Deletion of the human β-globin LCR 5′HS4 or 5′HS1 differentially affects β-like globin gene expression in β-YAC transgenic mice

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Blood Cells Molecules and Diseases

• Publication date

  2007-07-01

• Fields of study

  Biology

• Identifiers
  DOI 10.1016/J.BCMD.2007.02.006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Deletion of the core region of 5′ HS2 of the mouse β-globin locus control region reveals a distinct effect in comparison with human β-globin transgenes

  2006cited by this paper
• Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.

  2006cited by this paper
• Synergistic and Additive Properties of the Beta-Globin Locus Control Region (LCR) Revealed by 5′HS3 Deletion Mutations: Implication for LCR Chromatin Architecture

  2005cited by this paper
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  2003influential reference
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  2003cited by this paper
• Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.

  2003cited by this paper
• Activation of the β-like globin genes in transgenic mice is dependent on the presence of the β-locus control region

  2002cited by this paper
• Looping and interaction between hypersensitive sites in the active beta-globin locus.

  2002cited by this paper
• Activation of the beta-like globin genes in transgenic mice is dependent on the presence of the beta-locus control region.

  2002cited by this paper
• Sensitive ribonuclease protection assay employing glycogen as a carrier and a single inactivation/precipitation step.

  2001cited by this paper
• The 5'HS4 core element of the human beta-globin locus control region is required for high-level globin gene expression in definitive but not in primitive erythropoiesis.

  2001cited by this paper
• Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites.

  2001cited by this paper
• Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region.

  2000cited by this paper
• Hemopoietic lineage commitment decisions: in vivo evidence from a transgenic mouse model harboring micro LCR-betapro-LacZ as a transgene.

  2000cited by this paper
• Hemopoietic lineage commitment decisions: in vivo evidence from a transgenic mouse model harboring μLCR-βpro-LacZ as a transgene

  2000cited by this paper
• β-globin Gene Switching and DNase I Sensitivity of the Endogenous β-globin Locus in Mice Do Not Require the Locus Control Region

  2000cited by this paper
• Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice.

  2000cited by this paper
• The polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human beta-globin LCR.

  1999cited by this paper
• Correct function of the locus control region may require passage through a nonerythroid cellular environment.

  1999cited by this paper
• Hypersensitive Site 2 Specifies a Unique Function within the Human β-Globin Locus Control Region To Stimulate Globin Gene Transcription

  1999cited by this paper
• Description and Targeted Deletion of 5′ Hypersensitive Site 5 and 6 of the Mouse β-Globin Locus Control Region

  1998cited by this paper
• LCR-dependent gene expression in beta-globin YAC transgenics: detailed structural studies validate functional analysis even in the presence of fragmented YACs.

  1998cited by this paper
• Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region.

  1998cited by this paper
• Full activity from human beta-globin locus control region transgenes requires 5'HS1, distal beta-globin promoter, and 3' beta-globin sequences.

  1998cited by this paper
• Developmental Specificity of the Interaction between the Locus Control Region and Embryonic or Fetal Globin Genes in Transgenic Mice with an HS3 Core Deletion

  1998cited by this paper
• Full Activity From Human β-Globin Locus Control Region Transgenes Requires 5′HS1, Distal β-Globin Promoter, and 3′ β-Globin Sequences

  1998cited by this paper
• Locus control regions of mammalian beta-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights.

  1997cited by this paper
• Production of transgenic mice with yeast artificial chromosomes.

  1997cited by this paper
• Binary transgenic mouse model for studying the trans control of globin gene switching: evidence that GATA-1 is an in vivo repressor of human epsilon gene expression.

  1997cited by this paper
• Production and analysis of transgenic mice containing yeast artificial chromosomes.

  1997cited by this paper
• Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3

  1996cited by this paper
• Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.

  1996cited by this paper
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  1996influential reference
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  1995cited by this paper
• Transcription complex stability and chromatin dynamics in vivo

  1995influential reference
• Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

  1995cited by this paper
• Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element

  1994cited by this paper
• Globin gene server: a prototype E-mail database server featuring extensive multiple alignments and data compilation for electronic genetic analysis.

  1994cited by this paper
• Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes.

  1993cited by this paper
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  1993cited by this paper
• Role of gene order in developmental control of human gamma- and beta-globin gene expression

  1993cited by this paper
• Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

  1993influential reference
• Microinjection of intact 200- to 500-kb fragments of YAC DNA into mammalian cells.

  1993cited by this paper
• Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice.

  1992cited by this paper
• Activation of the beta-globin locus control region precedes commitment to the erythroid lineage.

  1992cited by this paper
• Hypersensitive site 4 of the human β globin locus control region

  1991cited by this paper
• Physical mapping of yeast artificial chromosomes containing sequences from the human beta-globin gene region.

  1991cited by this paper
• Hypersensitive site 4 of the human beta globin locus control region.

  1991cited by this paper
• The proximal element of the beta globin locus control region is not functionally required in vivo.

  1991cited by this paper
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  1990cited by this paper
• DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression.

  1990cited by this paper
• Detailed analysis of the site 3 region of the human beta‐globin dominant control region.

  1990cited by this paper
• Definition of the minimal requirements within the human beta‐globin gene and the dominant control region for high level expression.

  1990cited by this paper
• The beta-globin dominant control region.

  1989cited by this paper
• Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

  1989cited by this paper
• High-level erythroid expression of human alpha-globin genes in transgenic mice.

  1989cited by this paper
• The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

  1989cited by this paper
• Molecular analysis of the human beta-globin locus activation region.

  1989cited by this paper
• A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

  1989cited by this paper
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  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Identification of regulatory elements of human beta-like globin genes.

  1987cited by this paper
• Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids.

  1987cited by this paper
• Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns.

  1986cited by this paper
• An embryonic pattern of expression of a human fetal globin gene in transgenic mice

  1986cited by this paper
• A developmentally stable chromatin structure in the human beta-globin gene cluster.

  1986cited by this paper
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  1985cited by this paper
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  1985cited by this paper
• The "beta-like-globin" gene domain in human erythroid cells.

  1985cited by this paper
• Erythroid‐specific expression of human beta‐globin genes in transgenic mice.

  1985cited by this paper

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  2012cites this paper
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  2012cites this paper
• DNase I Hypersensitive Site II of the Human Growth Hormone Locus Control Region Mediates an Essential and Distinct Long-range Enhancer Function*

  2012cites this paper
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  2010cites this paper
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  2010cites this paper
• NF-E2 and USF cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin locus

  2009cites this paper
• The higher structure of chromatin in the LCR of the beta-globin locus changes during development.

  2009cites this paper
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  2008cites this paper