Estrogen receptor α and β heterodimers exert unique effects on estrogen- and tamoxifen- dependent gene expression in human U2OS osteosarcoma cells

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecular Endocrinology

• Publication date

  2005-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/ME.2004-0381
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Coactivator proteins as determinants of estrogen receptor structure and function: spectroscopic evidence for a novel coactivator-stabilized receptor conformation.

  2005cited by this paper
• Coregulator function: a key to understanding tissue specificity of selective receptor modulators.

  2004cited by this paper
• Single-Chain Estrogen Receptors (ERs) Reveal that the ERα/β Heterodimer Emulates Functions of the ERα Dimer in Genomic Estrogen Signaling Pathways

  2004cited by this paper
• General mechanisms of steroid receptors and receptor coregulator action

  2004cited by this paper
• NCBI GEO: mining millions of expression profiles—database and tools

  2004cited by this paper
• Identification and functional clustering of global gene expression differences between age-related cataract and clear human lenses and aged human lenses.

  2004cited by this paper
• Therapeutic targeting in the estrogen receptor hormonal pathway.

  2004cited by this paper
• Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer.

  2004cited by this paper
• The Relative Contribution Exerted by AF-1 and AF-2 Transactivation Functions in Estrogen Receptor α Transcriptional Activity Depends upon the Differentiation Stage of the Cell*

  2004cited by this paper
• Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors.

  2004cited by this paper
• The molecular determinants of estrogen receptor pharmacology.

  2004cited by this paper
• Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines.

  2003influential reference
• Kinetic analysis of estrogen receptor homo- and heterodimerization in vitro.

  2003cited by this paper
• Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors alpha and beta.

  2003cited by this paper
• Overview of estrogen action in osteoblasts: role of the ligand, the receptor, and the co-regulators.

  2003cited by this paper
• Modulation of estrogen receptor activity by selective coregulators.

  2003cited by this paper
• 17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context.

  2003cited by this paper
• Estrogen receptor isoform‐specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERα or ERβ

  2003influential reference
• Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors α and β

  2003cited by this paper
• Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta.

  2003cited by this paper
• AP-1 as a regulator of cell life and death

  2002cited by this paper
• A negative coregulator for the human ER.

  2002cited by this paper
• Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

  2002cited by this paper
• Biomedicine. Defining the "S" in SERMs.

  2002cited by this paper
• Defining the "S" in SERMs

  2002cited by this paper
• Differences in the abilities of estrogen receptors to integrate activation functions are critical for subtype-specific transcriptional responses.

  2002cited by this paper
• The human estrogen receptor alpha dimer binds a single SRC-1 coactivator molecule with an affinity dictated by agonist structure.

  2001cited by this paper
• Analysis of steroid hormone-induced histone acetylation by chromatin immunoprecipitation assay.

  2001cited by this paper
• Estrogen Receptors α and β Are Differentially Expressed in Developing Human Bone1

  2001cited by this paper
• Functional Differences between the Amino-Terminal Domains of Estrogen Receptors α and β

  2000cited by this paper
• Conformational Changes and Coactivator Recruitment by Novel Ligands for Estrogen Receptor-α and Estrogen Receptor-β: Correlations with Biological Character and Distinct Differences among SRC Coactivator Family Members.

  2000influential reference
• Estrogen receptor β acts as a dominant regulator of estrogen signaling

  2000cited by this paper
• The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens.

  1999cited by this paper
• Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor.

  1999cited by this paper
• Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

  1999cited by this paper
• Isoforms of steroid receptor co‐activator 1 differ in their ability to potentiate transcription by the oestrogen receptor

  1998cited by this paper
• The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.

  1998cited by this paper
• Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β.

  1998cited by this paper
• Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells.

  1997cited by this paper
• Molecular basis of agonism and antagonism in the oestrogen receptor

  1997cited by this paper
• Human Estrogen Receptor β Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor α*

  1997influential reference
• RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.

  1997cited by this paper
• Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta.

  1997cited by this paper
• Estrogen Receptors α and β Form Heterodimers on DNA*

  1997cited by this paper
• Expression of Estrogen Receptor β in Rat Bone.

  1997cited by this paper
• Cloning of a novel receptor expressed in rat prostate and ovary.

  1996cited by this paper
• Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

  1996cited by this paper
• TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors.

  1996cited by this paper
• ERβ: Identification and characterization of a novel human estrogen receptor

  1996cited by this paper
• Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

  1995cited by this paper
• The nuclear receptor superfamily: the second decade.

  1995influential reference
• Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells (*)

  1995cited by this paper
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

  1983cited by this paper
• Cloning of a novel estrogen receptor expressed in rat prostate and ovary

  year unknowncited by this paper

• Plastic chemicals disrupt molecular circadian rhythms via adenosine 1 receptor in vitro.

  2025cites this paper
• Sex based relative expression of estrogen receptors and tumor necrosis factor-alpha in liver affects hepatitis C virus viral pathogenesis

  2025cites this paper
• Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.

  2023cites this paper
• Osteoporosis Therapy: Mechanistic Antiresorptives

  2021cites this paper
• Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

  2020cites this paper
• Transcription factor-mediated regulation of the BCRP/ABCG2 efflux transporter: a review across tissues and species

  2020cites this paper
• Estrogens and progestins

  2020cites this paper
• Synaptic effects of estrogen.

  2020cites this paper
• Molecular mechanisms of estrogen receptor β-induced apoptosis and autophagy in tumors: implication for treating osteosarcoma

  2019cites this paper
• Incidence of androgen receptor and androgen receptor variant 7 coexpression in prostate cancer

  2019cites this paper
• Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones

  2019cites this paper
• Biology and Clinical Aspects of Estrogen Action on Bone

  2019cites this paper
• Estrogen Signaling in Arcuate Kiss1 Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice

  2018cites this paper
• Steroid Hormone Receptors and Signal Transduction Processes

  2018cites this paper
• Chemoprevention by Genistein

  2017cites this paper
• Hormone responsive genes involved in osteoporosis in post-menopausal women

  2017cites this paper
• Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety

  2017cites this paper
• Molecular mechanism of estrogen–estrogen receptor signaling

  2016cites this paper
• Assessment of estradiol-induced gene regulation and proliferation in an immortalized mouse immature Sertoli cell line.

  2016cites this paper
• Characterizing the Role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose Polymerase (TIPARP) in Estrogen Receptor Signalling

  2016cites this paper
• Klotho/fibroblast growth factor 23- and PTH-independent estrogen receptor-α-mediated direct downregulation of NaPi-IIa by estrogen in the mouse kidney.

  2016cites this paper
• Part III: Steroid Hormone Receptors and Signal Transduction Processes

  2016cites this paper
• Investigating the Balance Between Estrogen Receptor Mediated Cell Proliferation and Genomic Surveillance

  2016cites this paper
• Estrogen receptors alpha and beta in bone.

  2016cites this paper
• Deletion of Estrogen Receptor Beta in Osteoprogenitor Cells Increases Trabecular but Not Cortical Bone Mass in Female Mice

  2016cites this paper
• Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype.

  2015cites this paper
• Prognostic and predictive value of ERβ1 and ERβ2 in the Intergroup Exemestane Study (IES)-first results from PathIES†.

  2015cites this paper
• Estrogen receptor signaling during vertebrate development.

  2015cites this paper
• Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.

  2015cites this paper
• Effects of caffeine on the human circadian clock in vivo and in vitro

  2015cites this paper
• Regulation of DNA Damage Response by Estrogen Receptor β-Mediated Inhibition of Breast Cancer Associated Gene 2

  2015cites this paper
• Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ERα and ERβ) in rat kidney proximal tubule.

  2015cites this paper
• Evaluating Nutraceuticals for Selective Toxicity Toward Leukemia Stem Cells

  2015cites this paper
• Estrogen-related Receptor β Reduces the Subnuclear Mobility of Estrogen Receptor α and Suppresses Estrogen-dependent Cellular Function*

  2015cites this paper
• Steroid sulfatase mediated growth Sof human MG-63 pre-osteoblastic cells.

  2014cites this paper
• Régulation de l’activité transcriptionnelle des récepteurs des estrogènes (ER) par le récepteur à chimiokine CXCR4 et les récepteurs à activité tyrosine kinase ErbB2 et ErbB3

  2014influential citation
• Endocrine Disruptors (Xenoestrogens): An Overview

  2014cites this paper
• ERβ splice variant expression in four large cohorts of human breast cancer patient tumors

  2014cites this paper
• Inhibitory effects of tamoxifen and doxorubicin, alone and in combination, on the proliferation of the MG63 human osteosarcoma cell line

  2013cites this paper
• Proteinaceous microspheres for targeted RNA delivery prepared by an ultrasonic emulsification method.

  2013cites this paper
• Estradiol responsiveness of synaptopodin in hippocampal neurons is mediated by estrogen receptor β.

  2013cites this paper
• Human T47D-ERβ breast cancer cells with tetracycline-dependent ERβ expression reflect ERα/ERβ ratios in rat and human breast tissue.

  2013cites this paper
• Resveratrol induced neuroprotection is mediated via both estrogen receptor subtypes, ER(α) and ER(β).

  2013cites this paper
• Negative regulation of estrogen signaling by ERβ and RIP140 in ovarian cancer cells.

  2013cites this paper
• Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks.

  2013cites this paper
• Oestrogen receptors in breast cancer: basic mechanisms and clinical implications

  2013cites this paper
• Mapping ERβ Genomic Binding Sites Reveals Unique Genomic Features and Identifies EBF1 as an ERβ Interactor

  2013cites this paper
• A bi-faceted role of estrogen receptor β in breast cancer.

  2013cites this paper
• Carboxypeptidase M in apoptosis, adipogenesis and cancer.

  2013cites this paper
• Approaches for Searching of Modified Steroid Estrogen Analogues with Improved Biological Properties

  2012cites this paper
• Novel Modeling of Combinatorial miRNA Targeting Identifies SNP with Potential Role in Bone Density

  2012cites this paper
• Identification of Estrogen Receptor Dimer Selective Ligands Reveals Growth-Inhibitory Effects on Cells That Co-Express ERα and ERβ

  2012cites this paper
• The Role of Estrogen Receptor-β in Breast Cancer

  2012cites this paper
• Human ERa and ERb splice variants: understanding their domain structure in relation to their biological roles in breast cancer cell proliferation

  2012cites this paper
• Comparative evaluation of ERα and ERβ significance in breast cancer: state of the art

  2011cites this paper
• Estrogen Receptors: Therapies Targeted to Receptor Subtypes

  2011cites this paper
• 17β-estradiol signaling and regulation of Sertoli cell function

  2011cites this paper
• Sexual steroid regulation of spermatogenesis: new actors enter the stage

  2011cites this paper
• Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen

  2011influential citation
• Development of subtype-selective oestrogen receptor-based therapeutics

  2011cites this paper
• Chemopreventive effect of ERβ‐Selective agonist on intestinal tumorigenesis in ApcMin/+ Mice

  2011cites this paper
• Estrogen receptors similarly mediate the effects of 17β-estradiol on cellular responses but differ in their potencies

  2011cites this paper
• Androgens and estrogens in benign prostatic hyperplasia: past, present and future.

  2011cites this paper
• Pulmonary Infl ammation in Cystic Fibrosis: Impact of Innate Immunity and Estrogen

  2011cites this paper
• Differential Roles of Estrogen Receptors α and β in Control of B-Cell Maturation and Selection

  2011cites this paper
• Unravelling the mechanism of differential biological responses induced by food-borne xeno- and phyto-estrogenic compounds

  2010influential citation
• Identification and characterization of a novel estrogenic ligand actinopolymorphol A.

  2010cites this paper
• Estrogen regulation and physiopathologic significance of alternative promoters in breast cancer.

  2010cites this paper
• Selectively targeting estrogen receptors for cancer treatment.

  2010cites this paper
• Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy

  2010cites this paper
• Regulation of specific target genes and biological responses by estrogen receptor subtype agonists.

  2010cites this paper
• FOXA1 is a critical determinant of Estrogen Receptor function and endocrine response

  2010cites this paper
• Minireview: Estrogen receptor-beta: mechanistic insights from recent studies.

  2010cites this paper
• Alternative Splicing in Prostate and Breast Cancer

  2010cites this paper
• Estrogen receptor interactions and dynamics monitored in live cells by fluorescence cross-correlation spectroscopy.

  2010cites this paper
• Estrogen Receptors: Their Actions and Functional Roles in Health and Disease

  2010cites this paper
• Estrogen receptor beta protects against in vivo injury in RPE cells.

  2010cites this paper
• Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation

  2010influential citation
• Assessing the size of gene or RNAi effects in multifactor high-throughput experiments.

  2010cites this paper
• Down‐regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells

  2009cites this paper
• Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity.

  2009cites this paper
• Functional Analysis of MicroRNA-10b in Breast Carcinoma: A Dissertation

  2009cites this paper
• Carboxypeptidase M: Multiple alliances and unknown partners.

  2009cites this paper
• Hydrogel-mediated DNA delivery confers estrogenic response in nonresponsive osteoblast cells.

  2009cites this paper
• Immunohistochemical detection of estrogen receptors in fish scales.

  2009cites this paper
• Estradiol Stimulates Vasodilatory and Metabolic Pathways in Cultured Human Endothelial Cells

  2009cites this paper
• Role of environmental factors in mesenchymal stem cell biology

  2009cites this paper
• The gad2 Promoter Is a Transcriptional Target of Estrogen Receptor (ER) α and ERβ: A Unifying Hypothesis to Explain Diverse Effects of Estradiol

  2009cites this paper
• Binding of estrogen receptor alpha/beta heterodimers to chromatin in MCF-7 cells.

  2009cites this paper
• Loss of ERE binding activity by estrogen receptor‐α alters basal and estrogen‐stimulated bone‐related gene expression by osteoblastic cells

  2008cites this paper
• Up-regulation of estrogen receptor-beta expression during osteogenic differentiation of human periodontal ligament cells.

  2008cites this paper
• Influence of Cellular ERα/ERβ Ratio on the ERα-Agonist Induced Proliferation of Human T47D Breast Cancer Cells

  2008cites this paper
• Intermolecular interactions identify ligand-selective activity of estrogen receptor α/β dimers

  2008cites this paper
• The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin.

  2008cites this paper
• Sex steroid receptors expression and hormone‐induced cell proliferation in human osteosarcoma

  2008cites this paper
• Selective estrogen modulators as an anticancer tool: mechanisms of efficiency and resistance.

  2008cites this paper
• Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding.

  2008cites this paper
• Unique ER Cistromes Control Cell Type-Specific Gene Regulation

  2008influential citation
• Nuclear Receptors and Breast Cancer

  2008cites this paper
• Differential regulation of native estrogen receptor-regulatory elements by estradiol, tamoxifen, and raloxifene.

  2008cites this paper