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Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

Wasco Wruck,K. Kashofer,Samrina Rehman,A. Daskalaki,D. Berg,Ewa Gralka,Justyna Józefczuk,Katharina Drews,V. Pandey,C. Regenbrecht,C. Wierling,P. Turano,U. Korf,K. Zatloukal,H. Lehrach,H. Westerhoff,J. Adjaye

Published 2015 in Scientific Data

ABSTRACT

Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within, e.g., APOC3, PNPLA3, NCAN, TM6SF2 and PPP1R3B, correlate with NAFLD. Several studies have already investigated later stages of the disease. This study explores the early steatosis stage of NAFLD with the aim of identifying molecular mechanisms underlying the etiology of NAFLD. We analyzed liver biopsies and serum samples from patients with high- and low-grade steatosis (also pre-disease states) employing transcriptomics, ELISA-based serum protein analyses and metabolomics. Here, we provide a detailed description of the various related datasets produced in the course of this study. These datasets may help other researchers find new clues for the etiology of NAFLD and the mechanisms underlying its progression to more severe disease states. Design Type(s) parallel group design • transcription profiling by array design • protein expression profiling Measurement Type(s) transcription profiling assay • protein expression profiling • metabolite profiling Technology Type(s) microarray platform • ELISA • nuclear magnetic resonance assay Factor Type(s) disease stage • obesity Sample Characteristic(s) Homo sapiens • serum • liver Design Type(s) parallel group design • transcription profiling by array design • protein expression profiling Measurement Type(s) transcription profiling assay • protein expression profiling • metabolite profiling Technology Type(s) microarray platform • ELISA • nuclear magnetic resonance assay Factor Type(s) disease stage • obesity Sample Characteristic(s) Homo sapiens • serum • liver Machine-accessible metadata file describing the reported data (ISA-Tab format)

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