Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Circulation

• Publication date

  2014-02-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCULATIONAHA.113.008452PMID 24519927PMCID PMC4006305
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ultrastructural uncoupling between T-tubules and sarcoplasmic reticulum in human heart failure.

  2013cited by this paper
• Emerging mechanisms of T-tubule remodelling in heart failure.

  2013cited by this paper
• Ca2+‐dependent proteolysis of junctophilin‐1 and junctophilin‐2 in skeletal and cardiac muscle

  2013cited by this paper
• Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development.

  2013cited by this paper
• Colchicine Use Is Associated with Decreased Prevalence of Myocardial Infarction in Patients with Gout

  2012cited by this paper
• Mir-24 Regulates Junctophilin-2 Expression in Cardiomyocytes

  2012cited by this paper
• β‐Adrenergic receptor antagonists ameliorate myocyte T‐tubule remodeling following myocardial infarction

  2012cited by this paper
• PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes

  2011cited by this paper
• X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart

  2011cited by this paper
• Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes

  2011cited by this paper
• Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice

  2011influential reference
• Berbamine Increases Myocardial Contractility via a Ca2+-independent Mechanism

  2011cited by this paper
• T-Tubule Remodeling During Transition From Hypertrophy to Heart Failure

  2010influential reference
• The rate of loss of T‐tubules in cultured adult ventricular myocytes is species dependent

  2010cited by this paper
• Basis for MAP4 Dephosphorylation-related Microtubule Network Densification in Pressure Overload Cardiac Hypertrophy*

  2010cited by this paper
• BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules

  2010cited by this paper
• Axial Stretch of Rat Single Ventricular Cardiomyocytes Causes an Acute and Transient Increase in Ca2+ Spark Rate

  2009cited by this paper
• Adenosine regulation of microtubule dynamics in cardiac hypertrophy.

  2009cited by this paper
• Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel

  2009cited by this paper
• A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart.

  2008cited by this paper
• Isolation, culture, and functional analysis of adult mouse cardiomyocytes.

  2007cited by this paper
• Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions.

  2007cited by this paper
• Orphaned ryanodine receptors in the failing heart.

  2006cited by this paper
• Effect of cytoskeleton disruptors on L-type Ca channel distribution in rat ventricular myocytes.

  2005cited by this paper
• Kv1.5 Surface Expression Is Modulated by Retrograde Trafficking of Newly Endocytosed Channels by the Dynein Motor

  2005cited by this paper
• Reduced synchrony of Ca2+ release with loss of T-tubules-a comparison to Ca2+ release in human failing cardiomyocytes.

  2004cited by this paper
• Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.

  2004cited by this paper
• T‐Tubule Function in Mammalian Cardiac Myocytes

  2003cited by this paper
• Quantitation and distribution of beta-tubulin in human cardiac myocytes.

  2002cited by this paper
• Targeted Inhibition of Calcineurin in Pressure-overload Cardiac Hypertrophy

  2002cited by this paper
• Quantitation and Distribution of β-tubulin in Human Cardiac Myocytes

  2002cited by this paper
• Modulation of Ca2+ Signaling by Microtubule Disruption in Rat Ventricular Myocytes and Its Dependence on the Ruptured Patch-Clamp Configuration

  2001cited by this paper
• Microtubule Disruption by Colchicine Reversibly Enhances Calcium Signaling in Intact Rat Cardiac Myocytes

  2001cited by this paper
• Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells

  2001cited by this paper
• Heart Failure After Myocardial Infarction: Altered Excitation-Contraction Coupling

  2001cited by this paper
• Cardiocyte cytoskeleton in patients with left ventricular pressure overload hypertrophy.

  2001cited by this paper
• Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium.

  2000cited by this paper
• Dyssynchronous Ca2+ Sparks in Myocytes From Infarcted Hearts

  2000cited by this paper
• Junctophilins: a novel family of junctional membrane complex proteins.

  2000cited by this paper
• Microtubule disruption modulates Ca(2+) signaling in rat cardiac myocytes.

  2000cited by this paper
• Microtubule Depolymerization Normalizes In Vivo Myocardial Contractile Function in Dogs With Pressure-Overload Left Ventricular Hypertrophy

  2000cited by this paper
• Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling.

  1999cited by this paper
• Cytoskeletal role in the transition from compensated to decompensated hypertrophy during adult canine left ventricular pressure overloading.

  1998cited by this paper
• Microtubules are involved in early hypertrophic responses of myocardium during pressure overload.

  1998influential reference
• Microtubules are involved in early hypertrophic responses of myocardium during pressure overload.

  1998cited by this paper
• Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.

  1997cited by this paper
• Cytoskeletal mechanics in pressure-overload cardiac hypertrophy.

  1997cited by this paper
• Role of microtubules in myocyte contractile dysfunction during cardiac hypertrophy in the rat.

  1996cited by this paper
• Cytoskeletal role in the contractile dysfunction of cardiocytes from hypertrophied and failing right ventricular myocardium.

  1996cited by this paper
• Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture

  1996cited by this paper
• Paclitaxel (taxol)

  1995cited by this paper
• Paclitaxel by 3-hour infusion in combination with bolus doxorubicin in women with untreated metastatic breast cancer: high antitumor efficacy and cardiac effects in a dose-finding and sequence-finding study.

  1995cited by this paper
• Drug therapy : paclitaxel (Taxol)

  1995cited by this paper
• Role of microtubules in contractile dysfunction of hypertrophied cardiocytes.

  1994cited by this paper
• Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium.

  1993cited by this paper
• Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy.

  1991cited by this paper
• Cardiac disturbances during the administration of taxol.

  1991cited by this paper
• THE ULTRASTRUCTURE OF THE CAT MYOCARDIUM

  1969cited by this paper
• THE ULTRASTRUCTURE OF THE CAT MYOCARDIUM

  1969cited by this paper

• Guizhi Gancao Decoction Protects Against Doxorubicin-induced Cardiotoxicity by Intervening in Microtubule Acetylation.

  2026cites this paper
• [Mechanical response and disruption of the T-tubule microenvironment in the mammalian myocardium: a structural basis for cellular resilience].

  2025cites this paper
• Human induced pluripotent stem cell-derived cardiomyocytes for disease modeling and drug discovery

  2025cites this paper
• Nonstructural Roles of Junctophilin-2 in the Heart

  2025cites this paper
• Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction.

  2025cites this paper
• Ca2+ microdomain-based excitation-transcription coupling in cardiac myocytes and vascular smooth muscle cells

  2025cites this paper
• Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis

  2025cites this paper
• Reverse remodelling of the mitochondria and cytoskeleton after respiratory heart rate variability pacing of the failing sheep heart

  2025cites this paper
• Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy

  2025influential citation
• Functional analysis of JPH2-knockout cardiomyocytes identifies ECCD as a novel indicator in a human cardiac modelJPH2

  2025cites this paper
• From function to structure: how myofibrillogenesis influences the transverse–axial tubular system development and its peculiarities

  2025cites this paper
• Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is altered in striated muscle diseases

  2025cites this paper
• The Role of the MTUS1 Gene in the Development of Left Ventricular Noncompaction Cardiomyopathy—A Case Report

  2025cites this paper
• Impact of Sorbs2 dysfunction on cardiovascular diseases.

  2025cites this paper
• Regulation of cardiomyocyte intracellular trafficking and signal transduction by protein palmitoylation

  2024cites this paper
• Remodeling of T-Tubules and Associated Calcium Handling Dysfunction in Heart Failure: Mechanisms and Therapeutic Insights.

  2024cites this paper
• Efficacy of a cysteine protease inhibitor compared with enalapril in murine heart failure models

  2024cites this paper
• Microtubules and Cardiovascular Diseases: Insights into Pathology and Therapeutic Strategies.

  2024cites this paper
• Targeting Calpain-2-mediated Junctophilin-2 cleavage delays heart failure progression following myocardial infarction.

  2024cites this paper
• FGF13 deficiency ameliorates calcium signaling abnormality in heart failure by regulating microtubule stability.

  2024cites this paper
• Calpain inhibition protects against atrial fibrillation by mitigating diabetes-associated atrial fibrosis and calcium handling dysfunction in type 2 diabetes mice.

  2024cites this paper
• Ptpn23 Controls Cardiac T-Tubule Patterning by Promoting the Assembly of Dystrophin-Glycoprotein Complex

  2024cites this paper
• A Multi-omic and Multi-Species Analysis of Right Ventricular Failure

  2023cites this paper
• Structure, Function, and Regulation of the Junctophilin Family.

  2023cites this paper
• Microtubule-Mediated Regulation of β2AR Translation and Function in Failing Hearts

  2023cites this paper
• Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules.

  2023cites this paper
• Restoration of calcium release synchrony: A novel target for heart failure and ventricular arrhythmia.

  2023cites this paper
• A role of inflammaging in aortic aneurysm: new insights from bioinformatics analysis

  2023cites this paper
• The microtubule signature in cardiac disease: etiology, disease stage, and age dependency

  2023cites this paper
• T‐tubule recovery after detubulation in isolated mouse cardiomyocytes

  2023cites this paper
• A meta-analysis evaluating efficacy and safety of colchicine for prevention of major cardiovascular events in patients with coronary artery disease

  2023cites this paper
• DNA Methylation Analysis Identifies Novel Epigenetic Loci in Dilated Murine Heart upon Exposure to Volume Overload

  2023cites this paper
• Junctophilin-2 promotes cardiomyocyte survival by blocking MURF1-mediated Junctin ubiquitination and proteasome-dependentdegradation

  2022cites this paper
• Myocardial edema during chemotherapy for gynecologic malignancies: A cardiac magnetic resonance T2 mapping study

  2022cites this paper
• Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2‐Mediated Suppression of NLRP3 Inflammasome Activation

  2022cites this paper
• NMR resonance assignments of the DNA binding domain of mouse Junctophilin-2

  2022cites this paper
• Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules in Rodent Pulmonary Arterial Hypertension

  2022cites this paper
• The microtubule cytoskeleton in cardiac mechanics and heart failure

  2022cites this paper
• Gene Therapy With the N-Terminus of Junctophilin-2 Improves Heart Failure in Mice

  2022cites this paper
• Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules in Two Rodent Models of Pulmonary Arterial Hypertension

  2022cites this paper
• The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease

  2022cites this paper
• The role of junctophilin proteins in cellular function

  2022influential citation
• Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart

  2021cites this paper
• Severe T-System Remodeling in Pediatric Viral Myocarditis

  2021cites this paper
• Microtubules orchestrate local translation to enable cardiac growth

  2021cites this paper
• Mechanisms underlying pathological Ca2+ handling in diseases of the heart

  2021cites this paper
• Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart

  2021cites this paper
• Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility

  2021cites this paper
• Trans-cinnamaldehyde suppresses microtubule detyrosination and alleviates cardiac hypertrophy.

  2021cites this paper
• Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling.

  2021cites this paper
• Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy

  2021cites this paper
• The Physiology and Pathophysiology of T-Tubules in the Heart

  2021cites this paper
• Targeting JP2: A New Treatment for Pulmonary Hypertension

  2021cites this paper
• Xin-Ji-Er-Kang protects myocardial and renal injury in hypertensive heart failure in mice.

  2021cites this paper
• Integrin β1D Deficiency–Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy

  2020cites this paper
• Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium

  2020cites this paper
• Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes

  2020cites this paper
• Palmitoylation: A Fatty Regulator of Myocardial Electrophysiology

  2020cites this paper
• Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy

  2020cites this paper
• Destructive Role of TMAO in T-Tubule and Excitation-Contraction Coupling in the Adult Cardiomyocytes.

  2020cites this paper
• Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling

  2020cites this paper
• Nexilin is a New Player for Shaping T-Tubules in Cardiomyocytes.

  2020cites this paper
• The architecture and function of cardiac dyads

  2020cites this paper
• Disruption of transverse‐tubular network reduces energy efficiency in cardiac muscle contraction

  2020cites this paper
• Nanobar Array Assay Revealed Complementary Roles of BIN1 Splice Isoforms in Cardiac T-Tubule Morphogenesis.

  2020cites this paper
• Homozygous G650del nexilin variant causes cardiomyopathy in mice

  2020cites this paper
• Interaction of the Joining Region in Junctophilin-2 with the L-type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics.

  2020cites this paper
• AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP‐170

  2020cites this paper
• Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism

  2020cites this paper
• Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension.

  2020cites this paper
• Lingguizhugan decoction attenuates doxorubicin-induced heart failure in rats by improving TT-SR microstructural remodeling

  2019cites this paper
• Supporting the heart: Functions of the cardiomyocyte's non-sarcomeric cytoskeleton.

  2019cites this paper
• The SLMAP/Striatin complex: An emerging regulator of normal and abnormal cardiac excitation-contraction coupling.

  2019cites this paper
• Junctophilin-2 Protects Cardiomyocytes against Palmitate-induced Injury

  2019influential citation
• Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure

  2019cites this paper
• Adenosine kinase attenuates cardiomyocyte microtubule stabilization and protects against pressure overload-induced hypertrophy and LV dysfunction.

  2019cites this paper
• Cardiac microtubules in health and heart disease

  2019cites this paper
• Junctophilins emerge as novel therapeutic targets

  2019influential citation
• Pathogenesis and pathophysiology of heart failure with reduced ejection fraction: translation to human studies

  2019cites this paper
• Abnormal expression of miR-331 leads to impaired heart function.

  2019cites this paper
• Glucocorticoids preserve the t-tubular system in ventricular cardiomyocytes by upregulation of autophagic flux

  2019cites this paper
• Nexilin is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation.

  2019cites this paper
• Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers

  2019cites this paper
• Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs

  2018cites this paper
• Targeting Calpain for Heart Failure Therapy

  2018cites this paper
• Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

  2018cites this paper
• Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity.

  2018cites this paper
• E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator

  2018cites this paper
• Highly variable contractile performance correlates with myocyte content in trabeculae from failing human hearts

  2018cites this paper
• Correcting Calcium Dysregulation in Chronic Heart Failure Using SERCA2a Gene Therapy

  2018cites this paper
• Ion Channel Trafficking in the Heart

  2018cites this paper
• Dyadic Plasticity in Cardiomyocytes

  2018cites this paper
• Microtubules provide a viscoelastic resistance to myocyte motion

  2018cites this paper
• Key Role of the Membrane Trafficking of Nav1.5 Channel Protein in Antidepressant-Induced Brugada Syndrome

  2018cites this paper
• Increased collagen within the transverse tubules in human heart failure

  2017cites this paper
• Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics.

  2017cites this paper
• Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes

  2017cites this paper
• Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma?

  2017cites this paper
• T‐tubule remodeling and increased heterogeneity of calcium release during the progression to heart failure in intact rat ventricle

  2017influential citation
• MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress.

  2017cites this paper