Drug Target

  2024cites this paper
• Mitochondrial DAMPs: Key Mediators in Neuroinflammation and Neurodegenerative Disease Pathogenesis.

  2024cites this paper
• Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties

  2023cites this paper
• Bioinformatics analysis of potential common pathogenic mechanism for carotid atherosclerosis and Parkinson’s disease

  2023cites this paper
• Role of neuroinflammation in neurodegeneration development

  2023cites this paper
• P2X7 Receptor and Purinergic Signaling: Orchestrating Mitochondrial Dysfunction in Neurodegenerative Diseases

  2022cites this paper
• P2X7 Receptor Antagonist Reduces Fibrosis and Inflammation in a Mouse Model of Alpha-Sarcoglycan Muscular Dystrophy

  2022cites this paper
• Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation

  2022cites this paper
• The Significance of NLRP Inflammasome in Neuropsychiatric Disorders

  2022cites this paper
• P2X7 receptor/NLRP3 inflammasome complex and α‐synuclein in peripheral blood mononuclear cells: a prospective study in neo‐diagnosed, treatment‐naïve Parkinson’s disease

  2021cites this paper
• Antagonistic Roles of P2X7 and P2Y2 Receptors in Neurodegenerative Diseases

  2021cites this paper
• P2X7 Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches

  2021influential citation
• Role of P2X7 Receptors in Immune Responses During Neurodegeneration

  2021cites this paper
• Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications

  2020cites this paper
• Synthetic 1,4-Naphthoquinones inhibit P2X7 receptors in murine neuroblastoma cells.

  2020cites this paper
• Increased cerebrospinal fluid adenosine 5'-triphosphate in patients with amyotrophic lateral sclerosis

  2020cites this paper
• Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease

  2020cites this paper
• Plant natural products as source of new P2 receptors ligands.

  2020cites this paper
• ATP Signaling Controlling Dyskinesia Through P2X7 Receptors

  2020cites this paper
• The P2X7 Receptor: Central Hub of Brain Diseases

  2020cites this paper
• The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases

  2020influential citation
• Purinergic Signalling in Parkinson’s Disease: A Multi-target System to Combat Neurodegeneration

  2019cites this paper
• Advances in the Potential Biomarkers of Epilepsy

  2019cites this paper
• Age-specific effects of P2X7 receptors on olfactory function in mice.

  2019cites this paper
• Mapping the binding site of P2X7 receptor antagonists

  2019cites this paper
• Targeting Purinergic Signaling and Cell Therapy in Cardiovascular and Neurodegenerative Diseases.

  2019cites this paper
• P2Y6 and P2X7 Receptor Antagonism Exerts Neuroprotective/ Neuroregenerative Effects in an Animal Model of Parkinson’s Disease

  2019cites this paper
• Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A2A receptor over‐activation in a rat model of Parkinson's disease

  2019cites this paper
• P2X7: RECEPTOR DE MUERTE, CLAVE EN LA NEURODEGENERACIÓN

  2018influential citation
• P2X7 as a scavenger receptor for innate phagocytosis in the brain

  2018cites this paper
• The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

  2018cites this paper
• Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy

  2018cites this paper
• Effects of P2X7 receptor antagonists on hypoxia‐induced neonatal seizures in mice

  2017cites this paper
• Brilliant Blue G, but not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease

  2017cites this paper
• Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice

  2017cites this paper
• Neurotransmission systems in Parkinson’s disease

  2017cites this paper
• MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3

  2017cites this paper
• Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition

  2017cites this paper
• 25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspase-dependent apoptosis in human skin model: New insights into degenerative pathways.

  2017cites this paper
• P2RX7 purinoceptor as a therapeutic target in Duchenne muscular dystrophy

  2017cites this paper
• Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy.

  2016cites this paper
• Purinergic receptors in embryonic and adult neurogenesis.

  2016cites this paper
• P2X7R modulation of visually evoked synaptic responses in the retina

  2016cites this paper
• Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease

  2016cites this paper
• Purinergic signaling in Parkinson's disease. Relevance for treatment.

  2016cites this paper
• Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

  2016cites this paper
• Purinergic mechanisms in neuroinflammation: An update from molecules to behavior.

  2016cites this paper
• An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration.

  2016cites this paper
• Involvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury

  2016cites this paper
• Purinergic neurone-glia signalling in cognitive-related pathologies.

  2016cites this paper
• MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

  2016cites this paper
• Expression, Function and Targeting of the ATP-gated P2X7 receptor in epilepsy

  2015cites this paper
• Involvement of the P2X7 purinergic receptor in inflammation: an update of antagonists series since 2009 and their promising therapeutic potential.

  2015cites this paper
• Modulation of the neuronal network activity by P2X receptors and their involvement in neurological disorders.

  2015cites this paper
• P2X7 receptor is critical in α-synuclein--mediated microglial NADPH oxidase activation.

  2015cites this paper
• ATP as a multi-target danger signal in the brain

  2015influential citation
• P2X7 Receptor Modulation of Visual Responses in the Retina

  2015cites this paper
• P2X7 in Bipolar and Depressive Disorders

  2014cites this paper
• P2X7 receptor: an emerging target in central nervous system diseases.

  2014cites this paper
• P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System

  2014influential citation
• 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier integrity through a mechanism involving P2X7 receptors.

  2014cites this paper
• The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis.

  2014cites this paper
• Calcium ion influx in microglial cells: Physiological and therapeutic significance

  2014cites this paper
• The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease

  2014cites this paper
• Implication of purinergic P2X7 receptor in M. tuberculosis infection and host interaction mechanisms: a mouse model study.

  2013cites this paper
• interaction mechanisms: A mouse model study

  2013cites this paper
• The Therapeutic Potential of Modifying Inflammasomes and NOD-Like Receptors

  2013cites this paper
• The Therapeutic Potential of Modifying Inflammasomes and NOD-Like Receptors

  2013cites this paper
• Association of P2X7 receptor gene polymorphisms with sporadic Parkinson's disease in a Han Chinese population.

  2013cites this paper
• P2X receptors as targets for the treatment of status epilepticus

  2013cites this paper
• Microglial P2Y12 Deficiency/Inhibition Protects against Brain Ischemia

  2013cites this paper
• Inflammatory Pathways in Parkinson's Disease; A BNE Microarray Study

  2012cites this paper
• The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide‐induced haemorrhagic cystitis in mice

  2012cites this paper
• Ligand-gated ion channels: new insights into neurological disorders and ligand recognition.

  2012cites this paper
• Molecular and functional properties of P2X receptors—recent progress and persisting challenges

  2012cites this paper
• Purinergic Signalling in the Central Nervous System

  2012cites this paper
• PAPEL DO RECEPTOR P2X7 EM MODELO MURINO DE INFECÇÃO POR Mycobacterium tuberculosis.

  2012cites this paper
• Pathophysiology of astroglial purinergic signalling

  2012cites this paper
• The impact of commercially available purinergic ligands on purinergic signalling research

  2012cites this paper
• P2X Receptors as New Therapeutic Targets

  2011cites this paper
• Role of purinergic signalling in neuro-immune cells and adult neural progenitors.

  2011cites this paper
• The Hydrolysis of Striatal Adenine- and Guanine-Based Purines in a 6-Hydroxydopamine Rat Model of Parkinson’s Disease

  2011cites this paper
• Purinergic signalling: from normal behaviour to pathological brain function.

  2011cites this paper
• Role of purinergic receptors in CNS function and neuroprotection.

  2011cites this paper