Cytotoxic and apoptogenic properties of Nigella sativa and thymoquinone, its constituent, in human renal cell carcinoma are comparable with cisplatin

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Food and Agricultural Immunology

• Publication date

  2015-01-02

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1080/09540105.2013.878899
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance

  2017cited by this paper
• Recent developments in the treatment of renal cell carcinoma

  2013cited by this paper
• Antineoplastic Effects of Bee Honey and Nigella sativa on Hepatocellular Carcinoma Cells

  2012cited by this paper
• Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin

  2011cited by this paper
• Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo

  2010cited by this paper
• Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling

  2010cited by this paper
• Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species

  2010cited by this paper
• Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa

  2009influential reference
• Update on in vitro cytotoxicity assays for drug development

  2008cited by this paper
• Limitations of the MTT Assay in Cell Viability Testing

  2008cited by this paper
• In Vitro Challenge using Thymoquinone on Hepatocellular Carcinoma (HepG2) Cell Line

  2008cited by this paper
• Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways

  2008cited by this paper
• Natural products as sources of new drugs over the last 25 years.

  2007cited by this paper
• Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells

  2007cited by this paper
• Anti-tumor properties of blackseed (Nigella sativa L.) extracts.

  2007cited by this paper
• Thymoquinone: a promising anti-cancer drug from natural sources.

  2006cited by this paper
• The medicinal potential of black seed (Nigella sativa) and its components

  2006cited by this paper
• The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage

  2006cited by this paper
• Delayed apoptosis upon the treatment of Hep‐2 cells with black seed

  2006cited by this paper
• In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil.

  2005cited by this paper
• Plants as a source of anti-cancer agents.

  2005influential reference
• Immunomodulatory and therapeutic properties of the Nigella sativa L. seed.

  2005influential reference
• Thymoquinone induces apoptosis through activation of caspase‐8 and mitochondrial events in p53‐null myeloblastic leukemia HL‐60 cells

  2005cited by this paper
• Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes

  2004cited by this paper
• Immunosuppressive and cytotoxic properties of Nigella sativa

  2004cited by this paper
• Antitumor activity of an ethanol extract of Nigella sativa seeds

  2004cited by this paper
• Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism.

  2004cited by this paper
• Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells.

  2003cited by this paper
• Protective effect of Nigella sativa seeds against carbon tetrachloride-induced liver damage.

  2003cited by this paper
• Protection against diethylnitrosoamine-induced hepatocarcinogenesis by an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra: a preliminary study

  2003cited by this paper
• In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone.

  2003cited by this paper
• Thymoquinone Is a Potent Superoxide Anion Scavenger

  2003cited by this paper
• Chemopreventive Potential of Volatile Oil From Black Cumin (Nigella sativa L.) Seeds Against Rat Colon Carcinogenesis

  2003cited by this paper
• The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions.

  2002cited by this paper
• Morphological and Biochemical Aspects of Apoptosis, Oncosis and Necrosis

  2002cited by this paper
• Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis.

  2001cited by this paper
• Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds.

  2000cited by this paper
• Antioxidant activity of Nigella sativa essential oil

  2000cited by this paper
• Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone.

  1999cited by this paper
• Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice.

  1999cited by this paper
• Chemical composition and medicinal properties of Nigella sativa Linn.

  1999cited by this paper
• The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.

  1998cited by this paper
• Hepatoprotective activity of thymoquinone in isolated rat hepatocytes.

  1998cited by this paper
• Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity.

  1997cited by this paper
• Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation.

  1995cited by this paper
• The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action.

  1993cited by this paper
• Antitumour principles from Nigella sativa seeds.

  1992cited by this paper
• Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice.

  1991cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• [Inflammation and cancer].

  1974cited by this paper
• Renal cell carcinoma.

  1956cited by this paper

• Design, development and evaluation of self-microemulsifying drug delivery system of pazopanib for enhanced dissolution rate and cytotoxic potential

  2023cites this paper
• Mitochondrial Dysfunction and Induction of Apoptosis in Hepatocellular Carcinoma and Cholangiocarcinoma Cell Lines by Thymoquinone

  2022cites this paper
• A review of Nigella sativa and its active principles as anticancer agents

  2022cites this paper
• Therapeutic perspectives of the black cumin component thymoquinone: A review.

  2021cites this paper
• Anti-Inflammatory Activity of S. Marianum and N. Sativa Extracts on Macrophages.

  2021cites this paper
• Nigella sativa and cancer: A review focusing on breast cancer, inhibition of metastasis and enhancement of Natural Killer cell cytotoxicity.

  2020cites this paper
• 3‐Acetyl‐11‐keto‐β‐boswellic acid attenuated oxidative glutamate toxicity in neuron‐like cell lines by apoptosis inhibition

  2020cites this paper
• Isolation of thymoquinone from Nigella sativa L. and Thymus vulgaris L., and its anti-proliferative effect on HeLa cancer cell lines

  2019cites this paper
• Nigella sativa seed extract applicability in preparations against methicillin-resistant Staphylococcus aureus and effects on human dermal fibroblasts viability.

  2019cites this paper
• Induction of Apoptosis and Growth-Inhibition by Thymoquinone in ACHN and GP-293 Cell Lines in Comparable with Cis-Platinum

  2019cites this paper
• Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy.

  2019cites this paper
• Immunomodulatory perspectives of potential biological spices with special reference to cancer and diabetes

  2017cites this paper
• University of Alberta Mitochondrial Dysfunction and Induction of Apoptosis in Hepatocellular Carcinoma and Cholangiocarcinoma Cell Lines by Thymoquinone by

  2014cites this paper