Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cell Stem Cell

• Publication date

  2008-09-11

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.stem.2008.07.002PMID 18786419PMCID PMC2614339
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Experimental studies of the regeneration of Planaria maculata

  2015cited by this paper
• β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis

  2008cited by this paper
• Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

  2008cited by this paper
• Faculty Opinions recommendation of Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis.

  2008influential reference
• Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.

  2007cited by this paper
• smedinx-11 is a planarian stem cell gap junction gene required for regeneration and homeostasis

  2007cited by this paper
• Epithelial stem cells: turning over new leaves.

  2007cited by this paper
• Cell turnover and adult tissue homeostasis: from humans to planarians.

  2007cited by this paper
• Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile

  2007cited by this paper
• Characterization and categorization of fluorescence activated cell sorted planarian stem cells by ultrastructural analysis

  2007influential reference
• Upregulation of the creatine synthetic pathway in skeletal muscles of mature mdx mice.

  2007cited by this paper
• Highly Conserved Sequences Mediate the Dynamic Interplay of Basic Helix-Loop-Helix Proteins Regulating Retinogenesis*

  2007cited by this paper
• A Bruno-like gene is required for stem cell maintenance in planarians.

  2006influential reference
• The adult Drosophila posterior midgut is maintained by pluripotent stem cells

  2006cited by this paper
• Isolation of planarian X‐ray‐sensitive stem cells by fluorescence‐activated cell sorting

  2006influential reference
• The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.

  2006cited by this paper
• The role of combinational coding by homeodomain and bHLH transcription factors in retinal cell fate specification.

  2005cited by this paper
• Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.

  2005influential reference
• Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

  2005cited by this paper
• Regulation of temporal identity transitions in Drosophila neuroblasts.

  2005cited by this paper
• Stem Cell Self-Renewal Controlled by Chromatin Remodeling Factors

  2005cited by this paper
• SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells

  2005influential reference
• Creatine synthesis and transport during rat embryogenesis: Spatiotemporal expression of AGAT, GAMT and CT1

  2005cited by this paper
• Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.

  2005cited by this paper
• The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain.

  2005cited by this paper
• Fundamentals of planarian regeneration.

  2004cited by this paper
• A Signaling Role of Histone-binding Proteins and INHAT Subunits pp32 and Set/TAF-Iβ in Integrating Chromatin Hypoacetylation and Transcriptional Repression*

  2004cited by this paper
• An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

  2004cited by this paper
• Roles of the mammalian subventricular zone in cell replacement after brain injury.

  2004cited by this paper
• Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche.

  2004cited by this paper
• RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine

  2004influential reference
• Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients.

  2004cited by this paper
• Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians

  2003cited by this paper
• Identification of immunological reagents for use in the study of freshwater planarians by means of whole‐mount immunofluorescence and confocal microscopy

  2002cited by this paper
• The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments.

  2002cited by this paper
• Regulation of Histone Acetylation and Transcription by Nuclear Protein pp32, a Subunit of the INHAT Complex*

  2002cited by this paper
• Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells

  2002cited by this paper
• The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration

  2002influential reference
• Can stem cells cross lineage boundaries?

  2001cited by this paper
• Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny.

  2001cited by this paper
• Translating the Histone Code

  2001cited by this paper
• Stem cell potential: can anything make anything?

  2001cited by this paper
• Bromodeoxyuridine specifically labels the regenerative stem cells of planarians.

  2000cited by this paper
• Stem Cells Units of Development, Units of Regeneration, and Units in Evolution

  2000cited by this paper
• A niche maintaining germ line stem cells in the Drosophila ovary.

  2000cited by this paper
• Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function

  1999cited by this paper
• Creatine synthesis and transport systems in the male rat reproductive tract.

  1998cited by this paper
• Cytological approach to morphogenesis in the planarian blastema. II. The effect of neuropeptides.

  1997cited by this paper
• Identification of a lineage of multipotent hematopoietic progenitors.

  1997cited by this paper
• The aging of hematopoietic stem cells

  1996cited by this paper
• Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells

  1991cited by this paper
• Role of fixed parenchyma cells in blastema formation of the planarian Dugesia japonica.

  1991cited by this paper
• Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits.

  1985cited by this paper
• An Ultrastructural Study of the Chromatoid Body in Planarian Regenerative Cells

  1982influential reference
• Mitosis in the intact and regenerating planarian Dugesia mediterranea n.sp. I. Mitotic studies during growth, feeding and starvation

  1976cited by this paper
• The Invertebrates, Vol. II: Platyhelminthes and Rhynchocoela

  1951cited by this paper
• [Not Available].

  1949cited by this paper
• [Not Available].

  1947cited by this paper
• The inhibitive action of the Roentgen rays on regeneration in planarians

  1904cited by this paper
• The regeneration of the tail in lumbriculus

  1892cited by this paper

• Single-nucleotide m⁶A mapping uncovers redundant YTHDF function in planarian progenitor fate selection

  2026cites this paper
• RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a

  2026cites this paper
• A parenchymal niche regulates pluripotent stem cell function in planarians

  2025cites this paper
• Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians

  2025cites this paper
• 3D reconstruction of neuronal allometry and neuromuscular projections in asexual planarians using expansion tiling light sheet microscopy

  2025cites this paper
• Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians

  2025cites this paper
• Stochastic cell-intrinsic stem cell decisions control colony growth in planarians

  2025cites this paper
• Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells

  2025cites this paper
• Metabolites produced by agat+ cells support regeneration in the planarian Schmidtea mediterranea.

  2025cites this paper
• Extracellular Vesicles Derived From Regenerating Tissue Promote Stem Cell Proliferation in the Planarian Schmidtea mediterranea

  2025cites this paper
• Multi-omics analyses reveal DjTcf4 critical for proper timing of differentiation in planarian regeneration.

  2025cites this paper
• Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians

  2025cites this paper
• Genetic and Genomic Insights into Planarian Biology.

  2025cites this paper
• Developmental onset of planarian whole-body regeneration depends on axis reset

  2025cites this paper
• map3k1 is required for spatial restriction of progenitor differentiation in planarians

  2025cites this paper
• Enhanced RNA quality control maintains long-term regenerative ability in planarians

  2025cites this paper
• Key events relating to homeostasis and regeneration of freshwater planarians (Dugesia Japonica) after exposure to various ZnO-forms.

  2025cites this paper
• Phosphoproteomic analysis of X-ray-irradiated planarians provides novel insights into the DNA damage response.

  2025cites this paper
• Systemic identification and characterization of the conserved core NuRD complex in planarian

  2025cites this paper
• Reduced adult stem cell fate specification led to eye reduction in cave planarians

  2025cites this paper
• Prolonged starvation deepens quiescence in Vasa2/Piwi1-expressing cells of a sea anemone

  2025cites this paper
• Pluripotent Stem Cell Plasticity is Sculpted by a Slit-Independent Robo Pathway in a Regenerative Animal

  2025cites this paper
• Regeneration in the absence of canonical neoblasts in an early branching flatworm

  2025cites this paper
• Cell proliferation and cell death during whole‐body regeneration in the demosponge Halisarca dujardinii

  2025cites this paper
• FoxO is required for neoblast differentiation during planarian regeneration.

  2024cites this paper
• Notch Signaling Regulates Limb Regeneration through Hes1 and HeyL in the Chinese Mitten Crab.

  2024cites this paper
• Regeneration in the absence of canonical neoblasts in an early branching flatworm

  2024cites this paper
• Mining of potentially stem cell-related miRNAs in planarians

  2024influential citation
• Fibrillarin homologs regulate translation in divergent cell lineages during planarian homeostasis and regeneration

  2024cites this paper
• Purification and transcriptomic characterization of proliferative cells of Mesocestoides corti selectively affected by irradiation

  2024cites this paper
• A transcription factor atlas of stem cell fate in planarians

  2024cites this paper
• Extracellular vesicles promote proliferation in an animal model of regeneration

  2024cites this paper
• SoxB family genes delay regeneration and cause abnormal movement in Dugesia japonica

  2024cites this paper
• Purification of Planarian Stem Cells Using a Draq5-Based FACS Approach.

  2024cites this paper
• Profile of Alejandro Sánchez Alvarado: Winner of the 2023 Vilcek Prize in biomedical science

  2023cites this paper
• Stem Cell Bioengineering with Bioportides: Inhibition of Planarian Head Regeneration with Peptide Mimetics of Eyes Absent Proteins

  2023cites this paper
• Regeneration leads to global tissue rejuvenation in aging sexual planarians

  2023cites this paper
• Weak magnetic fields modulate superoxide to control planarian regeneration

  2023cites this paper
• The salamander blastema within the broader context of metazoan regeneration

  2023cites this paper
• Inhibition of ATM kinase rescues planarian regeneration after lethal radiation

  2023cites this paper
• An RNA/DNA-Based Flow Cytometry Approach for Isolating Slow-Cycling Stem Cells.

  2023cites this paper
• Allometry of cell types in planarians by single-cell transcriptomics

  2023cites this paper
• MRLC controls apoptotic cell death and functions to regulate epidermal development during planarian regeneration and homeostasis

  2023cites this paper
• Epidermal turnover in the planarian Schmidtea mediterranea involves basal cell extrusion and intestinal digestion

  2023cites this paper
• Single-cell atlases of two lophotrochozoan larvae highlight their complex evolutionary histories

  2023cites this paper
• Starvation resistance in planarians: multiple strategies to get a thrifty phenotype

  2023cites this paper
• Animal granulins: In the GRN scheme of things.

  2023cites this paper
• The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates

  2023cites this paper
• Fate specification is spatially intermingled across planarian stem cells

  2023cites this paper
• Planarians to schistosomes: an overview of flatworm cell-types and regulators

  2023cites this paper
• DjFARP Contributes to the Regeneration and Maintenance of the Brain through Activation of DjRac1 in Dugesia japonica

  2023cites this paper
• aristaless-like homeobox-3 is wound induced and promotes a low-Wnt environment required for planarian head regeneration

  2023cites this paper
• The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration

  2023cites this paper
• Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians

  2022cites this paper
• Cell quiescence in planarian stem cells, interplay between p53 and nutritional stimuli

  2022cites this paper
• High throughput expression-based phenotyping and RNAi screening reveals novel regulators of planarian stem cells

  2022cites this paper
• Finding the potency in planarians

  2022cites this paper
• RNAi Screen of RING/U-Box Domain Ubiquitin Ligases Identifies Critical Regulators of Tissue Regeneration in Planarians

  2022cites this paper
• Djptpn11 is indispensable for planarian regeneration by affecting early wound response genes expression and the Wnt pathway.

  2022cites this paper
• EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of Echinococcus multilocularis germinative cells via the EGFR-ERK pathway

  2022cites this paper
• Comparisons of cell proliferation and cell death from tornaria larva to juvenile worm in the hemichordate Schizocardium californicum

  2022cites this paper
• Somatic Expression of Stemness Genes in Aquatic Invertebrates

  2022cites this paper
• Fibrillarin-1 and Fibrillarin-2 are required for divergent cell lineage development in planarian homeostasis and regeneration

  2022cites this paper
• Planarian Stem Cells: Pluripotency Maintenance and Fate Determination

  2022cites this paper
• Monitoring Chromatin Regulation in Planarians Using Chromatin Immunoprecipitation Followed by Sequencing (ChIP-seq).

  2022cites this paper
• Non-traditional roles of immune cells in regeneration: an evolutionary perspective.

  2022cites this paper
• Heterotrimeric G proteins regulate planarian regeneration and behavior

  2022cites this paper
• Ancestral Stem Cell Reprogramming Genes Active in Hemichordate Regeneration

  2022cites this paper
• Developmental biology is poised to discover altogether new principles in biology in the 21st century

  2022cites this paper
• Comparisons of cell proliferation and cell death across life histories in the hemichordate Schizocardium californicum

  2022cites this paper
• Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates

  2022cites this paper
• Djhsp70s, especially Djhsp70c, play a key role in planarian regeneration and tissue homeostasis by regulating cell proliferation and apoptosis.

  2022cites this paper
• The planarian wound epidermis gene equinox is required for blastema formation in regeneration

  2022cites this paper
• Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians

  2022cites this paper
• Transcription Factors Active in the Anterior Blastema of Schmidtea mediterranea

  2021cites this paper
• Regeneration of Planarian Auricles and Reestablishment of Chemotactic Ability

  2021cites this paper
• U73122 and m-3M3FBS Regulate the GABAergic Neuron Regeneration via PLCβ in Planarian Dugesia japonica

  2021cites this paper
• Nematostella vectensis, an Emerging Model for Deciphering the Molecular and Cellular Mechanisms Underlying Whole-Body Regeneration

  2021cites this paper
• Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression

  2021influential citation
• Djnedd4L Is Required for Head Regeneration by Regulating Stem Cell Maintenance in Planarians

  2021cites this paper
• Positional Information and Stem Cells Combine to Result in Planarian Regeneration.

  2021cites this paper
• PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation

  2021cites this paper
• Identification of rare post-mitotic cell states induced by injury and required for whole-body regeneration in Schmidtea mediterranea

  2021cites this paper
• Embryonic development in the acoel Hofstenia miamia

  2021cites this paper
• Sub-Lethal 5-Fluorouracil Dose Challenges Planarian Stem Cells Promoting Transcriptional Profile Changes in the Pluripotent Sigma-Class Neoblasts

  2021cites this paper
• Protein Core Fucosylation Regulates Planarian Head Regeneration via Neoblast Proliferation

  2021cites this paper
• Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

  2021cites this paper
• Planarian Anatomy Ontology: a resource to connect data within and across experimental platforms

  2021cites this paper
• A pan‐metazoan concept for adult stem cells: the wobbling Penrose landscape

  2021cites this paper
• A Spatiotemporal Characterisation of Redox Molecules in Planarians, with a Focus on the Role of Glutathione during Regeneration

  2021cites this paper
• Planarian stem cells specify fate yet retain potency during the cell cycle.

  2021cites this paper
• Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect

  2021cites this paper
• β-thymosin is an essential regulator of stem cell proliferation and neuron regeneration in planarian (Dugesia japonica).

  2021cites this paper
• Collagen IV differentially regulates planarian stem cell potency and lineage progression

  2021cites this paper
• CBP/p300 homologs CBP2 and CBP3 play distinct roles in planarian stem cell function.

  2021cites this paper
• Intestine-enriched apolipoprotein b orthologs are required for stem cell differentiation and regeneration in planarians

  2021cites this paper
• RNAi screening of RING/U-box domain ubiquitin ligases identifies critical regulators of stem cells and tissue regeneration in planarians

  2021cites this paper
• activin-2 is required for regeneration of polarity on the planarian anterior-posterior axis

  2021cites this paper
• Tubgcp3 is a mitotic regulator of planarian epidermal differentiation.

  2021cites this paper
• Restoration of DNA Integrity and Cell Cycle by Electric Stimulation in Planarian Tissues Damaged by Ionizing Radiation

  2021influential citation