Mechanistic Insights Revealed by the Crystal Structure of a Histidine Kinase with Signal Transducer and Sensor Domains

Chen Wang,J. Sang,Jiawei Wang,Mingyan Su,J. S. Downey,Qinggan Wu,Shida Wang,Yongfei Cai,Xiaozheng Xu,Jun Wu,D. Senadheera,D. Cvitkovitch,Lin Chen,S. Goodman,A. Han

Published 2013 in PLoS Biology

ABSTRACT

A crystal structure reveals an elegant mechanistic switch whereby helical bending and catalytic domain rotation allow self-activation of a histidine kinase during a bacterial stress response.

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