Type‐A CpG oligonucleotides activate exclusively porcine natural interferon‐producing cells to secrete interferon‐α, tumour necrosis factor‐α and interleukin‐12

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Immunology

• Publication date

  2004-05-01

• Fields of study

  Biology

• Identifiers
  DOI 10.1111/j.1365-2567.2004.01856.xPMCID PMC1782461
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Classical swine fever virus interferes with cellular antiviral defense: evidence for a novel function of N(pro).

  2003cited by this paper
• C-kit positive porcine bone marrow progenitor cells identified and enriched using recombinant stem cell factor.

  2003cited by this paper
• Interferon-producing Cells Fail to Induce Proliferation of Naive T Cells but Can Promote Expansion and T Helper 1 Differentiation of Antigen-experienced Unpolarized T Cells

  2003cited by this paper
• TOLL-like receptors linking innate and adaptive immune response.

  2003cited by this paper
• Porcine peripheral blood dendritic cells and natural interferon‐producing cells

  2003cited by this paper
• CpG-A Oligonucleotides Induce a Monocyte-Derived Dendritic Cell-Like Phenotype That Preferentially Activates CD8 T Cells1

  2003cited by this paper
• The Roles of Toll-Like Receptor 9, MyD88, and DNA-Dependent Protein Kinase Catalytic Subunit in the Effects of Two Distinct CpG DNAs on Dendritic Cell Subsets1

  2003cited by this paper
• Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA viruses.

  2003cited by this paper
• Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.

  2003cited by this paper
• Classical Swine Fever Virus Interferes with Cellular Antiviral Defense: Evidence for a Novel Function of Npro

  2003cited by this paper
• Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection

  2003cited by this paper
• Natural Interferon-α Producing Cells: The Plasmacytoid Dendritic Cells

  2002cited by this paper
• CpG-oligodinucleotides as an effective adjuvant in pigs for intramuscular immunizations.

  2002cited by this paper
• Natural type I interferon-producing cells as a link between innate and adaptive immunity.

  2002cited by this paper
• CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells

  2002cited by this paper
• Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity.

  2002cited by this paper
• The Development of Murine Plasmacytoid Dendritic Cell Precursors Is Differentially Regulated by FLT3-ligand and Granulocyte/Macrophage Colony-Stimulating Factor

  2002cited by this paper
• Monocytes are required for optimum in vitro stimulation of bovine peripheral blood mononuclear cells by non-methylated CpG motifs.

  2002cited by this paper
• Interferon-producing cells: on the front line in immune responses against pathogens.

  2002cited by this paper
• Plasmacytoid dendritic cells: the key to CpG.

  2002cited by this paper
• Interferon (cid:2) / (cid:3) and Interleukin 12 Responses to Viral Infections: Pathways Regulating Dendritic Cell Cytokine Expression In Vivo

  2002cited by this paper
• CpG‐DNA aided cross‐presentation of soluble antigens by dendritic cells

  2002cited by this paper
• Natural interferon-alpha producing cells: the plasmacytoid dendritic cells.

  2002cited by this paper
• Interferon α/β and Interleukin 12 Responses to Viral Infections

  2002cited by this paper
• Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.

  2001cited by this paper
• Importance of CpG Dinucleotides in Activation of Natural IFN‐α‐Producing Cells by a Lupus‐Related Oligodeoxynucleotide

  2001cited by this paper
• Porcine dendritic cells generated in vitro: morphological, phenotypic and functional properties

  2001cited by this paper
• Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides.

  2001cited by this paper
• CpG Motif Identification for Veterinary and Laboratory Species Demonstrates That Sequence Recognition Is Highly Conserved

  2001cited by this paper
• Identification of CpG oligonucleotide sequences with high induction of IFN‐α/β in plasmacytoid dendritic cells

  2001cited by this paper
• Differential Regulation of Human Blood Dendritic Cell Subsets by IFNs1

  2001cited by this paper
• Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.

  2001cited by this paper
• The function of type I interferons in antimicrobial immunity.

  2000cited by this paper
• Intermediate stages in monocyte–macrophage differentiation modulate phenotype and susceptibility to virus infection

  1999cited by this paper
• Oligonucleotides Tethered to a Short Polyguanylic Acid Stretch Are Targeted to Macrophages: Enhanced Antiviral Activity of a Vesicular Stomatitis Virus-Specific Antisense Oligonucleotide

  1999cited by this paper
• Repeated Administration of Synthetic Oligodeoxynucleotides Expressing CpG Motifs Provides Long-Term Protection against Bacterial Infection

  1999cited by this paper
• The nature of the principal type 1 interferon-producing cells in human blood.

  1999cited by this paper
• Survival, maturation, and function of CD11c- and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines.

  1999cited by this paper
• Role of early cytokines, including alpha and beta interferons (IFN-α\β), in innate and adaptive immune responses to viral infections☆

  1998cited by this paper
• Coronavirus Pseudoparticles Formed with Recombinant M and E Proteins Induce Alpha Interferon Synthesis by Leukocytes

  1998cited by this paper
• Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections.

  1998cited by this paper
• The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand

  1997cited by this paper
• Stimulation of Natural Interferon-α/β-Producing Cells by Staphylococcus aureus

  1996cited by this paper
• Stimulation of natural interferon-alpha/beta-producing cells by Staphylococcus aureus.

  1996cited by this paper
• Coronavirus transmissible gastroenteritis virus-mediated induction of IFN alpha-mRNA in porcine leukocytes requires prior synthesis of soluble proteins.

  1994cited by this paper
• Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices.

  1993cited by this paper
• Age-related increase of porcine natural interferon α producing cell frequency and of interferon yield per cell

  1993cited by this paper
• A sensitive immunoassay for porcine interferon-alpha.

  1992cited by this paper
• Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

  1992cited by this paper
• Single amino acid changes in the viral glycoprotein M affect induction of alpha interferon by the coronavirus transmissible gastroenteritis virus

  1992cited by this paper
• A sensitive immunoassay for porcine interferon-α

  1992cited by this paper
• Characterization of blood mononuclear cells producing IFNα following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus)

  1990cited by this paper

• Mitochondrial dysfunction in PRRSV-2-infected macrophages

  2025cites this paper
• Age-dependent differences in type I interferon, IL-12 and pro-inflammatory cytokine production by porcine peripheral blood mononuclear cells in response to pseudorabies virus-infected cells

  2025cites this paper
• Sublingual immunization with E2-CD154 protein and the STING agonist c-di-AMP confers protection against classical swine fever virus in pigs

  2025cites this paper
• Differential innate immune activation by four different CpG-ODNs in porcine and murine cells: Implications for vaccine design.

  2025cites this paper
• Protection Against Transplacental Transmission of a Highly Virulent Classical Swine Fever Virus Two Weeks After Single-Dose FlagT4G Vaccination in Pregnant Sows

  2025cites this paper
• Plasmacytoid dendritic cell sensing of African swine fever virus-infected macrophages results in STING-dependent robust interferon-α production.

  2025cites this paper
• Fitness adaptations of Japanese encephalitis virus in pigs following vector-free serial passaging

  2024cites this paper
• FlagT4G Vaccine Prevents Transplacental Transmission of Highly Virulent Classical Swine Fever Virus after Single Vaccination in Pregnant Sows

  2024cites this paper
• The Attenuated Pseudorabies Virus Vaccine Strain Bartha Hyperactivates Plasmacytoid Dendritic Cells by Generating Large Amounts of Cell-Free Virus in Infected Epithelial Cells

  2022cites this paper
• Encapsidated-CpG ODN enhances immunogenicity of porcine circovirus type 2 virus-like particles.

  2022cites this paper
• Porcine Plasmacytoid Dendritic Cells Are Unique in Their Expression of a Functional NKp46 Receptor

  2022cites this paper
• Removal of the Erns RNase Activity and of the 3′ Untranslated Region Polyuridine Insertion in a Low-Virulence Classical Swine Fever Virus Triggers a Cytokine Storm and Lethal Disease

  2022cites this paper
• Baculovirus Vectors Induce the Production of Interferons in Swine: Their Potential in the Development of Antiviral Strategies

  2021cites this paper
• Alphaherpesvirus-induced activation of plasmacytoid dendritic cells depends on the viral glycoprotein gD and is inhibited by non-infectious light particles

  2021cites this paper
• Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs

  2021cites this paper
• Adjuvants for swine vaccines: Mechanisms of actions and adjuvant effects.

  2020cites this paper
• Use of IFN-Based Biotherapeutics to Harness the Host Against Foot-And-Mouth Disease

  2020cites this paper
• Absence of Long-Term Protection in Domestic Pigs Immunized with Attenuated African Swine Fever Virus Isolate OURT88/3 or BeninΔMGF Correlates with Increased Levels of Regulatory T Cells and Interleukin-10

  2020cites this paper
• Resident Plasmacytoid Dendritic Cells Patrol Vessels in the Naïve Limbus and Conjunctiva.

  2020cites this paper
• In vitro characterization of PRRSV isolates with different in vivo virulence using monocyte-derived macrophages.

  2019cites this paper
• Long-acting β2-adrenoreceptor agonists suppress type 1 interferon expression in human plasmacytoid dendritic cells via epigenetic regulation.

  2018cites this paper
• Nucleic Acids as Adjuvants

  2018cites this paper
• Immunogenicity of inactivated formalin-killed Photobacterium damselae subsp. piscicida combined with Toll-like receptor 9 agonist in Cobia Rachycentron canadum

  2018cites this paper
• Porcine B Cell Subset Responses to Toll-like Receptor Ligands

  2017cites this paper
• Vinpocetine Inhibited the CpG Oligodeoxynucleotide-induced Immune Response in Plasmacytoid Dendritic Cells

  2017cites this paper
• The Pseudorabies Virus Glycoprotein gE/gI Complex Suppresses Type I Interferon Production by Plasmacytoid Dendritic Cells

  2017cites this paper
• Dendritic Cell Sensing of Hydrophobic Di- and Triacylated Lipopeptides Self-Assembled within Synthetic Virus-like Particles

  2017cites this paper
• The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin

  2017cites this paper
• Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs

  2016cites this paper
• Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences

  2016cites this paper
• Sensing of Porcine Reproductive and Respiratory Syndrome Virus-Infected Macrophages by Plasmacytoid Dendritic Cells

  2016cites this paper
• Review of immunological responses to porcine coronaviruses and implications on population based control strategies in epidemic and endemic infections

  2016cites this paper
• Type I and III IFNs Produced by Plasmacytoid Dendritic Cells in Response to a Member of the Flaviviridae Suppress Cellular Immune Responses

  2016cites this paper
• Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines.

  2016cites this paper
• Classical Swine Fever Virus vs. Classical Swine Fever Virus: The Superinfection Exclusion Phenomenon in Experimentally Infected Wild Boar

  2016cites this paper
• Demostración de la capacidad protectora de candidatos vacunales contra el virus del dengue basados en la proteína de la cápsida y el oligodesoxinucleótido 39M

  2016cites this paper
• Porcine circovirus 2 immunology and viral evolution

  2015cites this paper
• Mucosal Veterinary Vaccines

  2015cites this paper
• Strategies for design and application of enteric viral vaccines.

  2015cites this paper
• Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation

  2015cites this paper
• Postnatal Persistent Infection with Classical Swine Fever Virus and Its Immunological Implications

  2015cites this paper
• Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs

  2015cites this paper
• Alginate-coated chitosan nanogels differentially modulate class-A and class-B CpG-ODN targeting of dendritic cells and intracellular delivery.

  2014cites this paper
• Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

  2014cites this paper
• The impact of CSFV on the immune response to control infection.

  2014cites this paper
• Virulence and genotype-associated infectivity of interferon-treated macrophages by porcine reproductive and respiratory syndrome viruses.

  2014cites this paper
• Bacteria-Induced IFN- Dendritic Cells and Can Thereby Mediate and Deliver Nucleic Acids to Plasmacytoid Porcine Cathelicidins Efficiently Complex

  2014cites this paper
• Porcine Cathelicidins Efficiently Complex and Deliver Nucleic Acids to Plasmacytoid Dendritic Cells and Can Thereby Mediate Bacteria-Induced IFN-α Responses

  2014cites this paper
• Porcine circovirus type 2 decreases the infection and replication of attenuated classical swine fever virus in porcine alveolar macrophages.

  2014cites this paper
• Phenotypic, Ultra-Structural, and Functional Characterization of Bovine Peripheral Blood Dendritic Cell Subsets

  2014cites this paper
• VirulenceStrains with Different Levels of Infection of Pigs with Haemophilus Changes in Macrophage Phenotype after

  2014cites this paper
• Alginate-coated chitosan nanogel capacity to modulate the effect of TLR ligands on blood dendritic cells.

  2013cites this paper
• Efficient Sensing of Infected Cells in Absence of Virus Particles by Blasmacytoid Dendritic Cells Is Blocked by the Viral Ribonuclease Erns

  2013cites this paper
• Changes in Macrophage Phenotype after Infection of Pigs with Haemophilus parasuis Strains with Different Levels of Virulence

  2013cites this paper
• Afferent Skin Lymph Plasmacytoid Dendritic Cells Migrate in

  2013cites this paper
• Enhanced immunogenicity induced by an alphavirus replicon-based pseudotyped baculovirus vaccine against porcine reproductive and respiratory syndrome virus.

  2013cites this paper
• Third generation DIVA vaccine towards classical swine fever virus. Efficacy in face of maternal immunity

  2013cites this paper
• Identification of the STAT1 gene and the characterisation of its immune response to immunostimulants, including nervous necrosis virus (NNV) infection, in Malabar grouper (Epinephelus malabaricus).

  2013cites this paper
• Regulation of Porcine Plasmacytoid Dendritic Cells by Cytokines

  2013cites this paper
• Impact of genotype 1 and 2 of porcine reproductive and respiratory syndrome viruses on interferon-α responses by plasmacytoid dendritic cells

  2013cites this paper
• Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: clinico-pathogenic aspects.

  2013cites this paper
• Phthalates suppress type I interferon in human plasmacytoid dendritic cells via epigenetic regulation

  2013cites this paper
• Porcine circovirus type 2 stimulates plasmacytoid dendritic cells in the presence of IFN-gamma.

  2013cites this paper
• The immunomodulation of porcine immune cells by innate and synthetic host defense peptides

  2013influential citation
• Third generation DIVA vaccine towards classical swine fever virus. Efficacy in face of maternal immunity

  2013cites this paper
• MF59 formulated with CpG ODN as a potent adjuvant of recombinant HSP65-MUC1 for inducing anti-MUC1+ tumor immunity in mice

  2012cites this paper
• Stimulation with a class A CpG oligonucleotide enhances resistance to infection with feline viruses from five different families

  2012cites this paper
• Viewpoint: factors involved in type I interferon responses during porcine virus infections.

  2012cites this paper
• Identification of a lineage negative cell population in bovine peripheral blood with the ability to mount a strong type I interferon response.

  2012cites this paper
• Npro of Classical Swine Fever Virus Prevents Type I Interferon-Mediated Priming of Conventional Dendritic Cells for Enhanced Interferon-α Response

  2012cites this paper
• Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses

  2012cites this paper
• Immunomodulatory properties of beta-sitosterol in pig immune responses.

  2012cites this paper
• The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig

  2012cites this paper
• Reduction of Classical Swine Fever Virus-Specific Cell Proliferative Response of Porcine Peripheral Blood Mononuclear Cells by Porcine Circovirus Type 2

  2012cites this paper
• Insights on the interaction between Haemophilus parasuis and alveolar macrophages

  2012cites this paper
• Cytokine production and proliferation upon in vitro oligodeoxyribonucleotide stimulation of equine peripheral blood mononuclear cells.

  2012cites this paper
• Title Stimulation with a class A CpG oligonucleotide enhances resistance to infection with feline viruses from five different families Permalink

  2012cites this paper
• TLR9 agonists: immune mechanisms and therapeutic potential in domestic animals.

  2012cites this paper
• Oral immunization with F4 fimbriae and CpG formulated with carboxymethyl starch enhances F4-specific mucosal immune response and modulates Th1 and Th2 cytokines in weaned pigs.

  2012cites this paper
• Immunomodulatory effect of swine CCL20 chemokine in DNA vaccination against CSFV.

  2011cites this paper
• Identification of cytosine‐phosphorothioate‐guanine oligodeoxynucleotide sequences that induce interferon‐γ production in feline immune cells

  2011cites this paper
• Resolution of neutrophilic inflammation by H2O2 in antigen-induced arthritis.

  2011cites this paper
• Genetic and immunobiological diversities of porcine reproductive and respiratory syndrome genotype I strains.

  2011influential citation
• Classical Swine Fever Virus Npro Limits Type I Interferon Induction in Plasmacytoid Dendritic Cells by Interacting with Interferon Regulatory Factor 7

  2011cites this paper
• Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates

  2011cites this paper
• Adjuvants and delivery systems in veterinary vaccinology: current state and future developments

  2011cites this paper
• Bovine Plasmacytoid Dendritic Cells Are the Major Source of Type I Interferon in Response to Foot-and-Mouth Disease Virus In Vitro and In Vivo

  2011cites this paper
• Porcine blood mononuclear cell cytokine responses to PAMP molecules: comparison of mRNA and protein production.

  2011cites this paper
• Efficient Sensing of Avian Influenza Viruses by Porcine Plasmacytoid Dendritic Cells

  2011cites this paper
• Cytokine induction by immunostimulatory DNA in porcine PBMC is impaired by a hairpin forming sequence motif from the genome of Porcine Circovirus type 2 (PCV2).

  2011cites this paper
• Porcine circovirus type 2 DNA influences cytoskeleton rearrangements in plasmacytoid and monocyte‐derived dendritic cells

  2011cites this paper
• Stability of expression of reference genes in porcine peripheral blood mononuclear and dendritic cells.

  2011cites this paper
• Innate immune responses to human rotavirus in the neonatal gnotobiotic piglet disease model

  2010cites this paper
• Interferon-gamma induction correlates with protection by DNA vaccine expressing E2 glycoprotein against classical swine fever virus infection in domestic pigs.

  2010cites this paper
• Differential activation and maturation of two porcine DC populations following TLR ligand stimulation.

  2010cites this paper
• Porcine Flt3 ligand and its receptor: generation of dendritic cells and identification of a new marker for porcine dendritic cells.

  2010cites this paper
• Loss of Plasmacytoid Dendritic Cell Function Coincides with Lymphopenia and Viremia During Foot-and-Mouth Disease Virus Infection

  2010cites this paper
• Interferon Alpha Characterization and Its Comparative Expression in PBM Cells of Capra hircus and Antelope cervicapra Cultured in the Presence of TLR9 Agonist

  2010cites this paper
• A comparison between isolated blood dendritic cells and monocyte‐derived dendritic cells in pigs

  2010cites this paper
• Therapeutic targeting of the innate immune system in domestic animals

  2010cites this paper