LKB1 regulates pancreatic beta cell size, polarity, and function.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cell Metabolism

• Publication date

  2009-10-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cmet.2009.08.010PMID 19808022PMCID PMC2790403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The LKB1–AMPK pathway: metabolism and growth control in tumour suppression

  2009cited by this paper
• Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

  2008cited by this paper
• Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

  2008cited by this paper
• Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2

  2008cited by this paper
• LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster

  2008cited by this paper
• Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

  2008cited by this paper
• Energy-dependent regulation of cell structure by AMP-activated protein kinase

  2007cited by this paper
• Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling.

  2007cited by this paper
• LKB1 modulates lung cancer differentiation and metastasis

  2007cited by this paper
• Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.

  2007cited by this paper
• Recovery from diabetes in mice by beta cell regeneration.

  2007cited by this paper
• LKB1 and AMPK maintain epithelial cell polarity under energetic stress

  2007cited by this paper
• LKB1/STRAD promotes axon initiation during neuronal polarization.

  2007cited by this paper
• LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.

  2007cited by this paper
• Formation and regeneration of the endocrine pancreas.

  2007cited by this paper
• The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.

  2007cited by this paper
• Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

  2007cited by this paper
• Lineage Tracing Evidence for In Vitro Dedifferentiation but Rare Proliferation of Mouse Pancreatic β-Cells

  2007cited by this paper
• AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

  2007cited by this paper
• Recovery from diabetes in mice by β cell regeneration

  2007cited by this paper
• The Role of AMPK and mTOR in Nutrient Sensing in Pancreatic β-Cells*

  2007cited by this paper
• LKB1-dependent signaling pathways.

  2006cited by this paper
• Novel genes identified by manual annotation and microarray expression analysis in the pancreas.

  2006cited by this paper
• The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.

  2006influential reference
• Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.

  2006cited by this paper
• Pancreatic beta cells: responding to the matrix.

  2006cited by this paper
• EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes

  2006cited by this paper
• Pancreatic β cells: Responding to the matrix

  2006cited by this paper
• The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle

  2006cited by this paper
• Selective Deletion of Pten in Pancreatic β Cells Leads to Increased Islet Mass and Resistance to STZ-Induced Diabetes

  2006influential reference
• Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside.

  2005cited by this paper
• Over-expression of AMP-activated protein kinase impairs pancreatic β-cell function in vivo

  2005cited by this paper
• Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo.

  2005cited by this paper
• Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis.

  2005cited by this paper
• Persistent Hyperinsulinemic Hypoglycemia in 15 Adults With Diffuse Nesidioblastosis: Diagnostic Criteria, Incidence, and Characterization of β-Cell Changes

  2005cited by this paper
• The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

  2005cited by this paper
• Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility.

  2005cited by this paper
• The LKB1 tumor suppressor negatively regulates mTOR signaling.

  2004cited by this paper
• orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization

  2004cited by this paper
• Inaugural Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

  2004cited by this paper
• Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.

  2004cited by this paper
• Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

  2004cited by this paper
• Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

  2004cited by this paper
• The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

  2004cited by this paper
• Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

  2004cited by this paper
• Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton

  2004influential reference
• TSC2 mediates cellular energy response to control cell growth and survival.

  2003cited by this paper
• Transcriptional program of the endocrine pancreas in mice and humans.

  2003cited by this paper
• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  2003cited by this paper
• Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression.

  2003influential reference
• Fusion Pore Dynamics and Insulin Granule Exocytosis in the Pancreatic Islet

  2002cited by this paper
• Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

  2002cited by this paper
• Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors.

  2002cited by this paper
• Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia.

  2001cited by this paper
• Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.

  2001influential reference
• Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia

  2001cited by this paper
• Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice

  2000cited by this paper
• Characterization of the Role of AMP-Activated Protein Kinase in the Regulation of Glucose-Activated Gene Expression Using Constitutively Active and Dominant Negative Forms of the Kinase

  2000cited by this paper
• Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways.

  1998cited by this paper
• Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains.

  1989cited by this paper
• Morphological Evidence for Pancreatic Polarity of β-Cell Within Islets of Langerhans

  1988influential reference

• Unlocking the Molecular Targets in Non-Small-Cell Lung Cancer and a Nanomedicine-Based Remedy.

  2025cites this paper
• Compartmentalized nutrient and hormone sensing in β-cells: the role of cilia.

  2025cites this paper
• Deletion of RalGAPβ protects pancreatic β cells and improves glycemic control

  2025cites this paper
• PRIME: an interpretable artificial intelligence model based on liquid biopsy improves prediction of progression risk in non-small cell lung cancer

  2025cites this paper
• Ras homolog enriched in brain 1 regulates β cell mass and β cell function via mTORC1/AMPK/Notch1 pathways

  2025cites this paper
• Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells

  2024cites this paper
• Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes

  2024cites this paper
• Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells

  2024cites this paper
• Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes

  2024cites this paper
• Sox9 regulates alternative splicing and pancreatic beta cell function

  2024cites this paper
• Lysosomal physiology and pancreatic lysosomal stress in diabetes mellitus

  2024cites this paper
• Directed insulin secretion from beta cells occurs at cortical sites devoid of microtubules at the edges of ELKS/LL5β patches

  2024cites this paper
• Paracrine Signaling by Pancreatic Islet Cilia.

  2024cites this paper
• BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes

  2023cites this paper
• Rediscovering Primary Cilia in Pancreatic Islets

  2023cites this paper
• Islet cilia and glucose homeostasis

  2022cites this paper
• mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1

  2022cites this paper
• Presynaptic-like mechanisms and the control of insulin secretion in pancreatic β-cells.

  2022cites this paper
• Cilia Action in Islets: Lessons From Mouse Models

  2022influential citation
• Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme

  2022influential citation
• Novel aspects of intra-islet communication: Primary cilia and filopodia.

  2022cites this paper
• Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes

  2021cites this paper
• Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

  2021cites this paper
• The Glucagon-Like Adipokinetic Hormone in Drosophila melanogaster – Biosynthesis and Secretion

  2021cites this paper
• AMPK Localization: A Key to Differential Energy Regulation

  2021cites this paper
• Machine Learning Algorithms, Applied to Intact Islets of Langerhans, Demonstrate Significantly Enhanced Insulin Staining at the Capillary Interface of Human Pancreatic β Cells

  2021cites this paper
• Inhibition of β-Catenin Activity Abolishes LKB1 Loss-Driven Pancreatic Cystadenoma in Mice

  2021cites this paper
• Functional maturation of immature β cells: A roadblock for stem cell therapy for type 1 diabetes

  2021cites this paper
• Phosphorylation of ribosomal protein S6 differentially affects mRNA translation based on ORF length

  2021cites this paper
• Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

  2021cites this paper
• Protein Kinases Signaling in Pancreatic Beta-cells Death and Type 2 Diabetes.

  2021cites this paper
• Transcriptomic and Quantitative Proteomic Profiling Reveals Signaling Pathways Critical for Pancreatic Islet Maturation.

  2020cites this paper
• LKB1 up-regulation inhibits hypothalamic inflammation and attenuates diet-induced obesity in mice.

  2020cites this paper
• Cloning and prokaryotic expression of the chicken liver kinase B1 (LKB1) and its localization in liver, heart and hypothalamus.

  2020cites this paper
• Shaping Pancreatic β-Cell Differentiation and Functioning: The Influence of Mechanotransduction

  2020cites this paper
• Maternal and paternal exercise regulate offspring metabolic health and beta cell phenotype

  2020cites this paper
• Maternal high-fat diet regulates glucose metabolism and pancreatic β cell phenotype in mouse offspring at weaning

  2020cites this paper
• The role of the islet niche on beta cell structure and function.

  2019cites this paper
• Animal models for modeling pancreatic cancer and novel drug discovery

  2019cites this paper
• Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas.

  2019cites this paper
• Loss of LAMTOR1 in pancreatic β-cells increases glucose-stimulated insulin secretion in mice

  2019influential citation
• ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells.

  2019cites this paper
• Primary Cilium, An Unsung Hero in Maintaining Functional β-cell Population

  2019cites this paper
• Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells

  2019cites this paper
• Association between LKB1 expression and prognosis of patients with solid tumours: an updated systematic review and meta-analysis

  2019cites this paper
• mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.

  2019cites this paper
• Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner

  2019cites this paper
• mTOR: A double‐edged sword for diabetes

  2019cites this paper
• Pancreatic Pericytes in Glucose Homeostasis and Diabetes.

  2019cites this paper
• AMPK and Friends: Central Regulators of β Cell Biology.

  2018cites this paper
• Intraventricular Injection of LKB1 Inhibits the Formation of Diet-Induced Obesity in Rats by Activating the AMPK-POMC Neurons-Sympathetic Nervous System Axis

  2018cites this paper
• Functional characterization of the cell polarity proteins Bazooka and LKB1

  2018cites this paper
• Role of JIP1-JNK Signaling in Beta-Cell Function and Autophagy

  2018influential citation
• Single molecule approaches for studying gene regulation in metabolic tissues

  2018cites this paper
• Local Integrin Activation in Pancreatic β Cells Targets Insulin Secretion to the Vasculature.

  2018cites this paper
• Lysosomes in nutrient signalling: A focus on pancreatic β‐cells

  2018cites this paper
• The Salt-Inducible Kinases: Emerging Metabolic Regulators.

  2018cites this paper
• Transcription factor-7–like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion

  2018influential citation
• University Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, cell growth, and insulin secretion

  2018influential citation
• SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDI&agr; in Male Islet &bgr; Cells

  2018cites this paper
• Controlling the master—upstream regulation of the tumor suppressor LKB1

  2018cites this paper
• Author Correction: Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

  2018cites this paper
• Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis

  2017cites this paper
• The RhoGAP Stard13 controls insulin secretion through F-actin remodeling

  2017cites this paper
• New Roles of Lkb1 in Regulating Adipose Tissue Development and Thermogenesis

  2017cites this paper
• Dissecting the role of AMP-activated protein kinase in human diseases

  2017cites this paper
• Cell polarity defines three distinct domains in pancreatic β-cells

  2017influential citation
• Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets

  2017cites this paper
• Liver kinase B1 restoration promotes exosome secretion and motility of lung cancer cells

  2017cites this paper
• Ribosomal Protein S6 Phosphorylation Is Involved in Novelty-Induced Locomotion, Synaptic Plasticity and mRNA Translation

  2017cites this paper
• A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK

  2017cites this paper
• University of Dundee Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

  2017cites this paper
• Characterization of b-cell Heterogeneity in the Islets of Langerhans

  2017influential citation
• Proinsulin C-peptide-mediated signalling and the search for its receptor

  2017cites this paper
• Deletion of Lkb1 in adult mice results in body weight reduction and lethality

  2016cites this paper
• Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance

  2016cites this paper
• Differential effects on β-cell mass by disruption of Bardet-Biedl syndrome or Alstrom syndrome genes.

  2016cites this paper
• Development of shRNA screens to identify effectors of three complex traits : neighbour suppression of tumour growth and proliferation and protection from lipotoxicity in β-cells

  2016cites this paper
• Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3

  2016cites this paper
• Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts.

  2016cites this paper
• Molecular Aspects of Glucose Regulation of Pancreatic β Cells

  2016cites this paper
• Impact of islet architecture on β-cell heterogeneity, plasticity and function

  2016cites this paper
• Clinical significance and role of LKB1 in gastric cancer.

  2016cites this paper
• Identification of proliferative and mature β-cells in the islets of Langerhans

  2016cites this paper
• Bistability: Requirements on Cell-Volume, Protein Diffusion, and Thermodynamics

  2015cites this paper
• Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes

  2015cites this paper
• Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

  2015cites this paper
• Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo

  2015cites this paper
• Ribosomal Protein S6 Phosphorylation: Four Decades of Research.

  2015cites this paper
• Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects

  2015influential citation
• Clinical significance and role of LKB 1 in gastric cancer

  2015cites this paper
• University of Birmingham Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects

  2015influential citation
• The Edges of Pancreatic Islet β Cells Constitute Adhesive and Signaling Microdomains.

  2015cites this paper
• LKB1 couples glucose metabolism to insulin secretion in mice

  2015cites this paper
• LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.

  2015cites this paper
• Lkb1 Deletion Promotes Ectopic Lipid Accumulation in Muscle Progenitor Cells and Mature Muscles

  2015cites this paper
• Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion

  2014cites this paper
• The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

  2014cites this paper
• Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation

  2014cites this paper
• LKB1 and AMPK differentially regulate pancreatic β-cell identity

  2014cites this paper