Genetic and Epigenetic Mechanisms of β-Globin Gene Switching

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Biochemistry (Moscow)

• Publication date

  2018-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1134/S0006297918040090PMID 29626925
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Epigenetic interplay at the β-globin locus.

  2017cited by this paper
• Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element

  2017cited by this paper
• Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure

  2017cited by this paper
• LDB1-mediated enhancer looping can be established independent of mediator and cohesin

  2017cited by this paper
• Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping

  2017cited by this paper
• Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.

  2016cited by this paper
• The molecular hallmarks of epigenetic control

  2016cited by this paper
• Epigenetic regulation of fetal globin gene expression in adult erythroid cells.

  2015cited by this paper
• EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.

  2015cited by this paper
• Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping.

  2015influential reference
• IKAROS: a multifunctional regulator of the polymerase II transcription cycle.

  2015cited by this paper
• The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription

  2014influential reference
• Reactivation of developmentally silenced globin genes by forced chromatin looping.

  2014cited by this paper
• 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

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• Hematopoiesis

  2013cited by this paper
• Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders

  2013cited by this paper
• Primitive and definitive erythropoiesis in mammals

  2013cited by this paper
• The switch from fetal to adult hemoglobin.

  2013cited by this paper
• Blood disorders: Epigenetically enhancing haemoglobin production

  2013cited by this paper
• Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

  2013influential reference
• Domains of α- and β-globin genes in the context of the structural-functional organization of the eukaryotic genome

  2012cited by this paper
• Blood management by transfusion triggers: when less is more.

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• Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A

  2012cited by this paper
• Sox6, jack of all trades: A versatile regulatory protein in vertebrate development

  2011cited by this paper
• Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells.

  2011cited by this paper
• Transcription Factors KLF1 and KLF2 Positively Regulate Embryonic and Fetal β-Globin Genes through Direct Promoter Binding*

  2011cited by this paper
• Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic β-Type Globin Promoters in Differentiated Adult Erythroid Cells

  2011cited by this paper
• A pilot study of subcutaneous decitabine in β-thalassemia intermedia.

  2011cited by this paper
• Crosstalk between histone modifications maintains the developmental pattern of gene expression on a tissue-specific locus

  2010cited by this paper
• H 4 R 3 methylation facilitates-globin transcription by regulating histone acetyltransferase binding and H 3 acetylation

  2010cited by this paper
• Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.

  2010cited by this paper
• DNA methylation and epigenetic control of cellular differentiation

  2010cited by this paper
• Advances in the understanding of haemoglobin switching

  2010cited by this paper
• NuRD mediates activating and repressive functions of GATA‐1 and FOG‐1 during blood development

  2010cited by this paper
• H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation.

  2010cited by this paper
• A genome-wide association identified the common genetic variants influence disease severity in β0-thalassemia/hemoglobin E

  2009cited by this paper
• A molecular model of chromatin organisation and transcription: how a multi‐RNA polymerase II machine transcribes and remodels the β‐globin locus during development

  2009cited by this paper
• Developmental and species-divergent globin switching are driven by BCL11A

  2009cited by this paper
• Common themes in siRNA-mediated epigenetic silencing pathways.

  2009cited by this paper
• PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

  2009cited by this paper
• Dual role for the methyltransferase G9a in the maintenance of β-globin gene transcription in adult erythroid cells

  2009cited by this paper
• Epigenetic interplay between histone modifications and DNA methylation in gene silencing.

  2008cited by this paper
• Joining the loops: β‐Globin gene regulation

  2008cited by this paper
• Histone deacetylase inhibitors and hemoglobin F induction in beta-thalassemia.

  2008cited by this paper
• Epigenetic control of complex loci during erythropoiesis.

  2008cited by this paper
• Beta-globin regulation and long-range interactions.

  2008cited by this paper
• Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A

  2008cited by this paper
• A positive role for NLI/Ldb1 in long-range beta-globin locus control region function.

  2007cited by this paper
• Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation.

  2007cited by this paper
• The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription.

  2007cited by this paper
• Deletion of the human β-globin LCR 5′HS4 or 5′HS1 differentially affects β-like globin gene expression in β-YAC transgenic mice

  2007cited by this paper
• A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

  2007cited by this paper
• Deletion of the human beta-globin LCR 5'HS4 or 5'HS1 differentially affects beta-like globin gene expression in beta-YAC transgenic mice.

  2007cited by this paper
• Intergenic Transcription, Cell-Cycle and the Developmentally Regulated Epigenetic Profile of the Human Beta-Globin Locus

  2007cited by this paper
• Histone acetylation at the human beta-globin locus changes with developmental age.

  2007cited by this paper
• Embryonic and fetal β‐globin gene repression by the orphan nuclear receptors, TR2 and TR4

  2007cited by this paper
• Developmental- and differentiation-specific patterns of human γ- and β-globin promoter DNA methylation

  2007cited by this paper
• Regulation of human fetal hemoglobin: new players, new complexities.

  2006cited by this paper
• Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development.

  2006cited by this paper
• Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2.

  2006cited by this paper
• Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region.

  2005cited by this paper
• Dicer-Dependent Turnover of Intergenic Transcripts from the Human β-Globin Gene Cluster

  2005cited by this paper
• Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

  2005cited by this paper
• Control of globin gene expression during development and erythroid differentiation.

  2005cited by this paper
• FOG‐1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA‐1

  2005cited by this paper
• Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics

  2004cited by this paper
• Histone acetylation at the human β-globin locus changes with developmental age

  2004cited by this paper
• The active spatial organization of the beta-globin locus requires the transcription factor EKLF.

  2004cited by this paper
• The Role of p22 NF-E4 in Human Globin Gene Switching*

  2004cited by this paper
• An embryonic-specific repressor element located 3' to the Agamma-globin gene influences transcription of the human beta-globin locus in transgenic mice.

  2004cited by this paper
• A Complex Chromatin Landscape Revealed by Patterns of Nuclease Sensitivity and Histone Modification within the Mouse β-Globin Locus

  2003cited by this paper
• Genomic domains and regulatory elements operating at the domain level.

  2003cited by this paper
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  2003cited by this paper
• The beta-globin nuclear compartment in development and erythroid differentiation.

  2003cited by this paper
• Regulation of the Globin Genes

  2002cited by this paper
• The insulation of genes from external enhancers and silencing chromatin

  2002cited by this paper
• Chromatin structure and transcriptional regulation of the beta-globin locus.

  2002cited by this paper
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• Chromatin Structure and Transcriptional Regulation of the β-Globin Locus

  2002cited by this paper
• Capturing Chromosome Conformation

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  2002cited by this paper
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  2001cited by this paper
• Intergenic Transcription in the Human β-Globin Gene Cluster

  2001cited by this paper
• The 5'HS4 core element of the human beta-globin locus control region is required for high-level globin gene expression in definitive but not in primitive erythropoiesis.

  2001cited by this paper
• Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation.

  2001cited by this paper
• Intergenic Transcription in the Human (cid:2) -Globin Gene Cluster

  2001cited by this paper
• Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci

  2001cited by this paper
• Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus

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• Chromatin domains and regulation of gene expression: familiar and enigmatic clusters of chicken globin genes.

  2001cited by this paper
• Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors*

  2000cited by this paper
• Evi9 Encodes a Novel Zinc Finger Protein That Physically Interacts with BCL6, a Known Human B-Cell Proto-Oncogene Product

  2000cited by this paper
• Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus.

  2000cited by this paper
• An Ikaros-Containing Chromatin-Remodeling Complex in Adult-Type Erythroid Cells

  2000cited by this paper
• Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain.

  2000cited by this paper
• Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci.

  1999cited by this paper
• MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

  1999cited by this paper

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• Long noncoding RNAs transcribed downstream of the human β-globin locus regulate β-globin gene expression.

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• Transcriptional Repressors of Fetal Globin Genes as Novel Therapeutic Targets in Beta-Thalassemia

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