Biological repair of the degenerated intervertebral disc by the injection of growth factors

No abstract is available for this paper.

• Publication year

  2008

• Venue

  European spine journal

• Publication date

  2008-11-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00586-008-0749-zPMID 19005698PMCID PMC2587664
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006influential reference
• Biologic modification of animal models of intervertebral disc degeneration.

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• The Effect of Bone Morphogenetic Protein-2 on Rat Intervertebral Disc Cells in Vitro

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• Investigation of the short-term effect of chemonucleolysis with chondroitinase ABC.

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• Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside.

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