Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2).

In nanomedicine, the widespread concern of nanoparticles in general, and dendrimers, in particular, is the analysis of key in-vivo physicochemical parameters to ensure the preclinical and clinical development of 'safe' bioactive nanomaterials. It is clear that for biomedical applications, biocompatible dendrimers, used as nanocarriers or active per se, should be devoid of toxicity and immunogenicity, and have adequate PK/PD behaviors (adequate exposure) in order to diffuse in different tissues. Functionalization of dendrimers has a dramatic effect on in-vivo physicochemical parameters. In this review, we highlighted key in-vivo physicochemical properties, based on data from biochemical, cellular and animal models, to provide biocompatible dendrimers. Up-to-date, only scarce studies have been described on this topic.

• Publication year

  2019

• Venue

  Drug Discovery Today

• Publication date

  2019-05-01

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1016/j.drudis.2019.03.001PMID 30904723
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Toxicology of Engineered Nanoparticles: Focus on Poly(amidoamine) Dendrimers

  2018cited by this paper
• Dendrimers for Drug Delivery

  2018cited by this paper
• Dendrimer encapsulated and conjugated delivery of berberine: A novel approach mitigating toxicity and improving in vivo pharmacokinetics.

  2017cited by this paper
• Non‐covalent formulation of active principles with dendrimers: Current state‐of‐the‐art and prospects for further development

  2017cited by this paper
• Dendrimers: syntheses, toxicity, and applications toward catalysis, environmental sciences, and nanomedecine

  2017cited by this paper
• Generation‐6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model

  2017cited by this paper
• Bench‐to‐bedside translation of dendrimers: Reality or utopia? A concise analysis

  2017cited by this paper
• A Review of Synthesis, Characterization and Applications of Functionalized Dendrimers

  2017cited by this paper
• Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo

  2017cited by this paper
• A novel doxorubicin loaded folic acid conjugated PAMAM modified with borneol, a nature dual-functional product of reducing PAMAM toxicity and boosting BBB penetration.

  2016cited by this paper
• PEGylated PAMAM dendrimers: Enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery.

  2016cited by this paper
• Accumulating nanoparticles by EPR: A route of no return.

  2016cited by this paper
• Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs.

  2016cited by this paper
• Dendritic, Oligomeric, and Polymeric Self-Immolative Molecular Amplification.

  2016cited by this paper
• Review on concrete nanotechnology

  2016cited by this paper
• Pulmonary delivery of rifampicin microspheres using lower generation polyamidoamine dendrimers as a carrier

  2016cited by this paper
• Dendrimers in Nanomedicine

  2016cited by this paper
• Ligand anchored poly(propyleneimine) dendrimers for brain targeting: Comparative in vitro and in vivo assessment.

  2016cited by this paper
• Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer?

  2016cited by this paper
• Surface functionality affects the biodistribution and microglia-targeting of intra-amniotically delivered dendrimers.

  2016cited by this paper
• Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution.

  2016cited by this paper
• Nanocarriers for cancer-targeted drug delivery

  2016cited by this paper
• Dendrimers – from organic synthesis to pharmaceutical applications: an update

  2015cited by this paper
• Glyconanosynthons as powerful scaffolds and building blocks for the rapid construction of multifaceted, dense and chiral dendrimers.

  2015cited by this paper
• Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles.

  2015cited by this paper
• Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls

  2015cited by this paper
• Recent Advances in Dendrimer Research for Cardiovascular Diseases.

  2015cited by this paper
• A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep

  2015cited by this paper
• Evaluation of cationic polyamidoamine dendrimers’ dermal toxicity in the rat skin model

  2015cited by this paper
• Nanomedicine and drug delivery: a mini review

  2014cited by this paper
• Dendrimers: synthesis, applications, and properties

  2014cited by this paper
• Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target?

  2013cited by this paper
• In vivo distribution and toxicity of PAMAM dendrimers in the central nervous system depend on their surface chemistry.

  2013cited by this paper
• Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry

  2013cited by this paper
• Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview.

  2013cited by this paper
• Nanomedicine for Drug Delivery and Therapeutics: Mishra/Nanomedicine

  2013cited by this paper
• “Janus” dendrimers: syntheses and properties

  2012cited by this paper
• Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging.

  2012cited by this paper
• Biocompatible polyurea dendrimers with pH-dependent fluorescence.

  2012cited by this paper
• Multifunctional dendritic polymers in nanomedicine: opportunities and challenges.

  2012cited by this paper
• Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers.

  2012cited by this paper
• Nanoparticle PEGylation for imaging and therapy.

  2011cited by this paper
• Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties.

  2011cited by this paper
• Nanomedicine(s) under the microscope.

  2011cited by this paper
• Biomedical applications of dendrimers: a tutorial.

  2011cited by this paper
• A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis

  2011cited by this paper
• Polyamidoamine dendrimers as gene delivery carriers in the inner ear: How to improve transfection efficiency.

  2011cited by this paper
• Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker.

  2011cited by this paper
• Designing Dendrimers for Drug Delivery and Imaging: Pharmacokinetic Considerations

  2011cited by this paper
• Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer.

  2010cited by this paper
• Poly propyl ether imine (PETIM) dendrimer: a novel non-toxic dendrimer for sustained drug delivery.

  2010cited by this paper
• In vitro mammalian cytotoxicological study of PAMAM dendrimers - towards quantitative structure activity relationships.

  2010cited by this paper
• Mechanistic insight into cell growth, internalization, and cytotoxicity of PAMAM dendrimers.

  2010cited by this paper
• Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes.

  2010cited by this paper
• Dendrimer toxicity: Let's meet the challenge.

  2010cited by this paper
• The 8 year thicket of triazine dendrimers: strategies, targets and applications

  2010cited by this paper
• Understanding specific and nonspecific toxicities: a requirement for the development of dendrimer-based pharmaceuticals.

  2010cited by this paper
• Biological properties of phosphorus dendrimers

  2010cited by this paper
• PAMAM dendrimers — diverse biomedical applications. Facts and unresolved questions

  2009cited by this paper
• Understanding biophysicochemical interactions at the nano-bio interface.

  2009cited by this paper
• Effects of nanomaterial physicochemical properties on in vivo toxicity.

  2009cited by this paper
• Surface-Engineered Dendrimers: a Solution for Toxicity Issues

  2009cited by this paper
• Delivery technologies for biopharmaceuticals

  2009cited by this paper
• Therapeutic and diagnostic applications of dendrimers for cancer treatment.

  2008cited by this paper
• Synthesis and characterization of nanoscale dendritic RGD clusters for potential applications in tissue engineering and drug delivery

  2007cited by this paper
• Glycoconjugated peptide dendrimers-based nanoparticulate system for the delivery of chloroquine phosphate.

  2007cited by this paper
• VivaGel™ (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection

  2007cited by this paper
• Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging.

  2007cited by this paper
• Influence of molecular architecture of polyether-co-polyester dendrimers on the encapsulation and release of methotrexate.

  2007cited by this paper
• Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability.

  2007cited by this paper
• Targeted nanoparticles for cancer therapy

  2007cited by this paper
• Developmental toxicity of low generation PAMAM dendrimers in zebrafish.

  2007cited by this paper
• Synthesis and characterization of water-soluble and photostable L-DOPA dendrimers.

  2006cited by this paper
• Transport of Poly(Amidoamine) Dendrimers across Caco-2 Cell Monolayers: Influence of Size, Charge and Fluorescent Labeling

  2006cited by this paper
• Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration.

  2006cited by this paper
• Design of phosphorylated dendritic architectures to promote human monocyte activation

  2006cited by this paper
• Water-soluble dendrimeric two-photon tracers for in vivo imaging.

  2006cited by this paper
• A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

  2006cited by this paper
• PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice.

  2006cited by this paper
• Dendrimers in biomedical applications--reflections on the field.

  2005cited by this paper
• Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer.

  2005cited by this paper
• Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting.

  2005cited by this paper
• Dendrimer biocompatibility and toxicity.

  2005cited by this paper
• Designing dendrimers for biological applications

  2005cited by this paper
• Water-soluble phosphorus-containing dendrimers

  2005cited by this paper
• Dendrimers and dendritic polymers in drug delivery.

  2005cited by this paper
• New trends in carbohydrate-based vaccines.

  2004cited by this paper
• Reduction of drug toxicity using dendrimers based on melamine.

  2004cited by this paper
• Cytotoxicity, hemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery.

  2004cited by this paper
• Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport.

  2004cited by this paper
• 3H Dendrimer Nanoparticle Organ/Tumor Distribution

  2004cited by this paper
• Preliminary evaluation of the behavior of fifth-generation thiophosphate dendrimer in biological systems.

  2004cited by this paper
• Engineering of Dendrimer Surfaces to Enhance Transepithelial Transport and Reduce Cytotoxicity

  2003cited by this paper
• "Lego" chemistry for the straightforward synthesis of dendrimers.

  2003cited by this paper
• The influence of surface modification on the cytotoxicity of PAMAM dendrimers.

  2003cited by this paper
• A PEGylated dendritic nanoparticulate carrier of fluorouracil.

  2003cited by this paper
• Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers.

  2002cited by this paper
• Polyester dendritic systems for drug delivery applications: design, synthesis, and characterization.

  2002cited by this paper
• Convergent dendrons and dendrimers: from synthesis to applications.

  2001cited by this paper
• Transport of poly amidoamine dendrimers across Madin-Darby canine kidney cells.

  2001cited by this paper

• Deuterated Nanopolymers for Renal and Lymphatic Imaging via Quantitative Deuterium MRI

  2025cites this paper
• Advances in nanomaterials for precision drug delivery: Insights into pharmacokinetics and toxicity

  2024cites this paper
• Effect of polyphenolic dendrimers on biological and artificial lipid membranes.

  2024cites this paper
• EFFECT OF PEGYLATED POLYPROPYLENE IMINE DENDRITIC ARCHITECTURE ON PHARMACOKINETICS OF PYRAZINAMIDE ON RABBITS

  2024cites this paper
• Aza-Michael promoted glycoconjugation of PETIM dendrimers and selectivity in mycobacterial growth inhibitions

  2023cites this paper
• Dendrimer-Mediated Delivery of DNA and RNA Vaccines

  2023cites this paper
• Physicochemical properties, pharmacokinetics, toxicology and application of nanocarriers.

  2023cites this paper
• Heparin-Coated Dendronized Hyperbranched Polymers for Antimalarial Targeted Delivery

  2022cites this paper
• PAMAM Dendrimers: A review of methodologies employed in biopharmaceutical classification.

  2022cites this paper
• Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death

  2022cites this paper
• Activation of the cGAS-STING pathway combined with CRISPR-Cas9 gene editing triggering long-term immunotherapy.

  2022cites this paper
• Toxicity of polyamidoamine dendrimers in vivo

  2022cites this paper
• A review on recent advances in nanomedicines for the treatment of pulmonary tuberculosis

  2022cites this paper
• Amphiphilic Triazine-Phosphorus Metallodendrons Possessing Anti-Cancer Stem Cell Activity

  2022cites this paper
• Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers

  2022cites this paper
• Triazine–Carbosilane Dendrimersomes Enhance Cellular Uptake and Phototoxic Activity of Rose Bengal in Basal Cell Skin Carcinoma Cells

  2022cites this paper
• First-in-Class Phosphorus Dendritic Framework, a Wide Surface Functional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn?

  2021cites this paper
• Synthesis and Shaping of Core-Shell Tecto Dendrimers for Biomedical Applications.

  2021cites this paper
• Facile Synthesis of Amphiphilic Fluorescent Phosphorus Dendron-Based Micelles as Antiproliferative Agents: First Investigations.

  2021cites this paper
• First-in-class and best-in-class dendrimer nanoplatforms from concept to clinic: Lessons learned moving forward.

  2021cites this paper
• There and back again: a dendrimer’s tale

  2021cites this paper
• Cationic Dendrimers for siRNA Delivery: An Overview of Methods for In Vitro/In Vivo Characterization.

  2021cites this paper
• Coordination-based molecular nanomaterials for biomedically relevant applications

  2021cites this paper
• Fate of Biomaterials Post Payload Delivery: Current Understanding and Future Perspectives

  2021cites this paper
• Safe Polycationic Dendrimers as Potent Oral In Vivo Inhibitors of Mycobacterium tuberculosis: A New Therapy to Take Down Tuberculosis.

  2021cites this paper
• Polymeric Materials as Potential Inhibitors Against SARS-CoV-2

  2021cites this paper
• Dendrimer– and polymeric nanoparticle–aptamer bioconjugates as nonviral delivery systems: a new approach in medicine

  2020cites this paper
• In vivo therapeutic applications of phosphorus dendrimers: state of the art.

  2020cites this paper
• New insights into the blue intrinsic fluorescence of oxidized PAMAM dendrimers considering their use as bionanomaterials.

  2020cites this paper
• Exosomes from different cells: Characteristics, modifications, and therapeutic applications.

  2020cites this paper
• MALDI-MS Imaging Analysis of Noninflammatory Type III Rotaxane Dendrimers.

  2020cites this paper
• Dendrimers towards translational nanotherapeutics: Concise key step analysis.

  2020cites this paper
• Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled In Silico-Experimental Studies. Part I: Covalent siRNA Nanocarriers

  2019cites this paper
• Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

  2019cites this paper
• Dendrimers and hyperbranched structures for biomedical applications

  2019cites this paper
• Dendrimer-Enabled Therapeutic Antisense Delivery Systems as Innovation in Medicine.

  2019cites this paper