Synaptically Induced Long-Term Modulation of Electrical Coupling in the Inferior Olive

Summary Electrical coupling mediated by gap junctions is widespread in the mammalian CNS, and the interplay between chemical and electrical synapses on the millisecond timescale is crucial for determining patterns of synchrony in many neural circuits. Here we show that activation of glutamatergic synapses drives long-term depression of electrical coupling between neurons of the inferior olive. We demonstrate that this plasticity is not triggered by postsynaptic spiking alone and that it requires calcium entry following synaptic NMDA receptor activation. These results reveal that glutamatergic synapses can instruct plasticity at electrical synapses, providing a means for excitatory inputs to homeostatically regulate the long-term dynamics of microzones in olivocerebellar circuits.

• Publication year

  2014

• Venue

  Neuron

• Publication date

  2014-03-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuron.2014.01.005PMID 24656251PMCID 3988996
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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