Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2013-09-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1313473110PMID 24082110PMCID PMC3808608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
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  2013cited by this paper
• Changes of the proteasomal system during the aging process.

  2012cited by this paper
• Fast gapped-read alignment with Bowtie 2

  2012cited by this paper
• Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

  2011influential reference
• Protein homeostasis and aging: The importance of exquisite quality control.

  2011cited by this paper
• Linking cell polarity, aging and rejuvenation

  2011cited by this paper
• Hot topics in aging research: protein translation and TOR signaling, 2010

  2011cited by this paper
• Genome sequencing reveals insights into physiology and longevity of the naked mole rat

  2011cited by this paper
• R2 Retrotransposons Encode a Self-Cleaving Ribozyme for Processing from an rRNA Cotranscript

  2010cited by this paper
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  2010cited by this paper
• mTOR: from growth signal integration to cancer, diabetes and ageing

  2010cited by this paper
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  2009cited by this paper
• The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA

  2009cited by this paper
• Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

  2009influential reference
• Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation

  2008cited by this paper
• Velvet: algorithms for de novo short read assembly using de Bruijn graphs.

  2008cited by this paper
• Disparate patterns of age‐related changes in lipid peroxidation in long‐lived naked mole‐rats and shorter‐lived mice

  2006cited by this paper
• Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration

  2006cited by this paper
• Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice.

  2006cited by this paper
• Protein homeostasis and molecular chaperones in aging

  2006cited by this paper
• mTOR, translation initiation and cancer

  2006cited by this paper
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  2006cited by this paper
• The frequency of translational misreading errors in E. coli is largely determined by tRNA competition.

  2006cited by this paper
• The naked mole-rat: a new long-living model for human aging research.

  2005cited by this paper
• Autophagy and Aging: The Importance of Maintaining "Clean" Cells

  2005cited by this paper
• Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.

  2004cited by this paper
• Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress

  2004cited by this paper
• Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.

  2003cited by this paper
• X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli

  2003cited by this paper
• Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

  2003cited by this paper
• Novel processing in a mammalian nuclear 28S pre‐rRNA: tissue‐specific elimination of an ‘intron’ bearing a hidden break site

  1999cited by this paper
• Translational fidelity: error-prone versus hyper-accurate ribosomes.

  1998cited by this paper
• Alterations in the chaperone activity of HSP70 in aging organisms.

  1997cited by this paper
• Characterization of a 54-nucleotide gap region in the 28S rRNA gene of Schistosoma mansoni.

  1991cited by this paper
• Sixteen discrete RNA components in the cytoplasmic ribosome of Euglena gracilis.

  1990cited by this paper
• The excision of intervening sequences from Salmonella 23S ribosomal RNA.

  1990cited by this paper
• Scrambled ribosomal RNA gene pieces in Chlamydomonas reinhardtii mitochondrial DNA.

  1988cited by this paper
• Molecular mechanism of introduction of the hidden break into the 28S rRNA of insects: implication based on structural studies.

  1986cited by this paper
• Walker's Mammals of the World, 4th Edition, Ronald M. Nowak, John L. Paradiso. The Johns Hopkins University Press, Baltimore, Maryland (1983), 1xi, +1-568 (Vol. I), xxv+569-1362 (Vol. II). Price $65.00

  1984cited by this paper
• On the translational error theory of aging.

  1977cited by this paper
• The maintenance of the accuracy of protein synthesis and its relevance to ageing.

  1963cited by this paper
• Competition

  1936cited by this paper

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  2026cites this paper
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  2025cites this paper
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  2025influential citation
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  2025cites this paper
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  2025cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2020cites this paper
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