Limbs in whales and limblessness in other vertebrates: mechanisms of evolutionary and developmental transformation and loss

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Evolution & Development

• Publication date

  2002-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1046/j.1525-142X.2002.02033.xPMID 12492145
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Genetics of the Skeleton (review)

  2015cited by this paper
• Divide , accumulate , differentiate : cell condensation skeletal development revisited

  2007cited by this paper
• Divide, accumulate, differentiate: cell condensation in skeletal development revisited.

  2004cited by this paper
• Developmental mechanism involved in the embryonic reduction of limbs in reptiles.

  2003cited by this paper
• Descent with modification: the unity underlying homology and homoplasy as seen through an analysis of development and evolution

  2003cited by this paper
• Evolution of development

  2003cited by this paper
• Developmental morphology of limb reduction in hemiergis (squamata: scincidae): chondrogenesis, osteogenesis, and heterochrony

  2002cited by this paper
• Starting from fins: parallelism in the evolution of limbs and genitalia: the fin‐to‐genitalia transition

  2002cited by this paper
• The mammals that conquered the seas.

  2002cited by this paper
• Encyclopedia of evolution

  2002cited by this paper
• Vestibular evidence for the evolution of aquatic behaviour in early cetaceans

  2002cited by this paper
• Whales

  2002cited by this paper
• Palaeontology and Evolutionary Developmental Biology: A Science of the Nineteenth and Twenty–first Centuries

  2002cited by this paper
• Origin of Whales from Early Artiodactyls: Hands and Feet of Eocene Protocetidae from Pakistan

  2001influential reference
• The Phylogenetic Position of Cetaceans: Further Combined Data Analyses, Comparisons with the Stratigraphic Record and a Discussion of Character Optimization1

  2001cited by this paper
• Whale Origins as a Poster Child for Macroevolution

  2001influential reference
• NEW GENUS OF DORUDONTINE ARCHAEOCETE (CETACEA) FROM THE MIDDLE‐TO‐LATE EOCENE OF SOUTH CAROLINA

  2001cited by this paper
• Deciphering whale origins with molecules and fossils

  2001cited by this paper
• Beyond heterochrony : the evolution of development

  2001cited by this paper
• Skeletons of terrestrial cetaceans and the relationship of whales to artiodactyls

  2001influential reference
• Development of the clavicles in birds and mammals.

  2001cited by this paper
• Evolution of transcriptional regulation.

  2000cited by this paper
• A fossil snake with limbs.

  2000cited by this paper
• Un nouveau serpent bipède du Cénomanien (Crétacé). Implications phylétiques

  2000cited by this paper
• Endless forms: the evolution of gene regulation and morphological diversity.

  2000cited by this paper
• A critical reappraisal of the fossil record of the bilaterian phyla

  2000cited by this paper
• Evolution: In search of the whales' sisters

  2000cited by this paper
• All for one and one for all: condensations and the initiation of skeletal development.

  2000cited by this paper
• Embryology of Dolphins

  2000cited by this paper
• A micropower dry-electrode ECG preamplifier

  2000cited by this paper
• Hox genes and the global patterning of the somitic mesoderm.

  2000cited by this paper
• Perspectives: evolutionary biology. Limbless tetrapods and snakes with legs.

  2000cited by this paper
• Nipping the Cambrian "explosion" in the bud?

  2000cited by this paper
• Nice snake, shame about the legs.

  2000cited by this paper
• Endless Forms: The Evolution of Gene Regulation and Morphological Diversity

  2000cited by this paper
• Patterns of correlated character evolution in flightless birds: a phylogenetic approach

  2000cited by this paper
• Embryology of dolphins. Staging and ageing of embryos and fetuses of some cetaceans.

  2000influential reference
• Limbless Tetrapods and Snakes with Legs

  2000cited by this paper
• A new, diminutive Eocene whale from Kachchh (Gujarat, India) and its implications for locomotor evolution of cetaceans

  2000cited by this paper
• The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs.

  1999cited by this paper
• Developmental basis of limblessness and axial patterning in snakes

  1999cited by this paper
• Developmental evolution: this side of paradise.

  1999cited by this paper
• From head to toe: conservation of molecular signals regulating limb and craniofacial morphogenesis

  1999cited by this paper
• The position of Cetacea within mammalia: phylogenetic analysis of morphological data from extinct and extant taxa.

  1999cited by this paper
• Dlx‐5 in limb initiation in the chick embryo

  1999cited by this paper
• Marine Mammals: Evolutionary Biology

  1999cited by this paper
• Biology of Marine Mammals

  1999cited by this paper
• Parsimony Analysis of Total Evidence from Extinct and Extant Taxa and the Cetacean‐Artiodactyl Question (Mammalia, Ungulata)

  1999cited by this paper
• The time of origin of whales and the role of behavioral changes in the terrestrial-aquatic transition

  1999cited by this paper
• The emergence of whales. Evolutionary patterns in the origin of Cetacea

  1999influential reference
• Have gene knockouts caused evolutionary reversals in the mammalian first arch?

  1998cited by this paper
• Anatomy and relationships of Pachyrhachis problematicus, a primitive snake with hindlimbs

  1998cited by this paper
• Evolution of Thermoregulatory Function in Cetacean Reproductive Systems

  1998influential reference
• The emergence of whales : evolutionary patterns in the origin of Cetacea

  1998influential reference
• The Emergence of Whales

  1998cited by this paper
• Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element.

  1998cited by this paper
• Whale ankles and evolutionary relationships

  1998cited by this paper
• The evolution of 'bricolage'.

  1998cited by this paper
• Modification of expression and cis-regulation of Hoxc8 in the evolution of diverged axial morphology.

  1998cited by this paper
• Middle to Late Eocene Basilosaurines and Dorudontines

  1998influential reference
• Limb osteology and ossification patterns in Cryptoclidus (Reptilia: Plesiosauroidea) with a review of sauropterygian limbs

  1997cited by this paper
• Hox9 genes and vertebrate limb specification

  1997cited by this paper
• Evolutionary biology: Even-toed fingerprints on whale ancestry

  1997influential reference
• Fossils, genes and the evolution of animal limbs

  1997cited by this paper
• Locomotor evolution in the earliest cetaceans: functional model, modern analogues, and paleontological evidence

  1997cited by this paper
• On the development of Cetacean extremities: I. Hind limb rudimentation in the Spotted dolphin (Stenella attenuata).

  1997cited by this paper
• On the development of Cetacean extremities: II. Morphogenesis and histogenesis of the flippers in the spotted dolphin (Stenella attenuata).

  1997influential reference
• Molecular evidence from retroposons that whales form a clade within even-toed ungulates

  1997cited by this paper
• Transitions from Drag-based to Lift-based Propulsion in Mammalian Swimming

  1996cited by this paper
• Ancalecetus simonsi, A New Dorudontine Archaeocete (Mammalia, Cetacea) from the Early Late Eocene of Wadi Hitan, Egypt

  1996cited by this paper
• Vestigialization and Loss of Nonfunctional Characters

  1995cited by this paper
• Homeotic genes and the evolution of arthropods and chordates

  1995cited by this paper
• Hox genes and the evolution of vertebrate axial morphology.

  1995cited by this paper
• Studies on the fetal development of the gubernaculum in cetacea

  1995cited by this paper
• Molecular phylogeny of cetaceans prompts revision of morphological transformations.

  1995cited by this paper
• Prenatal development of the integument in Delphinidae (Cetacea: Odontoceti)

  1995cited by this paper
• Atavisms and atavistic mutations

  1995cited by this paper
• New whale from the Eocene of Pakistan and the origin of cetacean swimming

  1994cited by this paper
• Dollo's law and the death and resurrection of genes.

  1994cited by this paper
• Molecular evidence for the inclusion of cetaceans within the order Artiodactyla.

  1994cited by this paper
• Fossil Evidence for the Origin of Aquatic Locomotion in Archaeocete Whales

  1994cited by this paper
• Origin of underwater hearing in whales

  1993cited by this paper
• Revised phylogeny of whales suggested by mitochondrial ribosomal DNA sequences

  1993cited by this paper
• A proposal to standardize tetrapod phalangeal formula designations

  1992cited by this paper
• DNA synthesis decline involved in the developmental arrest of the limb buds in the embryos of the slow worm, Anguis fragilis (L.).

  1992cited by this paper
• Marine Mammal Sensory Systems

  1992cited by this paper
• New Palaeontological Contributions to Limb Ontogeny and Phylogeny

  1991cited by this paper
• Developmental Patterning of the Vertebrate Limb

  1991cited by this paper
• The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds.

  1991cited by this paper
• HOX-7: Temporal Patterns of Expression in Normal and Limbless Chick Embryos

  1991cited by this paper
• A MODEL FOR DEVELOPMENT AND EVOLUTION OF COMPLEX MORPHOLOGICAL STRUCTURES

  1991cited by this paper
• The Bottlenose dolphin

  1990cited by this paper
• Rudiments of the clavicle in the embryos of whales (Cetacea)

  1990cited by this paper
• Hind Limbs of Eocene Basilosaurus: Evidence of Feet in Whales

  1990cited by this paper
• Swimming by sea otters: adaptations for low energetic cost locomotion

  1989cited by this paper
• Design Features and Mechanics of Axial Locomotion in Fish

  1989cited by this paper
• 2 – Osteology of the Bottlenose Dolphin

  1989cited by this paper
• A Review of the Origin of Snakes

  1988cited by this paper
• Vertebrate Paleontology and Evolution

  1988cited by this paper
• The genetics of the skeleton

  1987cited by this paper

• Measures of gene indispensability reveal the parallelism between phylogeny and ontogeny

  2026cites this paper
• Habitat and complex life cycles promote morphological diversity in salamander limb bones

  2025cites this paper
• Characteristics of neutrophil chemotaxis in bottlenose dolphin (Tursiops truncatus).

  2025cites this paper
• Adaptive evolution of BMP4 as a potential mechanism for flipper forelimb changes in cetaceans

  2025cites this paper
• A simple model reveals why complex evolutionary innovations follow predictable paths

  2025cites this paper
• Copulatory mechanics in ghost spiders (Amaurobioidinae, Anyphaenidae) reveals an independent regressive evolution of a key genital trait through functional replacement.

  2025cites this paper
• Comparative Morphology of Skeletal Development in Homo sapiens and Raja asterias: Divergent Stiffening Patterns Due to Different Matrix Calcification Processes

  2024cites this paper
• Conservation of rib skeleton regionalization in the homoplastic evolution of the snake-like body form in squamates

  2024cites this paper
• Convergent evolution in silico reveals shape and dynamic principles of directed locomotion

  2024cites this paper
• Parallelism between phylogeny and ontogeny

  2024cites this paper
• Relaxed selection in evolution of genes regulating limb development gives clue to variation in forelimb morphology of cetaceans and other mammals

  2024cites this paper
• Universal optimal design in the vertebrate limb pattern and lessons for bioinspired design

  2024cites this paper
• Developmental regulation of conserved non-coding element evolution provides insights into limb loss in squamates

  2023cites this paper
• Modelling evolutionary tempo and mode using formal morphological spaces and Markov chain principles.

  2023cites this paper
• Timing of organogenesis underscores the evolution of neonatal life histories and powered flight in bats

  2023cites this paper
• Go Extinct! An Award-Winning Evolution Game That Teaches Tree-Thinking as Students Pursue the Winning Strategy

  2023cites this paper
• Dollo meets Bergmann: morphological evolution in secondary aquatic mammals

  2023cites this paper
• Atavistic and vestigial anatomical structures in the head, neck, and spine: an overview

  2023cites this paper
• Eye convergence is evoked during larval prey capture (LPC) without visual stimulus and in blind cavefish

  2023cites this paper
• Convergent Anuran Middle Ear Loss Lacks a Universal, Adaptive Explanation

  2023cites this paper
• My road to the ants: A model clade for eco-evo-devo.

  2022cites this paper
• Whatever happened to reversion?

  2022cites this paper
• Divergence of Tbx4 hindlimb enhancer HLEA underlies the hindlimb loss during cetacean evolution.

  2022cites this paper
• Convergent evolution in silico reveals shape and dynamic principles of directed locomotion on the ground

  2022cites this paper
• Forward and reverse evolution of multivariate responses to cyanobacteria in experimental waterflea populations

  2022cites this paper
• Developmental basis of evolutionary lung loss in plethodontid salamanders

  2022cites this paper
• Snake-like limb loss in a Carboniferous amniote

  2022cites this paper
• Molecular Evolutionary Analyses of Tooth Genes Support Sequential Loss of Enamel and Teeth in Baleen Whales (Mysticeti)

  2021cites this paper
• The developmental hourglass model and recapitulation: An attempt to integrate the two models

  2021cites this paper
• A farewell to arms and legs: a review of limb reduction in squamates

  2021cites this paper
• (Non)Parallel developmental mechanisms in vertebrate appendage reduction and loss

  2021cites this paper
• Cetaceans as Exemplars of Evolution and Evolutionary Ecology: A Glossary

  2020cites this paper
• Whispers from vestigial nubbins: Arrested development provokes trait loss in toads

  2020cites this paper
• Convergent evolution of elongate forms in craniates and of locomotion in elongate squamate reptiles.

  2020cites this paper
• Locomotion and palaeoclimate explain the re-evolution of quadrupedal body form in Brachymeles lizards

  2020cites this paper
• Carpal Morphology and Function in the Earliest Cetaceans

  2020cites this paper
• Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus).

  2020cites this paper
• The iliosacral joint in lizards: an osteological and histological analysis

  2020cites this paper
• Accelerated Evolution of Limb-Related Gene Hoxd11 in the Common Ancestor of Cetaceans and Ruminants (Cetruminantia)

  2019cites this paper
• The Lamprey as a Model Vertebrate in Evolutionary Developmental Biology

  2019cites this paper
• Structural and environmental constraints on reduction of paired appendages among vertebrates

  2019cites this paper
• Iliac auricular surface morphofunctional study in felidae.

  2019cites this paper
• Cetacean Skull Telescoping Brings Evolution of Cranial Sutures into Focus

  2019cites this paper
• Gene expression changes associated with the evolutionary loss of a metabolic trait: lack of lipogenesis in parasitoids

  2019cites this paper
• Pectoral myology of limb-reduced worm lizards (Squamata, Amphisbaenia) suggests decoupling of the musculoskeletal system during the evolution of body elongation

  2019cites this paper
• Recapitulation-like developmental transitions of chromatin accessibility in vertebrates

  2019cites this paper
• Flap-Footed Lizards (Gekkota: Pygopodidae) Have Forelimbs, Albeit During Embryonic Development

  2019cites this paper
• Evolution by Reverting to Ancestral Characters

  2019cites this paper
• Evolution by Loss

  2019cites this paper
• Gene regulatory mechanisms underlying the evolutionary loss of a polygenic trait

  2018cites this paper
• Development and Evolutionary Constraints in Animals

  2018cites this paper
• Adaptation or Non-adaptation?

  2018cites this paper
• The convergent evolution of snake‐like forms by divergent evolutionary pathways in squamate reptiles *

  2018cites this paper
• Review and experimental evaluation of the embryonic development and evolutionary history of flipper development and hyperphalangy in dolphins (Cetacea: Mammalia)

  2018cites this paper
• Troglomorphic features of Astroblepus pholeter, a cavefish from Ecuador, and possible introgressive hybridization

  2018cites this paper
• Mc1r gene in Astroblepus pholeter and Astyanax mexicanus: Convergent regressive evolution of pigmentation across cavefish species.

  2018cites this paper
• Their loss is our gain: regressive evolution in vertebrates provides genomic models for uncovering human disease loci

  2017cites this paper
• Evolution of Motor Systems

  2017cites this paper
• Finding sacral: Developmental evolution of the axial skeleton of odontocetes (Cetacea)

  2017cites this paper
• Hip bone morphometrics of bottlenose dolphins (Tursiops truncatus) from Adriatic Sea: Sex determination and postnatal development

  2016cites this paper
• Embryogenesis and Development in Stenella attenuata and Other Cetaceans

  2016cites this paper
• 8. Paleontological Insights into Evolution and Development

  2016cites this paper
• Sexual dimorphism in pelvic bone shape of the North Pacific common minke whales (Balaenoptera acutorostrata).

  2016cites this paper
• Incipient regressive evolution of the circadian rhythms of a cave amphipod

  2016cites this paper
• Evolutionarily Degenerate Biological Structures: Terminology Through Time, and the Question of Terminological Consensus

  2016cites this paper
• Vestigial appendicular skeletons in the African and Malagasy skink species Feylinia grandisquamis, Melanoseps ater, Grandidierina lineata and Voeltzkowia mira

  2016cites this paper
• Appendicular skeleton of the vestigial-limbed African skink Eumecia anchietae

  2016cites this paper
• Ultrastructure, biomechanical and chemical properties of the vestigial dentition of a Cuvier's beaked whale

  2016cites this paper
• Selection on different genes with equivalent functions: the convergence story told by Hox genes along the evolution of aquatic mammalian lineages

  2016cites this paper
• Vestigial Biological Structures: A Classroom-Applicable Test of Creationist Hypotheses

  2015influential citation
• Associations between Hox genes molecular evolution and the evolution of morphological diversity in Squamata and Marsupialia

  2015cites this paper
• Sexual dimorphism and morphometric relationships in pelvic bones of Commerson's dolphins (Cephalorhynchus c. commersonii) from Tierra del Fuego, Argentina

  2015cites this paper
• A critical survey of vestigial structures in the postcranial skeletons of extant mammals

  2015cites this paper
• Evolution of skull and body shape in Triturus newts reconstructed from three‐dimensional morphometric data and phylogeny

  2014cites this paper
• Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor

  2014cites this paper
• Generating anatomical variation through mutations in networks – implications for evolution

  2014cites this paper
• Adaptive simplification and the evolution of gecko locomotion: Morphological and biomechanical consequences of losing adhesion

  2014cites this paper
• Evaluation of Obturator Foramen Suggests No Differences Between Sexes in Young Bovines

  2013cites this paper
• Geometric morphometrics for the study of hemicoxae sexual dimorphism in a local domestic equine breed

  2013cites this paper
• Case Report of Flipper Anatomic Anomaly of Sotalia guianensis From Sepetiba Bay, Rio de Janeiro

  2013cites this paper
• The evolutionary history of the development of the pelvic fin/hindlimb

  2013influential citation
• Vestigial Tooth Anatomy and Tusk Nomenclature for Monodon Monoceros

  2012cites this paper
• Combating the Assumption of Evolutionary Progress: Lessons from the Decay and Loss of Traits

  2012cites this paper
• 15 – Evolution by Reverting to Ancestral Characters

  2012cites this paper
• 14 – Evolution by Loss

  2012cites this paper
• 29+ Evidences for Macroevolution: The Scientific Case for Common Descent

  2012cites this paper
• Morphological pattern and molecular signaling during intervertebral and epiphyseal fusion in cetaceans and terrestrial mammals

  2012cites this paper
• Two proteins, One model organism On the functional characterization of Lkb1 and Ring1b in zebrafish

  2012cites this paper
• Whale Evolution: A Whale of a Tale

  2012cites this paper
• The Polycomb group protein Ring1b is essential for pectoral fin development

  2012cites this paper
• SELECTED , RECENT ACQUISITIONS January-February 2003 NATIONAL MARINE MAMMAL LABORATORY LIBRARY

  2011cites this paper
• medical, genetic, and evolutionary implications

  2011cites this paper
• Three-Dimensional Pelvis and Limb Anatomy of the Cenomanian Hind-Limbed Snake Eupodophis descouensi (Squamata, Ophidia) Revealed by Synchrotron-Radiation Computed Laminography

  2011cites this paper
• Atavisms: Medical, Genetic, and Evolutionary Implications

  2011cites this paper
• Holocephalan embryos provide evidence for gill arch appendage reduction and opercular evolution in cartilaginous fishes

  2011cites this paper
• Vestigial structures in the appendicular skeletons of eight African skink species (Squamata, Scincidae)

  2011cites this paper
• Novel insights into the regulation of limb development from ‘natural’ mammalian mutants

  2011cites this paper
• Phylogenetic analyses of MHC class II genes in bottlenose dolphins and their terrestrial relatives reveal pathogen-driven directional selection

  2010cites this paper
• On the Origin and Evolution of the Tripartite Brain

  2010cites this paper
• Desenvolvimento embrionário e a evolução da fossorialidade nos lagartos da tribo Gymnophthalmini (Squamata, Gymnophthalmidae)

  2010cites this paper