Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b.

No abstract is available for this paper.

• Publication year

  1977

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1977-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.74.7.2998PMID 70787PMCID PMC431380
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Molecular Structure of C4 and Its Cleavage Products

  1976cited by this paper
• The Serine Protease Nature of the C3 and C5 Convertases of the Classical and Alternative Complement Pathways

  1976cited by this paper
• The NH-2-terminal sequences of a subunit of the first component of human complement, C1s, and its activated form, C1s.

  1975cited by this paper
• Enzymatic activity of the second component of complement.

  1975cited by this paper
• Studies of complement complex C5b,6 eluted from--EAC-6: reaction of C5b,6 with EAC4b,3b and evidence on the role of C2a and C3b in the activation of C5.

  1974cited by this paper
• Purification, Molecular Properties, and Activation of C1 Proesterase, Cls

  1973cited by this paper
• Measurement of protein concentration with interferences optics.

  1969cited by this paper
• THE SECOND COMPONENT OF HUMAN COMPLEMENT: ITS ISOLATION, FRAGMENTATION BY C'1 ESTERASE, AND INCORPORATION INTO C'3 CONVERTASE

  1968cited by this paper
• On the Cleavage of C'2 by C'la

  1968cited by this paper
• FORMATION AND FUNCTIONAL SIGNIFICANCE OF A MOLECULAR COMPLEX DERIVED FROM THE SECOND AND THE FOURTH COMPONENT OF HUMAN COMPLEMENT

  1967cited by this paper
• Chemical Coupling of Peptides and Proteins to Polysaccharides by Means of Cyanogen Halides

  1967cited by this paper
• C'2ad, an inactive derivative of C'2 released during decay of EAC'4,2a.

  1966cited by this paper
• Reversible adsorption of C'2 by EAC'4: role of Mg2+, enumeration of competent SAC'4, two-step nature of C'2a fixation and estimation of its efficiency.

  1966cited by this paper
• DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS *

  1964cited by this paper
• Studies on the Second Component of Complement. II. The Nature of the Decay of EAC'1,4,2.

  1961cited by this paper

• Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors

  2024cites this paper
• A nanobody-based complement inhibitor targeting complement component 2 reduces hemolysis in a complement humanized mouse model of autoimmune hemolytic anemia.

  2023cites this paper
• Subversion of the Complement System by Pseudomonas aeruginosa

  2023cites this paper
• C2 by-pass: Cross-talk between the complement classical and alternative pathways.

  2022cites this paper
• The Complement System

  2018cites this paper
• United States Patent Gál

  2017cites this paper
• Complement Factor H related proteins and their biological role during bacterial infection

  2017cites this paper
• O papel do componente C3 do sistema complemento na infecção in vivo por Leptospira interrogans.

  2017cites this paper
• An investigation of the role of complement in acute myeloid leukaemia

  2016cites this paper
• Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases*

  2016cites this paper
• Expression and purification methods for the production of recombinant human complement component C2.

  2014cites this paper
• Assembly and Activation of Alternative Complement Components on Endothelial Cell-Anchored Ultra-Large Von Willebrand Factor Links Complement and Hemostasis-Thrombosis

  2013cites this paper
• UCSD MOLECULE PAGES Complement C 5

  2013cites this paper
• Role of the Soluble Complement Regulator Factor H in Microbial Survival and Host Infection Susceptibility

  2012cites this paper
• Identification and characterisation of novel plasma clot components

  2012influential citation
• Protease-1 and -2: A Study on Recombinant Mannan-Binding Lectin-Associated Serine Natural Substrates and Inhibitors of

  2012cites this paper
• Assessment of the Functional Role of the NTR Domain of Complement Component C3 using a Homologous Dmain Exchange Approach

  2011cites this paper
• Role of complement in tumour formation : Friend or foe?

  2010cites this paper
• Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases

  2010cites this paper
• The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation.

  2009cites this paper
• Cleavage of C2 in pathological serum and plasma studied by crossed immunoelectrophoresis.

  2009cites this paper
• Rekrutierung von Komplementregulatoren der Faktor H Proteinfamilie als Mechanismen der Immunevasion humanpathogener Erreger

  2008cites this paper
• Molecular Details of Serum Resistance of Yersinia enterocolitica

  2008cites this paper
• Recombinant rat complement regulatory proteins as therapeutic agents in inflammatory disease

  2006cites this paper
• Generation and characterisation of anti-C6 monoclonal antibodies in C6-deficient mice: the search for an anti-C6 therapy.

  2006cites this paper
• Furthering structural insight into complement active fragments of DAF using NMR spectroscopy

  2006cites this paper
• Expression of functional recombinant von Willebrand factor-A domain from human complement C2: a potential binding site for C4 and CRIT.

  2005cites this paper
• Biochemical and functional studies of a novel complement inhibitor, CRIT, with its interaction partners

  2005cites this paper
• Chemerin Activation by Serine Proteases of the Coagulation, Fibrinolytic, and Inflammatory Cascades*

  2005cites this paper
• The membrane attack complex

  2005cites this paper
• Interactions of soluble complement regulators with pathogenic bacteria

  2004cites this paper
• On the Site of C4 Deposition upon Complement Activation via the Mannan‐Binding Lectin Pathway or the Classical Pathway

  2003cites this paper
• Natural Substrates and Inhibitors of Mannan-Binding Lectin-Associated Serine Protease-1 and -2: A Study on Recombinant Catalytic Fragments 1

  2003cites this paper
• Catalytic Fragments Protease-1 and -2: A Study on Recombinant Mannan-Binding Lectin-Associated Serine Natural Substrates and Inhibitors of

  2003cites this paper
• Binding Site for Complement C 2-Chain of C 4 Share a β Trispanning and the Complement C 2 Receptor Inhibitor

  2002cites this paper
• Complement C2 Receptor Inhibitor Trispanning and the β-Chain of C4 Share a Binding Site for Complement C21

  2002cites this paper
• Two Clusters of Acidic Amino Acids Near the NH 2 Terminus of Complement Component C4 a*-Chain Are Important for

  2000cites this paper
• Complement Receptor 2 ( CD 21 ) Residues Essential for Its Binding to Structure-Guided Identification of C 3 d

  2000cites this paper
• Positively charged amino acids at the interface between alpha-chain CCP1 and CCP2 of C4BP are required for regulation of the classical C3-convertase.

  2000cites this paper
• Structure-Guided Identification of C3d Residues Essential for Its Binding to Complement Receptor 2 (CD21)1

  2000cites this paper
• Complement Receptor 2 Residues Essential for Its Binding to Structure-Guided Identification of C3d

  2000cites this paper
• Two Clusters of Acidic Amino Acids Near the NH2 Terminus of Complement Component C4 α′-Chain Are Important for C2 Binding1

  2000cites this paper
• Protease Mannose-Binding Lectin-Associated Serine Proteolytic Activities of Two Types of Terai and Teizo

  2000cites this paper
• Glycyrrhizin Inhibits the Lytic Pathway of Complement — Possible Mechanism of Its Anti‐Inflammatory Effect on Liver Cells in Viral Hepatitis —

  2000cites this paper
• Hereditary Angioneurotic Edema: Review of the Literature

  2000cites this paper
• Proteolytic Activities of Two Types of Mannose-Binding Lectin-Associated Serine Protease

  2000cites this paper
• Identification of Residues within the 727–767 Segment of Human Complement Component C3 Important for Its Interaction with Factor H and with Complement Receptor 1 (CR1, CD35)*

  1999cites this paper
• Components and Reactivity

  1998cites this paper
• Regulation of immune complex formation and clearance by histidine-rich glycoprotein

  1998cites this paper
• Hereditary angioneurotic edema and thromboembolic diseases: I: How symptoms of acute attacks change with aging.

  1998cites this paper
• The atypical serine proteases of the complement system.

  1998cites this paper
• Contribution of the complement control protein modules of C2 in C4b binding assessed by analysis of C2/factor B chimeras.

  1997cites this paper
• The amino-terminal module of the C4b-binding protein alpha-chain is crucial for C4b binding and factor I-cofactor function.

  1997cites this paper
• Chapter 10 Activation and control of the complement system

  1996cites this paper
• The complement system and inflammation

  1995cites this paper
• Expression and characterization of a recombinant C4b-binding protein lacking the beta-chain.

  1995cites this paper
• The Gly-54-->Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease.

  1995cites this paper
• Mutation of residues in the C3dg region of human complement component C3 corresponding to a proposed binding site for complement receptor type 2 (CR2, CD21) does not abolish binding of iC3b or C3dg to CR2.

  1995cites this paper
• Covalently-bound human C4b dimers consisting of C4B isotype show higher hemolytic activity than those of C4A in the C3-bypass complement pathway.

  1995cites this paper
• Interaction between serum amyloid P component and C4b-binding protein associated with inhibition of factor I-mediated C4b degradation.

  1994cites this paper
• Immune complex independent activation of complement, C1s secreted from hamster embryo malignant fibroblasts, Nil2C2 in serum free culture medium.

  1994cites this paper
• Interactions of human complement component C3 with factor B and with complement receptors type 1 (CR1, CD35) and type 3 (CR3, CD11b/CD18) involve an acidic sequence at the N-terminus of C3 alpha'-chain.

  1994cites this paper
• Purification and characterization of a novel substrate for plasma kallikrein (PK-120) in human plasma.

  1994cites this paper
• Involvement of the pertussis toxin-sensitive GTP-binding protein in regulation of expression and function of granulocyte complement receptor type 1 and type 3.

  1994cites this paper
• Complement and the Mononuclear Phagocyte System

  1993cites this paper
• Activation of the C4 and C2 components of complement by a proteinase in serum bactericidal factor, Ra reactive factor.

  1993cites this paper
• Substituted isocoumarins as inhibitors of complement serine proteases.

  1992cites this paper
• Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease

  1992cites this paper
• Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3.

  1992cites this paper
• Hereditary Angioedema

  1992cites this paper
• Mutagenesis of the Arg-Gly-Asp triplet in human complement component C3 does not abolish binding of iC3b to the leukocyte integrin complement receptor type III (CR3, CD11b/CD18).

  1992cites this paper
• Covalent binding of C3b to C4b within the classical complement pathway C5 convertase. Determination of amino acid residues involved in ester linkage formation.

  1992cites this paper
• Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46).

  1992cites this paper
• Preferential inactivation of the C5 convertase of the alternative complement pathway by factor I and membrane cofactor protein (MCP).

  1991cites this paper
• Granulocyte‐Dependent Extracellular Cytotoxicity is Enhanced by Complement C3bi and Independent of Phagocytosis

  1991cites this paper
• Heparin influence on the complex of serum amyloid P component and complement C4b-binding protein.

  1991cites this paper
• Localization of the covalent C3b-binding site on C4b within the complement classical pathway C5 convertase, C4b2a3b.

  1990cites this paper
• Effect of sodium chloride concentration on fluid-phase assembly and stability of the C3 convertase of the classical pathway of the complement system.

  1990cites this paper
• Molecular modeling of human complement component C4 and its fragments by X-ray and neutron solution scattering.

  1990cites this paper
• Hereditary angioedema: its diagnostic and management perspectives.

  1990cites this paper
• Independent association of serum amyloid P component, protein S, and complement C4b with complement C4b-binding protein and subsequent association of the complex with membranes.

  1990cites this paper
• C1 binding by mouse IgM. The effect of abnormal glycosylation at position 402 resulting from a serine to asparagine exchange at residue 406 of the mu-chain.

  1990cites this paper
• Participation of C3 and its ligands in complement activation.

  1990cites this paper
• Assembly of protein S and C4b-binding protein on membranes.

  1990cites this paper
• Functional properties of membrane cofactor protein of complement.

  1989cites this paper
• Effect of decay-accelerating factor on the assembly of the classical and alternative pathway C3 convertases in the presence of C4 or C3 nephritic factor.

  1989cites this paper
• cDNA cloning and expression of human complement component C2.

  1989cites this paper
• Complement and related clinical disorders.

  1989cites this paper
• Simultaneous detection of allotypes in native and activated human C2 by isoelectric focusing and silver staining.

  1989cites this paper
• The kallikrein-kinin system in inflammation.

  1989cites this paper
• Isolation and characterization of a novel plasma protein which binds to activated C4 of the classical complement pathway.

  1989cites this paper
• Role for the third constant domain of the IgG H chain in activation of complement in the presence of C1 inhibitor.

  1989cites this paper
• Complement and Complement Reactions

  1988cites this paper
• Structural superfamilies of the complement system.

  1988cites this paper
• The second component of human complement: detection of two hemolytic forms in plasma by pH variation.

  1988cites this paper
• Evidence for a C4b binding site on the C2b domain of C2.

  1988cites this paper
• C1 binding by murine IgM. The effect of a Pro-to-Ser exchange at residue 436 of the mu-chain.

  1988cites this paper
• The C4 and C2 but not C1 components of complement are responsible for the complement activation triggered by the Ra-reactive factor.

  1988cites this paper
• Radioassays for quantitation of intact complement proteins C2 and B in human serum.

  1988cites this paper
• Alternative complement pathway activation fragment Ba binds to C3b. Evidence that formation of the factor B-C3b complex involves two discrete points of contact.

  1987cites this paper