Folding of copper proteins: role of the metal?

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Quarterly Reviews of Biophysics (print)

• Publication date

  2018-03-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1017/S0033583518000021PMID 30912494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• superoxide dismutase

  2020cited by this paper
• Synergistic Effects of Copper Sites on Apparent Stability of Multicopper Oxidase, Fet3p

  2018cited by this paper
• Chaperonin studies: faith, luck, and a little help from our friends

  2017cited by this paper
• Unraveling amyloid formation paths of Parkinson's disease protein α-synuclein triggered by anionic vesicles

  2017cited by this paper
• Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein.

  2017cited by this paper
• Unfolding the chaperone story

  2017cited by this paper
• Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A

  2017cited by this paper
• The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics

  2017cited by this paper
• Defining the human copper proteome and analysis of its expression variation in cancers.

  2017cited by this paper
• Copper chaperone Atox1 plays role in breast cancer cell migration.

  2017cited by this paper
• Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast.

  2017cited by this paper
• Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells

  2016influential reference
• Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics

  2016cited by this paper
• Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics.

  2016cited by this paper
• The coming of age of de novo protein design

  2016cited by this paper
• Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B.

  2016cited by this paper
• The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1

  2016influential reference
• Extended functional repertoire for human copper chaperones

  2016cited by this paper
• Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease

  2016cited by this paper
• Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity

  2016cited by this paper
• Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's Disease

  2016cited by this paper
• Targeting copper in cancer therapy: 'Copper That Cancer'.

  2015influential reference
• Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.

  2015cited by this paper
• Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System*

  2015cited by this paper
• Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function

  2015cited by this paper
• Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts

  2015cited by this paper
• CopC protein from Pseudomonas fluorescens SBW25 features a conserved novel high-affinity Cu(II) binding site.

  2015cited by this paper
• Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro.

  2015cited by this paper
• The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion

  2015cited by this paper
• Enthalpy-entropy compensation at play in human copper ion transfer

  2015cited by this paper
• Binuclear Cu(A) Formation in Biosynthetic Models of Cu(A) in Azurin Proceeds via a Novel Cu(Cys)2His Mononuclear Copper Intermediate.

  2015cited by this paper
• Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase

  2015cited by this paper
• Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro

  2015cited by this paper
• Copper(I/II), α/β‐Synuclein and Amyloid‐β: Menage à Trois?

  2015cited by this paper
• Searching for harmony in transition-metal signaling.

  2015cited by this paper
• Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

  2015cited by this paper
• Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?

  2015cited by this paper
• EPR spectroscopy shows that the blood carrier protein, human serum albumin, closely interacts with the N-terminal domain of the copper transporter, Ctr1.

  2015influential reference
• Molecular simulations of metal-coupled protein folding.

  2015cited by this paper
• Differences in the binding of copper(I) to α- and β-synuclein.

  2015cited by this paper
• NMR studies of protein folding and binding in cells and cell-like environments.

  2015cited by this paper
• Synthetic crowding agent dextran causes excluded volume interactions exclusively to tracer protein apoazurin

  2014cited by this paper
• Copper as a key regulator of cell signalling pathways

  2014cited by this paper
• Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu(I).

  2014cited by this paper
• Metalloproteins Containing Cytochrome, Iron–Sulfur, or Copper Redox Centers

  2014cited by this paper
• Cisplatin handover between copper transporters: the effect of reducing agents

  2014cited by this paper
• Protein design: toward functional metalloenzymes.

  2014cited by this paper
• T versus D in the MTCXXC motif of copper transport proteins plays a role in directional metal transport

  2014influential reference
• Interactions between Metal-binding Domains Modulate Intracellular Targeting of Cu(I)-ATPase ATP7B, as Revealed by Nanobody Binding*

  2014cited by this paper
• Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways

  2014cited by this paper
• Copper and Copper Proteins in Parkinson's Disease

  2014cited by this paper
• Identification of the Valence and Coordination Environment of the Particulate Methane Monooxygenase Copper Centers by Advanced EPR Characterization

  2014cited by this paper
• Copper active sites in biology.

  2014cited by this paper
• A revised picture of the Cu(II)-α-synuclein complex: the role of N-terminal acetylation.

  2014cited by this paper
• Macromolecular crowding effects on two homologs of ribosomal protein s16: protein-dependent structural changes and local interactions.

  2014cited by this paper
• Small pH and salt variations radically alter the thermal stability of metal-binding domains in the copper transporter, Wilson disease protein.

  2013cited by this paper
• Mechanisms of copper homeostasis in bacteria

  2013cited by this paper
• Quantification of excluded volume effects on the folding landscape of Pseudomonas aeruginosa apoazurin in vitro.

  2013cited by this paper
• Interaction between the anticancer drug Cisplatin and the copper chaperone Atox1 in human melanoma cells.

  2013cited by this paper
• Copper binding promotes the interaction of cisplatin with human copper chaperone Atox1.

  2013cited by this paper
• Interaction Between Anticancer Drug Cisplatin and Copper Chaperone Atox 1 in Human Melanoma Cells

  2013cited by this paper
• Direct observation of protein unfolded state compaction in the presence of macromolecular crowding.

  2013cited by this paper
• Ion Pathways in the Sarcoplasmic Reticulum Ca2+-ATPase*

  2013cited by this paper
• The influence of protein folding on the copper affinities of trafficking and target sites.

  2013cited by this paper
• Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of CuI‐Loaded hCCS Domain 1 and Analysis of Disulfide‐Free hSOD1 Mutants

  2013cited by this paper
• Determinants for Simultaneous Binding of Copper and Platinum to Human Chaperone Atox1: Hitchhiking not Hijacking

  2013influential reference
• α-Synuclein as a ferrireductase.

  2013cited by this paper
• Effects of macromolecular crowding agents on protein folding in vitro and in silico

  2013cited by this paper
• Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.

  2013cited by this paper
• An Expanding Range of Functions for the Copper Chaperone/Antioxidant Protein Atox1

  2013cited by this paper
• Localization of copper and copper transporters in the human brain.

  2013cited by this paper
• Copper(I)-α-synuclein interaction: structural description of two independent and competing metal binding sites.

  2013cited by this paper
• Cellular distribution of copper to superoxide dismutase involves scaffolding by membranes

  2013influential reference
• Copper Is Required for Cobalt-Induced Transcriptional Activity of Hypoxia-Inducible Factor-1

  2012cited by this paper
• Effects of macromolecular crowding on the structural stability of human α-lactalbumin.

  2012cited by this paper
• Role of metal in folding and stability of copper proteins in vitro.

  2012cited by this paper
• Copper binding traps the folded state of the SCO protein from Bacillus subtilis.

  2012cited by this paper
• In Vitro Thermodynamic Dissection of Human Copper Transfer from Chaperone to Target Protein

  2012influential reference
• Reaction of platinum anticancer drugs and drug derivatives with a copper transporting protein, Atox1.

  2012influential reference
• A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

  2012cited by this paper
• Unexpected effects of macromolecular crowding on protein stability.

  2012cited by this paper
• Dynamics and stability of the metal binding domains of the Menkes ATPase and their interaction with metallochaperone HAH1.

  2012cited by this paper
• Role of Copper Transport Protein Antioxidant 1 in Angiotensin II–Induced Hypertension: A Key Regulator of Extracellular Superoxide Dismutase

  2012cited by this paper
• Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation

  2012cited by this paper
• Metal ions as modulators of protein conformation and misfolding in neurodegeneration

  2012influential reference
• Visualizing metal ions in cells: an overview of analytical techniques, approaches, and probes.

  2012cited by this paper
• Structural models of the human copper P-type ATPases ATP7A and ATP7B

  2012cited by this paper
• Macromolecular crowding and protein stability.

  2012cited by this paper
• Dynamic multibody protein interactions suggest versatile pathways for copper trafficking.

  2012cited by this paper
• In-cell NMR spectroscopy in Escherichia coli.

  2012influential reference
• Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS)

  2012cited by this paper
• Molecular Events Initiating Exit of a Copper-transporting ATPase ATP7B from the Trans-Golgi Network*

  2012cited by this paper
• Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

  2012cited by this paper
• Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components

  2011cited by this paper
• Functional Role of Two Interhelical Disulfide Bonds in Human Cox17 Protein from a Structural Perspective*

  2011influential reference
• Protein stability and folding kinetics in the nucleus and endoplasmic reticulum of eucaryotic cells.

  2011cited by this paper
• Copper: an essential metal in biology.

  2011cited by this paper
• Lysyl oxidase: a potential target for cancer therapy

  2011cited by this paper
• In-cell NMR in E. coli to Monitor Maturation Steps of hSOD1

  2011influential reference
• Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

  2011cited by this paper

• Synergistic Dual Ag/Cu Ion Implantation to Enhance Antimicrobial Defense on Boston Keratoprosthesis

  2025cites this paper
• Cuproptosis-related genes associated with mitochondrial dysfunction in Parkinson’s disease

  2025cites this paper
• Inhibitory mechanism of tyrosinase-induced browning in Agaricus bisporus by garlic-derived H2S: Nucleophilic attack leading to catalytic-cu flexible loop collapse and thiol-persulfidation.

  2025cites this paper
• Downregulation of Parahippocampal Copper Chaperone for Superoxide Dismutase in Alzheimer’s Disease

  2025cites this paper
• Copper mediated follicular atresia: Implications for granulosa cell death.

  2024cites this paper
• Intensified functional expression of recombinant Zymomonas mobilis zinc-dependent alcohol dehydrogenase I.

  2024cites this paper
• Catalytic mechanism of tyrosinases.

  2024cites this paper
• Comprehensiveness cuproptosis related genes study for prognosis and medication sensitiveness across cancers, and validation in prostate cancer

  2024cites this paper
• Integrating reduced amino acid composition into PSSM for improving copper ion-binding protein prediction.

  2023cites this paper
• Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease.

  2023cites this paper
• Modulation of biomolecular phase behavior by metal ions.

  2023cites this paper
• Construction of a Cuproptosis-Related Gene Signature for Predicting Prognosis in Gastric Cancer

  2023cites this paper
• Design of a Flexible, Zn-Selective Protein Scaffold that Displays Anti-Irving-Williams Behavior.

  2022cites this paper
• Highly Sensitive and Specific Responses of Oyster Hemocytes to Copper Exposure: Single-Cell Transcriptomic Analysis of Different Cell Populations.

  2022cites this paper
• Rapid self-calibrating fluorescent detection of copper (II) ions in wine with high accuracy.

  2022cites this paper
• Investigations of cellular copper metabolism in ovarian cancer cells using a ratiometric fluorescent copper dye

  2022cites this paper
• ATP7A-Regulated Enzyme Metalation and Trafficking in the Menkes Disease Puzzle

  2021cites this paper
• The Zero-Order Loop in Apoazurin Modulates Folding Mechanism In Silico.

  2021cites this paper
• A novel multi-stimuli-responsive organogel sensor for detecting Cu2+ and Co2+ based on benzotriazole derivative

  2021cites this paper
• Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications

  2021cites this paper
• Study on metal binding capacity of the freshwater crab Sinopotamon henanense’s recombinant copper specific binding metallothionein expressed in Escherichia coli

  2021cites this paper
• Zinc Determines Dynamical Properties and Aggregation Kinetics of Human Insulin

  2020cites this paper
• 3D domain swapping of azurin from Alcaligenes xylosoxidans.

  2020cites this paper
• Domain-swapped Alcaligenes xylosoxidans azurin dimer

  2020cites this paper
• Cholinesterase from the Liver of Diodon hystrix for Detection of Metal Ions

  2020cites this paper
• Multimodal Response to Copper Binding in Superoxide Dismutase Dynamics.

  2020cites this paper
• The emerging value of copper-64 for molecular imaging and therapy.

  2020cites this paper
• Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess

  2020cites this paper
• Copper Chaperone Atox1 Interacts with Cell Cycle Proteins

  2018cites this paper
• Platinum drugs, copper transporters and copper chelators

  2018cites this paper