The levator ani muscle of the rat as an index of myotrophic activity of steroidal hormones.

1. The effects of castration and of various steroids upon the weight and water content of the levator ani muscle of the male rat were studied. This muscle is notably smaller in the castrate than in the normal rat at 60 days and can be restored to normal weight, or even rendered hypertrophic, by the administration of certain steroids. 2. The response in weight of the levator ani muscle to administration of various steroids parallels closely their known protein-anabolic activity. The myotrophic effect is distinct from the androgenic effect. 3. By this assay, pituitary growth hormone, unesterified testosterone, testosterone propionate and methyl testosterone are potent myotrophic agents; progesterone is moderately active; and estradiol dipropionate, cis-testosterone, desoxycorticosterone acetate, and ethinyl testosterone produce no significant increase in weight of the muscle.

• Publication year

  1950

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1950-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)04222-3PMID 15429015
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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