Inhibitory effects of flavonoids on molybdenum hydroxylases activity

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Expert Opinion on Drug Metabolism & Toxicology

• Publication date

  2010-01-22

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1517/17425250903426164PMID 20095789
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Use of Silymarin in the Treatment of Liver Diseases

  2012cited by this paper
• Silymarin: A Review of its Clinical Properties in the Management of Hepatic Disorders

  2012cited by this paper
• Mosby's Handbook of Herbs and Natural Supplements

  2010cited by this paper
• International Immunonutrition Workshop Session 1 : Antioxidants and the immune system Flavonoids as anti-inflammatory agents

  2010cited by this paper
• Inhibitory Effects of Tart Cherry (Prunus cerasus) Juice on Xanthine Oxidoreductase Activity and its Hypouricemic and Antioxidant Effects on Rats.

  2009influential reference
• Measurement of xanthine oxidase inhibition activity of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method.

  2009influential reference
• Drug-drug interactions of silymarin on the perspective of pharmacokinetics.

  2009cited by this paper
• Inhibitory effects of flavonoids on aldehyde oxidase activity.

  2009influential reference
• Antioxidant properties and xanthine oxidase inhibitory effects of Tamus communis L. root extracts

  2009cited by this paper
• New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin.

  2009cited by this paper
• Effect of dietary flavonoids on pathways involved in drug metabolism

  2008influential reference
• The Effect of Tart Cherry-Enriched Diets on Abdominal Fat Gene Expression in Rats

  2008cited by this paper
• Hypouricemic and antioxidant activities of Allium cepa Lilliaceae and quercetin in normal and hyperuricemic rats.

  2008cited by this paper
• Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats.

  2008cited by this paper
• Microbial metabolism of dietary phenolic compounds in the colon

  2008cited by this paper
• Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral application.

  2008cited by this paper
• Developmental changes of aldehyde oxidase in postnatal rat liver.

  2007cited by this paper
• Hypouricemic action of selected flavonoids in mice: structure-activity relationships.

  2007influential reference
• The Biochemistry of Drug Metabolism – An Introduction

  2007cited by this paper
• Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues.

  2007cited by this paper
• The Biochemistry of Drug Metabolism — An Introduction. Part 2. Redox Reactions and Their Enzymes

  2007cited by this paper
• Drug-metabolizing ability of molybdenum hydroxylases.

  2006cited by this paper
• Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics

  2006cited by this paper
• ESTIMATION OF ALDEHYDE OXIDASE ACTIVITY IN VIVO FROM CONVERSION RATIO OF N1-METHYLNICOTINAMIDE TO PYRIDONES, AND INTRASPECIES VARIATION OF THE ENZYME ACTIVITY IN RATS

  2006cited by this paper
• Molybdenum and tungsten enzymes: the xanthine oxidase family.

  2006influential reference
• Inhibitory effects of Ruta graveolens L. extract on guinea pig liver aldehyde oxidase.

  2006influential reference
• An integrated database of flavonoids

  2006cited by this paper
• Inhibitory Effects of Ruta graveolens L. Extract on Guinea Pig Liver Aldehyde Oxidase

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• Variation in the content of bioactive flavonoids in different brands of orange and grapefruit juices

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• In vivo-in vitro relationship of methotrexate 7-hydroxylation by aldehyde oxidase in four different strain rats.

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• The role of oxidants and free radicals in reperfusion injury.

  2006cited by this paper
• Reactive radical scavenging and xanthine oxidase inhibition of proanthocyanidins from Carallia brachiata

  2006cited by this paper
• Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

  2006cited by this paper
• Molybdenum-containing hydroxylases.

  2005cited by this paper
• Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans.

  2005cited by this paper
• Potent inhibition of human liver aldehyde oxidase by raloxifene.

  2004cited by this paper
• Flavonoids in Food and Their Health Benefits

  2004cited by this paper
• Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products.

  2004cited by this paper
• Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.

  2004influential reference
• Human Liver Aldehyde Oxidase: Inhibition by 239 Drugs

  2004cited by this paper
• Serial Review: Flavonoids and Isoflavones (Phytoestrogens: Absorption, Metabolism, and Bioactivity) Serial Review Editor: Catherine Rice-Evans FLAVONOIDS AND THE BRAIN: INTERACTIONS AT THE BLOOD-BRAIN BARRIER AND THEIR PHYSIOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM

  2004cited by this paper
• Physiological Roles of Xanthine Oxidoreductase

  2004cited by this paper
• Flavonoids and isoflavones: absorption, metabolism, and bioactivity.

  2004cited by this paper
• Phytoestrogens and breast cancer.

  2004cited by this paper
• IN VITRO STUDY OF INTERACTION OF SOME PHENOTHIAZINES AND PURINES WITH FAMCICLOVIRMETABOLISM CATALYZED BY GUINEA PIG LIVER ALDEHYDE OXIDASE

  2004cited by this paper
• Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology

  2004cited by this paper
• Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells.

  2003cited by this paper
• Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with quercetin.

  2003cited by this paper
• Xanthine oxidoreductase is central to the evolution and function of the innate immune system.

  2003cited by this paper
• Physiological responses of a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: III. Silymarin inhibits T-lymphocyte function at low doses but stimulates inflammatory processes at high doses.

  2003cited by this paper
• Effect of Ruta graveolens L. and Euphorbia peplus L. anti-inflammatory extracts on nutritional status of rats and the safety of their use.

  2002cited by this paper
• Molecular modeling of flavonoids that inhibits xanthine oxidase.

  2002influential reference
• Effect of Milk Thistle on the Pharmacokinetics of Indinavir in Healthy Volunteers

  2002cited by this paper
• Bioavailability and metabolism.

  2002cited by this paper
• Phytoestrogens and breast cancer.

  2002cited by this paper
• Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables

  2002cited by this paper
• Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro.

  2002cited by this paper
• The biochemistry and medical significance of the flavonoids.

  2002influential reference
• Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids.

  2002influential reference
• Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships.

  2002cited by this paper
• Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin.

  2001cited by this paper
• The Biological Chemistry of the Elements: The Inorganic Chemistry of Life

  2001cited by this paper
• Various cooking methods and the flavonoid content in onion.

  2001cited by this paper
• Degradation products of cyanidin glycosides from tart cherries and their bioactivities.

  2001cited by this paper
• Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice.

  2001cited by this paper
• Enzyme Systems that Metabolise Drugs and Other Xenobiotics

  2001influential reference
• Water-soluble glycosides from Ruta graveolens.

  2001cited by this paper
• Dietary intake and bioavailability of polyphenols.

  2000cited by this paper
• Advances in flavonoid research since 1992.

  2000cited by this paper
• In vitro anti-mycotic activity of some medicinal plants containing flavonoids.

  2000cited by this paper
• Cynomolgus monkey liver aldehyde oxidase: extremely high oxidase activity and an attempt at purification.

  2000cited by this paper
• Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout.

  2000influential reference
• Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway.

  2000cited by this paper
• Degradation of Flavonoid Glycosides and Aglycones During in vitro Fermentation with Human Faecal Flora

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• Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption.

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• Aldehyde Oxidase‐catalysed Oxidation of Methotrexate in the Liver of Guinea‐pig, Rabbit and Man

  1999cited by this paper
• Inhibition of xanthine oxidase by flavonoids.

  1999influential reference
• Health-promoting properties of common herbs.

  1999cited by this paper
• Variation of Hepatic Methotrexate 7‐Hydroxylase Activity in Animals and Humans

  1999cited by this paper
• Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout.

  1999cited by this paper
• Traditional antihelmintic, antiparasitic and repellent uses of plants in Central Italy.

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• 2Phytoestrogens and breast cancer

  1998cited by this paper
• Flavonoids: Dietary occurrence and biochemical activity

  1998cited by this paper
• Phytoestrogens and breast cancer.

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• A review of plants used in the treatment of liver disease: part 1.

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• Structure-activity relationships of gagaminine and its derivatives on the inhibition of hepatic aldehyde oxidase activity and lipid peroxidation

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• Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.

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• Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts.

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• Isolation and characterization of the human aldehyde oxidase gene: conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin.

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• Milk Thistle (Silybum marianum) for the Therapy of Liver Disease

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• The cardiovascular effects of green beans (Phaseolus aureus), common rue (Ruta graveolens), and kelp (Laminaria japonica) in rats.

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• Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis).

  1997influential reference
• In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.

  1997cited by this paper
• The role of non—P450 enzymes in drug oxidation.

  1997cited by this paper
• Xanthine Oxidase Inhibitory Activity of Flavonoids and Tannins from Hexachlamys edulis (Myrtaceae)

  1996cited by this paper
• Role of aldehyde oxidase in biogenic amine metabolism.

  1995cited by this paper
• Anthocyanidines as inhibitors of xanthine oxidase.

  1995cited by this paper
• Properties of rabbit liver aldehyde oxidase and the relationship of the enzyme to xanthine oxidase and dehydrogenase.

  1995cited by this paper
• Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro.

  1994cited by this paper

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• A comprehensive review of in silico approaches for the prediction and modulation of aldehyde oxidase-mediated drug metabolism: The current features, challenges and future perspectives.

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• Poziotinib and bovine serum albumin binding characterization and influence of quercetin, rutin, naringenin and sinapic acid on their binding interaction.

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• Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis.

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• Total polyphenol content and antioxidants capacity of three Africans antipyretic plants

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• Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice

  2017cites this paper
• An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery

  2017cites this paper
• Resonance light scattering determination of 6-mercaptopurine coupled with HPLC technique.

  2016cites this paper
• Structural features of guinea pig aldehyde oxidase inhibitory activities of flavonoids explored using QSAR and molecular modeling studies

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• Inhibition of guinea pig aldehyde oxidase activity by different flavonoid compounds: An in vitro study.

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• In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome.

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