Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF‐κB‐independent, FoxO1‐dependent mechanism

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Cellular Physiology

• Publication date

  2006-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcp.20757
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation.

  2005cited by this paper
• Improved muscle healing through enhanced regeneration and reduced fibrosis in myostatin-null mice

  2005cited by this paper
• Regulation of GDF-8 signaling by the p38 MAPK.

  2005cited by this paper
• Ubiquitin signalling in the NF-κB pathway

  2005cited by this paper
• The Ankrd2, Cdkn1c and calcyclin genes are under the control of MyoD during myogenic differentiation.

  2005cited by this paper
• Ubiquitin signalling in the NF-kappaB pathway.

  2005cited by this paper
• TNF- acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle

  2005cited by this paper
• Myostatin and NF-κB Regulate Skeletal Myogenesis Through Distinct Signaling Pathways

  2005cited by this paper
• Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

  2004influential reference
• Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis.

  2004cited by this paper
• Myostatin inhibits rhabdomyosarcoma cell proliferation through an Rb-independent pathway

  2004cited by this paper
• Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex.

  2004influential reference
• Myostatin mutation associated with gross muscle hypertrophy in a child.

  2004cited by this paper
• Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

  2004cited by this paper
• The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.

  2004cited by this paper
• The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo.

  2003cited by this paper
• Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression.

  2003cited by this paper
• The calpain system.

  2003cited by this paper
• The 'cancer cachectic factor'

  2003cited by this paper
• Myostatin negatively regulates satellite cell activation and self-renewal

  2003cited by this paper
• Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy.

  2002cited by this paper
• Molecular regulation of muscle cachexia: it may be more than the proteasome.

  2002cited by this paper
• Induction of Cachexia in Mice by Systemically Administered Myostatin

  2002influential reference
• Myostatin Inhibits Myoblast Differentiation by Down-regulating MyoD Expression*

  2002cited by this paper
• Anticytokine treatment prevents the increase in the activity of ATP-ubiquitin- and Ca(2+)-dependent proteolytic systems in the muscle of tumour-bearing rats.

  2002cited by this paper
• Functional improvement of dystrophic muscle by myostatin blockade

  2002cited by this paper
• Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting.

  2002cited by this paper
• Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression.

  2002cited by this paper
• Peroxisome proliferator-activated receptor gamma ligands differentially modulate muscle cell differentiation and MyoD gene expression via peroxisome proliferator-activated receptor gamma -dependent and -independent pathways.

  2001cited by this paper
• Effects of resistance training on the rate of muscle protein synthesis in frail elderly people.

  2001cited by this paper
• Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients.

  2001cited by this paper
• Myogenic satellite cells: physiology to molecular biology.

  2001cited by this paper
• Myostatin, insulin‐like growth factor‐1, and leukemia inhibitory factor mRNAs are upregulated in chronic human disuse muscle atrophy

  2001cited by this paper
• Peroxisome Proliferator-activated Receptor γ Ligands Differentially Modulate Muscle Cell Differentiation and MyoD Gene Expression via Peroxisome Proliferator-activated Receptor γ-dependent and -independent Pathways

  2001cited by this paper
• Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

  2001cited by this paper
• Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

  2001cited by this paper
• NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes.

  2000cited by this paper
• Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight.

  2000cited by this paper
• Modulation of myostatin expression during modified muscle use

  2000cited by this paper
• NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.

  2000influential reference
• MyoD(-/-) satellite cells in single-fiber culture are differentiation defective and MRF4 deficient.

  2000cited by this paper
• Cultured myf5 null and myoD null muscle precursor cells display distinct growth defects

  2000cited by this paper
• Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation*

  2000cited by this paper
• NF-κB mediates the protein loss induced by TNF-α in differentiated skeletal muscle myotubes

  2000cited by this paper
• The cancer anorexia-cachexia syndrome.

  2000cited by this paper
• NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

  1999cited by this paper
• Use of recombinant human soluble TNF receptor in anorectic tumor-bearing rats.

  1999cited by this paper
• Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading.

  1999cited by this paper
• Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration.

  1999cited by this paper
• Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats.

  1999influential reference
• Transgenic rescue of congenital heart disease and spina bifida in Splotch mice.

  1999cited by this paper
• Myostatin, a transforming growth factor‐β superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct

  1999cited by this paper
• Multiple Roles for the MyoD Basic Region in Transmission of Transcriptional Activation Signals and Interaction with MEF2

  1998cited by this paper
• Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha.

  1998cited by this paper
• Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α

  1998cited by this paper
• Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.

  1998influential reference
• Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD.

  1997cited by this paper
• A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

  1997cited by this paper
• Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.

  1997cited by this paper
• Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue.

  1997cited by this paper
• A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

  1997cited by this paper
• Identification and characterization of an IkappaB kinase.

  1997cited by this paper
• Identification and Characterization of an IκB Kinase

  1997cited by this paper
• Proinflammatory cytokines, nutritional support, and the cachexia syndrome

  1997cited by this paper
• The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

  1997cited by this paper
• The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.

  1997cited by this paper
• MyoD is required for myogenic stem cell function in adult skeletal muscle.

  1996influential reference
• Pax3 Inhibits Myogenic Differentiation of Cultured Myoblast Cells (*)

  1995cited by this paper
• Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

  1995cited by this paper
• Altered macrophage activity and tumor necrosis factor: tumor necrosis and host cachexia.

  1989cited by this paper
• Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

  1977cited by this paper

• The therapeutic potential of Myoki, a novel peptide in muscle atrophy: mechanisms and applications.

  2026cites this paper
• ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the common marmoset (Callithrix jacchus)

  2026cites this paper
• Nuclear Factor κB Signaling Revisited: Its Role in Skeletal Muscle and Exercise.

  2025cites this paper
• Androgens as the “old age stick” in skeletal muscle

  2025cites this paper
• Research Progress on Myokines and Chronic Kidney Disease

  2025cites this paper
• Irisin: muscle’s novel player in endoplasmic reticulum stress and disease

  2025cites this paper
• Mechanisms, assessment, and exercise interventions for skeletal muscle dysfunction post-chemotherapy in breast cancer: from inflammation factors to clinical practice

  2025cites this paper
• Mitigating Doxorubicin-Induced Skeletal Muscle Toxicity: A Review of Oxidative Stress Mechanisms and the Therapeutic Role of Exercise

  2025cites this paper
• Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies

  2025cites this paper
• Aging: a Struggle for Beneficial to Overcome Negative Factors made by Muscle and Bone.

  2025cites this paper
• Endurance exercise remodels skeletal muscle by suppressing Ythdf1-mediated myostatin expression

  2025cites this paper
• Side effects of glucocorticoids: in vivo models and underlying mechanisms

  2025cites this paper
• Mechanisms of endurance and resistance exercise in type 2 diabetes mellitus: A Narrative review.

  2025cites this paper
• Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia

  2025cites this paper
• Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets.

  2024cites this paper
• Glycyrrhiza uralensis extract improves dexamethasone-induced sarcopenia via regulating myostatin- and FoxO3a-mediated E3 ubiquitin ligase

  2024cites this paper
• Significance of dietary quinoa husk (Chenopodium quinoa) in gene regulation for stress mitigation in fish

  2024cites this paper
• Effect of the combination of Lithospermum erythrorhizon and Lonicera japonica on dexamethasone-induced muscle atrophy in mice

  2024cites this paper
• IGF-1 and myostatin-mediated co-regulation in skeletal muscle and bone of Daurian ground squirrels (Spermophilus dauricus) during different hibernation stages.

  2024cites this paper
• Improving lambs’ temperament, performance, and fecundity under three different housing conditions via oxidative stress reduction, metabolic and growth genes regulation by turmeric supplementation

  2024cites this paper
• Understanding the molecular mechanism of arsenic and ammonia toxicity and high-temperature stress in Pangasianodon hypophthalmus

  2024cites this paper
• Photobiomodulation therapy moderates cancer cachexia-associated muscle wasting through activating PI3K/AKT/FoxO3a pathway

  2024cites this paper
• The Influence of Stress and Binge-Patterned Alcohol Drinking on Mouse Skeletal Muscle Protein Synthesis and Degradation Pathways

  2024cites this paper
• LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice

  2024cites this paper
• Effects of Resistance Exercise and Essential Amino Acid Intake on Muscle Quality, Myokine, and Inflammation Factors in Young Adult Males

  2024cites this paper
• The Role of TGF-β Signaling in Muscle Atrophy, Sarcopenia and Cancer Cachexia.

  2024cites this paper
• Restoring Skeletal Muscle Health through Exercise in Breast Cancer Patients and after Receiving Chemotherapy

  2024cites this paper
• KLF10: a point of convergence in cancer cachexia

  2024cites this paper
• In Vitro Models for Cancer-Associated Cachexia: The Complex Modelling of a Multiorgan Syndrome

  2024cites this paper
• Pathological studies on skeletal muscle atrophy in common fish products from El-Jubail Province, Saudi Arabia

  2024cites this paper
• Direct comparison of the diagnostic performance of growth differentiation factor 8 in pediatric versus adult heart failure.

  2024cites this paper
• Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis

  2024cites this paper
• Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy.

  2023cites this paper
• [GDF5: a therapeutic candidate for combating sarcopenia].

  2023cites this paper
• Skeletal muscle growth activity of Olive Flounder (Paralichthys olivaceus) meat digest

  2023cites this paper
• Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review

  2023cites this paper
• Inhibiting myostatin signaling partially mitigates structural and functional adaptations to hindlimb suspension in mice

  2023cites this paper
• A causative role for periarticular skeletal muscle weakness in the progression of joint damage and pain in OA

  2023cites this paper
• Myostatin-mediated regulation of skeletal muscle damage post-acute Aeromonas hydrophila infection in Nile tilapia (Oreochromis niloticus L.)

  2023cites this paper
• A single bout of prior resistance exercise attenuates muscle atrophy and declines in myofibrillar protein synthesis during bed‐rest in older men

  2023influential citation
• Growth Traits and Sperm Proteomics Analyses of Myostatin Gene-Edited Chinese Yellow Cattle

  2022cites this paper
• Tumor cell anabolism and host tissue catabolism-energetic inefficiency during cancer cachexia

  2022cites this paper
• Clinical-Like Cryotherapy in Acute Knee Arthritis Protects Neuromuscular Junctions of Quadriceps and Reduces Joint Inflammation in Mice

  2022cites this paper
• Myostatin: Basic biology to clinical application.

  2022cites this paper
• Osteosarcopenia in autoimmune cholestatic liver diseases: Causes, management, and challenges

  2022cites this paper
• Sex-specific role of myostatin signaling in neonatal muscle growth, denervation atrophy, and neuromuscular contractures

  2022cites this paper
• Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis

  2022cites this paper
• Sarcopenia in the setting of nonalcoholic fatty liver

  2022cites this paper
• Inflammation in chronic kidney disease

  2022cites this paper
• Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

  2022cites this paper
• Skeletal muscle and metabolic flexibility in response to changing energy demands in wild birds

  2022cites this paper
• Acute In Vitro and In Vivo Effects of Dexamethasone in the Vocal Folds: a Pilot Study

  2022cites this paper
• Myostatin: a multifunctional role in human female reproduction and fertility – a short review

  2022cites this paper
• Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression.

  2022cites this paper
• The Effects of Dietary Supplements, Nutraceutical Agents, and Physical Exercise on Myostatin Levels: Hope or Hype?

  2022cites this paper
• Causes and treatment of protein-energy wasting in kidney disease

  2022cites this paper
• Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies

  2022cites this paper
• Redox Signaling and Sarcopenia: Searching for the Primary Suspect

  2021cites this paper
• Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance

  2021cites this paper
• Regulation of Myostatin on the Growth and Development of Skeletal Muscle

  2021cites this paper
• High glucose induces apoptosis, glycogen accumulation and suppresses protein synthesis in muscle cells of olive flounder Paralichthys olivaceus

  2021cites this paper
• Myostatin gene inactivation increases post-mortem calpain-dependent muscle proteolysis in mice.

  2021cites this paper
• Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice

  2021cites this paper
• The Effects of Marine Algal Polyphenols, Phlorotannins, on Skeletal Muscle Growth in C2C12 Muscle Cells via Smad and IGF-1 Signaling Pathways

  2021cites this paper
• Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification

  2021cites this paper
• Myostatin increases the expression of matrix metalloproteinase genes to promote preadipocytes differentiation in pigs

  2021cites this paper
• Myostatin and Related Factors Are Involved in Skeletal Muscle Protein Breakdown in Growing Broilers Exposed to Constant Heat Stress

  2021cites this paper
• Anticachectic regulator analysis reveals Perp-dependent antitumorigenic properties of 3-methyladenine in pancreatic cancer

  2021cites this paper
• Isolation and Characterization of Compounds from Glycyrrhiza uralensis as Therapeutic Agents for the Muscle Disorders

  2021cites this paper
• Molecular Mechanisms of Muscle Fatigue

  2021cites this paper
• Amino acids in acute-on-chronic liver failure: Another piece of the puzzle?

  2021cites this paper
• Nutraceuticals for the treatment of sarcopenia in chronic liver disease.

  2021cites this paper
• Sarcopenia; functional concerns, molecular mechanisms involved, and seafood as a nutritional intervention – review article

  2021cites this paper
• H19X‐encoded miR‐322(424)/miR‐503 regulates muscle mass by targeting translation initiation factors

  2021cites this paper
• CT Attenuation and Cross-sectional-area Index of the Pectoralis Are Associated With Prognosis in Sarcoma Patients

  2021cites this paper
• Ishige okamurae and diphloroethohydoxycarmalol inhibit palmitic acid-impaired skeletal myogenesis and improve muscle regenerative potential

  2021cites this paper
• Exercise Training as Therapeutic Approach in Cancer Cachexia: A Review of Potential Anti-inflammatory Effect on Muscle Wasting

  2021cites this paper
• Myokines: A potential key factor in development, treatment, and biomarker of sarcopenia

  2021cites this paper
• Sarcopenia and the inflammatory cytokines

  2021cites this paper
• FKBP51 and the molecular chaperoning of metabolism.

  2021cites this paper
• Shared and Distinct Mechanisms of Skeletal Muscle Atrophy: A Narrative Review.

  2021cites this paper
• Principles of the activin receptor signaling pathway and its inhibition.

  2021cites this paper
• Degradation of ribosome and chaperone proteins is attenuated during the Differentiation of Replicatively Aged C2C12 Myoblasts

  2021cites this paper
• Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs

  2021cites this paper
• MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle

  2020cites this paper
• TGF-β Regulates Collagen Type I Expression in Myoblasts and Myotubes via Transient Ctgf and Fgf-2 Expression

  2020cites this paper
• Muscle protein breakdown is impaired during immobilization compared to during a subsequent retraining period in older men: no effect of anti-inflammatory medication

  2020cites this paper
• MT‐102 prevents tissue wasting and improves survival in a rat model of severe cancer cachexia

  2020influential citation
• Skeletal Muscle Disuse Atrophy and the Rehabilitative Role of Protein in Recovery from Musculoskeletal Injury.

  2020cites this paper
• Muscle Atrophy

  2020influential citation
• The effect of high intensity interval training on some atrophic and anti-atrophic gene expression in rat skeletal muscle with diabetes

  2020cites this paper
• The effect of short‐term exercise prehabilitation on skeletal muscle protein synthesis and atrophy during bed rest in older men

  2020cites this paper
• Myostatin-1 Inhibits Cell Proliferation by Inhibiting the mTOR Signal Pathway and MRFs, and Activating the Ubiquitin-Proteasomal System in Skeletal Muscle Cells of Japanese Flounder Paralichthys olivaceus

  2020cites this paper
• Comparative analysis of activin receptor type-IIA gene expression in two distinct chicken lines

  2020cites this paper
• Muscular weakness and muscle wasting in the critically ill

  2020cites this paper
• Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies.

  2020cites this paper
• Exercise Reduces the Resumption of Tumor Growth and Proteolytic Pathways in the Skeletal Muscle of Mice Following Chemotherapy

  2020cites this paper
• Sarcopenia - Molecular Mechanisms and Open Questions.

  2020cites this paper
• Skeletal Muscle and the Effects of Ammonia Toxicity in Fish, Mammalian, and Avian Species: A Comparative Review Based on Molecular Research

  2020cites this paper
• Cellular and molecular features of neurogenic skeletal muscle atrophy.

  2020cites this paper