Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question1

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Immunology

• Publication date

  2001-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.166.2.973PMID 11145675
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cutting edge: alloimmune responses against major and minor histocompatibility antigens: distinct division kinetics and requirement for CD28 costimulation.

  1999cited by this paper
• Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

  1999cited by this paper
• Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

  1999cited by this paper
• Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity.

  1999influential reference
• A New Look at T Cells

  1998cited by this paper
• Positive Selection Through a Motif in the αβ T Cell Receptor

  1998cited by this paper
• Positive selection through a motif in the alphabeta T cell receptor.

  1998cited by this paper
• Cellular alloreactivity of human cord blood cells detected by T-cell frequency analysis and a human skin explant model.

  1998cited by this paper
• T cell memory.

  1998cited by this paper
• Helper T cell differentiation is controlled by the cell cycle.

  1998cited by this paper
• Visualizing memory phenotype development after in vitro stimulation of CD4(+) T cells.

  1998cited by this paper
• High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice.

  1998cited by this paper
• The peripheral T-cell pool: regulation by non-antigen induced proliferation?

  1997cited by this paper
• Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

  1997influential reference
• Fas ligand-mediated bystander lysis of syngeneic cells in response to an allogeneic stimulus.

  1997cited by this paper
• From Naive to Memory T Cells

  1996cited by this paper
• The molecular basis of allorecognition.

  1993cited by this paper
• LIMITING DILUTION ANALYSIS FOR ALLOREACTIVE, TCGF‐SECRETORY T CELLS: TWO RELATED LDA METHODS THAT DISCRIMINATE BETWEEN UNSTIMULATED PRECURSOR T CELLS AND IN VIVO‐ALLOACTIVATED T CELLS

  1989cited by this paper
• Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

  1989cited by this paper
• The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

  1987cited by this paper
• ANALYSIS OF THE ALLOREACTIVE T CELL REPERTOIRE IN MAN: I. DIFFERENCES IN PRECURSOR FREQUENCY FOR CYTOTOXIC T CELL RESPONSES AGAINST ALLOGENEIC MHC MOLECULES IN UNRELATED INDIVIDUALS

  1987cited by this paper
• High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules.

  1986cited by this paper
• Clones of cytotoxic T lymphocytes reactive to haptenated allogeneic cells: precursor frequency and characteristics as determined by a split-culture approach.

  1983cited by this paper
• Quantitative studies on T cell diversity. II. Determination of the frequencies and Lyt phenotypes of two types of precursor cells for alloreactive cytotoxic T cells in polyclonally and specifically activated splenic T cells

  1981cited by this paper
• Recognition of polymorphic H-2 domains by T lymphocytes. I. Functional role of different H-2 domains for the generation of alloreactive cytotoxic T lymphocytes and determination of precursor frequencies

  1981cited by this paper
• Limiting Dilution Analysis of Alloantigen-Reactive T Lymphocytes

  1979cited by this paper
• Limiting dilution analysis of alloantigen-reactive T lymphocytes. I. Comparison of precursor frequencies for proliferative and cytolytic responses.

  1979cited by this paper
• Limiting Dilution Analysis of Alloantigen-Reactive T Lymphocytes I. Comparison of Precursor Frequencies for Proliferative and Cytolytic Responses

  1979cited by this paper
• Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?

  1977cited by this paper
• Early cellular events in a systemic graft-vs.-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex

  1975cited by this paper
• The proportion of lymphocytes capable of recognizing strong transplantation antigens in vivo.

  1973cited by this paper
• THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION

  1969cited by this paper

• Targeting cell surface VISTA expression on allospecific naïve T cells promotes tolerance.

  2025cites this paper
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  2025cites this paper
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• Regulatory T cell therapy in solid organ transplantation: clinical applications and laboratory monitoring strategies

  2025cites this paper
• Mixed Leukocyte Reaction Using Human Blood Monocyte-Derived Dendritic Cells and Memory CD4+ T Cells.

  2025cites this paper
• Combined Tumor Cell and Lysate-Based Vaccines for Immunotherapy of Primary and Recurrent Glioblastoma (GBM)

  2025cites this paper
• γδ T Cells’ Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models

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• Preconditioning donors with corticosteroids improves early lung graft immunity

  2025cites this paper
• A strategy to reconstitute immunity without GVHD via adoptive allogeneic Tscm therapy

  2024cites this paper
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  2024cites this paper
• Implications of MHC-restricted immunopeptidome in transplantation

  2024cites this paper
• Pathophysiology and preclinical relevance of experimental graft-versus-host disease in humanized mice

  2024cites this paper
• Allorecognition Unveiled: Integrating Recent Breakthroughs Into the Current Paradigm

  2024cites this paper
• Intercellular transfer of MHC molecules in T cell alloimmunity and allotransplantation

  2024cites this paper
• Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity

  2024cites this paper
• A novel hypothesis on mechanisms and potential role of host cell membrane proteins incorporated into the viral envelope in alloreactivity

  2024cites this paper
• Solid organ transplantation: solid but not yet spectacular

  2024influential citation
• MHC and Peptide Specificity Underpin CD8+ T cell Direct Alloresponse.

  2024cites this paper
• Transplantation elicits a clonally diverse CD8+ T cell response that is comprised of potent CD43+ effectors

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection

  2023cites this paper
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  2023cites this paper
• Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice

  2023cites this paper
• Establishment of operational tolerance to sustain antitumor immunotherapy.

  2022cites this paper
• Analysis of T-Cell Receptor Repertoire in Transplantation: Fingerprint of T Cell-mediated Alloresponse

  2022cites this paper
• [Preclinical study of T cell receptor specifically reactive with KRAS G12V mutation in the treatment of malignant tumors].

  2022cites this paper
• Pathways of Antigen Recognition by T Cells in Allograft Rejection.

  2022cites this paper
• A MLR-Based Approach to Analyze Regulators of T Lymphocyte Activation In Vivo

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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• Allograft recognition by recipient's natural killer cells: Molecular mechanisms and role in transplant rejection

  2021cites this paper
• CD8+ T-Cell Repertoire in Human Leukocyte Antigen Class I-Mismatched Alloreactive Immune Response

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• Ex vivo delivery of regulatory T-cells for control of alloimmune priming in the donor lung

  2021cites this paper
• TAP dysfunction in dendritic cells enables non-canonical cross-presentation for T cell priming

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• Heterologous Immunity of Virus-Specific T Cells Leading to Alloreactivity: Possible Implications for Solid Organ Transplantation

  2021cites this paper
• Lessons from transmissible cancers for immunotherapy and transplant

  2021cites this paper
• Regulatory B cells: TIM‐1, transplant tolerance, and rejection

  2021cites this paper
• A post-preservation vascular flush removes significant populations of donor leukocytes prior to lung transplantation.

  2020cites this paper
• Extracellular vesicles as mediators of alloimmunity and their therapeutic potential in liver transplantation

  2020cites this paper
• T cell receptor repertoires within liver allografts are different to those in the peripheral blood.

  2020cites this paper
• CAR-Tregs as a Strategy for Inducing Graft Tolerance

  2020cites this paper
• Pre-existing Alloreactive T and B Cells and Their Possible Relevance for Pre-transplant Risk Estimation in Kidney Transplant Recipients

  2020cites this paper
• Class II HLA mismatch improves outcomes following haploidentical transplantation with posttransplant cyclophosphamide.

  2020cites this paper
• Germinal centre autoantibody responses following heart transplantation

  2020influential citation
• Involvement of Gut Microbiota in Solid Organ Transplantation

  2020cites this paper
• Rapid assessment of T-cell receptor specificity of the immune repertoire

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Costimulation Blockade in Transplantation.

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Control of Transplantation Inflammation

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms

  2017cites this paper
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  2017cites this paper
• Memory T cells: A helpful guard for allogeneic hematopoietic stem cell transplantation without causing graft-versus-host disease.

  2017cites this paper
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  2017influential citation
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  2017cites this paper