Epigenetic regulation of the innate immune response to infection

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Nature reviews. Immunology

• Publication date

  2019-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s41577-019-0151-6PMID 30918351
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

  2019cited by this paper
• Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation

  2018cited by this paper
• The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

  2018cited by this paper
• Epigenetic control of CD8+ T cell differentiation

  2018cited by this paper
• PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response.

  2018cited by this paper
• C-type lectins in immunity and homeostasis

  2018cited by this paper
• BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis.

  2018cited by this paper
• Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy.

  2018cited by this paper
• Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

  2018cited by this paper
• Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

  2018cited by this paper
• Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

  2018cited by this paper
• Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis

  2018cited by this paper
• Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response.

  2018cited by this paper
• O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity.

  2018cited by this paper
• Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

  2018cited by this paper
• Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown.

  2018cited by this paper
• Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

  2018cited by this paper
• Demethylase Kdm6a epigenetically promotes IL-6 and IFN-β production in macrophages.

  2017cited by this paper
• Statistical and integrative system-level analysis of DNA methylation data

  2017cited by this paper
• TET-mediated active DNA demethylation: mechanism, function and beyond

  2017cited by this paper
• Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I mediated immunity

  2017cited by this paper
• MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response

  2017cited by this paper
• Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

  2017cited by this paper
• The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages

  2017cited by this paper
• Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.

  2017cited by this paper
• Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

  2017cited by this paper
• An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism

  2017cited by this paper
• α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

  2017cited by this paper
• The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleus

  2017cited by this paper
• RNA modifications go viral

  2017cited by this paper
• Gene regulation in the immune system by long noncoding RNAs

  2017cited by this paper
• Sensing Self and Foreign Circular RNAs by Intron Identity.

  2017cited by this paper
• Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition

  2017cited by this paper
• Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

  2017cited by this paper
• Immunobiology of Long Noncoding RNAs.

  2017cited by this paper
• MKL1 is an epigenetic mediator of TNF‐α‐induced proinflammatory transcription in macrophages by interacting with ASH2

  2017cited by this paper
• The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3

  2017cited by this paper
• Dynamic RNA Modifications in Gene Expression Regulation.

  2017cited by this paper
• The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation

  2017cited by this paper
• Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response

  2017cited by this paper
• Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha

  2017cited by this paper
• Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival

  2017cited by this paper
• Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.

  2016cited by this paper
• Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

  2016cited by this paper
• TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection

  2016cited by this paper
• A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.

  2016cited by this paper
• Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

  2016cited by this paper
• Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

  2016cited by this paper
• β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

  2016cited by this paper
• TET3 Inhibits Type I IFN Production Independent of DNA Demethylation.

  2016cited by this paper
• RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

  2016cited by this paper
• Trained immunity: A program of innate immune memory in health and disease

  2016cited by this paper
• DNA methylation on N6-adenine in mammalian embryonic stem cells

  2016cited by this paper
• The molecular hallmarks of epigenetic control

  2016cited by this paper
• From profiles to function in epigenomics

  2016cited by this paper
• Systems Approaches towards Molecular Profiling of Human Immunity.

  2016cited by this paper
• Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response

  2016cited by this paper
• Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

  2016cited by this paper
• H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.

  2016cited by this paper
• Epigenetics: A New Model for Intracellular Parasite-Host Cell Regulation.

  2016cited by this paper
• Targeting chromatin kinases reveals their role in inducible transcription of inflammatory genes

  2016cited by this paper
• Rb selectively inhibits innate IFN-β production by enhancing deacetylation of IFN-β promoter through HDAC1 and HDAC8.

  2016cited by this paper
• Insights into newly discovered marks and readers of epigenetic information.

  2016cited by this paper
• Single-molecule decoding of combinatorially modified nucleosomes

  2016cited by this paper
• Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

  2015cited by this paper
• Histone Lysine Methyltransferase Ezh1 Promotes TLR-Triggered Inflammatory Cytokine Production by Suppressing Tollip

  2015cited by this paper
• Epigenomics: Roadmap for regulation

  2015cited by this paper
• Epigenetics in rheumatoid arthritis

  2015cited by this paper
• Epigenetics in autoimmune diseases: Pathogenesis and prospects for therapy.

  2015cited by this paper
• Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3

  2015cited by this paper
• Exogenous thymine DNA glycosylase regulates epigenetic modifications and meiotic cell cycle progression of mouse oocytes.

  2015cited by this paper
• Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs

  2015cited by this paper
• Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

  2015cited by this paper
• An Adenine Code for DNA: A Second Life for N6-Methyladenine.

  2015cited by this paper
• Long noncoding RNAs in innate immunity

  2015cited by this paper
• The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF

  2015cited by this paper
• Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.

  2015cited by this paper
• Exon-intron circular RNAs regulate transcription in the nucleus

  2015cited by this paper
• Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy

  2015cited by this paper
• Unique features of long non-coding RNA biogenesis and function

  2015cited by this paper
• Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation.

  2015cited by this paper
• RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo

  2015cited by this paper
• Single-cell epigenomics: techniques and emerging applications

  2015cited by this paper
• Epigenetic modulation of metabolic decisions.

  2015cited by this paper
• Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ.

  2015cited by this paper
• NF-κB: Regulation by Methylation.

  2015cited by this paper
• Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease

  2015cited by this paper
• RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

  2015cited by this paper
• Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

  2015cited by this paper
• Akirin2 is critical for inducing inflammatory genes by bridging IκB‐ζ and the SWI/SNF complex

  2014cited by this paper
• mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

  2014cited by this paper
• Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

  2014cited by this paper
• Advances in the profiling of DNA modifications: cytosine methylation and beyond

  2014cited by this paper
• Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages

  2014cited by this paper
• Type VI secretion system effectors: poisons with a purpose

  2014cited by this paper
• The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection

  2014cited by this paper
• Chromatin contributions to the regulation of innate immunity.

  2014cited by this paper
• Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity.

  2014cited by this paper
• Death Domain-associated Protein 6 (Daxx) Selectively Represses IL-6 Transcription through Histone Deacetylase 1 (HDAC1)-mediated Histone Deacetylation in Macrophages*

  2014cited by this paper
• MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex

  2014cited by this paper

• The involvement of miRNAs in the enhanced immune response of oysters via haemocyte-mediated immune priming

  2026cites this paper
• Editorial: Immunomics in aquaculture: deciphering the immune landscape of aquacultured animals through omics technologies.

  2026cites this paper
• STING inhibition and BD1-selective BET blockade limit ischemia-reperfusion-induced hepatic tissue remodeling by suppressing pro-inflammasome signaling.

  2026cites this paper
• Prolactin and 17β-Estradiol Are Epigenetic Regulators That Modify the Effector Response of Bovine Macrophages During Staphylococcus aureus Challenge

  2026cites this paper
• Host-yeast interactions and its influence on health and disease

  2026cites this paper
• Potentiating Chemo‐Immunotherapy via a Programmable Nanocapsule‐Hydrogel Platform for Sequential Tumor Microenvironment Remodeling

  2026cites this paper
• Take control of expression: effector-mediated modulation of the host transcriptional machinery

  2026cites this paper
• Recent perspectives on macrophage memory: types, mechanisms, and characteristics in pulmonary diseases

  2026cites this paper
• H3K27me3-Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion.

  2026cites this paper
• Histone demethylase KDM4B epigenetically controls NLRP3 expression to enhance inflammatory responses.

  2026cites this paper
• Estimation of sST2 and CXCR3 levels in serum of patients with chronic and acute pyelonephritis caused by E. coli

  2025cites this paper
• Pharmacology of Epitranscriptomic Modifications: Decoding the Therapeutic Potential of RNA Modifications in Drug Resistance.

  2025cites this paper
• Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity.

  2025cites this paper
• Histone lysine demethylase 5 regulates haemocyte proliferation during immune priming in the oyster Crassostrea gigas.

  2025cites this paper
• Oxidative, Genotoxic and Epigenotoxic Effects of Pimpla turionellae Venom at Pharmacological Perspective

  2025cites this paper
• Epigenetic modifications and immune responses in HIV-infected infants: a narrative review

  2025cites this paper
• Xuanbai Chengqi Decoction Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the EZH2/EGR1/TXNIP Signaling Pathway.

  2025cites this paper
• In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation

  2025cites this paper
• Low‐Coverage Whole‐Genome Analysis of Population Structure, Bottlenecks, and Selection in Indiana Bats Before and After White‐Nose Syndrome

  2025cites this paper
• Protein swarm-based cause-effect analysis: effects of microRNAs on cooperation networks linking COVID-19 infections, atherosclerosis, and Alzheimer's disease

  2025cites this paper
• Immuno-epigenetic paradigms in coronavirus infection

  2025cites this paper
• Mediator complex subunit MED23 dampens antiviral innate immunity by restricting RIG-I expression

  2025cites this paper
• The functional Mi-2/Foxo complex targets PGRP-SC2 for the Drosophila immune defense against bacterial infection

  2025cites this paper
• Conserved chromatin regulators control the transcriptional immune response to intracellular pathogens in Caenorhabditis elegans

  2025cites this paper
• The Roles of Histone H3K18 Lactylation, Acetylation, and Lactylation/Acetylation Ratio as Potential Biomarkers in the Diagnosis and Severity Assessment of Sepsis and Septic Shock

  2025cites this paper
• The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation

  2025cites this paper
• Improving the odds of survival: transgenerational effects of infections

  2025cites this paper
• A novel ROR1-targeting antibody-PROTAC conjugate promotes BRD4 degradation for solid tumor treatment

  2025cites this paper
• Melatonin Modulates ZAP70 and CD40 Transcripts via Histone Modifications in Canine Ileum Epithelial Cells

  2025cites this paper
• Immunoregulatory role of exosomal circRNAs in the tumor microenvironment

  2025cites this paper
• TEAMwork: Interplay of Post‐Transcriptional Mechanisms, Epigenetics and Metabolism in (Auto‐)Immunity

  2025cites this paper
• The Effect of Phenamacril on Soil Microbial Communities and Resistance Development in Fusarium fujikuroi.

  2025cites this paper
• MicroRNAs in the abscopal effect: bridging radiotherapy and systemic anti-tumor immunity for enhanced cancer therapy

  2025cites this paper
• Post-translational modifications: Bridging viral infections and inflammatory bowel disease.

  2025cites this paper
• Glycerophospholipid metabolism licenses IgE-mediated mast cell degranulation.

  2025cites this paper
• Constraints and tunability of antigen-agnostic memory durability

  2025cites this paper
• Multifunctional Nanocarrier Drug Delivery Systems: From Diverse Design to Precise Biomedical Applications

  2025cites this paper
• Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

  2025cites this paper
• Molecular characterization, transcriptional profiling, and immune functional analysis of CD94 from Nile tilapia (Oreochromis niloticus).

  2025cites this paper
• A Pseudomonas aeruginosa quorum-sensing metabolite manipulates macrophage ferroptosis through a methylation pathway

  2025cites this paper
• Aging as the wound that fails to heal: a bioenergetic continuum of resolution failure

  2025cites this paper
• Central Role of Toll-like Receptor-9 Gene Function in Inflammation-Mediated Neuronal Plasticity: Implications for Long-Term Memory Development

  2025cites this paper
• Exploratory analysis of epigenetic dynamics and small extracellular vesicles in Penaeus vannamei hemocytes under inactivated Vibrio parahaemolyticus priming.

  2025cites this paper
• Genetic determinants of monocyte splicing are enriched for disease susceptibility loci

  2025cites this paper
• Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy

  2025cites this paper
• Differential Methylation Patterns Predict HBsAg Seroconversion in Hepatitis B Virus Reactivation Patients

  2025cites this paper
• Copper Homeostasis at the Crossroads of Cellular Metabolism, Epigenetic Regulation and Protein Trafficking

  2025cites this paper
• Epigenetic biomarkers of inflammation in studies on mental health: Current applications, limitations, and future directions.

  2025cites this paper
• Lysine demethylase 6 (KDM6): A promising therapeutic target in autoimmune disorders and cancer.

  2025cites this paper
• Steroid hormone ouabain cooperates with Na+,K+-ATPase to improve innate immunity against bacterial infections through a non-classic training mechanism regulated by mrna reprogramming

  2025cites this paper
• Anesthetic-induced epigenetic alterations: mechanisms and long-term clinical implications

  2025cites this paper
• RSV-Induced Epigenetic Reprogramming: Mechanisms and Therapeutic Opportunities

  2025cites this paper
• Polyphenols-mediated immune regulation: Metabolite-driven epigenetic regulatory mechanisms.

  2025cites this paper
• Epigenetic reprogramming of the host immune system during acute HIV

  2025cites this paper
• Neuro-Immune Communication at the Core of Craving-Associated Brain Structural Network Reconfiguration in Methamphetamine Users

  2024cites this paper
• Epigenetic Alterations That Are the Backbone of Immune Evasion in T-cell Malignancies

  2024cites this paper
• Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3.

  2024cites this paper
• Vaccine Strategies Against RNA Viruses: Current Advances and Future Directions

  2024cites this paper
• NEIL1 block IFN-β production and enhance vRNP function to facilitate influenza A virus proliferation

  2024cites this paper
• KDM4 Regulates the Glycolysis of Hemocytes in the Immune Priming of Eriocheir sinensis

  2024cites this paper
• Comprehensive multi-omics analysis identifies chromatin regulator-related signatures and TFF1 as a therapeutic target in lung adenocarcinoma through a 429-combination machine learning approach

  2024cites this paper
• Epigenetic mechanisms of alveolar macrophage activation in chemical-induced acute lung injury

  2024cites this paper
• Host-directed therapies modulating innate immunity against infection in hematologic malignancies.

  2024cites this paper
• Polo-like kinase 2 promotes microglial activation via regulation of the HSP90α/IKKβ pathway.

  2024cites this paper
• Microbiota and Lipotoxicity.

  2024cites this paper
• P-stalk ribosomes act as master regulators of cytokine-mediated processes.

  2024cites this paper
• Inducible antibacterial responses in macrophages

  2024cites this paper
• Prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective study

  2024cites this paper
• Temporally-coordinated bivalent histone modifications of BCG1 enable fungal invasion and immune evasion

  2024cites this paper
• The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis

  2024cites this paper
• PROTAC‐Mediated HDAC7 Protein Degradation Unveils Its Deacetylase‐Independent Proinflammatory Function in Macrophages

  2024cites this paper
• Assessing Marine Ecosystem Health Using Multi-Omic Analysis of Blue Mussel Liquid Biopsies: A Case Study within a National Marine Park.

  2024cites this paper
• Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments

  2024cites this paper
• How does orthodontic tooth movement influence the dental pulp? RNA-sequencing on human premolars.

  2024cites this paper
• E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP‐1 Proteasomal Degradation

  2024cites this paper
• Immune Homeostasis: A Novel Example of Teamwork.

  2024cites this paper
• Bromodomain and Extraterminal Domain Protein 2 in Multiple Human Diseases

  2024cites this paper
• m6A Reader YTHDC1 Impairs Respiratory Syncytial Virus Infection by Downregulating Membrane CX3CR1 Expression

  2024cites this paper
• Epigenetic Mechanisms in Sepsis-Associated Acute Kidney Injury

  2024cites this paper
• Streptavidin‐Biotin Complexes as Tools for Modulating an Important DNA Epigenetic Modification†

  2024cites this paper
• Epigenetic regulation of innate immune dynamics during inflammation.

  2024cites this paper
• Methyltransferase Setd2 prevents T cell–mediated autoimmune diseases via phospholipid remodeling

  2024cites this paper
• Analog epigenetic memory revealed by targeted chromatin editing

  2024cites this paper
• The Role of Changes in Structure and Dynamics of Chromatin due to COVID-19

  2024cites this paper
• The Modification of H3K4me3 Enhanced the Expression of CgTLR3 in Hemocytes to Increase CgIL17-1 Production in the Immune Priming of Crassostrea gigas

  2024cites this paper
• Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity.

  2024cites this paper
• Genetic and Epigenetic Determinants of COVID-19 Susceptibility: A Systematic Review.

  2024cites this paper
• S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens

  2024cites this paper
• Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis

  2024cites this paper
• Epigenetic variation impacts individual differences in the transcriptional response to influenza infection

  2024cites this paper
• Beyond Genes: Epiregulomes as Molecular Commanders in Innate Immunity.

  2024cites this paper
• The RNA m6A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression

  2023cites this paper
• Advances in Research on Protein Arginine Methyltransferase 2: Functions and Diseases.

  2023cites this paper
• METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.

  2023cites this paper
• RNA m6A Methylation Suppresses Insect Juvenile Hormone Degradation to Minimize Fitness Costs in Response to A Pathogenic Attack

  2023cites this paper
• ncRNAs: an unexplored cellular defense mechanism in leprosy

  2023cites this paper
• Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation

  2023cites this paper
• Genome-wide chromatin interaction profiling reveals a vital role of super-enhancers and rearrangements in host enhancer contacts during BmNPV infection

  2023cites this paper
• Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases

  2023cites this paper
• The regulation of antiviral innate immunity through non-m6A RNA modifications

  2023cites this paper